Amino acid dipepetide frequency for Pistricoccus aurantiacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.946AlaAla: 10.946 ± 0.117	1.122AlaCys: 1.122 ± 0.037	5.177AlaAsp: 5.177 ± 0.067	6.395AlaGlu: 6.395 ± 0.087	3.791AlaPhe: 3.791 ± 0.064	8.366AlaGly: 8.366 ± 0.097	2.052AlaHis: 2.052 ± 0.042	5.698AlaIle: 5.698 ± 0.087	3.39AlaLys: 3.39 ± 0.064	13.391AlaLeu: 13.391 ± 0.139	3.1AlaMet: 3.1 ± 0.051	2.818AlaAsn: 2.818 ± 0.06	4.528AlaPro: 4.528 ± 0.073	4.232AlaGln: 4.232 ± 0.063	7.683AlaArg: 7.683 ± 0.107	6.016AlaSer: 6.016 ± 0.081	5.091AlaThr: 5.091 ± 0.076	6.793AlaVal: 6.793 ± 0.08	1.828AlaTrp: 1.828 ± 0.04	2.459AlaTyr: 2.459 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.911CysAla: 0.911 ± 0.033	0.143CysCys: 0.143 ± 0.011	0.542CysAsp: 0.542 ± 0.018	0.56CysGlu: 0.56 ± 0.024	0.354CysPhe: 0.354 ± 0.018	0.874CysGly: 0.874 ± 0.033	0.364CysHis: 0.364 ± 0.022	0.398CysIle: 0.398 ± 0.018	0.242CysLys: 0.242 ± 0.014	1.047CysLeu: 1.047 ± 0.031	0.181CysMet: 0.181 ± 0.012	0.245CysAsn: 0.245 ± 0.015	0.522CysPro: 0.522 ± 0.023	0.376CysGln: 0.376 ± 0.019	0.725CysArg: 0.725 ± 0.03	0.527CysSer: 0.527 ± 0.021	0.397CysThr: 0.397 ± 0.022	0.63CysVal: 0.63 ± 0.026	0.131CysTrp: 0.131 ± 0.01	0.279CysTyr: 0.279 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.972AspAla: 5.972 ± 0.082	0.516AspCys: 0.516 ± 0.021	3.455AspAsp: 3.455 ± 0.067	4.084AspGlu: 4.084 ± 0.072	2.22AspPhe: 2.22 ± 0.05	4.199AspGly: 4.199 ± 0.072	1.282AspHis: 1.282 ± 0.034	3.127AspIle: 3.127 ± 0.062	1.97AspLys: 1.97 ± 0.052	5.511AspLeu: 5.511 ± 0.073	1.342AspMet: 1.342 ± 0.037	1.728AspAsn: 1.728 ± 0.042	3.02AspPro: 3.02 ± 0.059	2.244AspGln: 2.244 ± 0.047	3.679AspArg: 3.679 ± 0.068	3.159AspSer: 3.159 ± 0.05	3.029AspThr: 3.029 ± 0.058	3.566AspVal: 3.566 ± 0.053	1.128AspTrp: 1.128 ± 0.036	1.854AspTyr: 1.854 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.477GluAla: 7.477 ± 0.093	0.487GluCys: 0.487 ± 0.024	3.502GluAsp: 3.502 ± 0.059	4.195GluGlu: 4.195 ± 0.073	1.8GluPhe: 1.8 ± 0.039	4.61GluGly: 4.61 ± 0.068	1.697GluHis: 1.697 ± 0.04	3.411GluIle: 3.411 ± 0.06	2.408GluLys: 2.408 ± 0.053	7.007GluLeu: 7.007 ± 0.093	1.45GluMet: 1.45 ± 0.034	1.897GluAsn: 1.897 ± 0.044	2.791GluPro: 2.791 ± 0.057	3.221GluGln: 3.221 ± 0.059	5.792GluArg: 5.792 ± 0.077	3.274GluSer: 3.274 ± 0.06	3.487GluThr: 3.487 ± 0.065	4.245GluVal: 4.245 ± 0.074	0.874GluTrp: 0.874 ± 0.026	1.343GluTyr: 