Amino acid dipepetide frequency for Marinobacter sp. Z-D5-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.39AlaAla: 10.39 ± 0.409
0.736AlaCys: 0.736 ± 0.135
5.649AlaAsp: 5.649 ± 0.325
6.607AlaGlu: 6.607 ± 0.386
3.954AlaPhe: 3.954 ± 0.311
8.662AlaGly: 8.662 ± 0.449
1.523AlaHis: 1.523 ± 0.173
5.974AlaIle: 5.974 ± 0.307
3.304AlaLys: 3.304 ± 0.268
11.606AlaLeu: 11.606 ± 0.536
3.064AlaMet: 3.064 ± 0.304
3.629AlaAsn: 3.629 ± 0.315
4.279AlaPro: 4.279 ± 0.279
3.252AlaGln: 3.252 ± 0.25
5.871AlaArg: 5.871 ± 0.335
4.998AlaSer: 4.998 ± 0.341
5.101AlaThr: 5.101 ± 0.369
7.155AlaVal: 7.155 ± 0.37
1.592AlaTrp: 1.592 ± 0.175
2.14AlaTyr: 2.14 ± 0.182
0.0AlaXaa: 0.0 ± 0.0
Cys
0.924CysAla: 0.924 ± 0.124
0.017CysCys: 0.017 ± 0.018
0.616CysAsp: 0.616 ± 0.105
0.445CysGlu: 0.445 ± 0.106
0.359CysPhe: 0.359 ± 0.071
0.736CysGly: 0.736 ± 0.113
0.223CysHis: 0.223 ± 0.071
0.325CysIle: 0.325 ± 0.075
0.325CysLys: 0.325 ± 0.078
0.856CysLeu: 0.856 ± 0.131
0.12CysMet: 0.12 ± 0.044
0.274CysAsn: 0.274 ± 0.067
0.548CysPro: 0.548 ± 0.101
0.445CysGln: 0.445 ± 0.085
0.359CysArg: 0.359 ± 0.065
0.514CysSer: 0.514 ± 0.099
0.308CysThr: 0.308 ± 0.077
0.548CysVal: 0.548 ± 0.098
0.12CysTrp: 0.12 ± 0.05
0.223CysTyr: 0.223 ± 0.059
0.0CysXaa: 0.0 ± 0.0
Asp
4.981AspAla: 4.981 ± 0.267
0.445AspCys: 0.445 ± 0.091
3.201AspAsp: 3.201 ± 0.325
3.937AspGlu: 3.937 ± 0.287
2.294AspPhe: 2.294 ± 0.22
4.519AspGly: 4.519 ± 0.311
1.113AspHis: 1.113 ± 0.136
3.047AspIle: 3.047 ± 0.286
1.883AspLys: 1.883 ± 0.206
5.7AspLeu: 5.7 ± 0.332
1.797AspMet: 1.797 ± 0.221
1.797AspAsn: 1.797 ± 0.184
2.533AspPro: 2.533 ± 0.241
2.311AspGln: 2.311 ± 0.171
3.201AspArg: 3.201 ± 0.216
2.996AspSer: 2.996 ± 0.256
3.15AspThr: 3.15 ± 0.216
3.971AspVal: 3.971 ± 0.262
0.753AspTrp: 0.753 ± 0.11
2.02AspTyr: 2.02 ± 0.22
0.0AspXaa: 0.0 ± 0.0
Glu
7.053GluAla: 7.053 ± 0.465
0.514GluCys: 0.514 ± 0.1
3.252GluAsp: 3.252 ± 0.236
4.553GluGlu: 4.553 ± 0.367
1.951GluPhe: 1.951 ± 0.186
4.81GluGly: 4.81 ± 0.296
1.181GluHis: 1.181 ± 0.178
3.389GluIle: 3.389 ± 0.245
2.978GluLys: 2.978 ± 0.248
7.429GluLeu: 7.429 ± 0.351
1.66GluMet: 1.66 ± 0.193
2.636GluAsn: 2.636 ± 0.244
3.081GluPro: 3.081 ± 0.225
3.971GluGln: 3.971 ± 0.33
4.776GluArg: 4.776 ± 0.33
3.851GluSer: 3.851 ± 0.238
3.338GluThr: 3.338 ± 0.241
4.913GluVal: 4.913 ± 0.378
0.839GluTrp: 0.839 ± 0.123
1.506GluTyr: 1.506 ± 0.142
0.0GluXaa: 0.0 ± 0.0
Phe
3.458PheAla: 3.458 ± 0.289
0.342PheCys: 0.342 ± 0.076
2.242PheAsp: 2.242 ± 0.218
2.636PheGlu: 2.636 ± 0.208
1.506PhePhe: 1.506 ± 0.19
2.91PheGly: 2.91 ± 0.267
0.702PheHis: 0.702 ± 0.127
1.866PheIle: 1.866 ± 0.205
0.993PheLys: 0.993 ± 0.161
3.389PheLeu: 3.389 ± 0.219
0.753PheMet: 0.753 ± 0.094
1.506PheAsn: 1.506 ± 0.17
1.695PhePro: 1.695 ± 0.183
1.13PheGln: 1.13 ± 0.146
3.098PheArg: 3.098 ± 0.253
3.03PheSer: 3.03 ± 0.259
2.191PheThr: 2.191 ± 0.181
3.15PheVal: 3.15 ± 0.221
0.582PheTrp: 0.582 ± 0.13
1.078PheTyr: 1.078 ± 0.12
0.0PheXaa: 0.0 ± 0.0
Gly
7.053GlyAla: 7.053 ± 0.393
0.822GlyCys: 0.822 ± 0.108
4.331GlyAsp: 4.331 ± 0.283
5.324GlyGlu: 5.324 ± 0.302
3.663GlyPhe: 3.663 ± 0.262
6.162GlyGly: 6.162 ± 0.456
1.609GlyHis: 1.609 ± 0.173
4.827GlyIle: 4.827 ± 0.324
3.115GlyLys: 3.115 ± 0.268
8.371GlyLeu: 8.371 ± 0.509
2.037GlyMet: 2.037 ± 0.241
2.842GlyAsn: 2.842 ± 0.286
2.687GlyPro: 2.687 ± 0.245
3.167GlyGln: 3.167 ± 0.232
4.947GlyArg: 4.947 ± 0.344
5.289GlySer: 5.289 ± 0.373
4.331GlyThr: 4.331 ± 0.343
5.803GlyVal: 5.803 ± 0.325
1.369GlyTrp: 1.369 ± 0.155
2.499GlyTyr: 2.499 ± 0.204
0.0GlyXaa: 0.0 ± 0.0
His
1.609HisAla: 1.609 ± 0.175
0.377HisCys: 0.377 ± 0.078
0.839HisAsp: 0.839 ± 0.13
1.181HisGlu: 1.181 ± 0.148
0.685HisPhe: 0.685 ± 0.115
1.883HisGly: 1.883 ± 0.208
0.719HisHis: 0.719 ± 0.139
0.856HisIle: 0.856 ± 0.118
0.685HisLys: 0.685 ± 0.123
1.986HisLeu: 1.986 ± 0.199
0.394HisMet: 0.394 ± 0.091
0.599HisAsn: 0.599 ± 0.094
1.335HisPro: 1.335 ± 0.161
0.822HisGln: 0.822 ± 0.133
1.455HisArg: 1.455 ± 0.177
1.113HisSer: 1.113 ± 0.142
0.856HisThr: 0.856 ± 0.111
1.181HisVal: 1.181 ± 0.139
0.359HisTrp: 0.359 ± 0.082
0.599HisTyr: 0.599 ± 0.088
0.0HisXaa: 0.0 ± 0.0
Ile
5.991IleAla: 5.991 ± 0.387
0.428IleCys: 0.428 ± 0.099
3.321IleAsp: 3.321 ± 0.226
4.279IleGlu: 4.279 ± 0.31
1.523IlePhe: 1.523 ± 0.178
4.742IleGly: 4.742 ± 0.28
0.924IleHis: 0.924 ± 0.125
2.807IleIle: 2.807 ± 0.257
1.746IleLys: 1.746 ± 0.17
5.033IleLeu: 5.033 ± 0.312
0.959IleMet: 0.959 ± 0.137
2.105IleAsn: 2.105 ± 0.179
2.174IlePro: 2.174 ± 0.215
2.003IleGln: 2.003 ± 0.213
3.68IleArg: 3.68 ± 0.243
3.372IleSer: 3.372 ± 0.233
3.304IleThr: 3.304 ± 0.268
3.68IleVal: 3.68 ± 0.247
0.599IleTrp: 0.599 ± 0.106
1.369IleTyr: 1.369 ± 0.143
0.0IleXaa: 0.0 ± 0.0
Lys
3.903LysAla: 3.903 ± 0.36
0.103LysCys: 0.103 ± 0.053
2.14LysAsp: 2.14 ± 0.207
2.345LysGlu: 2.345 ± 0.277
1.181LysPhe: 1.181 ± 0.146
2.619LysGly: 2.619 ± 0.209
0.719LysHis: 0.719 ± 0.108
1.746LysIle: 1.746 ± 0.176
1.592LysLys: 1.592 ± 0.209
3.578LysLeu: 3.578 ± 0.297
0.805LysMet: 0.805 ± 0.136
1.061LysAsn: 1.061 ± 0.124
1.951LysPro: 1.951 ± 0.202
1.489LysGln: 1.489 ± 0.175
2.636LysArg: 2.636 ± 0.261
1.814LysSer: 1.814 ± 0.185
2.088LysThr: 2.088 ± 0.169
2.739LysVal: 2.739 ± 0.224
0.411LysTrp: 0.411 ± 0.084
0.719LysTyr: 0.719 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
11.623LeuAla: 11.623 ± 0.582
1.113LeuCys: 1.113 ± 0.134
5.392LeuAsp: 5.392 ± 0.33
7.309LeuGlu: 7.309 ± 0.39
4.108LeuPhe: 4.108 ± 0.305
8.131LeuGly: 8.131 ± 0.506
2.174LeuHis: 2.174 ± 0.201
6.111LeuIle: 6.111 ± 0.37
4.759LeuLys: 4.759 ± 0.291
11.058LeuLeu: 11.058 ± 0.688
2.705LeuMet: 2.705 ± 0.217
3.783LeuAsn: 3.783 ± 0.287
5.324LeuPro: 5.324 ± 0.328
4.04LeuGln: 4.04 ± 0.283
6.488LeuArg: 6.488 ± 0.394
6.368LeuSer: 6.368 ± 0.305
5.632LeuThr: 5.632 ± 0.271
8.097LeuVal: 8.097 ± 0.461
1.318LeuTrp: 1.318 ± 0.167
2.123LeuTyr: 2.123 ± 0.217
0.0LeuXaa: 0.0 ± 0.0
Met
2.978MetAla: 2.978 ± 0.244
0.086MetCys: 0.086 ± 0.038
1.335MetAsp: 1.335 ± 0.127
1.455MetGlu: 1.455 ± 0.163
0.65MetPhe: 0.65 ± 0.13
1.951MetGly: 1.951 ± 0.196
0.411MetHis: 0.411 ± 0.091
1.232MetIle: 1.232 ± 0.175
0.941MetLys: 0.941 ± 0.126
2.876MetLeu: 2.876 ± 0.276
0.565MetMet: 0.565 ± 0.093
0.993MetAsn: 0.993 ± 0.147
1.301MetPro: 1.301 ± 0.141
0.822MetGln: 0.822 ± 0.127
1.25MetArg: 1.25 ± 0.167
1.523MetSer: 1.523 ± 0.176
1.814MetThr: 1.814 ± 0.192
2.157MetVal: 2.157 ± 0.186
0.137MetTrp: 0.137 ± 0.045
0.428MetTyr: 0.428 ± 0.088
0.0MetXaa: 0.0 ± 0.0
Asn
3.389AsnAla: 3.389 ± 0.223
0.325AsnCys: 0.325 ± 0.074
1.609AsnAsp: 1.609 ± 0.177
1.832AsnGlu: 1.832 ± 0.154
1.369AsnPhe: 1.369 ± 0.172
2.927AsnGly: 2.927 ± 0.286
0.787AsnHis: 0.787 ± 0.118
2.054AsnIle: 2.054 ± 0.172
1.25AsnLys: 1.25 ± 0.14
4.006AsnLeu: 4.006 ± 0.289
0.856AsnMet: 0.856 ± 0.137
1.318AsnAsn: 1.318 ± 0.188
2.003AsnPro: 2.003 ± 0.217
1.301AsnGln: 1.301 ± 0.154
2.602AsnArg: 2.602 ± 0.222
1.712AsnSer: 1.712 ± 0.219
1.746AsnThr: 1.746 ± 0.168
2.14AsnVal: 2.14 ± 0.208
0.565AsnTrp: 0.565 ± 0.116
1.078AsnTyr: 1.078 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
4.416ProAla: 4.416 ± 0.305
0.394ProCys: 0.394 ± 0.081
3.732ProAsp: 3.732 ± 0.28
4.314ProGlu: 4.314 ± 0.29
2.105ProPhe: 2.105 ± 0.208
4.262ProGly: 4.262 ± 0.281
0.805ProHis: 0.805 ± 0.133
2.003ProIle: 2.003 ± 0.193
1.369ProLys: 1.369 ± 0.129
4.502ProLeu: 4.502 ± 0.301
1.232ProMet: 1.232 ± 0.132
1.523ProAsn: 1.523 ± 0.18
1.609ProPro: 1.609 ± 0.167
1.609ProGln: 1.609 ± 0.175
1.934ProArg: 1.934 ± 0.187
2.482ProSer: 2.482 ± 0.217
1.78ProThr: 1.78 ± 0.211
3.886ProVal: 3.886 ± 0.287
0.77ProTrp: 0.77 ± 0.121
1.027ProTyr: 1.027 ± 0.135
0.0ProXaa: 0.0 ± 0.0
Gln
4.433GlnAla: 4.433 ± 0.284
0.274GlnCys: 0.274 ± 0.058
1.849GlnAsp: 1.849 ± 0.209
2.67GlnGlu: 2.67 ± 0.222
1.318GlnPhe: 1.318 ± 0.173
2.961GlnGly: 2.961 ± 0.253
0.856GlnHis: 0.856 ± 0.128
2.294GlnIle: 2.294 ± 0.187
1.455GlnLys: 1.455 ± 0.147
4.16GlnLeu: 4.16 ± 0.305
0.839GlnMet: 0.839 ± 0.109
1.421GlnAsn: 1.421 ± 0.17
1.541GlnPro: 1.541 ± 0.168
2.105GlnGln: 2.105 ± 0.29
2.705GlnArg: 2.705 ± 0.341
2.516GlnSer: 2.516 ± 0.203
2.379GlnThr: 2.379 ± 0.195
3.013GlnVal: 3.013 ± 0.227
0.822GlnTrp: 0.822 ± 0.125
0.993GlnTyr: 0.993 ± 0.115
0.0GlnXaa: 0.0 ± 0.0
Arg
5.649ArgAla: 5.649 ± 0.338
0.514ArgCys: 0.514 ± 0.103
3.201ArgAsp: 3.201 ± 0.254
4.485ArgGlu: 4.485 ± 0.33
2.807ArgPhe: 2.807 ± 0.207
3.886ArgGly: 3.886 ± 0.273
1.198ArgHis: 1.198 ± 0.128
3.338ArgIle: 3.338 ± 0.217
2.414ArgLys: 2.414 ± 0.24
7.258ArgLeu: 7.258 ± 0.416
1.66ArgMet: 1.66 ± 0.194
2.277ArgAsn: 2.277 ± 0.187
2.807ArgPro: 2.807 ± 0.204
3.475ArgGln: 3.475 ± 0.273
4.297ArgArg: 4.297 ± 0.304
3.56ArgSer: 3.56 ± 0.228
2.842ArgThr: 2.842 ± 0.247
4.502ArgVal: 4.502 ± 0.316
0.77ArgTrp: 0.77 ± 0.141
2.071ArgTyr: 2.071 ± 0.232
0.0ArgXaa: 0.0 ± 0.0
Ser
5.906SerAla: 5.906 ± 0.333
0.257SerCys: 0.257 ± 0.068
3.475SerAsp: 3.475 ± 0.247
4.125SerGlu: 4.125 ± 0.29
2.294SerPhe: 2.294 ± 0.195
5.529SerGly: 5.529 ± 0.378
1.232SerHis: 1.232 ± 0.144
3.013SerIle: 3.013 ± 0.208
1.592SerLys: 1.592 ± 0.192
6.488SerLeu: 6.488 ± 0.404
1.472SerMet: 1.472 ± 0.168
2.088SerAsn: 2.088 ± 0.226
2.739SerPro: 2.739 ± 0.24
2.277SerGln: 2.277 ± 0.22
3.612SerArg: 3.612 ± 0.252
3.269SerSer: 3.269 ± 0.292
2.516SerThr: 2.516 ± 0.219
4.382SerVal: 4.382 ± 0.261
0.873SerTrp: 0.873 ± 0.117
1.335SerTyr: 1.335 ± 0.152
0.0SerXaa: 0.0 ± 0.0
Thr
5.05ThrAla: 5.05 ± 0.377
0.342ThrCys: 0.342 ± 0.077
2.687ThrAsp: 2.687 ± 0.27
3.184ThrGlu: 3.184 ± 0.211
2.02ThrPhe: 2.02 ± 0.224
5.289ThrGly: 5.289 ± 0.284
0.959ThrHis: 0.959 ± 0.129
2.893ThrIle: 2.893 ± 0.23
1.592ThrLys: 1.592 ± 0.167
6.556ThrLeu: 6.556 ± 0.349
1.284ThrMet: 1.284 ± 0.151
1.506ThrAsn: 1.506 ± 0.169
2.568ThrPro: 2.568 ± 0.181
2.02ThrGln: 2.02 ± 0.21
3.133ThrArg: 3.133 ± 0.242
3.03ThrSer: 3.03 ± 0.226
2.824ThrThr: 2.824 ± 0.248
4.006ThrVal: 4.006 ± 0.258
0.599ThrTrp: 0.599 ± 0.085
1.078ThrTyr: 1.078 ± 0.156
0.0ThrXaa: 0.0 ± 0.0
Val
7.823ValAla: 7.823 ± 0.393
0.719ValCys: 0.719 ± 0.104
4.519ValAsp: 4.519 ± 0.313
4.57ValGlu: 4.57 ± 0.267
2.824ValPhe: 2.824 ± 0.236
5.512ValGly: 5.512 ± 0.307
1.421ValHis: 1.421 ± 0.193
4.485ValIle: 4.485 ± 0.237
2.499ValLys: 2.499 ± 0.261
7.737ValLeu: 7.737 ± 0.387
1.832ValMet: 1.832 ± 0.178
2.157ValAsn: 2.157 ± 0.226
3.526ValPro: 3.526 ± 0.242
2.088ValGln: 2.088 ± 0.2
4.416ValArg: 4.416 ± 0.246
4.742ValSer: 4.742 ± 0.302
4.673ValThr: 4.673 ± 0.307
6.316ValVal: 6.316 ± 0.394
0.77ValTrp: 0.77 ± 0.132
1.695ValTyr: 1.695 ± 0.172
0.0ValXaa: 0.0 ± 0.0
Trp
0.907TrpAla: 0.907 ± 0.132
0.24TrpCys: 0.24 ± 0.059
0.856TrpAsp: 0.856 ± 0.134
0.736TrpGlu: 0.736 ± 0.139
0.531TrpPhe: 0.531 ± 0.106
0.787TrpGly: 0.787 ± 0.149
0.462TrpHis: 0.462 ± 0.092
0.77TrpIle: 0.77 ± 0.111
0.291TrpLys: 0.291 ± 0.073
2.294TrpLeu: 2.294 ± 0.26
0.291TrpMet: 0.291 ± 0.079
0.531TrpAsn: 0.531 ± 0.093
0.65TrpPro: 0.65 ± 0.122
0.873TrpGln: 0.873 ± 0.098
0.924TrpArg: 0.924 ± 0.119
0.719TrpSer: 0.719 ± 0.124
0.582TrpThr: 0.582 ± 0.108
0.941TrpVal: 0.941 ± 0.116
0.223TrpTrp: 0.223 ± 0.063
0.308TrpTyr: 0.308 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.951TyrAla: 1.951 ± 0.191
0.24TyrCys: 0.24 ± 0.06
1.404TyrAsp: 1.404 ± 0.15
1.695TyrGlu: 1.695 ± 0.174
1.113TyrPhe: 1.113 ± 0.119
1.969TyrGly: 1.969 ± 0.212
0.514TyrHis: 0.514 ± 0.094
1.01TyrIle: 1.01 ± 0.114
0.873TyrLys: 0.873 ± 0.137
2.773TyrLeu: 2.773 ± 0.218
0.565TyrMet: 0.565 ± 0.093
0.822TyrAsn: 0.822 ± 0.105
1.404TyrPro: 1.404 ± 0.17
1.404TyrGln: 1.404 ± 0.149
1.626TyrArg: 1.626 ± 0.165
1.575TyrSer: 1.575 ± 0.163
1.164TyrThr: 1.164 ± 0.128
1.746TyrVal: 1.746 ± 0.17
0.445TyrTrp: 0.445 ± 0.085
0.753TyrTyr: 0.753 ± 0.131
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 201 proteins (58420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski