Amino acid dipepetide frequency for Luteimonas sp. J16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.107AlaAla: 20.107 ± 0.234	1.43AlaCys: 1.43 ± 0.045	7.481AlaAsp: 7.481 ± 0.1	7.074AlaGlu: 7.074 ± 0.1	4.235AlaPhe: 4.235 ± 0.077	13.009AlaGly: 13.009 ± 0.172	2.775AlaHis: 2.775 ± 0.06	5.394AlaIle: 5.394 ± 0.075	2.408AlaLys: 2.408 ± 0.071	16.242AlaLeu: 16.242 ± 0.195	3.519AlaMet: 3.519 ± 0.061	2.555AlaAsn: 2.555 ± 0.053	7.475AlaPro: 7.475 ± 0.12	4.656AlaGln: 4.656 ± 0.077	12.714AlaArg: 12.714 ± 0.145	6.307AlaSer: 6.307 ± 0.077	6.445AlaThr: 6.445 ± 0.088	9.125AlaVal: 9.125 ± 0.123	2.469AlaTrp: 2.469 ± 0.056	2.455AlaTyr: 2.455 ± 0.05	0.076AlaXaa: 0.076 ± 0.008
Cys	1.135CysAla: 1.135 ± 0.04	0.114CysCys: 0.114 ± 0.011	0.483CysAsp: 0.483 ± 0.022	0.472CysGlu: 0.472 ± 0.023	0.278CysPhe: 0.278 ± 0.019	0.963CysGly: 0.963 ± 0.036	0.234CysHis: 0.234 ± 0.015	0.316CysIle: 0.316 ± 0.019	0.13CysLys: 0.13 ± 0.013	0.801CysLeu: 0.801 ± 0.029	0.142CysMet: 0.142 ± 0.013	0.191CysAsn: 0.191 ± 0.014	0.432CysPro: 0.432 ± 0.023	0.211CysGln: 0.211 ± 0.015	0.685CysArg: 0.685 ± 0.025	0.382CysSer: 0.382 ± 0.018	0.423CysThr: 0.423 ± 0.022	0.657CysVal: 0.657 ± 0.025	0.123CysTrp: 0.123 ± 0.012	0.19CysTyr: 0.19 ± 0.013	0.003CysXaa: 0.003 ± 0.002
Asp	9.377AspAla: 9.377 ± 0.117	0.443AspCys: 0.443 ± 0.021	3.615AspAsp: 3.615 ± 0.065	3.553AspGlu: 3.553 ± 0.067	1.964AspPhe: 1.964 ± 0.046	6.714AspGly: 6.714 ± 0.091	1.194AspHis: 1.194 ± 0.038	2.212AspIle: 2.212 ± 0.049	0.989AspLys: 0.989 ± 0.037	5.726AspLeu: 5.726 ± 0.084	1.075AspMet: 1.075 ± 0.031	1.123AspAsn: 1.123 ± 0.04	4.39AspPro: 4.39 ± 0.062	1.526AspGln: 1.526 ± 0.045	4.693AspArg: 4.693 ± 0.076	2.156AspSer: 2.156 ± 0.046	2.446AspThr: 2.446 ± 0.048	4.276AspVal: 4.276 ± 0.062	1.141AspTrp: 1.141 ± 0.037	1.506AspTyr: 1.506 ± 0.045	0.009AspXaa: 0.009 ± 0.003
Glu	8.307GluAla: 8.307 ± 0.123	0.38GluCys: 0.38 ± 0.021	2.862GluAsp: 2.862 ± 0.055	2.775GluGlu: 2.775 ± 0.065	1.831GluPhe: 1.831 ± 0.046	4.585GluGly: 4.585 ± 0.071	1.383GluHis: 1.383 ± 0.039	2.315GluIle: 2.315 ± 0.049	1.259GluLys: 1.259 ± 0.042	6.301GluLeu: 6.301 ± 0.08	0.948GluMet: 0.948 ± 0.035	1.0GluAsn: 1.0 ± 0.033	3.029GluPro: 3.029 ± 0.06	2.222GluGln: 2.222 ± 0.051	5.985GluArg: 5.985 ± 0.079	2.349GluSer: 2.349 ± 0.05	2.332GluThr: 2.332 ± 0.048	4.429GluVal: 4.429 ± 0.072	0.791GluTrp: 0.791 ± 0.028	1.24GluTyr: 1.24 ± 0.04	0.014GluXaa: 0.014 ± 0.004
Phe	4.437PheAla: 4.437 ± 0.072	0.339PheCys: 0.339 ± 0.021	2.746PheAsp: 2.746 ± 0.051	2.164PheGlu: 2.164 ± 0.046	1.109PhePhe: 1.109 ± 0.039	3.295PheGly: 3.295 ± 0.063	0.779PheHis: 0.779 ± 0.027	1.125PheIle: 1.125 ± 0.035	0.614PheLys: 0.614 ± 0.025	3.012PheLeu: 3.012 ± 0.065	0.598PheMet: 0.598 ± 0.024	0.901PheAsn: 0.901 ± 0.032	1.454PhePro: 1.454 ± 0.037	0.851PheGln: 0.851 ± 0.024	2.336PheArg: 2.336 ± 0.052	1.748PheSer: 1.748 ± 0.044	1.516PheThr: 1.516 ± 0.039	2.556PheVal: 2.556 ± 0.05	0.487PheTrp: 0.487 ± 0.024	0.742PheTyr: 0.742 ± 0.029	0.006PheXaa: 0.006 ± 0.002
Gly	10.194GlyAla: 10.194 ± 0.127	0.84GlyCys: 0.84 ± 0.034	5.472GlyAsp: 5.472 ± 0.084	5.375GlyGlu: 5.375 ± 0.079	3.48GlyPhe: 3.48 ± 0.056	8.201GlyGly: 8.201 ± 0.131	2.326GlyHis: 2.326 ± 0.045	4.003GlyIle: 4.003 ± 0.069	2.339GlyLys: 2.339 ± 0.061	9.244GlyLeu: 9.244 ± 0.107	2.437GlyMet: 2.437 ± 0.046	2.119GlyAsn: 2.119 ± 0.054	3.926GlyPro: 3.926 ± 0.066	3.013GlyGln: 3.013 ± 0.067	8.016GlyArg: 8.016 ± 0.097	4.388GlySer: 4.388 ± 0.077	4.553GlyThr: 4.553 ± 0.073	6.769GlyVal: 6.769 ± 0.083	1.825GlyTrp: 1.825 ± 0.044	2.318GlyTyr: 2.318 ± 0.044	0.061GlyXaa: 0.061 ± 0.008
His	3.393HisAla: 3.393 ± 0.067	0.261HisCys: 0.261 ± 0.017	1.394HisAsp: 1.394 ± 0.039	1.113HisGlu: 1.113 ± 0.033	0.77HisPhe: 0.77 ± 0.03	2.496HisGly: 2.496 ± 0.054	0.593HisHis: 0.593 ± 0.027	0.651HisIle: 0.651 ± 0.024	0.383HisLys: 0.383 ± 0.02	2.218HisLeu: 2.218 ± 0.056	0.378HisMet: 0.378 ± 0.022	0.426HisAsn: 0.426 ± 0.021	1.641HisPro: 1.641 ± 0.041	0.582HisGln: 0.582 ± 0.024	1.942HisArg: 1.942 ± 0.046	0.806HisSer: 0.806 ± 0.029	0.844HisThr: 0.844 ± 0.028	1.78HisVal: 1.78 ± 0.046	0.446HisTrp: 0.446 ± 0.023	0.58HisTyr: 0.58 ± 0.023	0.005HisXaa: 0.005 ± 0.002
Ile	5.816IleAla: 5.816 ± 0.083	0.267IleCys: 0.267 ± 0.017	3.161IleAsp: 3.161 ± 0.056	2.884IleGlu: 2.884 ± 0.067	0.869IlePhe: 0.869 ± 0.033	3.914IleGly: 3.914 ± 0.069	0.791IleHis: 0.791 ± 0.03	1.077IleIle: 1.077 ± 0.036	0.801IleLys: 0.801 ± 0.03	2.854IleLeu: 2.854 ± 0.06	0.444IleMet: 0.444 ± 0.023	0.959IleAsn: 0.959 ± 0.036	1.936IlePro: 1.936 ± 0.049	0.94IleGln: 0.94 ± 0.033	2.777IleArg: 2.777 ± 0.052	1.679IleSer: 1.679 ± 0.041	1.741IleThr: 1.741 ± 0.047	3.074IleVal: 3.074 ± 0.061	0.378IleTrp: 0.378 ± 0.021	0.673IleTyr: 0.673 ± 0.023	0.009IleXaa: 0.009 ± 0.003
Lys	2.673LysAla: 2.673 ± 0.078	0.111LysCys: 0.111 ± 0.01	1.018LysAsp: 1.018 ± 0.037	0.899LysGlu: 0.899 ± 0.034	0.562LysPhe: 0.562 ± 0.021	1.615LysGly: 1.615 ± 0.051	0.377LysHis: 0.377 ± 0.021	0.775LysIle: 0.775 ± 0.029	0.686LysLys: 0.686 ± 0.052	2.16LysLeu: 2.16 ± 0.054	0.416LysMet: 0.416 ± 0.023	0.408LysAsn: 0.408 ± 0.023	1.31LysPro: 1.31 ± 0.039	0.744LysGln: 0.744 ± 0.034	1.66LysArg: 1.66 ± 0.04	0.98LysSer: 0.98 ± 0.04	1.022LysThr: 1.022 ± 0.034	1.779LysVal: 1.779 ± 0.055	0.241LysTrp: 0.241 ± 0.015	0.485LysTyr: 0.485 ± 0.026	0.003LysXaa: 0.003 ± 0.002
Leu	16.594LeuAla: 16.594 ± 0.174	0.943LeuCys: 0.943 ± 0.035	7.003LeuAsp: 7.003 ± 0.086	6.237LeuGlu: 6.237 ± 0.087	3.335LeuPhe: 3.335 ± 0.057	8.804LeuGly: 8.804 ± 0.109	2.482LeuHis: 2.482 ± 0.055	2.628LeuIle: 2.628 ± 0.056	2.112LeuLys: 2.112 ± 0.056	11.948LeuLeu: 11.948 ± 0.147	1.945LeuMet: 1.945 ± 0.042	1.868LeuAsn: 1.868 ± 0.05	6.671LeuPro: 6.671 ± 0.097	3.547LeuGln: 3.547 ± 0.063	10.058LeuArg: 10.058 ± 0.127	5.138LeuSer: 5.138 ± 0.069	3.944LeuThr: 3.944 ± 0.07	9.087LeuVal: 9.087 ± 0.106	1.341LeuTrp: 1.341 ± 0.04	2.105LeuTyr: 2.105 ± 0.051	0.043LeuXaa: 0.043 ± 0.008
Met	2.77MetAla: 2.77 ± 0.061	0.133MetCys: 0.133 ± 0.01	1.053MetAsp: 1.053 ± 0.033	0.944MetGlu: 0.944 ± 0.032	0.644MetPhe: 0.644 ± 0.026	1.551MetGly: 1.551 ± 0.039	0.467MetHis: 0.467 ± 0.022	0.686MetIle: 0.686 ± 0.027	0.579MetLys: 0.579 ± 0.023	2.317MetLeu: 2.317 ± 0.045	0.406MetMet: 0.406 ± 0.02	0.556MetAsn: 0.556 ± 0.023	1.47MetPro: 1.47 ± 0.039	0.785MetGln: 0.785 ± 0.027	1.909MetArg: 1.909 ± 0.044	1.343MetSer: 1.343 ± 0.035	1.229MetThr: 1.229 ± 0.039	1.464MetVal: 1.464 ± 0.04	0.206MetTrp: 0.206 ± 0.015	0.343MetTyr: 0.343 ± 0.017	0.003MetXaa: 0.003 ± 0.002
Asn	2.79AsnAla: 2.79 ± 0.054	0.178AsnCys: 0.178 ± 0.015	1.131AsnAsp: 1.131 ± 0.035	1.001AsnGlu: 1.001 ± 0.036	0.742AsnPhe: 0.742 ± 0.031	1.895AsnGly: 1.895 ± 0.057	0.448AsnHis: 0.448 ± 0.021	0.914AsnIle: 0.914 ± 0.03	0.408AsnLys: 0.408 ± 0.021	2.184AsnLeu: 2.184 ± 0.06	0.371AsnMet: 0.371 ± 0.021	0.481AsnAsn: 0.481 ± 0.026	1.636AsnPro: 1.636 ± 0.043	0.579AsnGln: 0.579 ± 0.024	1.702AsnArg: 1.702 ± 0.044	0.852AsnSer: 0.852 ± 0.031	1.027AsnThr: 1.027 ± 0.037	1.579AsnVal: 1.579 ± 0.043	0.341AsnTrp: 0.341 ± 0.022	0.52AsnTyr: 0.52 ± 0.027	0.004AsnXaa: 0.004 ± 0.002
Pro	8.52ProAla: 8.52 ± 0.133	0.367ProCys: 0.367 ± 0.019	4.263ProAsp: 4.263 ± 0.064	3.699ProGlu: 3.699 ± 0.064	1.635ProPhe: 1.635 ± 0.041	6.316ProGly: 6.316 ± 0.097	1.156ProHis: 1.156 ± 0.031	1.598ProIle: 1.598 ± 0.037	0.981ProLys: 0.981 ± 0.032	5.642ProLeu: 5.642 ± 0.081	1.257ProMet: 1.257 ± 0.034	0.961ProAsn: 0.961 ± 0.035	3.806ProPro: 3.806 ± 0.089	1.79ProGln: 1.79 ± 0.047	4.497ProArg: 4.497 ± 0.072	2.578ProSer: 2.578 ± 0.051	2.216ProThr: 2.216 ± 0.054	4.844ProVal: 4.844 ± 0.078	0.957ProTrp: 0.957 ± 0.037	1.174ProTyr: 1.174 ± 0.036	0.029ProXaa: 0.029 ± 0.005
Gln	5.194GlnAla: 5.194 ± 0.085	0.213GlnCys: 0.213 ± 0.015	1.421GlnAsp: 1.421 ± 0.033	1.34GlnGlu: 1.34 ± 0.04	0.957GlnPhe: 0.957 ± 0.027	2.501GlnGly: 2.501 ± 0.051	0.661GlnHis: 0.661 ± 0.026	1.111GlnIle: 1.111 ± 0.037	0.632GlnLys: 0.632 ± 0.026	3.524GlnLeu: 3.524 ± 0.058	0.666GlnMet: 0.666 ± 0.026	0.52GlnAsn: 0.52 ± 0.023	2.006GlnPro: 2.006 ± 0.056	1.382GlnGln: 1.382 ± 0.041	3.211GlnArg: 3.211 ± 0.065	1.375GlnSer: 1.375 ± 0.042	1.14GlnThr: 1.14 ± 0.035	2.892GlnVal: 2.892 ± 0.056	0.543GlnTrp: 0.543 ± 0.024	0.648GlnTyr: 0.648 ± 0.025	0.01GlnXaa: 0.01 ± 0.003
Arg	10.612ArgAla: 10.612 ± 0.128	0.624ArgCys: 0.624 ± 0.03	5.332ArgAsp: 5.332 ± 0.078	5.864ArgGlu: 5.864 ± 0.08	3.217ArgPhe: 3.217 ± 0.065	6.546ArgGly: 6.546 ± 0.091	2.383ArgHis: 2.383 ± 0.05	4.329ArgIle: 4.329 ± 0.066	1.777ArgLys: 1.777 ± 0.048	10.008ArgLeu: 10.008 ± 0.113	2.179ArgMet: 2.179 ± 0.048	1.971ArgAsn: 1.971 ± 0.048	4.627ArgPro: 4.627 ± 0.08	3.081ArgGln: 3.081 ± 0.061	8.222ArgArg: 8.222 ± 0.093	3.697ArgSer: 3.697 ± 0.064	3.707ArgThr: 3.707 ± 0.06	6.29ArgVal: 6.29 ± 0.088	1.552ArgTrp: 1.552 ± 0.041	2.29ArgTyr: 2.29 ± 0.052	0.047ArgXaa: 0.047 ± 0.006
Ser	5.63SerAla: 5.63 ± 0.077	0.337SerCys: 0.337 ± 0.016	2.453SerAsp: 2.453 ± 0.053	2.192SerGlu: 2.192 ± 0.048	1.612SerPhe: 1.612 ± 0.04	4.814SerGly: 4.814 ± 0.06	1.044SerHis: 1.044 ± 0.037	1.896SerIle: 1.896 ± 0.052	0.893SerLys: 0.893 ± 0.032	4.794SerLeu: 4.794 ± 0.081	0.972SerMet: 0.972 ± 0.035	1.107SerAsn: 1.107 ± 0.035	2.813SerPro: 2.813 ± 0.057	1.366SerGln: 1.366 ± 0.037	3.983SerArg: 3.983 ± 0.063	2.356SerSer: 2.356 ± 0.061	2.375SerThr: 2.375 ± 0.049	3.338SerVal: 3.338 ± 0.059	0.692SerTrp: 0.692 ± 0.032	1.05SerTyr: 1.05 ± 0.04	0.014SerXaa: 0.014 ± 0.004
Thr	5.337ThrAla: 5.337 ± 0.07	0.382ThrCys: 0.382 ± 0.022	2.225ThrAsp: 2.225 ± 0.046	1.819ThrGlu: 1.819 ± 0.044	1.389ThrPhe: 1.389 ± 0.037	4.869ThrGly: 4.869 ± 0.069	0.914ThrHis: 0.914 ± 0.028	1.925ThrIle: 1.925 ± 0.044	0.688ThrLys: 0.688 ± 0.035	5.429ThrLeu: 5.429 ± 0.072	0.903ThrMet: 0.903 ± 0.029	0.824ThrAsn: 0.824 ± 0.03	3.117ThrPro: 3.117 ± 0.063	1.099ThrGln: 1.099 ± 0.033	3.787ThrArg: 3.787 ± 0.057	2.021ThrSer: 2.021 ± 0.046	2.317ThrThr: 2.317 ± 0.054	3.801ThrVal: 3.801 ± 0.073	0.714ThrTrp: 0.714 ± 0.03	0.89ThrTyr: 0.89 ± 0.034	0.009ThrXaa: 0.009 ± 0.003
Val	10.744ValAla: 10.744 ± 0.127	0.647ValCys: 0.647 ± 0.026	4.914ValAsp: 4.914 ± 0.069	5.109ValGlu: 5.109 ± 0.064	2.692ValPhe: 2.692 ± 0.049	5.806ValGly: 5.806 ± 0.087	1.796ValHis: 1.796 ± 0.044	2.653ValIle: 2.653 ± 0.054	1.459ValLys: 1.459 ± 0.052	8.829ValLeu: 8.829 ± 0.098	1.429ValMet: 1.429 ± 0.039	1.791ValAsn: 1.791 ± 0.045	4.468ValPro: 4.468 ± 0.07	2.291ValGln: 2.291 ± 0.05	6.319ValArg: 6.319 ± 0.089	3.718ValSer: 3.718 ± 0.069	3.295ValThr: 3.295 ± 0.063	7.114ValVal: 7.114 ± 0.12	0.895ValTrp: 0.895 ± 0.03	1.511ValTyr: 1.511 ± 0.037	0.023ValXaa: 0.023 ± 0.005
Trp	1.417TrpAla: 1.417 ± 0.038	0.166TrpCys: 0.166 ± 0.012	0.747TrpAsp: 0.747 ± 0.031	0.661TrpGlu: 0.661 ± 0.029	0.634TrpPhe: 0.634 ± 0.025	0.961TrpGly: 0.961 ± 0.038	0.413TrpHis: 0.413 ± 0.019	0.749TrpIle: 0.749 ± 0.026	0.421TrpLys: 0.421 ± 0.021	2.281TrpLeu: 2.281 ± 0.053	0.402TrpMet: 0.402 ± 0.023	0.474TrpAsn: 0.474 ± 0.019	0.897TrpPro: 0.897 ± 0.032	0.638TrpGln: 0.638 ± 0.022	1.685TrpArg: 1.685 ± 0.044	0.808TrpSer: 0.808 ± 0.03	0.815TrpThr: 0.815 ± 0.028	0.952TrpVal: 0.952 ± 0.034	0.362TrpTrp: 0.362 ± 0.021	0.395TrpTyr: 0.395 ± 0.02	0.009TrpXaa: 0.009 ± 0.003
Tyr	2.842TyrAla: 2.842 ± 0.051	0.182TyrCys: 0.182 ± 0.013	1.343TyrAsp: 1.343 ± 0.044	1.139TyrGlu: 1.139 ± 0.03	0.852TyrPhe: 0.852 ± 0.032	1.995TyrGly: 1.995 ± 0.045	0.48TyrHis: 0.48 ± 0.023	0.682TyrIle: 0.682 ± 0.029	0.357TyrLys: 0.357 ± 0.023	2.266TyrLeu: 2.266 ± 0.045	0.371TyrMet: 0.371 ± 0.02	0.544TyrAsn: 0.544 ± 0.029	1.146TyrPro: 1.146 ± 0.033	0.636TyrGln: 0.636 ± 0.028	2.124TyrArg: 2.124 ± 0.047	1.031TyrSer: 1.031 ± 0.037	1.062TyrThr: 1.062 ± 0.036	1.684TyrVal: 1.684 ± 0.043	0.38TyrTrp: 0.38 ± 0.021	0.586TyrTyr: 0.586 ± 0.026	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.063XaaAla: 0.063 ± 0.008	0.009XaaCys: 0.009 ± 0.003	0.01XaaAsp: 0.01 ± 0.003	0.023XaaGlu: 0.023 ± 0.005	0.008XaaPhe: 0.008 ± 0.003	0.049XaaGly: 0.049 ± 0.007	0.005XaaHis: 0.005 ± 0.002	0.004XaaIle: 0.004 ± 0.002	0.007XaaLys: 0.007 ± 0.003	0.053XaaLeu: 0.053 ± 0.008	0.0XaaMet: 0.0 ± 0.0	0.005XaaAsn: 0.005 ± 0.002	0.037XaaPro: 0.037 ± 0.005	0.01XaaGln: 0.01 ± 0.003	0.049XaaArg: 0.049 ± 0.006	0.019XaaSer: 0.019 ± 0.004	0.01XaaThr: 0.01 ± 0.003	0.012XaaVal: 0.012 ± 0.003	0.003XaaTrp: 0.003 ± 0.002	0.003XaaTyr: 0.003 ± 0.002	0.105XaaXaa: 0.105 ± 0.022

Statistics based on 3050 proteins (1002375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---