Amino acid dipepetide frequency for Streptococcus satellite phage Javan560

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.948AlaAla: 1.948 ± 0.958
0.487AlaCys: 0.487 ± 0.587
6.332AlaAsp: 6.332 ± 2.583
7.793AlaGlu: 7.793 ± 2.167
1.461AlaPhe: 1.461 ± 0.786
3.41AlaGly: 3.41 ± 1.176
0.487AlaHis: 0.487 ± 0.595
6.332AlaIle: 6.332 ± 1.266
7.793AlaLys: 7.793 ± 2.409
4.384AlaLeu: 4.384 ± 1.506
5.358AlaMet: 5.358 ± 1.569
1.461AlaAsn: 1.461 ± 0.778
0.0AlaPro: 0.0 ± 0.0
2.435AlaGln: 2.435 ± 1.229
1.948AlaArg: 1.948 ± 0.756
5.845AlaSer: 5.845 ± 1.403
4.384AlaThr: 4.384 ± 2.247
1.461AlaVal: 1.461 ± 0.742
0.487AlaTrp: 0.487 ± 0.402
1.948AlaTyr: 1.948 ± 0.983
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.487CysPhe: 0.487 ± 0.522
0.974CysGly: 0.974 ± 0.714
0.0CysHis: 0.0 ± 0.0
0.487CysIle: 0.487 ± 0.472
0.974CysLys: 0.974 ± 0.914
0.487CysLeu: 0.487 ± 0.587
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.487CysPro: 0.487 ± 0.472
0.0CysGln: 0.0 ± 0.0
0.487CysArg: 0.487 ± 0.402
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.435AspAla: 2.435 ± 1.138
0.487AspCys: 0.487 ± 0.472
1.948AspAsp: 1.948 ± 0.766
5.845AspGlu: 5.845 ± 1.563
3.41AspPhe: 3.41 ± 1.305
3.41AspGly: 3.41 ± 1.253
0.974AspHis: 0.974 ± 0.685
8.281AspIle: 8.281 ± 1.623
6.332AspLys: 6.332 ± 1.499
2.923AspLeu: 2.923 ± 1.198
2.435AspMet: 2.435 ± 1.315
4.871AspAsn: 4.871 ± 1.32
0.974AspPro: 0.974 ± 0.47
0.974AspGln: 0.974 ± 0.714
1.461AspArg: 1.461 ± 0.743
2.435AspSer: 2.435 ± 1.166
1.948AspThr: 1.948 ± 1.049
1.948AspVal: 1.948 ± 0.908
0.974AspTrp: 0.974 ± 0.628
4.871AspTyr: 4.871 ± 0.93
0.0AspXaa: 0.0 ± 0.0
Glu
5.358GluAla: 5.358 ± 1.39
0.0GluCys: 0.0 ± 0.0
5.845GluAsp: 5.845 ± 1.901
4.871GluGlu: 4.871 ± 2.233
2.435GluPhe: 2.435 ± 0.899
3.41GluGly: 3.41 ± 1.325
1.948GluHis: 1.948 ± 1.289
4.384GluIle: 4.384 ± 1.738
6.332GluLys: 6.332 ± 1.264
17.535GluLeu: 17.535 ± 3.624
2.923GluMet: 2.923 ± 0.981
3.897GluAsn: 3.897 ± 1.44
0.487GluPro: 0.487 ± 0.458
5.845GluGln: 5.845 ± 2.042
5.358GluArg: 5.358 ± 2.122
2.435GluSer: 2.435 ± 1.047
4.871GluThr: 4.871 ± 1.076
6.819GluVal: 6.819 ± 1.804
0.487GluTrp: 0.487 ± 0.492
2.923GluTyr: 2.923 ± 1.387
0.0GluXaa: 0.0 ± 0.0
Phe
2.435PheAla: 2.435 ± 1.017
0.0PheCys: 0.0 ± 0.0
1.948PheAsp: 1.948 ± 1.003
4.384PheGlu: 4.384 ± 1.281
0.487PhePhe: 0.487 ± 0.522
1.948PheGly: 1.948 ± 1.13
0.974PheHis: 0.974 ± 0.47
0.974PheIle: 0.974 ± 0.639
2.923PheLys: 2.923 ± 1.117
5.358PheLeu: 5.358 ± 1.127
0.974PheMet: 0.974 ± 0.662
1.948PheAsn: 1.948 ± 0.75
0.487PhePro: 0.487 ± 0.472
1.461PheGln: 1.461 ± 1.057
1.948PheArg: 1.948 ± 0.957
0.487PheSer: 0.487 ± 0.402
1.461PheThr: 1.461 ± 0.786
0.487PheVal: 0.487 ± 0.458
0.0PheTrp: 0.0 ± 0.0
2.435PheTyr: 2.435 ± 0.918
0.0PheXaa: 0.0 ± 0.0
Gly
3.41GlyAla: 3.41 ± 1.739
0.487GlyCys: 0.487 ± 0.402
1.461GlyAsp: 1.461 ± 1.292
4.384GlyGlu: 4.384 ± 1.155
1.948GlyPhe: 1.948 ± 0.778
1.948GlyGly: 1.948 ± 1.241
1.461GlyHis: 1.461 ± 0.616
3.41GlyIle: 3.41 ± 0.984
3.897GlyLys: 3.897 ± 1.153
6.332GlyLeu: 6.332 ± 1.193
1.461GlyMet: 1.461 ± 1.207
2.435GlyAsn: 2.435 ± 1.381
0.0GlyPro: 0.0 ± 0.0
2.923GlyGln: 2.923 ± 1.151
2.923GlyArg: 2.923 ± 0.839
2.435GlySer: 2.435 ± 1.292
1.461GlyThr: 1.461 ± 0.882
3.897GlyVal: 3.897 ± 1.066
0.487GlyTrp: 0.487 ± 0.458
4.384GlyTyr: 4.384 ± 2.041
0.0GlyXaa: 0.0 ± 0.0
His
1.461HisAla: 1.461 ± 0.873
0.0HisCys: 0.0 ± 0.0
1.461HisAsp: 1.461 ± 0.764
0.487HisGlu: 0.487 ± 0.595
0.974HisPhe: 0.974 ± 0.639
1.948HisGly: 1.948 ± 0.782
0.0HisHis: 0.0 ± 0.0
0.974HisIle: 0.974 ± 0.775
0.487HisLys: 0.487 ± 0.492
2.435HisLeu: 2.435 ± 0.709
0.0HisMet: 0.0 ± 0.0
0.487HisAsn: 0.487 ± 0.587
0.974HisPro: 0.974 ± 0.752
0.0HisGln: 0.0 ± 0.0
0.974HisArg: 0.974 ± 0.597
0.487HisSer: 0.487 ± 0.402
2.435HisThr: 2.435 ± 0.889
0.974HisVal: 0.974 ± 0.639
0.487HisTrp: 0.487 ± 0.402
0.974HisTyr: 0.974 ± 0.47
0.0HisXaa: 0.0 ± 0.0
Ile
4.384IleAla: 4.384 ± 1.897
0.0IleCys: 0.0 ± 0.0
5.358IleAsp: 5.358 ± 0.93
4.871IleGlu: 4.871 ± 2.046
1.948IlePhe: 1.948 ± 1.004
2.435IleGly: 2.435 ± 0.941
1.461IleHis: 1.461 ± 0.873
4.384IleIle: 4.384 ± 1.245
5.845IleLys: 5.845 ± 2.193
7.306IleLeu: 7.306 ± 1.568
0.487IleMet: 0.487 ± 0.402
3.897IleAsn: 3.897 ± 1.711
2.435IlePro: 2.435 ± 1.209
1.461IleGln: 1.461 ± 0.674
6.332IleArg: 6.332 ± 1.794
5.358IleSer: 5.358 ± 1.802
6.332IleThr: 6.332 ± 1.188
2.435IleVal: 2.435 ± 0.999
0.974IleTrp: 0.974 ± 0.85
2.435IleTyr: 2.435 ± 0.899
0.0IleXaa: 0.0 ± 0.0
Lys
8.281LysAla: 8.281 ± 1.84
1.461LysCys: 1.461 ± 0.936