1.343 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.619PheAla: 3.619 ± 0.059	0.418PheCys: 0.418 ± 0.018	2.61PheAsp: 2.61 ± 0.052	2.334PheGlu: 2.334 ± 0.048	1.46PhePhe: 1.46 ± 0.048	3.167PheGly: 3.167 ± 0.055	0.841PheHis: 0.841 ± 0.025	1.791PheIle: 1.791 ± 0.048	1.075PheLys: 1.075 ± 0.027	3.568PheLeu: 3.568 ± 0.075	0.834PheMet: 0.834 ± 0.028	1.139PheAsn: 1.139 ± 0.033	1.504PhePro: 1.504 ± 0.037	1.21PheGln: 1.21 ± 0.035	1.908PheArg: 1.908 ± 0.048	2.413PheSer: 2.413 ± 0.051	1.987PheThr: 1.987 ± 0.049	2.516PheVal: 2.516 ± 0.052	0.545PheTrp: 0.545 ± 0.023	1.027PheTyr: 1.027 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.153GlyAla: 7.153 ± 0.084	0.906GlyCys: 0.906 ± 0.023	4.329GlyAsp: 4.329 ± 0.06	5.437GlyGlu: 5.437 ± 0.076	3.325GlyPhe: 3.325 ± 0.07	6.24GlyGly: 6.24 ± 0.094	1.875GlyHis: 1.875 ± 0.044	4.678GlyIle: 4.678 ± 0.076	3.102GlyLys: 3.102 ± 0.054	9.02GlyLeu: 9.02 ± 0.107	2.296GlyMet: 2.296 ± 0.051	2.314GlyAsn: 2.314 ± 0.049	2.618GlyPro: 2.618 ± 0.052	3.077GlyGln: 3.077 ± 0.06	5.162GlyArg: 5.162 ± 0.079	4.246GlySer: 4.246 ± 0.063	3.476GlyThr: 3.476 ± 0.061	5.775GlyVal: 5.775 ± 0.086	1.455GlyTrp: 1.455 ± 0.043	2.328GlyTyr: 2.328 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.217HisAla: 2.217 ± 0.046	0.349HisCys: 0.349 ± 0.018	1.295HisAsp: 1.295 ± 0.033	1.279HisGlu: 1.279 ± 0.038	0.995HisPhe: 0.995 ± 0.032	1.958HisGly: 1.958 ± 0.035	0.722HisHis: 0.722 ± 0.025	0.969HisIle: 0.969 ± 0.032	0.621HisLys: 0.621 ± 0.023	2.579HisLeu: 2.579 ± 0.054	0.447HisMet: 0.447 ± 0.022	0.575HisAsn: 0.575 ± 0.025	1.515HisPro: 1.515 ± 0.038	1.012HisGln: 1.012 ± 0.03	1.809HisArg: 1.809 ± 0.041	1.162HisSer: 1.162 ± 0.033	0.939HisThr: 0.939 ± 0.026	1.341HisVal: 1.341 ± 0.036	0.449HisTrp: 0.449 ± 0.021	0.84HisTyr: 0.84 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.033IleAla: 6.033 ± 0.074	0.453IleCys: 0.453 ± 0.019	3.777IleAsp: 3.777 ± 0.06	3.946IleGlu: 3.946 ± 0.058	1.679IlePhe: 1.679 ± 0.044	4.464IleGly: 4.464 ± 0.074	1.104IleHis: 1.104 ± 0.033	2.264IleIle: 2.264 ± 0.044	1.676IleLys: 1.676 ± 0.043	4.778IleLeu: 4.778 ± 0.083	0.975IleMet: 0.975 ± 0.034	1.624IleAsn: 1.624 ± 0.036	2.449IlePro: 2.449 ± 0.054	1.628IleGln: 1.628 ± 0.04	3.079IleArg: 3.079 ± 0.054	2.93IleSer: 2.93 ± 0.052	2.684IleThr: 2.684 ± 0.051	3.582IleVal: 3.582 ± 0.071	0.574IleTrp: 0.574 ± 0.023	1.193IleTyr: 1.193 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.731LysAla: 3.731 ± 0.063	0.167LysCys: 0.167 ± 0.014	1.739LysAsp: 1.739 ± 0.037	2.087LysGlu: 2.087 ± 0.05	0.744LysPhe: 0.744 ± 0.029	2.442LysGly: 2.442 ± 0.048	0.734LysHis: 0.734 ± 0.025	1.427LysIle: 1.427 ± 0.041	1.305LysLys: 1.305 ± 0.039	3.25LysLeu: 3.25 ± 0.061	0.726LysMet: 0.726 ± 0.025	0.874LysAsn: 0.874 ± 0.03	1.809LysPro: 1.809 ± 0.043	1.479LysGln: 1.479 ± 0.035	2.936LysArg: 2.936 ± 0.056	1.791LysSer: 1.791 ± 0.048	1.786LysThr: 1.786 ± 0.04	2.248LysVal: 2.248 ± 0.054	0.349LysTrp: 0.349 ± 0.018	0.641LysTyr: 0.641 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.743LeuAla: 13.743 ± 0.15	1.047LeuCys: 1.047 ± 0.034	7.086LeuAsp: 7.086 ± 0.091	8.03LeuGlu: 8.03 ± 0.102	3.99LeuPhe: 3.99 ± 0.077	9.382LeuGly: 9.382 ± 0.124	2.276LeuHis: 2.276 ± 0.052	6.071LeuIle: 6.071 ± 0.084	4.018LeuLys: 4.018 ± 0.066	12.553LeuLeu: 12.553 ± 0.172	2.902LeuMet: 2.902 ± 0.058	3.139LeuAsn: 3.139 ± 0.062	6.062LeuPro: 6.062 ± 0.089	3.425LeuGln: 3.425 ± 0.062	6.873LeuArg: 6.873 ± 0.089	6.877LeuSer: 6.877 ± 0.084	5.738LeuThr: 5.738 ± 0.073	7.861LeuVal: 7.861 ± 0.086	1.559LeuTrp: 1.559 ± 0.047	2.583LeuTyr: 2.583 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.879MetAla: 2.879 ± 0.048	0.14MetCys: 0.14 ± 0.01	1.163MetAsp: 1.163 ± 0.034	1.262MetGlu: 1.262 ± 0.036	0.682MetPhe: 0.682 ± 0.025	1.799MetGly: 1.799 ± 0.044	0.501MetHis: 0.501 ± 0.02	1.326MetIle: 1.326 ± 0.04	0.926MetLys: 0.926 ± 0.032	2.837MetLeu: 2.837 ± 0.062	0.639MetMet: 0.639 ± 0.025	0.867MetAsn: 0.867 ± 0.033	1.392MetPro: 1.392 ± 0.037	1.021MetGln: 1.021 ± 0.032	1.621MetArg: 1.621 ± 0.035	1.609MetSer: 1.609 ± 0.04	1.66MetThr: 1.66 ± 0.038	1.623MetVal: 1.623 ± 0.038	0.2MetTrp: 0.2 ± 0.012	0.346MetTyr: 0.346 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.05AsnAla: 3.05 ± 0.065	0.26AsnCys: 0.26 ± 0.017	1.665AsnAsp: 1.665 ± 0.043	1.527AsnGlu: 1.527 ± 0.037	0.985AsnPhe: 0.985 ± 0.03	2.134AsnGly: 2.134 ± 0.044	0.659AsnHis: 0.659 ± 0.024	1.466AsnIle: 1.466 ± 0.037	0.761AsnLys: 0.761 ± 0.028	3.071AsnLeu: 3.071 ± 0.054	0.624AsnMet: 0.624 ± 0.023	0.758AsnAsn: 0.758 ± 0.03	1.892AsnPro: 1.892 ± 0.048	1.183AsnGln: 1.183 ± 0.034	1.998AsnArg: 1.998 ± 0.045	1.342AsnSer: 1.342 ± 0.034	1.412AsnThr: 1.412 ± 0.037	1.866AsnVal: 1.866 ± 0.048	0.407AsnTrp: 0.407 ± 0.02	0.715AsnTyr: 0.715 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.713ProAla: 4.713 ± 0.073	0.387ProCys: 0.387 ± 0.021	3.054ProAsp: 3.054 ± 0.058	3.827ProGlu: 3.827 ± 0.068	1.772ProPhe: 1.772 ± 0.045	4.128ProGly: 4.128 ± 0.063	0.984ProHis: 0.984 ± 0.03	2.24ProIle: 2.24 ± 0.041	1.418ProLys: 1.418 ± 0.039	5.55ProLeu: 5.55 ± 0.083	1.226ProMet: 1.226 ± 0.04	1.295ProAsn: 1.295 ± 0.035	2.178ProPro: 2.178 ± 0.05	2.059ProGln: 2.059 ± 0.044	3.21ProArg: 3.21 ± 0.058	2.702ProSer: 2.702 ± 0.053	2.19ProThr: 2.19 ± 0.045	3.621ProVal: 3.621 ± 0.059	0.919ProTrp: 0.919 ± 0.027	1.204ProTyr: 1.204 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.54GlnAla: 5.54 ± 0.088	0.305GlnCys: 0.305 ± 0.017	2.153GlnAsp: 2.153 ± 0.045	2.605GlnGlu: 2.605 ± 0.046	1.08GlnPhe: 1.08 ± 0.031	3.609GlnGly: 3.609 ± 0.065	0.862GlnHis: 0.862 ± 0.027	1.638GlnIle: 1.638 ± 0.037	1.082GlnLys: 1.082 ± 0.038	4.167GlnLeu: 4.167 ± 0.068	0.839GlnMet: 0.839 ± 0.031	0.912GlnAsn: 0.912 ± 0.032	1.999GlnPro: 1.999 ± 0.047	2.249GlnGln: 2.249 ± 0.057	3.589GlnArg: 3.589 ± 0.069	1.971GlnSer: 1.971 ± 0.042	1.847GlnThr: 1.847 ± 0.041	3.032GlnVal: 3.032 ± 0.057	0.704GlnTrp: 0.704 ± 0.025	0.79GlnTyr: 0.79 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.959ArgAla: 5.959 ± 0.087	0.666ArgCys: 0.666 ± 0.026	4.036ArgAsp: 4.036 ± 0.064	5.189ArgGlu: 5.189 ± 0.071	3.067ArgPhe: 3.067 ± 0.052	4.422ArgGly: 4.422 ± 0.068	2.181ArgHis: 2.181 ± 0.051	3.746ArgIle: 3.746 ± 0.059	2.115ArgLys: 2.115 ± 0.047	9.848ArgLeu: 9.848 ± 0.125	1.651ArgMet: 1.651 ± 0.035	1.838ArgAsn: 1.838 ± 0.039	2.997ArgPro: 2.997 ± 0.052	3.799ArgGln: 3.799 ± 0.074	5.988ArgArg: 5.988 ± 0.088	3.33ArgSer: 3.33 ± 0.055	2.685ArgThr: 2.685 ± 0.049	4.765ArgVal: 4.765 ± 0.075	1.182ArgTrp: 1.182 ± 0.03	2.241ArgTyr: 2.241 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.239SerAla: 5.239 ± 0.072	0.494SerCys: 0.494 ± 0.022	3.065SerAsp: 3.065 ± 0.059	3.192SerGlu: 3.192 ± 0.056	2.066SerPhe: 2.066 ± 0.047	4.953SerGly: 4.953 ± 0.064	1.335SerHis: 1.335 ± 0.034	2.649SerIle: 2.649 ± 0.053	1.593SerLys: 1.593 ± 0.044	6.777SerLeu: 6.777 ± 0.086	1.477SerMet: 1.477 ± 0.033	1.457SerAsn: 1.457 ± 0.038	2.849SerPro: 2.849 ± 0.052	2.391SerGln: 2.391 ± 0.046	4.415SerArg: 4.415 ± 0.075	3.322SerSer: 3.322 ± 0.056	2.611SerThr: 2.611 ± 0.05	3.717SerVal: 3.717 ± 0.068	0.836SerTrp: 0.836 ± 0.03	1.34SerTyr: 1.34 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.768ThrAla: 4.768 ± 0.08	0.439ThrCys: 0.439 ± 0.021	2.515ThrAsp: 2.515 ± 0.051	2.465ThrGlu: 2.465 ± 0.05	1.83ThrPhe: 1.83 ± 0.042	4.096ThrGly: 4.096 ± 0.062	1.135ThrHis: 1.135 ± 0.032	2.165ThrIle: 2.165 ± 0.046	1.118ThrLys: 1.118 ± 0.034	7.216ThrLeu: 7.216 ± 0.088	0.94ThrMet: 0.94 ± 0.032	1.204ThrAsn: 1.204 ± 0.035	3.287ThrPro: 3.287 ± 0.063	2.049ThrGln: 2.049 ± 0.045	3.49ThrArg: 3.49 ± 0.058	2.854ThrSer: 2.854 ± 0.049	2.595ThrThr: 2.595 ± 0.05	3.279ThrVal: 3.279 ± 0.056	0.684ThrTrp: 0.684 ± 0.026	1.13ThrTyr: 1.13 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	7.337ValAla: 7.337 ± 0.082	0.652ValCys: 0.652 ± 0.024	4.009ValAsp: 4.009 ± 0.067	4.66ValGlu: 4.66 ± 0.069	2.554ValPhe: 2.554 ± 0.05	4.91ValGly: 4.91 ± 0.076	1.38ValHis: 1.38 ± 0.039	4.047ValIle: 4.047 ± 0.062	2.352ValLys: 2.352 ± 0.053	7.362ValLeu: 7.362 ± 0.083	1.909ValMet: 1.909 ± 0.042	2.028ValAsn: 2.028 ± 0.045	3.203ValPro: 3.203 ± 0.051	2.119ValGln: 2.119 ± 0.044	4.026ValArg: 4.026 ± 0.067	4.092ValSer: 4.092 ± 0.062	3.831ValThr: 3.831 ± 0.057	5.306ValVal: 5.306 ± 0.08	0.853ValTrp: 0.853 ± 0.031	1.585ValTyr: 1.585 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.173TrpAla: 1.173 ± 0.035	0.203TrpCys: 0.203 ± 0.011	0.609TrpAsp: 0.609 ± 0.024	0.703TrpGlu: 0.703 ± 0.023	0.561TrpPhe: 0.561 ± 0.021	1.018TrpGly: 1.018 ± 0.031	0.403TrpHis: 0.403 ± 0.018	0.78TrpIle: 0.78 ± 0.03	0.463TrpLys: 0.463 ± 0.021	2.547TrpLeu: 2.547 ± 0.062	0.433TrpMet: 0.433 ± 0.023	0.408TrpAsn: 0.408 ± 0.018	0.749TrpPro: 0.749 ± 0.03	1.033TrpGln: 1.033 ± 0.032	1.309TrpArg: 1.309 ± 0.038	0.797TrpSer: 0.797 ± 0.03	0.63TrpThr: 0.63 ± 0.029	0.93TrpVal: 0.93 ± 0.029	0.36TrpTrp: 0.36 ± 0.018	0.38TrpTyr: 0.38 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.416TyrAla: 2.416 ± 0.052	0.294TyrCys: 0.294 ± 0.016	1.303TyrAsp: 1.303 ± 0.035	1.191TyrGlu: 1.191 ± 0.033	1.014TyrPhe: 1.014 ± 0.034	2.042TyrGly: 2.042 ± 0.041	0.685TyrHis: 0.685 ± 0.021	0.998TyrIle: 0.998 ± 0.033	0.629TyrLys: 0.629 ± 0.023	3.138TyrLeu: 3.138 ± 0.058	0.5TyrMet: 0.5 ± 0.022	0.654TyrAsn: 0.654 ± 0.029	1.313TyrPro: 1.313 ± 0.037	1.167TyrGln: 1.167 ± 0.037	2.413TyrArg: 2.413 ± 0.049	1.365TyrSer: 1.365 ± 0.034	1.185TyrThr: 1.185 ± 0.031	1.524TyrVal: 1.524 ± 0.037	0.451TyrTrp: 0.451 ± 0.023	0.765TyrTyr: 0.765 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3396 proteins (1106925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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