Amino acid dipepetide frequency for Rhodocyclus tenuis (Rhodospirillum tenue)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.291AlaAla: 20.291 ± 0.277	1.337AlaCys: 1.337 ± 0.05	7.679AlaAsp: 7.679 ± 0.11	7.81AlaGlu: 7.81 ± 0.119	4.048AlaPhe: 4.048 ± 0.069	10.798AlaGly: 10.798 ± 0.144	2.88AlaHis: 2.88 ± 0.067	5.921AlaIle: 5.921 ± 0.081	3.47AlaLys: 3.47 ± 0.086	15.639AlaLeu: 15.639 ± 0.162	2.949AlaMet: 2.949 ± 0.062	3.281AlaAsn: 3.281 ± 0.078	6.672AlaPro: 6.672 ± 0.135	5.279AlaGln: 5.279 ± 0.099	9.96AlaArg: 9.96 ± 0.146	7.479AlaSer: 7.479 ± 0.113	6.565AlaThr: 6.565 ± 0.089	8.773AlaVal: 8.773 ± 0.112	1.637AlaTrp: 1.637 ± 0.051	2.412AlaTyr: 2.412 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.37CysAla: 1.37 ± 0.049	0.129CysCys: 0.129 ± 0.013	0.58CysAsp: 0.58 ± 0.028	0.52CysGlu: 0.52 ± 0.026	0.347CysPhe: 0.347 ± 0.021	1.039CysGly: 1.039 ± 0.036	0.301CysHis: 0.301 ± 0.02	0.372CysIle: 0.372 ± 0.022	0.207CysLys: 0.207 ± 0.017	0.995CysLeu: 0.995 ± 0.032	0.165CysMet: 0.165 ± 0.016	0.245CysAsn: 0.245 ± 0.017	0.543CysPro: 0.543 ± 0.029	0.281CysGln: 0.281 ± 0.017	0.808CysArg: 0.808 ± 0.034	0.537CysSer: 0.537 ± 0.027	0.436CysThr: 0.436 ± 0.025	0.731CysVal: 0.731 ± 0.029	0.133CysTrp: 0.133 ± 0.012	0.289CysTyr: 0.289 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.902AspAla: 7.902 ± 0.117	0.574AspCys: 0.574 ± 0.027	3.273AspAsp: 3.273 ± 0.073	3.701AspGlu: 3.701 ± 0.07	2.298AspPhe: 2.298 ± 0.053	4.482AspGly: 4.482 ± 0.077	0.963AspHis: 0.963 ± 0.038	2.82AspIle: 2.82 ± 0.057	1.488AspLys: 1.488 ± 0.054	5.503AspLeu: 5.503 ± 0.083	1.011AspMet: 1.011 ± 0.033	1.211AspAsn: 1.211 ± 0.04	2.697AspPro: 2.697 ± 0.059	1.395AspGln: 1.395 ± 0.043	3.315AspArg: 3.315 ± 0.071	2.811AspSer: 2.811 ± 0.056	2.62AspThr: 2.62 ± 0.047	3.925AspVal: 3.925 ± 0.065	0.992AspTrp: 0.992 ± 0.036	1.51AspTyr: 1.51 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.492GluAla: 7.492 ± 0.106	0.545GluCys: 0.545 ± 0.029	2.285GluAsp: 2.285 ± 0.053	3.118GluGlu: 3.118 ± 0.081	2.045GluPhe: 2.045 ± 0.061	3.709GluGly: 3.709 ± 0.063	1.479GluHis: 1.479 ± 0.045	3.312GluIle: 3.312 ± 0.067	2.277GluLys: 2.277 ± 0.065	6.04GluLeu: 6.04 ± 0.092	1.411GluMet: 1.411 ± 0.041	1.56GluAsn: 1.56 ± 0.05	2.117GluPro: 2.117 ± 0.058	2.349GluGln: 2.349 ± 0.059	5.425GluArg: 5.425 ± 0.096	2.941GluSer: 2.941 ± 0.065	3.041GluThr: 3.041 ± 0.063	3.932GluVal: 3.932 ± 0.08	0.734GluTrp: 0.734 ± 0.03	1.062GluTyr: 1.062 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	5.13PheAla: 5.13 ± 0.082	0.443PheCys: 0.443 ± 0.023	2.264PheAsp: 2.264 ± 0.052	1.848PheGlu: 1.848 ± 0.054	1.537PhePhe: 1.537 ± 0.049	3.302PheGly: 3.302 ± 0.067	0.728PheHis: 0.728 ± 0.034	1.698PheIle: 1.698 ± 0.047	0.916PheLys: 0.916 ± 0.036	3.257PheLeu: 3.257 ± 0.078	0.674PheMet: 0.674 ± 0.033	1.126PheAsn: 1.126 ± 0.039	1.554PhePro: 1.554 ± 0.046	0.924PheGln: 0.924 ± 0.032	2.201PheArg: 2.201 ± 0.046	2.403PheSer: 2.403 ± 0.061	1.747PheThr: 1.747 ± 0.045	2.813PheVal: 2.813 ± 0.057	0.44PheTrp: 0.44 ± 0.026	0.871PheTyr: 0.871 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.185GlyAla: 9.185 ± 0.124	0.922GlyCys: 0.922 ± 0.033	4.451GlyAsp: 4.451 ± 0.075	5.377GlyGlu: 5.377 ± 0.084	3.244GlyPhe: 3.244 ± 0.066	6.602GlyGly: 6.602 ± 0.124	1.715GlyHis: 1.715 ± 0.044	4.325GlyIle: 4.325 ± 0.069	3.124GlyLys: 3.124 ± 0.072	7.948GlyLeu: 7.948 ± 0.103	1.894GlyMet: 1.894 ± 0.053	2.106GlyAsn: 2.106 ± 0.065	2.191GlyPro: 2.191 ± 0.057	2.726GlyGln: 2.726 ± 0.062	5.889GlyArg: 5.889 ± 0.103	4.409GlySer: 4.409 ± 0.097	3.61GlyThr: 3.61 ± 0.078	6.606GlyVal: 6.606 ± 0.088	1.174GlyTrp: 1.174 ± 0.038	2.113GlyTyr: 2.113 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.838HisAla: 2.838 ± 0.067	0.322HisCys: 0.322 ± 0.022	1.237HisAsp: 1.237 ± 0.038	1.196HisGlu: 1.196 ± 0.042	0.968HisPhe: 0.968 ± 0.037	2.099HisGly: 2.099 ± 0.052	0.531HisHis: 0.531 ± 0.024	0.908HisIle: 0.908 ± 0.03	0.508HisLys: 0.508 ± 0.025	2.361HisLeu: 2.361 ± 0.055	0.375HisMet: 0.375 ± 0.022	0.486HisAsn: 0.486 ± 0.024	1.402HisPro: 1.402 ± 0.044	0.644HisGln: 0.644 ± 0.026	1.499HisArg: 1.499 ± 0.052	1.115HisSer: 1.115 ± 0.033	0.947HisThr: 0.947 ± 0.034	1.425HisVal: 1.425 ± 0.041	0.355HisTrp: 0.355 ± 0.021	0.667HisTyr: 0.667 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.862IleAla: 6.862 ± 0.097	0.452IleCys: 0.452 ± 0.024	3.629IleAsp: 3.629 ± 0.072	3.414IleGlu: 3.414 ± 0.061	1.502IlePhe: 1.502 ± 0.047	4.489IleGly: 4.489 ± 0.072	0.989IleHis: 0.989 ± 0.032	1.965IleIle: 1.965 ± 0.048	1.434IleLys: 1.434 ± 0.05	3.866IleLeu: 3.866 ± 0.073	0.709IleMet: 0.709 ± 0.033	1.551IleAsn: 1.551 ± 0.048	2.127IlePro: 2.127 ± 0.057	1.187IleGln: 1.187 ± 0.039	3.029IleArg: 3.029 ± 0.062	2.702IleSer: 2.702 ± 0.059	2.361IleThr: 2.361 ± 0.059	3.936IleVal: 3.936 ± 0.068	0.396IleTrp: 0.396 ± 0.022	1.033IleTyr: 1.033 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.539LysAla: 3.539 ± 0.075	0.178LysCys: 0.178 ± 0.015	1.405LysAsp: 1.405 ± 0.043	1.633LysGlu: 1.633 ± 0.05	0.842LysPhe: 0.842 ± 0.033	2.087LysGly: 2.087 ± 0.053	0.569LysHis: 0.569 ± 0.028	1.653LysIle: 1.653 ± 0.05	1.414LysLys: 1.414 ± 0.06	3.121LysLeu: 3.121 ± 0.064	0.681LysMet: 0.681 ± 0.03	1.02LysAsn: 1.02 ± 0.041	1.708LysPro: 1.708 ± 0.049	1.014LysGln: 1.014 ± 0.032	2.128LysArg: 2.128 ± 0.058	1.729LysSer: 1.729 ± 0.043	1.856LysThr: 1.856 ± 0.052	2.115LysVal: 2.115 ± 0.049	0.28LysTrp: 0.28 ± 0.019	0.647LysTyr: 0.647 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	16.932LeuAla: 16.932 ± 0.185	1.1LeuCys: 1.1 ± 0.039	6.319LeuAsp: 6.319 ± 0.09	5.351LeuGlu: 5.351 ± 0.084	3.66LeuPhe: 3.66 ± 0.079	8.29LeuGly: 8.29 ± 0.107	2.3LeuHis: 2.3 ± 0.06	5.124LeuIle: 5.124 ± 0.077	3.3LeuLys: 3.3 ± 0.068	12.262LeuLeu: 12.262 ± 0.169	2.009LeuMet: 2.009 ± 0.05	2.662LeuAsn: 2.662 ± 0.064	6.55LeuPro: 6.55 ± 0.096	3.27LeuGln: 3.27 ± 0.064	8.52LeuArg: 8.52 ± 0.096	6.474LeuSer: 6.474 ± 0.091	5.664LeuThr: 5.664 ± 0.072	7.285LeuVal: 7.285 ± 0.127	1.207LeuTrp: 1.207 ± 0.044	2.036LeuTyr: 2.036 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.48MetAla: 2.48 ± 0.051	0.144MetCys: 0.144 ± 0.014	0.82MetAsp: 0.82 ± 0.027	0.903MetGlu: 0.903 ± 0.033	0.548MetPhe: 0.548 ± 0.028	1.417MetGly: 1.417 ± 0.046	0.467MetHis: 0.467 ± 0.022	1.063MetIle: 1.063 ± 0.038	0.81MetLys: 0.81 ± 0.032	2.288MetLeu: 2.288 ± 0.05	0.475MetMet: 0.475 ± 0.029	0.709MetAsn: 0.709 ± 0.027	1.286MetPro: 1.286 ± 0.037	0.868MetGln: 0.868 ± 0.029	1.544MetArg: 1.544 ± 0.042	1.535MetSer: 1.535 ± 0.041	1.237MetThr: 1.237 ± 0.037	1.293MetVal: 1.293 ± 0.04	0.143MetTrp: 0.143 ± 0.014	0.293MetTyr: 0.293 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.422AsnAla: 3.422 ± 0.079	0.286AsnCys: 0.286 ± 0.016	1.394AsnAsp: 1.394 ± 0.04	1.358AsnGlu: 1.358 ± 0.042	0.971AsnPhe: 0.971 ± 0.035	2.21AsnGly: 2.21 ± 0.066	0.484AsnHis: 0.484 ± 0.022	1.264AsnIle: 1.264 ± 0.037	0.734AsnLys: 0.734 ± 0.032	2.64AsnLeu: 2.64 ± 0.054	0.47AsnMet: 0.47 ± 0.027	0.714AsnAsn: 0.714 ± 0.033	1.702AsnPro: 1.702 ± 0.043	0.735AsnGln: 0.735 ± 0.033	1.742AsnArg: 1.742 ± 0.044	1.257AsnSer: 1.257 ± 0.045	1.308AsnThr: 1.308 ± 0.043	1.883AsnVal: 1.883 ± 0.052	0.371AsnTrp: 0.371 ± 0.017	0.63AsnTyr: 0.63 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	7.487ProAla: 7.487 ± 0.137	0.419ProCys: 0.419 ± 0.022	2.922ProAsp: 2.922 ± 0.047	3.344ProGlu: 3.344 ± 0.08	1.78ProPhe: 1.78 ± 0.045	4.061ProGly: 4.061 ± 0.07	1.061ProHis: 1.061 ± 0.033	1.943ProIle: 1.943 ± 0.051	1.317ProLys: 1.317 ± 0.043	5.792ProLeu: 5.792 ± 0.087	0.953ProMet: 0.953 ± 0.031	1.14ProAsn: 1.14 ± 0.042	3.043ProPro: 3.043 ± 0.077	1.85ProGln: 1.85 ± 0.05	3.051ProArg: 3.051 ± 0.077	2.629ProSer: 2.629 ± 0.062	2.552ProThr: 2.552 ± 0.053	3.927ProVal: 3.927 ± 0.069	0.693ProTrp: 0.693 ± 0.028	1.085ProTyr: 1.085 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.597GlnAla: 4.597 ± 0.088	0.293GlnCys: 0.293 ± 0.017	1.284GlnAsp: 1.284 ± 0.039	1.75GlnGlu: 1.75 ± 0.05	1.069GlnPhe: 1.069 ± 0.035	2.502GlnGly: 2.502 ± 0.057	0.909GlnHis: 0.909 ± 0.035	1.844GlnIle: 1.844 ± 0.049	1.138GlnLys: 1.138 ± 0.03	3.961GlnLeu: 3.961 ± 0.069	0.844GlnMet: 0.844 ± 0.036	0.802GlnAsn: 0.802 ± 0.028	1.819GlnPro: 1.819 ± 0.048	1.743GlnGln: 1.743 ± 0.065	3.257GlnArg: 3.257 ± 0.066	1.964GlnSer: 1.964 ± 0.054	1.902GlnThr: 1.902 ± 0.054	2.285GlnVal: 2.285 ± 0.055	0.452GlnTrp: 0.452 ± 0.022	0.653GlnTyr: 0.653 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.442ArgAla: 8.442 ± 0.115	0.707ArgCys: 0.707 ± 0.027	3.917ArgAsp: 3.917 ± 0.073	4.888ArgGlu: 4.888 ± 0.086	3.11ArgPhe: 3.11 ± 0.062	4.778ArgGly: 4.778 ± 0.074	2.057ArgHis: 2.057 ± 0.056	3.771ArgIle: 3.771 ± 0.061	1.949ArgLys: 1.949 ± 0.045	9.28ArgLeu: 9.28 ± 0.126	1.603ArgMet: 1.603 ± 0.046	1.802ArgAsn: 1.802 ± 0.047	3.456ArgPro: 3.456 ± 0.062	3.399ArgGln: 3.399 ± 0.064	6.484ArgArg: 6.484 ± 0.095	3.459ArgSer: 3.459 ± 0.07	2.988ArgThr: 2.988 ± 0.067	5.397ArgVal: 5.397 ± 0.074	1.1ArgTrp: 1.1 ± 0.039	1.991ArgTyr: 1.991 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	7.437SerAla: 7.437 ± 0.112	0.469SerCys: 0.469 ± 0.024	2.92SerAsp: 2.92 ± 0.059	2.989SerGlu: 2.989 ± 0.06	2.05SerPhe: 2.05 ± 0.051	5.437SerGly: 5.437 ± 0.111	1.099SerHis: 1.099 ± 0.033	2.502SerIle: 2.502 ± 0.054	1.353SerLys: 1.353 ± 0.045	6.437SerLeu: 6.437 ± 0.102	1.134SerMet: 1.134 ± 0.038	1.305SerAsn: 1.305 ± 0.045	3.182SerPro: 3.182 ± 0.072	1.724SerGln: 1.724 ± 0.048	3.717SerArg: 3.717 ± 0.063	3.288SerSer: 3.288 ± 0.086	2.811SerThr: 2.811 ± 0.07	4.086SerVal: 4.086 ± 0.07	0.591SerTrp: 0.591 ± 0.026	1.171SerTyr: 1.171 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.024ThrAla: 6.024 ± 0.085	0.429ThrCys: 0.429 ± 0.027	2.293ThrAsp: 2.293 ± 0.053	2.09ThrGlu: 2.09 ± 0.054	1.581ThrPhe: 1.581 ± 0.047	4.135ThrGly: 4.135 ± 0.078	1.199ThrHis: 1.199 ± 0.038	2.14ThrIle: 2.14 ± 0.054	1.02ThrLys: 1.02 ± 0.039	6.858ThrLeu: 6.858 ± 0.104	0.803ThrMet: 0.803 ± 0.03	1.115ThrAsn: 1.115 ± 0.039	3.987ThrPro: 3.987 ± 0.07	1.918ThrGln: 1.918 ± 0.047	3.62ThrArg: 3.62 ± 0.06	2.58ThrSer: 2.58 ± 0.065	2.854ThrThr: 2.854 ± 0.074	3.633ThrVal: 3.633 ± 0.076	0.486ThrTrp: 0.486 ± 0.024	0.965ThrTyr: 0.965 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.818ValAla: 9.818 ± 0.113	0.856ValCys: 0.856 ± 0.036	4.224ValAsp: 4.224 ± 0.077	4.046ValGlu: 4.046 ± 0.078	2.851ValPhe: 2.851 ± 0.06	5.53ValGly: 5.53 ± 0.1	1.358ValHis: 1.358 ± 0.037	3.633ValIle: 3.633 ± 0.075	2.209ValLys: 2.209 ± 0.057	7.655ValLeu: 7.655 ± 0.112	1.555ValMet: 1.555 ± 0.044	1.806ValAsn: 1.806 ± 0.05	3.271ValPro: 3.271 ± 0.066	2.109ValGln: 2.109 ± 0.049	5.261ValArg: 5.261 ± 0.088	4.518ValSer: 4.518 ± 0.077	3.616ValThr: 3.616 ± 0.07	6.021ValVal: 6.021 ± 0.102	0.88ValTrp: 0.88 ± 0.034	1.342ValTyr: 1.342 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.037	0.151TrpCys: 0.151 ± 0.013	0.466TrpAsp: 0.466 ± 0.025	0.534TrpGlu: 0.534 ± 0.025	0.456TrpPhe: 0.456 ± 0.026	0.777TrpGly: 0.777 ± 0.033	0.315TrpHis: 0.315 ± 0.018	0.612TrpIle: 0.612 ± 0.03	0.412TrpLys: 0.412 ± 0.025	1.96TrpLeu: 1.96 ± 0.054	0.29TrpMet: 0.29 ± 0.017	0.369TrpAsn: 0.369 ± 0.022	0.609TrpPro: 0.609 ± 0.032	0.812TrpGln: 0.812 ± 0.028	1.222TrpArg: 1.222 ± 0.039	0.686TrpSer: 0.686 ± 0.032	0.51TrpThr: 0.51 ± 0.025	0.851TrpVal: 0.851 ± 0.035	0.213TrpTrp: 0.213 ± 0.016	0.261TrpTyr: 0.261 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.539TyrAla: 2.539 ± 0.051	0.274TyrCys: 0.274 ± 0.018	1.13TyrAsp: 1.13 ± 0.038	1.004TyrGlu: 1.004 ± 0.035	0.969TyrPhe: 0.969 ± 0.033	1.865TyrGly: 1.865 ± 0.051	0.478TyrHis: 0.478 ± 0.025	0.759TyrIle: 0.759 ± 0.029	0.541TyrLys: 0.541 ± 0.03	2.453TyrLeu: 2.453 ± 0.044	0.313TyrMet: 0.313 ± 0.02	0.566TyrAsn: 0.566 ± 0.027	1.131TyrPro: 1.131 ± 0.039	0.842TyrGln: 0.842 ± 0.031	1.907TyrArg: 1.907 ± 0.045	1.188TyrSer: 1.188 ± 0.034	1.108TyrThr: 1.108 ± 0.034	1.641TyrVal: 1.641 ± 0.054	0.324TyrTrp: 0.324 ± 0.019	0.577TyrTyr: 0.577 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2603 proteins (876443 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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