3.897LysAsp: 3.897 ± 1.135
10.229LysGlu: 10.229 ± 1.193
1.948LysPhe: 1.948 ± 0.874
3.897LysGly: 3.897 ± 1.598
3.41LysHis: 3.41 ± 1.046
5.845LysIle: 5.845 ± 1.423
10.716LysLys: 10.716 ± 3.013
10.229LysLeu: 10.229 ± 2.726
1.948LysMet: 1.948 ± 1.037
7.306LysAsn: 7.306 ± 1.614
2.923LysPro: 2.923 ± 1.058
4.384LysGln: 4.384 ± 1.171
3.41LysArg: 3.41 ± 1.025
4.384LysSer: 4.384 ± 2.221
8.768LysThr: 8.768 ± 2.135
2.435LysVal: 2.435 ± 0.852
0.487LysTrp: 0.487 ± 0.587
1.948LysTyr: 1.948 ± 0.907
0.0LysXaa: 0.0 ± 0.0
Leu
7.793LeuAla: 7.793 ± 1.658
0.0LeuCys: 0.0 ± 0.0
8.281LeuAsp: 8.281 ± 1.36
14.126LeuGlu: 14.126 ± 3.717
3.897LeuPhe: 3.897 ± 1.46
6.332LeuGly: 6.332 ± 1.963
1.461LeuHis: 1.461 ± 0.931
3.897LeuIle: 3.897 ± 1.507
12.177LeuLys: 12.177 ± 2.296
10.716LeuLeu: 10.716 ± 2.026
0.974LeuMet: 0.974 ± 0.573
4.871LeuAsn: 4.871 ± 2.047
3.897LeuPro: 3.897 ± 2.197
6.819LeuGln: 6.819 ± 1.626
2.923LeuArg: 2.923 ± 1.694
2.923LeuSer: 2.923 ± 1.483
9.742LeuThr: 9.742 ± 1.789
1.948LeuVal: 1.948 ± 0.868
0.974LeuTrp: 0.974 ± 0.645
3.41LeuTyr: 3.41 ± 1.436
0.0LeuXaa: 0.0 ± 0.0
Met
4.384MetAla: 4.384 ± 1.465
0.0MetCys: 0.0 ± 0.0
2.435MetAsp: 2.435 ± 0.901
1.461MetGlu: 1.461 ± 0.681
0.487MetPhe: 0.487 ± 0.522
0.974MetGly: 0.974 ± 0.707
0.0MetHis: 0.0 ± 0.0
1.461MetIle: 1.461 ± 0.624
3.897MetLys: 3.897 ± 2.16
1.461MetLeu: 1.461 ± 0.821
0.974MetMet: 0.974 ± 0.634
0.974MetAsn: 0.974 ± 0.707
0.487MetPro: 0.487 ± 0.496
1.461MetGln: 1.461 ± 0.813
0.974MetArg: 0.974 ± 0.581
0.974MetSer: 0.974 ± 0.698
3.41MetThr: 3.41 ± 1.399
0.974MetVal: 0.974 ± 0.782
0.487MetTrp: 0.487 ± 0.629
0.487MetTyr: 0.487 ± 0.595
0.0MetXaa: 0.0 ± 0.0
Asn
4.384AsnAla: 4.384 ± 2.134
0.0AsnCys: 0.0 ± 0.0
0.974AsnAsp: 0.974 ± 0.66
3.897AsnGlu: 3.897 ± 1.201
1.948AsnPhe: 1.948 ± 0.801
1.948AsnGly: 1.948 ± 1.129
0.487AsnHis: 0.487 ± 0.402
4.384AsnIle: 4.384 ± 1.884
4.384AsnLys: 4.384 ± 1.085
3.41AsnLeu: 3.41 ± 1.134
1.948AsnMet: 1.948 ± 1.163
2.923AsnAsn: 2.923 ± 1.218
2.923AsnPro: 2.923 ± 1.4
0.487AsnGln: 0.487 ± 0.522
2.923AsnArg: 2.923 ± 1.162
4.871AsnSer: 4.871 ± 1.588
3.897AsnThr: 3.897 ± 1.377
1.461AsnVal: 1.461 ± 0.744
0.487AsnTrp: 0.487 ± 0.472
1.948AsnTyr: 1.948 ± 0.997
0.0AsnXaa: 0.0 ± 0.0
Pro
1.461ProAla: 1.461 ± 0.765
0.0ProCys: 0.0 ± 0.0
2.923ProAsp: 2.923 ± 1.067
1.461ProGlu: 1.461 ± 0.678
1.461ProPhe: 1.461 ± 0.939
0.487ProGly: 0.487 ± 0.567
0.487ProHis: 0.487 ± 0.492
0.487ProIle: 0.487 ± 0.492
2.435ProLys: 2.435 ± 0.957
2.435ProLeu: 2.435 ± 1.166
0.487ProMet: 0.487 ± 0.629
1.461ProAsn: 1.461 ± 0.931
0.974ProPro: 0.974 ± 0.659
1.461ProGln: 1.461 ± 0.882
1.948ProArg: 1.948 ± 0.72
0.0ProSer: 0.0 ± 0.0
1.461ProThr: 1.461 ± 1.209
0.487ProVal: 0.487 ± 0.492
0.0ProTrp: 0.0 ± 0.0
0.974ProTyr: 0.974 ± 0.805
0.0ProXaa: 0.0 ± 0.0
Gln
4.384GlnAla: 4.384 ± 0.951
0.0GlnCys: 0.0 ± 0.0
1.948GlnAsp: 1.948 ± 0.97
4.384GlnGlu: 4.384 ± 1.473
1.948GlnPhe: 1.948 ± 0.68
3.41GlnGly: 3.41 ± 1.237
0.974GlnHis: 0.974 ± 0.47
2.923GlnIle: 2.923 ± 0.894
3.41GlnLys: 3.41 ± 1.171
3.41GlnLeu: 3.41 ± 1.166
0.974GlnMet: 0.974 ± 0.796
2.923GlnAsn: 2.923 ± 1.501
0.974GlnPro: 0.974 ± 0.658
2.923GlnGln: 2.923 ± 1.133
3.41GlnArg: 3.41 ± 1.13
2.923GlnSer: 2.923 ± 0.927
3.897GlnThr: 3.897 ± 1.623
0.974GlnVal: 0.974 ± 0.582
0.487GlnTrp: 0.487 ± 0.425
1.948GlnTyr: 1.948 ± 1.127
0.0GlnXaa: 0.0 ± 0.0
Arg
2.923ArgAla: 2.923 ± 1.048
0.0ArgCys: 0.0 ± 0.0
2.923ArgAsp: 2.923 ± 1.154
4.384ArgGlu: 4.384 ± 1.182
0.487ArgPhe: 0.487 ± 0.425
2.435ArgGly: 2.435 ± 0.926
0.487ArgHis: 0.487 ± 0.402
3.897ArgIle: 3.897 ± 1.172
3.41ArgLys: 3.41 ± 1.275
7.793ArgLeu: 7.793 ± 1.433
1.461ArgMet: 1.461 ± 1.034
1.461ArgAsn: 1.461 ± 0.929
0.487ArgPro: 0.487 ± 0.587
4.384ArgGln: 4.384 ± 1.555
2.923ArgArg: 2.923 ± 1.137
2.923ArgSer: 2.923 ± 1.019
0.974ArgThr: 0.974 ± 0.583
3.41ArgVal: 3.41 ± 1.775
1.461ArgTrp: 1.461 ± 0.826
2.435ArgTyr: 2.435 ± 0.934
0.0ArgXaa: 0.0 ± 0.0
Ser
1.461SerAla: 1.461 ± 0.652
0.487SerCys: 0.487 ± 0.472
3.897SerAsp: 3.897 ± 0.827
4.384SerGlu: 4.384 ± 1.374
1.461SerPhe: 1.461 ± 1.374
1.948SerGly: 1.948 ± 0.785
1.461SerHis: 1.461 ± 0.778
6.332SerIle: 6.332 ± 1.726
4.871SerLys: 4.871 ± 2.442
4.384SerLeu: 4.384 ± 1.131
1.461SerMet: 1.461 ± 0.811
0.974SerAsn: 0.974 ± 0.582
0.974SerPro: 0.974 ± 0.47
2.435SerGln: 2.435 ± 1.198
0.974SerArg: 0.974 ± 0.612
0.487SerSer: 0.487 ± 0.425
2.435SerThr: 2.435 ± 1.25
4.384SerVal: 4.384 ± 1.269
0.0SerTrp: 0.0 ± 0.0
2.923SerTyr: 2.923 ± 0.931
0.0SerXaa: 0.0 ± 0.0
Thr
3.897ThrAla: 3.897 ± 1.907
0.0ThrCys: 0.0 ± 0.0
3.41ThrAsp: 3.41 ± 0.862
2.923ThrGlu: 2.923 ± 1.415
2.435ThrPhe: 2.435 ± 0.99
5.845ThrGly: 5.845 ± 1.646
0.974ThrHis: 0.974 ± 0.597
6.819ThrIle: 6.819 ± 1.598
6.819ThrLys: 6.819 ± 2.112
5.845ThrLeu: 5.845 ± 1.312
1.461ThrMet: 1.461 ± 0.543
2.923ThrAsn: 2.923 ± 1.263
1.948ThrPro: 1.948 ± 0.999
4.384ThrGln: 4.384 ± 1.572
4.384ThrArg: 4.384 ± 1.625
1.948ThrSer: 1.948 ± 0.74
3.41ThrThr: 3.41 ± 1.324
5.358ThrVal: 5.358 ± 1.524
0.487ThrTrp: 0.487 ± 0.425
0.487ThrTyr: 0.487 ± 0.496
0.0ThrXaa: 0.0 ± 0.0
Val
1.948ValAla: 1.948 ± 0.868
0.487ValCys: 0.487 ± 0.492
1.461ValAsp: 1.461 ± 0.794
3.41ValGlu: 3.41 ± 1.381
1.461ValPhe: 1.461 ± 0.665
2.435ValGly: 2.435 ± 1.101
0.487ValHis: 0.487 ± 0.472
2.435ValIle: 2.435 ± 1.121
6.332ValLys: 6.332 ± 2.344
2.923ValLeu: 2.923 ± 0.867
1.461ValMet: 1.461 ± 0.712
1.461ValAsn: 1.461 ± 0.679
0.974ValPro: 0.974 ± 0.548
2.435ValGln: 2.435 ± 1.081
0.487ValArg: 0.487 ± 0.425
4.384ValSer: 4.384 ± 1.128
2.435ValThr: 2.435 ± 1.264
1.948ValVal: 1.948 ± 0.94
0.0ValTrp: 0.0 ± 0.0
2.435ValTyr: 2.435 ± 1.078
0.0ValXaa: 0.0 ± 0.0
Trp
1.461TrpAla: 1.461 ± 0.86
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.461TrpGlu: 1.461 ± 0.753
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.487TrpIle: 0.487 ± 0.527
0.487TrpLys: 0.487 ± 0.425
0.974TrpLeu: 0.974 ± 0.613
0.0TrpMet: 0.0 ± 0.0
0.974TrpAsn: 0.974 ± 0.612
0.0TrpPro: 0.0 ± 0.0
0.487TrpGln: 0.487 ± 0.472
0.487TrpArg: 0.487 ± 0.492
0.487TrpSer: 0.487 ± 0.402
0.487TrpThr: 0.487 ± 0.402
0.0TrpVal: 0.0 ± 0.0
0.487TrpTrp: 0.487 ± 0.402
0.974TrpTyr: 0.974 ± 0.914
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.948TyrAla: 1.948 ± 0.923
0.487TyrCys: 0.487 ± 0.587
2.435TyrAsp: 2.435 ± 0.892
3.41TyrGlu: 3.41 ± 1.416
2.435TyrPhe: 2.435 ± 1.151
1.948TyrGly: 1.948 ± 0.959
0.487TyrHis: 0.487 ± 0.522
1.948TyrIle: 1.948 ± 0.945
4.871TyrLys: 4.871 ± 2.002
6.819TyrLeu: 6.819 ± 1.669
0.487TyrMet: 0.487 ± 0.425
2.435TyrAsn: 2.435 ± 0.854
0.487TyrPro: 0.487 ± 0.402
1.461TyrGln: 1.461 ± 0.604
4.384TyrArg: 4.384 ± 1.173
1.948TyrSer: 1.948 ± 1.056
1.948TyrThr: 1.948 ± 0.988
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
1.948TyrTyr: 1.948 ± 0.832
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski