Amino acid dipepetide frequency for Aspergillus caelatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.002AlaAla: 8.002 ± 0.05	1.17AlaCys: 1.17 ± 0.014	3.988AlaAsp: 3.988 ± 0.028	4.731AlaGlu: 4.731 ± 0.038	3.228AlaPhe: 3.228 ± 0.024	5.524AlaGly: 5.524 ± 0.031	1.79AlaHis: 1.79 ± 0.017	4.46AlaIle: 4.46 ± 0.029	3.649AlaLys: 3.649 ± 0.028	7.783AlaLeu: 7.783 ± 0.041	1.988AlaMet: 1.988 ± 0.017	2.867AlaAsn: 2.867 ± 0.021	4.259AlaPro: 4.259 ± 0.032	3.188AlaGln: 3.188 ± 0.024	4.564AlaArg: 4.564 ± 0.031	6.838AlaSer: 6.838 ± 0.037	5.035AlaThr: 5.035 ± 0.029	5.399AlaVal: 5.399 ± 0.033	1.199AlaTrp: 1.199 ± 0.014	2.284AlaTyr: 2.284 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.012	0.282CysCys: 0.282 ± 0.007	0.747CysAsp: 0.747 ± 0.013	0.641CysGlu: 0.641 ± 0.01	0.614CysPhe: 0.614 ± 0.01	1.013CysGly: 1.013 ± 0.014	0.38CysHis: 0.38 ± 0.008	0.83CysIle: 0.83 ± 0.013	0.526CysLys: 0.526 ± 0.01	1.46CysLeu: 1.46 ± 0.017	0.311CysMet: 0.311 ± 0.007	0.491CysAsn: 0.491 ± 0.009	0.718CysPro: 0.718 ± 0.015	0.527CysGln: 0.527 ± 0.008	0.85CysArg: 0.85 ± 0.013	1.071CysSer: 1.071 ± 0.014	0.769CysThr: 0.769 ± 0.012	0.9CysVal: 0.9 ± 0.014	0.229CysTrp: 0.229 ± 0.006	0.418CysTyr: 0.418 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.346AspAla: 4.346 ± 0.03	0.667AspCys: 0.667 ± 0.011	3.704AspAsp: 3.704 ± 0.036	4.002AspGlu: 4.002 ± 0.031	2.144AspPhe: 2.144 ± 0.021	3.889AspGly: 3.889 ± 0.03	1.277AspHis: 1.277 ± 0.014	3.283AspIle: 3.283 ± 0.025	2.241AspLys: 2.241 ± 0.022	5.093AspLeu: 5.093 ± 0.032	1.264AspMet: 1.264 ± 0.015	1.963AspAsn: 1.963 ± 0.019	3.306AspPro: 3.306 ± 0.026	1.927AspGln: 1.927 ± 0.018	3.044AspArg: 3.044 ± 0.026	4.071AspSer: 4.071 ± 0.036	2.989AspThr: 2.989 ± 0.02	3.607AspVal: 3.607 ± 0.024	0.895AspTrp: 0.895 ± 0.01	1.698AspTyr: 1.698 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.971GluAla: 4.971 ± 0.041	0.696GluCys: 0.696 ± 0.011	3.864GluAsp: 3.864 ± 0.036	5.024GluGlu: 5.024 ± 0.052	1.972GluPhe: 1.972 ± 0.018	3.632GluGly: 3.632 ± 0.029	1.392GluHis: 1.392 ± 0.016	3.095GluIle: 3.095 ± 0.02	3.493GluLys: 3.493 ± 0.035	5.135GluLeu: 5.135 ± 0.034	1.406GluMet: 1.406 ± 0.014	2.35GluAsn: 2.35 ± 0.022	2.693GluPro: 2.693 ± 0.036	2.448GluGln: 2.448 ± 0.023	3.728GluArg: 3.728 ± 0.031	4.31GluSer: 4.31 ± 0.03	3.475GluThr: 3.475 ± 0.025	3.497GluVal: 3.497 ± 0.027	0.889GluTrp: 0.889 ± 0.012	1.759GluTyr: 1.759 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.067PheAla: 3.067 ± 0.025	0.645PheCys: 0.645 ± 0.01	2.272PheAsp: 2.272 ± 0.019	2.084PheGlu: 2.084 ± 0.018	1.791PhePhe: 1.791 ± 0.022	2.906PheGly: 2.906 ± 0.027	1.012PheHis: 1.012 ± 0.014	2.017PheIle: 2.017 ± 0.019	1.464PheLys: 1.464 ± 0.014	3.832PheLeu: 3.832 ± 0.029	0.829PheMet: 0.829 ± 0.012	1.502PheAsn: 1.502 ± 0.018	2.105PhePro: 2.105 ± 0.021	1.488PheGln: 1.488 ± 0.015	2.033PheArg: 2.033 ± 0.017	3.122PheSer: 3.122 ± 0.026	2.281PheThr: 2.281 ± 0.019	2.48PheVal: 2.48 ± 0.022	0.708PheTrp: 0.708 ± 0.011	1.241PheTyr: 1.241 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.109GlyAla: 5.109 ± 0.031	0.985GlyCys: 0.985 ± 0.014	3.528GlyAsp: 3.528 ± 0.028	3.51GlyGlu: 3.51 ± 0.028	2.942GlyPhe: 2.942 ± 0.028	5.331GlyGly: 5.331 ± 0.043	1.719GlyHis: 1.719 ± 0.017	3.817GlyIle: 3.817 ± 0.03	3.296GlyLys: 3.296 ± 0.03	6.366GlyLeu: 6.366 ± 0.033	1.567GlyMet: 1.567 ± 0.017	2.58GlyAsn: 2.58 ± 0.021	3.306GlyPro: 3.306 ± 0.026	2.572GlyGln: 2.572 ± 0.02	3.914GlyArg: 3.914 ± 0.029	5.652GlySer: 5.652 ± 0.032	3.992GlyThr: 3.992 ± 0.026	4.546GlyVal: 4.546 ± 0.03	1.242GlyTrp: 1.242 ± 0.014	2.319GlyTyr: 2.319 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.826HisAla: 1.826 ± 0.017	0.384HisCys: 0.384 ± 0.008	1.328HisAsp: 1.328 ± 0.016	1.334HisGlu: 1.334 ± 0.014	0.957HisPhe: 0.957 ± 0.012	1.781HisGly: 1.781 ± 0.02	0.856HisHis: 0.856 ± 0.017	1.355HisIle: 1.355 ± 0.014	0.88HisLys: 0.88 ± 0.013	2.363HisLeu: 2.363 ± 0.019	0.532HisMet: 0.532 ± 0.009	0.885HisAsn: 0.885 ± 0.013	1.689HisPro: 1.689 ± 0.019	0.96HisGln: 0.96 ± 0.013	1.578HisArg: 1.578 ± 0.017	1.945HisSer: 1.945 ± 0.022	1.328HisThr: 1.328 ± 0.018	1.462HisVal: 1.462 ± 0.016	0.386HisTrp: 0.386 ± 0.008	0.765HisTyr: 0.765 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.367IleAla: 4.367 ± 0.031	0.885IleCys: 0.885 ± 0.013	2.911IleAsp: 2.911 ± 0.023	2.886IleGlu: 2.886 ± 0.023	2.207IlePhe: 2.207 ± 0.024	3.496IleGly: 3.496 ± 0.032	1.327IleHis: 1.327 ± 0.016	2.796IleIle: 2.796 ± 0.025	2.068IleLys: 2.068 ± 0.019	5.022IleLeu: 5.022 ± 0.031	1.093IleMet: 1.093 ± 0.013	1.909IleAsn: 1.909 ± 0.017	3.277IlePro: 3.277 ± 0.021	2.07IleGln: 2.07 ± 0.018	2.878IleArg: 2.878 ± 0.023	4.167IleSer: 4.167 ± 0.024	3.005IleThr: 3.005 ± 0.021	3.433IleVal: 3.433 ± 0.027	0.792IleTrp: 0.792 ± 0.013	1.629IleTyr: 1.629 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.911LysAla: 3.911 ± 0.027	0.573LysCys: 0.573 ± 0.011	2.681LysAsp: 2.681 ± 0.023	3.182LysGlu: 3.182 ± 0.037	1.392LysPhe: 1.392 ± 0.015	2.877LysGly: 2.877 ± 0.026	1.077LysHis: 1.077 ± 0.013	2.174LysIle: 2.174 ± 0.02	2.826LysLys: 2.826 ± 0.04	3.962LysLeu: 3.962 ± 0.031	0.904LysMet: 0.904 ± 0.012	1.702LysAsn: 1.702 ± 0.018	2.527LysPro: 2.527 ± 0.024	1.782LysGln: 1.782 ± 0.018	3.114LysArg: 3.114 ± 0.028	3.301LysSer: 3.301 ± 0.027	2.608LysThr: 2.608 ± 0.021	2.767LysVal: 2.767 ± 0.023	0.667LysTrp: 0.667 ± 0.009	1.393LysTyr: 1.393 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.775LeuAla: 7.775 ± 0.042	1.38LeuCys: 1.38 ± 0.015	5.176LeuAsp: 5.176 ± 0.034	5.525LeuGlu: 5.525 ± 0.039	3.656LeuPhe: 3.656 ± 0.028	6.246LeuGly: 6.246 ± 0.035	2.376LeuHis: 2.376 ± 0.021	4.302LeuIle: 4.302 ± 0.03	4.023LeuLys: 4.023 ± 0.028	8.925LeuLeu: 8.925 ± 0.054	1.913LeuMet: 1.913 ± 0.019	3.337LeuAsn: 3.337 ± 0.025	5.538LeuPro: 5.538 ± 0.035	3.966LeuGln: 3.966 ± 0.028	5.798LeuArg: 5.798 ± 0.036	7.767LeuSer: 7.767 ± 0.038	5.004LeuThr: 5.004 ± 0.03	5.753LeuVal: 5.753 ± 0.036	1.32LeuTrp: 1.32 ± 0.016	2.661LeuTyr: 2.661 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.161MetAla: 2.161 ± 0.019	0.284MetCys: 0.284 ± 0.008	1.23MetAsp: 1.23 ± 0.014	1.289MetGlu: 1.289 ± 0.016	0.771MetPhe: 0.771 ± 0.011	1.505MetGly: 1.505 ± 0.017	0.493MetHis: 0.493 ± 0.009	1.089MetIle: 1.089 ± 0.013	1.004MetLys: 1.004 ± 0.01	1.914MetLeu: 1.914 ± 0.02	0.565MetMet: 0.565 ± 0.01	0.84MetAsn: 0.84 ± 0.013	1.195MetPro: 1.195 ± 0.015	0.867MetGln: 0.867 ± 0.011	1.248MetArg: 1.248 ± 0.013	1.871MetSer: 1.871 ± 0.018	1.347MetThr: 1.347 ± 0.013	1.426MetVal: 1.426 ± 0.014	0.283MetTrp: 0.283 ± 0.006	0.563MetTyr: 0.563 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.023	0.517AsnCys: 0.517 ± 0.009	1.979AsnAsp: 1.979 ± 0.016	2.076AsnGlu: 2.076 ± 0.019	1.4AsnPhe: 1.4 ± 0.016	2.959AsnGly: 2.959 ± 0.023	0.901AsnHis: 0.901 ± 0.013	2.225AsnIle: 2.225 ± 0.02	1.513AsnLys: 1.513 ± 0.015	3.327AsnLeu: 3.327 ± 0.025	0.876AsnMet: 0.876 ± 0.011	1.52AsnAsn: 1.52 ± 0.017	2.502AsnPro: 2.502 ± 0.022	1.375AsnGln: 1.375 ± 0.016	1.974AsnArg: 1.974 ± 0.018	2.768AsnSer: 2.768 ± 0.021	2.264AsnThr: 2.264 ± 0.021	2.444AsnVal: 2.444 ± 0.02	0.613AsnTrp: 0.613 ± 0.011	1.138AsnTyr: 1.138 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.61ProAla: 4.61 ± 0.033	0.609ProCys: 0.609 ± 0.011	3.157ProAsp: 3.157 ± 0.025	3.827ProGlu: 3.827 ± 0.035	2.18ProPhe: 2.18 ± 0.021	3.858ProGly: 3.858 ± 0.029	1.328ProHis: 1.328 ± 0.016	2.6ProIle: 2.6 ± 0.022	2.484ProLys: 2.484 ± 0.021	4.769ProLeu: 4.769 ± 0.033	1.093ProMet: 1.093 ± 0.012	2.208ProAsn: 2.208 ± 0.021	4.346ProPro: 4.346 ± 0.062	2.369ProGln: 2.369 ± 0.023	3.236ProArg: 3.236 ± 0.027	5.772ProSer: 5.772 ± 0.04	3.858ProThr: 3.858 ± 0.03	3.608ProVal: 3.608 ± 0.025	0.808ProTrp: 0.808 ± 0.014	1.593ProTyr: 1.593 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.257GlnAla: 3.257 ± 0.024	0.516GlnCys: 0.516 ± 0.009	2.05GlnAsp: 2.05 ± 0.017	2.444GlnGlu: 2.444 ± 0.021	1.341GlnPhe: 1.341 ± 0.012	2.488GlnGly: 2.488 ± 0.022	1.052GlnHis: 1.052 ± 0.014	1.988GlnIle: 1.988 ± 0.018	1.971GlnLys: 1.971 ± 0.019	3.576GlnLeu: 3.576 ± 0.025	0.887GlnMet: 0.887 ± 0.011	1.599GlnAsn: 1.599 ± 0.018	2.428GlnPro: 2.428 ± 0.027	2.197GlnGln: 2.197 ± 0.035	2.564GlnArg: 2.564 ± 0.021	3.179GlnSer: 3.179 ± 0.024	2.31GlnThr: 2.31 ± 0.02	2.243GlnVal: 2.243 ± 0.019	0.627GlnTrp: 0.627 ± 0.01	1.249GlnTyr: 1.249 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.385ArgAla: 4.385 ± 0.029	0.785ArgCys: 0.785 ± 0.013	3.235ArgAsp: 3.235 ± 0.025	3.645ArgGlu: 3.645 ± 0.033	2.225ArgPhe: 2.225 ± 0.019	3.532ArgGly: 3.532 ± 0.029	1.562ArgHis: 1.562 ± 0.018	2.949ArgIle: 2.949 ± 0.022	3.223ArgLys: 3.223 ± 0.025	5.615ArgLeu: 5.615 ± 0.034	1.292ArgMet: 1.292 ± 0.014	2.255ArgAsn: 2.255 ± 0.018	3.286ArgPro: 3.286 ± 0.029	2.551ArgGln: 2.551 ± 0.017	4.756ArgArg: 4.756 ± 0.038	4.635ArgSer: 4.635 ± 0.037	3.203ArgThr: 3.203 ± 0.023	3.446ArgVal: 3.446 ± 0.019	0.998ArgTrp: 0.998 ± 0.012	1.792ArgTyr: 1.792 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.397SerAla: 6.397 ± 0.037	1.019SerCys: 1.019 ± 0.015	4.248SerAsp: 4.248 ± 0.032	4.178SerGlu: 4.178 ± 0.028	3.23SerPhe: 3.23 ± 0.024	5.525SerGly: 5.525 ± 0.029	2.008SerHis: 2.008 ± 0.019	4.249SerIle: 4.249 ± 0.026	3.537SerLys: 3.537 ± 0.028	7.633SerLeu: 7.633 ± 0.042	1.737SerMet: 1.737 ± 0.018	3.041SerAsn: 3.041 ± 0.021	5.191SerPro: 5.191 ± 0.038	3.329SerGln: 3.329 ± 0.027	4.88SerArg: 4.88 ± 0.035	8.459SerSer: 8.459 ± 0.058	5.46SerThr: 5.46 ± 0.034	4.784SerVal: 4.784 ± 0.027	1.221SerTrp: 1.221 ± 0.012	2.214SerTyr: 2.214 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.033ThrAla: 5.033 ± 0.027	0.817ThrCys: 0.817 ± 0.012	2.899ThrAsp: 2.899 ± 0.024	3.176ThrGlu: 3.176 ± 0.023	2.324ThrPhe: 2.324 ± 0.021	4.305ThrGly: 4.305 ± 0.033	1.33ThrHis: 1.33 ± 0.013	3.249ThrIle: 3.249 ± 0.023	2.492ThrLys: 2.492 ± 0.024	5.402ThrLeu: 5.402 ± 0.033	1.237ThrMet: 1.237 ± 0.014	2.134ThrAsn: 2.134 ± 0.02	4.038ThrPro: 4.038 ± 0.03	2.101ThrGln: 2.101 ± 0.02	3.009ThrArg: 3.009 ± 0.025	5.148ThrSer: 5.148 ± 0.028	4.097ThrThr: 4.097 ± 0.033	3.955ThrVal: 3.955 ± 0.028	0.933ThrTrp: 0.933 ± 0.012	1.746ThrTyr: 1.746 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.186ValAla: 5.186 ± 0.031	0.917ValCys: 0.917 ± 0.014	3.752ValAsp: 3.752 ± 0.027	3.778ValGlu: 3.778 ± 0.028	2.608ValPhe: 2.608 ± 0.026	4.181ValGly: 4.181 ± 0.03	1.503ValHis: 1.503 ± 0.013	3.247ValIle: 3.247 ± 0.026	2.765ValLys: 2.765 ± 0.026	5.831ValLeu: 5.831 ± 0.031	1.376ValMet: 1.376 ± 0.015	2.359ValAsn: 2.359 ± 0.02	3.631ValPro: 3.631 ± 0.026	2.457ValGln: 2.457 ± 0.02	3.457ValArg: 3.457 ± 0.024	4.925ValSer: 4.925 ± 0.029	3.665ValThr: 3.665 ± 0.026	4.409ValVal: 4.409 ± 0.03	0.924ValTrp: 0.924 ± 0.014	1.936ValTyr: 1.936 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.178TrpAla: 1.178 ± 0.014	0.217TrpCys: 0.217 ± 0.005	0.941TrpAsp: 0.941 ± 0.014	0.883TrpGlu: 0.883 ± 0.012	0.588TrpPhe: 0.588 ± 0.01	1.003TrpGly: 1.003 ± 0.013	0.384TrpHis: 0.384 ± 0.008	0.852TrpIle: 0.852 ± 0.014	0.852TrpLys: 0.852 ± 0.012	1.494TrpLeu: 1.494 ± 0.017	0.397TrpMet: 0.397 ± 0.008	0.683TrpAsn: 0.683 ± 0.012	0.648TrpPro: 0.648 ± 0.012	0.598TrpGln: 0.598 ± 0.009	0.983TrpArg: 0.983 ± 0.013	1.118TrpSer: 1.118 ± 0.013	0.97TrpThr: 0.97 ± 0.013	0.962TrpVal: 0.962 ± 0.011	0.301TrpTrp: 0.301 ± 0.008	0.474TrpTyr: 0.474 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.02	0.464TyrCys: 0.464 ± 0.009	1.72TyrAsp: 1.72 ± 0.017	1.615TyrGlu: 1.615 ± 0.016	1.31TyrPhe: 1.31 ± 0.015	2.242TyrGly: 2.242 ± 0.02	0.824TyrHis: 0.824 ± 0.011	1.641TyrIle: 1.641 ± 0.014	1.114TyrLys: 1.114 ± 0.014	2.939TyrLeu: 2.939 ± 0.023	0.677TyrMet: 0.677 ± 0.01	1.22TyrAsn: 1.22 ± 0.017	1.63TyrPro: 1.63 ± 0.018	1.193TyrGln: 1.193 ± 0.014	1.762TyrArg: 1.762 ± 0.018	2.222TyrSer: 2.222 ± 0.02	1.765TyrThr: 1.765 ± 0.019	1.786TyrVal: 1.786 ± 0.017	0.491TyrTrp: 0.491 ± 0.009	1.049TyrTyr: 1.049 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 13914 proteins (6418083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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