Amino acid dipepetide frequency for Feline immunodeficiency virus (isolate Petaluma) (FIV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.046AlaAla: 6.046 ± 2.929
1.68AlaCys: 1.68 ± 0.42
2.015AlaAsp: 2.015 ± 0.748
5.71AlaGlu: 5.71 ± 1.707
2.015AlaPhe: 2.015 ± 0.566
5.375AlaGly: 5.375 ± 0.685
0.672AlaHis: 0.672 ± 0.59
5.71AlaIle: 5.71 ± 1.15
3.359AlaLys: 3.359 ± 0.66
5.039AlaLeu: 5.039 ± 1.755
3.023AlaMet: 3.023 ± 1.538
2.687AlaAsn: 2.687 ± 1.484
3.695AlaPro: 3.695 ± 1.324
2.351AlaGln: 2.351 ± 0.909
2.687AlaArg: 2.687 ± 1.266
1.008AlaSer: 1.008 ± 0.694
3.023AlaThr: 3.023 ± 1.435
2.687AlaVal: 2.687 ± 1.171
1.008AlaTrp: 1.008 ± 0.26
1.344AlaTyr: 1.344 ± 0.311
0.0AlaXaa: 0.0 ± 0.0
Cys
1.008CysAla: 1.008 ± 0.26
1.008CysCys: 1.008 ± 0.903
0.672CysAsp: 0.672 ± 0.315
0.0CysGlu: 0.0 ± 0.0
0.336CysPhe: 0.336 ± 0.346
2.351CysGly: 2.351 ± 1.364
0.336CysHis: 0.336 ± 0.264
1.68CysIle: 1.68 ± 0.643
2.015CysLys: 2.015 ± 0.822
1.68CysLeu: 1.68 ± 1.063
0.336CysMet: 0.336 ± 0.264
2.351CysAsn: 2.351 ± 1.02
0.672CysPro: 0.672 ± 0.256
1.344CysGln: 1.344 ± 0.419
1.68CysArg: 1.68 ± 0.611
1.344CysSer: 1.344 ± 0.311
2.351CysThr: 2.351 ± 0.95
0.336CysVal: 0.336 ± 0.231
1.344CysTrp: 1.344 ± 0.974
1.344CysTyr: 1.344 ± 0.712
0.0CysXaa: 0.0 ± 0.0
Asp
1.344AspAla: 1.344 ± 0.617
2.351AspCys: 2.351 ± 0.436
1.008AspAsp: 1.008 ± 0.365
3.023AspGlu: 3.023 ± 0.976
3.023AspPhe: 3.023 ± 1.018
1.008AspGly: 1.008 ± 0.694
0.0AspHis: 0.0 ± 0.0
4.703AspIle: 4.703 ± 0.59
2.351AspLys: 2.351 ± 0.988
3.695AspLeu: 3.695 ± 0.498
1.344AspMet: 1.344 ± 0.779
2.687AspAsn: 2.687 ± 1.248
3.023AspPro: 3.023 ± 0.662
1.008AspGln: 1.008 ± 0.62
1.68AspArg: 1.68 ± 0.711
1.68AspSer: 1.68 ± 1.085
2.687AspThr: 2.687 ± 0.561
0.336AspVal: 0.336 ± 0.231
1.68AspTrp: 1.68 ± 0.597
2.687AspTyr: 2.687 ± 0.717
0.0AspXaa: 0.0 ± 0.0
Glu
5.375GluAla: 5.375 ± 1.001
0.336GluCys: 0.336 ± 0.264
3.023GluAsp: 3.023 ± 1.22
10.749GluGlu: 10.749 ± 2.147
1.008GluPhe: 1.008 ± 0.41
6.718GluGly: 6.718 ± 1.116
0.672GluHis: 0.672 ± 0.256
7.39GluIle: 7.39 ± 0.842
8.734GluLys: 8.734 ± 1.462
5.375GluLeu: 5.375 ± 1.254
1.68GluMet: 1.68 ± 0.443
1.68GluAsn: 1.68 ± 0.825
2.015GluPro: 2.015 ± 0.538
2.687GluGln: 2.687 ± 0.623
3.023GluArg: 3.023 ± 1.168
2.687GluSer: 2.687 ± 0.879
3.023GluThr: 3.023 ± 0.834
5.71GluVal: 5.71 ± 0.524
1.008GluTrp: 1.008 ± 0.576
1.68GluTyr: 1.68 ± 0.457
0.0GluXaa: 0.0 ± 0.0
Phe
3.023PheAla: 3.023 ± 1.028
0.336PheCys: 0.336 ± 0.264
1.344PheAsp: 1.344 ± 0.558
0.336PheGlu: 0.336 ± 0.231
0.336PhePhe: 0.336 ± 0.264
2.687PheGly: 2.687 ± 0.546
1.008PheHis: 1.008 ± 0.365
2.015PheIle: 2.015 ± 0.541
2.351PheLys: 2.351 ± 0.85
2.351PheLeu: 2.351 ± 0.754
0.672PheMet: 0.672 ± 0.589
2.015PheAsn: 2.015 ± 0.719
0.0PhePro: 0.0 ± 0.0
0.336PheGln: 0.336 ± 0.231
2.687PheArg: 2.687 ± 1.132
1.344PheSer: 1.344 ± 0.53
2.351PheThr: 2.351 ± 0.598
2.351PheVal: 2.351 ± 1.341
0.672PheTrp: 0.672 ± 0.67
0.672PheTyr: 0.672 ± 0.67
0.0PheXaa: 0.0 ± 0.0
Gly
4.031GlyAla: 4.031 ± 1.474
1.68GlyCys: 1.68 ± 0.776
3.023GlyAsp: 3.023 ± 0.74
4.367GlyGlu: 4.367 ± 1.388
2.351GlyPhe: 2.351 ± 0.794
5.039GlyGly: 5.039 ± 1.176
1.008GlyHis: 1.008 ± 0.62
5.039GlyIle: 5.039 ± 0.628
7.054GlyLys: 7.054 ± 1.783
5.71GlyLeu: 5.71 ± 1.371
1.344GlyMet: 1.344 ± 0.451
5.71GlyAsn: 5.71 ± 1.351
5.039GlyPro: 5.039 ± 0.491
1.008GlyGln: 1.008 ± 0.432
3.695GlyArg: 3.695 ± 0.824
4.703GlySer: 4.703 ± 0.691
2.687GlyThr: 2.687 ± 0.898
5.039GlyVal: 5.039 ± 0.733
1.008GlyTrp: 1.008 ± 0.365
4.703GlyTyr: 4.703 ± 1.455
0.0GlyXaa: 0.0 ± 0.0
His
0.672HisAla: 0.672 ± 0.256
0.336HisCys: 0.336 ± 0.264
0.336HisAsp: 0.336 ± 0.264
0.672HisGlu: 0.672 ± 0.463
0.672HisPhe: 0.672 ± 0.256
0.336HisGly: 0.336 ± 0.264
0.0HisHis: 0.0 ± 0.0
0.336HisIle: 0.336 ± 0.231
1.344HisLys: 1.344 ± 0.615
2.015HisLeu: 2.015 ± 0.819
0.0HisMet: 0.0 ± 0.0
0.336HisAsn: 0.336 ± 0.231
1.008HisPro: 1.008 ± 0.432
1.68HisGln: 1.68 ± 0.825
0.336HisArg: 0.336 ± 0.264
1.008HisSer: 1.008 ± 0.544
1.008HisThr: 1.008 ± 0.365
0.672HisVal: 0.672 ± 0.256
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.023IleAla: 3.023 ± 0.633
1.008IleCys: 1.008 ± 0.511
3.359IleAsp: 3.359 ± 0.658
4.031IleGlu: 4.031 ± 0.808
2.351IlePhe: 2.351 ± 0.672
7.39IleGly: 7.39 ± 1.181
2.015IleHis: 2.015 ± 0.767
4.703IleIle: 4.703 ± 1.784
5.039IleLys: 5.039 ± 1.827
5.375IleLeu: 5.375 ± 1.374
1.344IleMet: 1.344 ± 0.556
3.359IleAsn: 3.359 ± 1.286
5.375IlePro: 5.375 ± 2.045
4.367IleGln: 4.367 ± 0.636
5.039IleArg: 5.039 ± 1.188
3.359IleSer: 3.359 ± 0.916
2.687IleThr: 2.687 ± 0.756
2.015IleVal: 2.015 ± 0.8
2.015IleTrp: 2.015 ± 0.767
2.351IleTyr: 2.351 ± 0.801
0.0IleXaa: 0.0 ± 0.0
Lys
7.054LysAla: 7.054 ± 1.182
1.68LysCys: 1.68 ± 0.889
2.687LysAsp: 2.687 ± 1.177
6.382LysGlu: 6.382 ± 1.53
4.031LysPhe: 4.031 ± 0.641
3.359LysGly: 3.359 ± 1.268
0.672LysHis: 0.672 ± 0.463
4.703LysIle: 4.703 ± 1.461
7.726LysLys: 7.726 ± 2.27
7.054LysLeu: 7.054 ± 1.678
3.359LysMet: 3.359 ± 0.769
2.015LysAsn: 2.015 ± 0.426
2.015LysPro: 2.015 ± 1.39
3.695LysGln: 3.695 ± 0.498
5.039LysArg: 5.039 ± 1.892
2.687LysSer: 2.687 ± 0.566
2.015LysThr: 2.015 ± 0.729
5.039LysVal: 5.039 ± 1.276
2.687LysTrp: 2.687 ± 1.123
0.672LysTyr: 0.672 ± 0.451
0.0LysXaa: 0.0 ± 0.0
Leu
5.375LeuAla: 5.375 ± 1.516
1.344LeuCys: 1.344 ± 0.656
5.71LeuAsp: 5.71 ± 1.608
7.39LeuGlu: 7.39 ± 1.643
2.687LeuPhe: 2.687 ± 1.992
6.718LeuGly: 6.718 ± 2.273
0.672LeuHis: 0.672 ± 0.256
4.703LeuIle: 4.703 ± 1.472
5.039LeuLys: 5.039 ± 0.852
7.726LeuLeu: 7.726 ± 0.929
1.68LeuMet: 1.68 ± 0.978
3.359LeuAsn: 3.359 ± 1.296
5.375LeuPro: 5.375 ± 1.326
7.054LeuGln: 7.054 ± 1.39
6.046LeuArg: 6.046 ± 1.139
5.039LeuSer: 5.039 ± 1.082
3.695LeuThr: 3.695 ± 1.063
3.695LeuVal: 3.695 ± 1.241
2.015LeuTrp: 2.015 ± 0.745
2.015LeuTyr: 2.015 ± 0.586
0.0LeuXaa: 0.0 ± 0.0
Met
3.695MetAla: 3.695 ± 1.482
0.336MetCys: 0.336 ± 0.463
2.015MetAsp: 2.015 ± 0.816
3.359MetGlu: 3.359 ± 0.711
0.0MetPhe: 0.0 ± 0.0
1.68MetGly: 1.68 ± 0.921
0.0MetHis: 0.0 ± 0.0
2.351MetIle: 2.351 ± 0.96
1.008MetLys: 1.008 ± 0.26
2.687MetLeu: 2.687 ± 0.95
1.344MetMet: 1.344 ± 0.756
0.672MetAsn: 0.672 ± 0.256
0.672MetPro: 0.672 ± 0.382
1.344MetGln: 1.344 ± 1.007
1.008MetArg: 1.008 ± 0.41
2.015MetSer: 2.015 ± 0.566
1.344MetThr: 1.344 ± 0.687
1.68MetVal: 1.68 ± 0.811
1.008MetTrp: 1.008 ± 0.875
1.68MetTyr: 1.68 ± 0.776
0.0MetXaa: 0.0 ± 0.0
Asn
2.687AsnAla: 2.687 ± 0.725
1.68AsnCys: 1.68 ± 1.03
0.336AsnAsp: 0.336 ± 0.44
2.015AsnGlu: 2.015 ± 0.614
1.68AsnPhe: 1.68 ± 0.701
3.359AsnGly: 3.359 ± 0.752
1.008AsnHis: 1.008 ± 0.41
5.039AsnIle: 5.039 ± 1.242
3.023AsnLys: 3.023 ± 0.579
3.359AsnLeu: 3.359 ± 0.596
2.687AsnMet: 2.687 ± 0.397
3.023AsnAsn: 3.023 ± 1.417
3.695AsnPro: 3.695 ± 1.332
4.031AsnGln: 4.031 ± 1.063
3.023AsnArg: 3.023 ± 1.244
3.359AsnSer: 3.359 ± 0.596
2.015AsnThr: 2.015 ± 0.58
3.695AsnVal: 3.695 ± 0.831
1.68AsnTrp: 1.68 ± 0.65
2.351AsnTyr: 2.351 ± 0.762
0.0AsnXaa: 0.0 ± 0.0
Pro
1.68ProAla: 1.68 ± 0.811
1.008ProCys: 1.008 ± 0.41
3.023ProAsp: 3.023 ± 0.476
5.375ProGlu: 5.375 ± 1.128
1.344ProPhe: 1.344 ± 0.558
6.718ProGly: 6.718 ± 1.486
0.672ProHis: 0.672 ± 0.463
1.008ProIle: 1.008 ± 0.432
3.023ProLys: 3.023 ± 1.102
4.367ProLeu: 4.367 ± 0.628
0.672ProMet: 0.672 ± 0.315
1.344ProAsn: 1.344 ± 0.511
3.359ProPro: 3.359 ± 1.11
3.695ProGln: 3.695 ± 0.92
2.687ProArg: 2.687 ± 0.779
3.023ProSer: 3.023 ± 0.653
2.015ProThr: 2.015 ± 0.475
3.023ProVal: 3.023 ± 0.407
0.336ProTrp: 0.336 ± 0.231
2.015ProTyr: 2.015 ± 0.802
0.0ProXaa: 0.0 ± 0.0
Gln
2.351GlnAla: 2.351 ± 1.024
2.015GlnCys: 2.015 ± 0.76
1.68GlnAsp: 1.68 ± 0.721
4.367GlnGlu: 4.367 ± 0.992
0.336GlnPhe: 0.336 ± 0.264
3.359GlnGly: 3.359 ± 0.888
0.0GlnHis: 0.0 ± 0.0
2.687GlnIle: 2.687 ± 0.838
4.367GlnLys: 4.367 ± 2.341
5.375GlnLeu: 5.375 ± 1.507
2.351GlnMet: 2.351 ± 0.805
3.359GlnAsn: 3.359 ± 0.491
3.023GlnPro: 3.023 ± 0.91
2.351GlnGln: 2.351 ± 0.525
2.015GlnArg: 2.015 ± 1.176
2.687GlnSer: 2.687 ± 0.792
2.351GlnThr: 2.351 ± 0.815
3.695GlnVal: 3.695 ± 0.67
1.68GlnTrp: 1.68 ± 0.636
2.687GlnTyr: 2.687 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
3.359ArgAla: 3.359 ± 1.047
1.008ArgCys: 1.008 ± 0.558
2.015ArgAsp: 2.015 ± 0.854
4.031ArgGlu: 4.031 ± 1.086
2.351ArgPhe: 2.351 ± 0.985
3.023ArgGly: 3.023 ± 0.954
0.672ArgHis: 0.672 ± 0.256
3.023ArgIle: 3.023 ± 0.889
4.031ArgLys: 4.031 ± 1.582
4.703ArgLeu: 4.703 ± 2.399
2.015ArgMet: 2.015 ± 1.294
4.031ArgAsn: 4.031 ± 2.115
1.68ArgPro: 1.68 ± 0.635
4.367ArgGln: 4.367 ± 0.88
6.046ArgArg: 6.046 ± 1.376
1.008ArgSer: 1.008 ± 0.433
1.68ArgThr: 1.68 ± 0.61
3.359ArgVal: 3.359 ± 1.494
1.68ArgTrp: 1.68 ± 1.03
1.344ArgTyr: 1.344 ± 0.656
0.0ArgXaa: 0.0 ± 0.0
Ser
1.68SerAla: 1.68 ± 0.711
1.344SerCys: 1.344 ± 0.451
1.68SerAsp: 1.68 ± 0.703
3.359SerGlu: 3.359 ± 0.884
0.672SerPhe: 0.672 ± 0.589
3.695SerGly: 3.695 ± 1.05
0.336SerHis: 0.336 ± 0.346
3.359SerIle: 3.359 ± 0.638
3.023SerLys: 3.023 ± 0.917
6.046SerLeu: 6.046 ± 0.949
1.008SerMet: 1.008 ± 0.855
4.031SerAsn: 4.031 ± 1.016
3.023SerPro: 3.023 ± 1.51
3.023SerGln: 3.023 ± 0.454
2.015SerArg: 2.015 ± 1.083
4.031SerSer: 4.031 ± 1.181
4.031SerThr: 4.031 ± 1.594
0.672SerVal: 0.672 ± 0.256
2.015SerTrp: 2.015 ± 0.75
1.008SerTyr: 1.008 ± 0.465
0.0SerXaa: 0.0 ± 0.0
Thr
4.031ThrAla: 4.031 ± 1.401
1.344ThrCys: 1.344 ± 0.712
2.351ThrAsp: 2.351 ± 0.502
3.359ThrGlu: 3.359 ± 1.123
0.672ThrPhe: 0.672 ± 0.528
5.039ThrGly: 5.039 ± 1.05
1.008ThrHis: 1.008 ± 0.26
2.687ThrIle: 2.687 ± 0.853
2.351ThrLys: 2.351 ± 1.155
6.046ThrLeu: 6.046 ± 0.824
1.008ThrMet: 1.008 ± 0.465
1.68ThrAsn: 1.68 ± 0.643
2.015ThrPro: 2.015 ± 0.745
2.015ThrGln: 2.015 ± 0.681
2.351ThrArg: 2.351 ± 0.977
3.359ThrSer: 3.359 ± 0.961
3.023ThrThr: 3.023 ± 1.237
2.687ThrVal: 2.687 ± 0.657
1.344ThrTrp: 1.344 ± 0.615
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
2.015ValAla: 2.015 ± 0.947
1.008ValCys: 1.008 ± 0.432
3.023ValAsp: 3.023 ± 1.223
3.359ValGlu: 3.359 ± 1.286
1.008ValPhe: 1.008 ± 0.432
3.023ValGly: 3.023 ± 0.776
1.344ValHis: 1.344 ± 0.511
3.359ValIle: 3.359 ± 0.582
5.039ValLys: 5.039 ± 1.122
5.375ValLeu: 5.375 ± 1.369
2.351ValMet: 2.351 ± 0.306
3.023ValAsn: 3.023 ± 0.919
3.359ValPro: 3.359 ± 0.741
2.687ValGln: 2.687 ± 1.11
0.672ValArg: 0.672 ± 0.451
3.023ValSer: 3.023 ± 1.476
3.359ValThr: 3.359 ± 1.308
2.015ValVal: 2.015 ± 0.58
1.008ValTrp: 1.008 ± 0.41
0.672ValTyr: 0.672 ± 0.256
0.0ValXaa: 0.0 ± 0.0
Trp
2.015TrpAla: 2.015 ± 0.58
1.008TrpCys: 1.008 ± 0.853
1.008TrpAsp: 1.008 ± 0.662
1.344TrpGlu: 1.344 ± 0.712
0.672TrpPhe: 0.672 ± 0.382
2.015TrpGly: 2.015 ± 0.659
0.336TrpHis: 0.336 ± 0.463
2.687TrpIle: 2.687 ± 0.55
1.68TrpLys: 1.68 ± 0.611
0.336TrpLeu: 0.336 ± 0.264
0.336TrpMet: 0.336 ± 0.231
3.023TrpAsn: 3.023 ± 1.18
0.672TrpPro: 0.672 ± 0.449
1.68TrpGln: 1.68 ± 0.852
2.015TrpArg: 2.015 ± 0.709
1.008TrpSer: 1.008 ± 0.875
1.344TrpThr: 1.344 ± 0.615
1.008TrpVal: 1.008 ± 0.41
1.008TrpTrp: 1.008 ± 0.566
1.68TrpTyr: 1.68 ± 0.383
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.672TyrAla: 0.672 ± 0.463
1.68TyrCys: 1.68 ± 1.074
1.008TyrAsp: 1.008 ± 0.432
1.344TyrGlu: 1.344 ± 0.615
1.344TyrPhe: 1.344 ± 0.617
1.344TyrGly: 1.344 ± 0.511
0.336TyrHis: 0.336 ± 0.264
3.023TyrIle: 3.023 ± 1.854
2.015TyrLys: 2.015 ± 0.426
3.023TyrLeu: 3.023 ± 1.062
1.008TyrMet: 1.008 ± 0.41
3.359TyrAsn: 3.359 ± 2.275
0.672TyrPro: 0.672 ± 0.315
2.015TyrGln: 2.015 ± 0.82
1.68TyrArg: 1.68 ± 1.404
2.015TyrSer: 2.015 ± 1.116
1.68TyrThr: 1.68 ± 0.703
1.008TyrVal: 1.008 ± 0.511
1.68TyrTrp: 1.68 ± 0.881
1.68TyrTyr: 1.68 ± 0.728
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski