Amino acid dipepetide frequency for Streptomyces glauciniger

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.181AlaAla: 23.181 ± 0.165	1.087AlaCys: 1.087 ± 0.023	8.423AlaAsp: 8.423 ± 0.057	8.667AlaGlu: 8.667 ± 0.068	3.62AlaPhe: 3.62 ± 0.041	14.043AlaGly: 14.043 ± 0.095	2.918AlaHis: 2.918 ± 0.04	3.313AlaIle: 3.313 ± 0.036	2.548AlaLys: 2.548 ± 0.039	15.012AlaLeu: 15.012 ± 0.115	2.588AlaMet: 2.588 ± 0.029	1.817AlaAsn: 1.817 ± 0.031	7.498AlaPro: 7.498 ± 0.064	3.615AlaGln: 3.615 ± 0.04	10.675AlaArg: 10.675 ± 0.077	6.034AlaSer: 6.034 ± 0.047	7.038AlaThr: 7.038 ± 0.05	13.185AlaVal: 13.185 ± 0.087	1.987AlaTrp: 1.987 ± 0.026	2.779AlaTyr: 2.779 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.074CysAla: 1.074 ± 0.019	0.095CysCys: 0.095 ± 0.006	0.465CysAsp: 0.465 ± 0.014	0.398CysGlu: 0.398 ± 0.011	0.213CysPhe: 0.213 ± 0.008	0.972CysGly: 0.972 ± 0.019	0.193CysHis: 0.193 ± 0.009	0.163CysIle: 0.163 ± 0.008	0.1CysLys: 0.1 ± 0.006	0.724CysLeu: 0.724 ± 0.017	0.115CysMet: 0.115 ± 0.007	0.126CysAsn: 0.126 ± 0.007	0.471CysPro: 0.471 ± 0.015	0.165CysGln: 0.165 ± 0.007	0.636CysArg: 0.636 ± 0.016	0.429CysSer: 0.429 ± 0.012	0.501CysThr: 0.501 ± 0.014	0.639CysVal: 0.639 ± 0.017	0.129CysTrp: 0.129 ± 0.007	0.147CysTyr: 0.147 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.967AspAla: 7.967 ± 0.07	0.414AspCys: 0.414 ± 0.013	3.596AspAsp: 3.596 ± 0.045	3.759AspGlu: 3.759 ± 0.034	1.646AspPhe: 1.646 ± 0.024	6.644AspGly: 6.644 ± 0.055	1.404AspHis: 1.404 ± 0.028	1.725AspIle: 1.725 ± 0.027	1.027AspLys: 1.027 ± 0.024	6.265AspLeu: 6.265 ± 0.055	0.775AspMet: 0.775 ± 0.018	0.923AspAsn: 0.923 ± 0.023	4.606AspPro: 4.606 ± 0.039	1.421AspGln: 1.421 ± 0.024	5.015AspArg: 5.015 ± 0.046	2.397AspSer: 2.397 ± 0.031	3.166AspThr: 3.166 ± 0.035	4.943AspVal: 4.943 ± 0.044	1.024AspTrp: 1.024 ± 0.02	1.101AspTyr: 1.101 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.455GluAla: 7.455 ± 0.07	0.382GluCys: 0.382 ± 0.011	2.954GluAsp: 2.954 ± 0.038	3.513GluGlu: 3.513 ± 0.045	1.402GluPhe: 1.402 ± 0.026	4.374GluGly: 4.374 ± 0.04	1.563GluHis: 1.563 ± 0.024	2.032GluIle: 2.032 ± 0.031	1.14GluLys: 1.14 ± 0.027	6.583GluLeu: 6.583 ± 0.057	0.818GluMet: 0.818 ± 0.018	0.919GluAsn: 0.919 ± 0.018	3.352GluPro: 3.352 ± 0.045	2.134GluGln: 2.134 ± 0.031	5.508GluArg: 5.508 ± 0.05	2.401GluSer: 2.401 ± 0.031	2.674GluThr: 2.674 ± 0.03	4.473GluVal: 4.473 ± 0.045	0.765GluTrp: 0.765 ± 0.017	1.085GluTyr: 1.085 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.712PheAla: 3.712 ± 0.04	0.248PheCys: 0.248 ± 0.009	1.907PheAsp: 1.907 ± 0.031	1.356PheGlu: 1.356 ± 0.024	0.861PhePhe: 0.861 ± 0.021	3.065PheGly: 3.065 ± 0.037	0.635PheHis: 0.635 ± 0.013	0.654PheIle: 0.654 ± 0.017	0.443PheLys: 0.443 ± 0.013	2.583PheLeu: 2.583 ± 0.036	0.39PheMet: 0.39 ± 0.012	0.526PheAsn: 0.526 ± 0.014	1.415PhePro: 1.415 ± 0.024	0.654PheGln: 0.654 ± 0.015	1.932PheArg: 1.932 ± 0.031	1.399PheSer: 1.399 ± 0.021	2.013PheThr: 2.013 ± 0.027	2.252PheVal: 2.252 ± 0.031	0.43PheTrp: 0.43 ± 0.014	0.554PheTyr: 0.554 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.571GlyAla: 11.571 ± 0.09	0.825GlyCys: 0.825 ± 0.02	5.502GlyAsp: 5.502 ± 0.052	5.126GlyGlu: 5.126 ± 0.049	2.9GlyPhe: 2.9 ± 0.038	9.473GlyGly: 9.473 ± 0.084	2.481GlyHis: 2.481 ± 0.026	3.347GlyIle: 3.347 ± 0.04	2.237GlyLys: 2.237 ± 0.041	9.683GlyLeu: 9.683 ± 0.067	2.039GlyMet: 2.039 ± 0.029	1.803GlyAsn: 1.803 ± 0.032	5.521GlyPro: 5.521 ± 0.05	2.48GlyGln: 2.48 ± 0.031	8.379GlyArg: 8.379 ± 0.063	5.43GlySer: 5.43 ± 0.049	6.783GlyThr: 6.783 ± 0.064	7.722GlyVal: 7.722 ± 0.067	1.742GlyTrp: 1.742 ± 0.023	2.283GlyTyr: 2.283 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.826HisAla: 2.826 ± 0.035	0.2HisCys: 0.2 ± 0.007	1.412HisAsp: 1.412 ± 0.025	1.23HisGlu: 1.23 ± 0.02	0.676HisPhe: 0.676 ± 0.014	2.536HisGly: 2.536 ± 0.035	0.718HisHis: 0.718 ± 0.015	0.644HisIle: 0.644 ± 0.017	0.32HisLys: 0.32 ± 0.011	2.436HisLeu: 2.436 ± 0.031	0.367HisMet: 0.367 ± 0.013	0.35HisAsn: 0.35 ± 0.013	1.884HisPro: 1.884 ± 0.029	0.601HisGln: 0.601 ± 0.016	2.128HisArg: 2.128 ± 0.032	1.033HisSer: 1.033 ± 0.019	1.304HisThr: 1.304 ± 0.021	1.824HisVal: 1.824 ± 0.027	0.369HisTrp: 0.369 ± 0.012	0.484HisTyr: 0.484 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.657IleAla: 4.657 ± 0.042	0.255IleCys: 0.255 ± 0.009	2.107IleAsp: 2.107 ± 0.032	1.744IleGlu: 1.744 ± 0.029	0.626IlePhe: 0.626 ± 0.017	3.449IleGly: 3.449 ± 0.037	0.579IleHis: 0.579 ± 0.015	0.775IleIle: 0.775 ± 0.021	0.64IleLys: 0.64 ± 0.017	2.19IleLeu: 2.19 ± 0.031	0.404IleMet: 0.404 ± 0.012	0.625IleAsn: 0.625 ± 0.016	1.661IlePro: 1.661 ± 0.022	0.615IleGln: 0.615 ± 0.016	2.18IleArg: 2.18 ± 0.031	1.564IleSer: 1.564 ± 0.025	2.085IleThr: 2.085 ± 0.029	2.569IleVal: 2.569 ± 0.032	0.369IleTrp: 0.369 ± 0.011	0.485IleTyr: 0.485 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.719LysAla: 2.719 ± 0.042	0.1LysCys: 0.1 ± 0.007	1.175LysAsp: 1.175 ± 0.024	1.007LysGlu: 1.007 ± 0.021	0.387LysPhe: 0.387 ± 0.012	1.7LysGly: 1.7 ± 0.037	0.395LysHis: 0.395 ± 0.012	0.721LysIle: 0.721 ± 0.017	0.645LysLys: 0.645 ± 0.022	1.759LysLeu: 1.759 ± 0.031	0.31LysMet: 0.31 ± 0.01	0.431LysAsn: 0.431 ± 0.014	1.173LysPro: 1.173 ± 0.023	0.591LysGln: 0.591 ± 0.015	1.292LysArg: 1.292 ± 0.024	1.008LysSer: 1.008 ± 0.022	1.084LysThr: 1.084 ± 0.023	1.745LysVal: 1.745 ± 0.032	0.24LysTrp: 0.24 ± 0.01	0.393LysTyr: 0.393 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.342LeuAla: 15.342 ± 0.107	0.808LeuCys: 0.808 ± 0.019	6.681LeuAsp: 6.681 ± 0.054	4.802LeuGlu: 4.802 ± 0.046	2.587LeuPhe: 2.587 ± 0.039	9.269LeuGly: 9.269 ± 0.064	2.308LeuHis: 2.308 ± 0.031	3.021LeuIle: 3.021 ± 0.036	1.726LeuLys: 1.726 ± 0.028	11.277LeuLeu: 11.277 ± 0.085	1.609LeuMet: 1.609 ± 0.025	1.566LeuAsn: 1.566 ± 0.026	6.712LeuPro: 6.712 ± 0.063	2.238LeuGln: 2.238 ± 0.027	9.062LeuArg: 9.062 ± 0.073	5.253LeuSer: 5.253 ± 0.044	6.798LeuThr: 6.798 ± 0.052	8.972LeuVal: 8.972 ± 0.072	1.322LeuTrp: 1.322 ± 0.023	1.868LeuTyr: 1.868 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.287MetAla: 2.287 ± 0.031	0.134MetCys: 0.134 ± 0.007	0.929MetAsp: 0.929 ± 0.019	0.739MetGlu: 0.739 ± 0.02	0.411MetPhe: 0.411 ± 0.014	1.321MetGly: 1.321 ± 0.022	0.366MetHis: 0.366 ± 0.012	0.59MetIle: 0.59 ± 0.016	0.383MetLys: 0.383 ± 0.013	1.635MetLeu: 1.635 ± 0.027	0.278MetMet: 0.278 ± 0.011	0.415MetAsn: 0.415 ± 0.012	1.092MetPro: 1.092 ± 0.018	0.416MetGln: 0.416 ± 0.012	1.48MetArg: 1.48 ± 0.025	1.276MetSer: 1.276 ± 0.021	1.482MetThr: 1.482 ± 0.023	1.276MetVal: 1.276 ± 0.021	0.209MetTrp: 0.209 ± 0.008	0.311MetTyr: 0.311 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.168AsnAla: 2.168 ± 0.031	0.153AsnCys: 0.153 ± 0.008	0.924AsnAsp: 0.924 ± 0.019	0.776AsnGlu: 0.776 ± 0.018	0.461AsnPhe: 0.461 ± 0.013	1.913AsnGly: 1.913 ± 0.035	0.382AsnHis: 0.382 ± 0.012	0.553AsnIle: 0.553 ± 0.016	0.343AsnLys: 0.343 ± 0.013	1.581AsnLeu: 1.581 ± 0.029	0.266AsnMet: 0.266 ± 0.009	0.429AsnAsn: 0.429 ± 0.016	1.306AsnPro: 1.306 ± 0.025	0.448AsnGln: 0.448 ± 0.013	1.254AsnArg: 1.254 ± 0.018	0.837AsnSer: 0.837 ± 0.021	1.055AsnThr: 1.055 ± 0.024	1.326AsnVal: 1.326 ± 0.028	0.263AsnTrp: 0.263 ± 0.011	0.376AsnTyr: 0.376 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	9.259ProAla: 9.259 ± 0.078	0.34ProCys: 0.34 ± 0.012	4.419ProAsp: 4.419 ± 0.037	4.326ProGlu: 4.326 ± 0.045	1.543ProPhe: 1.543 ± 0.026	7.233ProGly: 7.233 ± 0.057	1.432ProHis: 1.432 ± 0.022	1.227ProIle: 1.227 ± 0.027	1.036ProLys: 1.036 ± 0.022	5.49ProLeu: 5.49 ± 0.047	0.977ProMet: 0.977 ± 0.023	0.834ProAsn: 0.834 ± 0.019	3.673ProPro: 3.673 ± 0.055	1.784ProGln: 1.784 ± 0.029	4.282ProArg: 4.282 ± 0.043	3.206ProSer: 3.206 ± 0.045	2.967ProThr: 2.967 ± 0.038	5.667ProVal: 5.667 ± 0.05	0.957ProTrp: 0.957 ± 0.02	1.379ProTyr: 1.379 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.711GlnAla: 3.711 ± 0.043	0.172GlnCys: 0.172 ± 0.008	1.406GlnAsp: 1.406 ± 0.027	1.384GlnGlu: 1.384 ± 0.023	0.651GlnPhe: 0.651 ± 0.015	2.252GlnGly: 2.252 ± 0.031	0.606GlnHis: 0.606 ± 0.015	0.997GlnIle: 0.997 ± 0.022	0.51GlnLys: 0.51 ± 0.016	2.717GlnLeu: 2.717 ± 0.031	0.434GlnMet: 0.434 ± 0.013	0.468GlnAsn: 0.468 ± 0.014	1.628GlnPro: 1.628 ± 0.027	1.13GlnGln: 1.13 ± 0.031	2.312GlnArg: 2.312 ± 0.03	1.206GlnSer: 1.206 ± 0.022	1.268GlnThr: 1.268 ± 0.024	2.296GlnVal: 2.296 ± 0.032	0.472GlnTrp: 0.472 ± 0.013	0.584GlnTyr: 0.584 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.18ArgAla: 10.18 ± 0.081	0.616ArgCys: 0.616 ± 0.014	4.392ArgAsp: 4.392 ± 0.042	4.862ArgGlu: 4.862 ± 0.046	2.416ArgPhe: 2.416 ± 0.027	6.223ArgGly: 6.223 ± 0.047	2.352ArgHis: 2.352 ± 0.032	3.216ArgIle: 3.216 ± 0.039	1.526ArgLys: 1.526 ± 0.024	9.243ArgLeu: 9.243 ± 0.068	1.787ArgMet: 1.787 ± 0.029	1.334ArgAsn: 1.334 ± 0.024	5.203ArgPro: 5.203 ± 0.046	2.291ArgGln: 2.291 ± 0.027	8.209ArgArg: 8.209 ± 0.07	4.093ArgSer: 4.093 ± 0.039	5.442ArgThr: 5.442 ± 0.041	6.084ArgVal: 6.084 ± 0.054	1.44ArgTrp: 1.44 ± 0.022	1.815ArgTyr: 1.815 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.837SerAla: 6.837 ± 0.058	0.423SerCys: 0.423 ± 0.013	2.572SerAsp: 2.572 ± 0.037	2.235SerGlu: 2.235 ± 0.031	1.511SerPhe: 1.511 ± 0.022	6.072SerGly: 6.072 ± 0.053	1.005SerHis: 1.005 ± 0.023	1.33SerIle: 1.33 ± 0.025	0.899SerLys: 0.899 ± 0.02	4.729SerLeu: 4.729 ± 0.045	1.004SerMet: 1.004 ± 0.018	0.825SerAsn: 0.825 ± 0.018	3.235SerPro: 3.235 ± 0.041	1.179SerGln: 1.179 ± 0.02	3.759SerArg: 3.759 ± 0.038	2.72SerSer: 2.72 ± 0.041	2.909SerThr: 2.909 ± 0.04	4.346SerVal: 4.346 ± 0.036	0.906SerTrp: 0.906 ± 0.019	1.162SerTyr: 1.162 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.292ThrAla: 9.292 ± 0.066	0.427ThrCys: 0.427 ± 0.013	3.506ThrAsp: 3.506 ± 0.042	3.031ThrGlu: 3.031 ± 0.034	1.527ThrPhe: 1.527 ± 0.027	6.876ThrGly: 6.876 ± 0.058	1.179ThrHis: 1.179 ± 0.021	1.6ThrIle: 1.6 ± 0.026	1.047ThrLys: 1.047 ± 0.025	5.556ThrLeu: 5.556 ± 0.048	0.928ThrMet: 0.928 ± 0.019	0.919ThrAsn: 0.919 ± 0.022	4.082ThrPro: 4.082 ± 0.04	1.301ThrGln: 1.301 ± 0.024	3.974ThrArg: 3.974 ± 0.038	3.087ThrSer: 3.087 ± 0.033	3.768ThrThr: 3.768 ± 0.043	6.196ThrVal: 6.196 ± 0.061	0.934ThrTrp: 0.934 ± 0.022	1.297ThrTyr: 1.297 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.26ValAla: 11.26 ± 0.071	0.751ValCys: 0.751 ± 0.017	5.084ValAsp: 5.084 ± 0.042	4.64ValGlu: 4.64 ± 0.052	2.454ValPhe: 2.454 ± 0.03	6.561ValGly: 6.561 ± 0.065	2.056ValHis: 2.056 ± 0.025	2.677ValIle: 2.677 ± 0.03	1.616ValLys: 1.616 ± 0.028	9.929ValLeu: 9.929 ± 0.078	1.418ValMet: 1.418 ± 0.024	1.689ValAsn: 1.689 ± 0.028	5.639ValPro: 5.639 ± 0.049	1.977ValGln: 1.977 ± 0.027	7.357ValArg: 7.357 ± 0.056	4.362ValSer: 4.362 ± 0.045	5.902ValThr: 5.902 ± 0.049	8.399ValVal: 8.399 ± 0.073	1.206ValTrp: 1.206 ± 0.023	1.574ValTyr: 1.574 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.739TrpAla: 1.739 ± 0.027	0.151TrpCys: 0.151 ± 0.009	0.875TrpAsp: 0.875 ± 0.018	0.765TrpGlu: 0.765 ± 0.018	0.528TrpPhe: 0.528 ± 0.014	1.113TrpGly: 1.113 ± 0.026	0.394TrpHis: 0.394 ± 0.012	0.53TrpIle: 0.53 ± 0.015	0.346TrpLys: 0.346 ± 0.012	1.775TrpLeu: 1.775 ± 0.026	0.275TrpMet: 0.275 ± 0.01	0.429TrpAsn: 0.429 ± 0.013	0.821TrpPro: 0.821 ± 0.017	0.59TrpGln: 0.59 ± 0.016	1.383TrpArg: 1.383 ± 0.022	0.989TrpSer: 0.989 ± 0.021	1.057TrpThr: 1.057 ± 0.017	0.99TrpVal: 0.99 ± 0.02	0.33TrpTrp: 0.33 ± 0.01	0.377TrpTyr: 0.377 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.789TyrAla: 2.789 ± 0.032	0.177TyrCys: 0.177 ± 0.007	1.491TyrAsp: 1.491 ± 0.03	1.166TyrGlu: 1.166 ± 0.021	0.607TyrPhe: 0.607 ± 0.015	2.235TyrGly: 2.235 ± 0.033	0.377TyrHis: 0.377 ± 0.012	0.462TyrIle: 0.462 ± 0.012	0.344TyrLys: 0.344 ± 0.012	2.054TyrLeu: 2.054 ± 0.023	0.251TyrMet: 0.251 ± 0.012	0.387TyrAsn: 0.387 ± 0.014	1.059TyrPro: 1.059 ± 0.021	0.572TyrGln: 0.572 ± 0.015	1.908TyrArg: 1.908 ± 0.029	0.934TyrSer: 0.934 ± 0.021	1.231TyrThr: 1.231 ± 0.022	1.643TyrVal: 1.643 ± 0.027	0.365TyrTrp: 0.365 ± 0.012	0.449TyrTyr: 0.449 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8673 proteins (2848599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---