Amino acid dipepetide frequency for Lleida bat lyssavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.949AlaAla: 1.949 ± 1.159
0.835AlaCys: 0.835 ± 0.918
2.506AlaAsp: 2.506 ± 0.575
2.785AlaGlu: 2.785 ± 1.317
1.114AlaPhe: 1.114 ± 0.692
2.785AlaGly: 2.785 ± 0.878
1.671AlaHis: 1.671 ± 0.79
3.62AlaIle: 3.62 ± 1.049
3.063AlaLys: 3.063 ± 0.801
4.177AlaLeu: 4.177 ± 1.214
1.392AlaMet: 1.392 ± 0.794
1.671AlaAsn: 1.671 ± 0.773
1.114AlaPro: 1.114 ± 1.12
1.392AlaGln: 1.392 ± 0.283
2.506AlaArg: 2.506 ± 0.633
2.785AlaSer: 2.785 ± 0.878
1.671AlaThr: 1.671 ± 1.274
1.392AlaVal: 1.392 ± 0.885
0.278AlaTrp: 0.278 ± 0.155
1.671AlaTyr: 1.671 ± 0.702
0.0AlaXaa: 0.0 ± 0.0
Cys
1.114CysAla: 1.114 ± 0.717
0.278CysCys: 0.278 ± 0.155
0.835CysAsp: 0.835 ± 0.615
0.278CysGlu: 0.278 ± 0.353
0.278CysPhe: 0.278 ± 0.155
1.114CysGly: 1.114 ± 0.554
0.557CysHis: 0.557 ± 0.462
1.392CysIle: 1.392 ± 0.896
0.835CysLys: 0.835 ± 0.278
1.949CysLeu: 1.949 ± 0.839
0.0CysMet: 0.0 ± 0.149
0.278CysAsn: 0.278 ± 0.155
1.671CysPro: 1.671 ± 0.517
0.835CysGln: 0.835 ± 0.448
1.114CysArg: 1.114 ± 0.466
1.671CysSer: 1.671 ± 0.458
0.835CysThr: 0.835 ± 0.811
0.0CysVal: 0.0 ± 0.0
0.278CysTrp: 0.278 ± 0.155
0.835CysTyr: 0.835 ± 0.385
0.0CysXaa: 0.0 ± 0.0
Asp
1.114AspAla: 1.114 ± 0.65
1.392AspCys: 1.392 ± 0.386
4.177AspAsp: 4.177 ± 1.803
3.899AspGlu: 3.899 ± 2.568
3.62AspPhe: 3.62 ± 0.758
2.228AspGly: 2.228 ± 0.453
1.949AspHis: 1.949 ± 1.27
4.177AspIle: 4.177 ± 2.003
3.063AspLys: 3.063 ± 1.183
6.405AspLeu: 6.405 ± 1.735
1.392AspMet: 1.392 ± 0.43
2.228AspAsn: 2.228 ± 0.734
4.456AspPro: 4.456 ± 0.763
2.785AspGln: 2.785 ± 0.668
1.671AspArg: 1.671 ± 0.639
5.848AspSer: 5.848 ± 0.638
3.063AspThr: 3.063 ± 0.6
2.785AspVal: 2.785 ± 0.785
0.835AspTrp: 0.835 ± 0.282
1.949AspTyr: 1.949 ± 0.749
0.0AspXaa: 0.0 ± 0.0
Glu
3.62GluAla: 3.62 ± 0.969
1.114GluCys: 1.114 ± 0.554
5.291GluAsp: 5.291 ± 3.345
4.734GluGlu: 4.734 ± 1.924
3.62GluPhe: 3.62 ± 0.618
4.456GluGly: 4.456 ± 1.427
0.557GluHis: 0.557 ± 0.636
4.734GluIle: 4.734 ± 0.507
3.063GluLys: 3.063 ± 1.138
4.177GluLeu: 4.177 ± 0.431
3.063GluMet: 3.063 ± 0.982
2.228GluAsn: 2.228 ± 0.83
2.228GluPro: 2.228 ± 0.553
1.392GluGln: 1.392 ± 1.522
2.228GluArg: 2.228 ± 0.582
6.126GluSer: 6.126 ± 0.82
2.228GluThr: 2.228 ± 1.111
3.342GluVal: 3.342 ± 0.842
0.835GluTrp: 0.835 ± 0.278
1.949GluTyr: 1.949 ± 0.846
0.0GluXaa: 0.0 ± 0.0
Phe
1.392PheAla: 1.392 ± 0.629
0.278PheCys: 0.278 ± 0.523
3.342PheAsp: 3.342 ± 1.512
3.063PheGlu: 3.063 ± 1.385
2.228PhePhe: 2.228 ± 1.03
1.114PheGly: 1.114 ± 0.3
1.949PheHis: 1.949 ± 0.452
2.785PheIle: 2.785 ± 0.891
3.899PheLys: 3.899 ± 0.575
5.013PheLeu: 5.013 ± 0.66
0.557PheMet: 0.557 ± 0.362
3.063PheAsn: 3.063 ± 0.751
2.785PhePro: 2.785 ± 0.83
2.506PheGln: 2.506 ± 1.334
4.177PheArg: 4.177 ± 1.0
3.342PheSer: 3.342 ± 0.888
1.114PheThr: 1.114 ± 0.3
2.506PheVal: 2.506 ± 0.892
0.835PheTrp: 0.835 ± 0.448
0.835PheTyr: 0.835 ± 0.466
0.0PheXaa: 0.0 ± 0.0
Gly
2.228GlyAla: 2.228 ± 0.582
0.835GlyCys: 0.835 ± 0.282
3.899GlyAsp: 3.899 ± 0.619
2.785GlyGlu: 2.785 ± 1.423
1.114GlyPhe: 1.114 ± 0.3
3.899GlyGly: 3.899 ± 0.753
0.835GlyHis: 0.835 ± 0.385
3.62GlyIle: 3.62 ± 0.988
2.785GlyLys: 2.785 ± 0.867
9.19GlyLeu: 9.19 ± 0.844
0.835GlyMet: 0.835 ± 0.549
2.785GlyAsn: 2.785 ± 0.535
2.228GlyPro: 2.228 ± 0.603
3.342GlyGln: 3.342 ± 0.906
2.506GlyArg: 2.506 ± 0.405
3.342GlySer: 3.342 ± 0.739
3.342GlyThr: 3.342 ± 0.823
3.063GlyVal: 3.063 ± 1.512
0.278GlyTrp: 0.278 ± 0.155
2.506GlyTyr: 2.506 ± 0.793
0.0GlyXaa: 0.0 ± 0.0
His
0.835HisAla: 0.835 ± 0.282
0.0HisCys: 0.0 ± 0.0
1.114HisAsp: 1.114 ± 0.34
0.835HisGlu: 0.835 ± 0.282
1.392HisPhe: 1.392 ± 0.885
1.671HisGly: 1.671 ± 0.556
0.557HisHis: 0.557 ± 0.258
3.063HisIle: 3.063 ± 0.98
1.392HisLys: 1.392 ± 0.518
2.785HisLeu: 2.785 ± 0.592
0.835HisMet: 0.835 ± 0.385
0.278HisAsn: 0.278 ± 0.155
1.671HisPro: 1.671 ± 0.607
0.835HisGln: 0.835 ± 0.471
0.835HisArg: 0.835 ± 0.278
1.671HisSer: 1.671 ± 0.664
1.114HisThr: 1.114 ± 0.3
0.278HisVal: 0.278 ± 0.155
0.835HisTrp: 0.835 ± 0.466
1.114HisTyr: 1.114 ± 0.554
0.0HisXaa: 0.0 ± 0.0
Ile
1.949IleAla: 1.949 ± 0.875
2.228IleCys: 2.228 ± 0.552
5.291IleAsp: 5.291 ± 0.595
3.063IleGlu: 3.063 ± 0.63
1.949IlePhe: 1.949 ± 0.976
3.342IleGly: 3.342 ± 0.882
1.114IleHis: 1.114 ± 0.376
5.569IleIle: 5.569 ± 1.325
2.785IleLys: 2.785 ± 0.83
8.354IleLeu: 8.354 ± 2.608
1.114IleMet: 1.114 ± 0.74
3.342IleAsn: 3.342 ± 1.366
3.342IlePro: 3.342 ± 0.547
2.228IleGln: 2.228 ± 1.474
5.848IleArg: 5.848 ± 0.858
7.24IleSer: 7.24 ± 2.546
5.013IleThr: 5.013 ± 0.436
3.899IleVal: 3.899 ± 0.55
1.392IleTrp: 1.392 ± 0.627
2.506IleTyr: 2.506 ± 1.045
0.0IleXaa: 0.0 ± 0.0
Lys
1.671LysAla: 1.671 ± 0.431
0.557LysCys: 0.557 ± 0.705
3.342LysAsp: 3.342 ± 0.675
4.177LysGlu: 4.177 ± 1.4
1.392LysPhe: 1.392 ± 1.13
3.063LysGly: 3.063 ± 0.407
0.557LysHis: 0.557 ± 0.362
4.177LysIle: 4.177 ± 1.051
3.899LysLys: 3.899 ± 1.752
4.734LysLeu: 4.734 ± 1.533
3.342LysMet: 3.342 ± 1.097
1.671LysAsn: 1.671 ± 0.305
2.785LysPro: 2.785 ± 0.664
1.392LysGln: 1.392 ± 0.94
4.177LysArg: 4.177 ± 0.863
6.683LysSer: 6.683 ± 0.448
4.177LysThr: 4.177 ± 0.607
4.456LysVal: 4.456 ± 1.125
1.114LysTrp: 1.114 ± 0.355
1.949LysTyr: 1.949 ± 0.24
0.0LysXaa: 0.0 ± 0.0
Leu
3.899LeuAla: 3.899 ± 0.889
1.392LeuCys: 1.392 ± 0.283
4.177LeuAsp: 4.177 ± 0.966
6.126LeuGlu: 6.126 ± 1.077
5.013LeuPhe: 5.013 ± 1.481
5.013LeuGly: 5.013 ± 0.447
0.835LeuHis: 0.835 ± 0.278
8.354LeuIle: 8.354 ± 1.433
8.354LeuLys: 8.354 ± 1.19
9.19LeuLeu: 9.19 ± 2.328
3.899LeuMet: 3.899 ± 1.199
5.013LeuAsn: 5.013 ± 1.443
3.063LeuPro: 3.063 ± 0.912
3.342LeuGln: 3.342 ± 0.644
6.962LeuArg: 6.962 ± 0.993
10.86LeuSer: 10.86 ± 2.273
3.899LeuThr: 3.899 ± 1.189
7.24LeuVal: 7.24 ± 0.323
1.392LeuTrp: 1.392 ± 0.301
4.456LeuTyr: 4.456 ± 0.989
0.0LeuXaa: 0.0 ± 0.0
Met
1.392MetAla: 1.392 ± 0.301
0.557MetCys: 0.557 ± 0.258
1.392MetAsp: 1.392 ± 0.283
1.392MetGlu: 1.392 ± 0.91
2.506MetPhe: 2.506 ± 0.978
1.392MetGly: 1.392 ± 0.654
0.557MetHis: 0.557 ± 0.556
3.342MetIle: 3.342 ± 0.776
0.835MetLys: 0.835 ± 0.466
2.228MetLeu: 2.228 ± 0.634
0.835MetMet: 0.835 ± 0.282
1.392MetAsn: 1.392 ± 1.212
0.557MetPro: 0.557 ± 0.658
0.835MetGln: 0.835 ± 0.918
1.392MetArg: 1.392 ± 0.948
2.785MetSer: 2.785 ± 0.49
2.506MetThr: 2.506 ± 0.557
1.114MetVal: 1.114 ± 0.554
0.0MetTrp: 0.0 ± 0.0
0.278MetTyr: 0.278 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
2.228AsnAla: 2.228 ± 0.6
1.114AsnCys: 1.114 ± 0.466
1.114AsnAsp: 1.114 ± 0.42
1.392AsnGlu: 1.392 ± 0.566
3.342AsnPhe: 3.342 ± 1.183
1.114AsnGly: 1.114 ± 1.036
1.114AsnHis: 1.114 ± 0.402
5.013AsnIle: 5.013 ± 1.516
1.671AsnLys: 1.671 ± 0.517
4.456AsnLeu: 4.456 ± 1.403
0.278AsnMet: 0.278 ± 0.353
0.557AsnAsn: 0.557 ± 0.31
3.063AsnPro: 3.063 ± 0.756
0.557AsnGln: 0.557 ± 0.277
3.342AsnArg: 3.342 ± 0.925
4.177AsnSer: 4.177 ± 0.733
2.506AsnThr: 2.506 ± 0.644
1.114AsnVal: 1.114 ± 0.376
2.506AsnTrp: 2.506 ± 0.747
1.114AsnTyr: 1.114 ± 0.3
0.0AsnXaa: 0.0 ± 0.0
Pro
1.671ProAla: 1.671 ± 0.771
0.278ProCys: 0.278 ± 0.155
3.62ProAsp: 3.62 ± 1.673
5.291ProGlu: 5.291 ± 1.293
0.835ProPhe: 0.835 ± 0.282
3.063ProGly: 3.063 ± 0.718
1.114ProHis: 1.114 ± 0.515
2.785ProIle: 2.785 ± 0.591
3.342ProLys: 3.342 ± 1.067
5.569ProLeu: 5.569 ± 1.147
0.278ProMet: 0.278 ± 0.371
1.671ProAsn: 1.671 ± 0.702
2.785ProPro: 2.785 ± 1.793
0.835ProGln: 0.835 ± 0.466
1.949ProArg: 1.949 ± 0.815
5.291ProSer: 5.291 ± 1.151
2.228ProThr: 2.228 ± 0.582
1.949ProVal: 1.949 ± 0.505
0.557ProTrp: 0.557 ± 0.705
1.114ProTyr: 1.114 ± 0.692
0.0ProXaa: 0.0 ± 0.0
Gln
2.228GlnAla: 2.228 ± 0.848
0.557GlnCys: 0.557 ± 0.631
2.506GlnAsp: 2.506 ± 1.721
3.342GlnGlu: 3.342 ± 0.633
1.671GlnPhe: 1.671 ± 0.587
1.671GlnGly: 1.671 ± 0.431
0.557GlnHis: 0.557 ± 0.31
2.228GlnIle: 2.228 ± 1.35
1.949GlnLys: 1.949 ± 0.779
3.342GlnLeu: 3.342 ± 1.041
0.835GlnMet: 0.835 ± 0.36
2.228GlnAsn: 2.228 ± 0.848
0.557GlnPro: 0.557 ± 0.31
0.0GlnGln: 0.0 ± 0.0
1.671GlnArg: 1.671 ± 0.343
1.949GlnSer: 1.949 ± 0.904
2.506GlnThr: 2.506 ± 0.742
2.228GlnVal: 2.228 ± 0.498
0.557GlnTrp: 0.557 ± 0.462
0.278GlnTyr: 0.278 ± 0.318
0.0GlnXaa: 0.0 ± 0.0
Arg
2.228ArgAla: 2.228 ± 0.459
0.557ArgCys: 0.557 ± 0.31
2.785ArgAsp: 2.785 ± 0.451
3.063ArgGlu: 3.063 ± 0.755
3.342ArgPhe: 3.342 ± 0.925
4.456ArgGly: 4.456 ± 1.535
1.392ArgHis: 1.392 ± 0.426
2.785ArgIle: 2.785 ± 0.804
2.506ArgLys: 2.506 ± 0.735
5.291ArgLeu: 5.291 ± 0.691
2.228ArgMet: 2.228 ± 0.562
2.785ArgAsn: 2.785 ± 1.133
2.228ArgPro: 2.228 ± 0.788
2.228ArgGln: 2.228 ± 0.932
2.785ArgArg: 2.785 ± 1.383
6.126ArgSer: 6.126 ± 1.02
4.177ArgThr: 4.177 ± 0.819
4.734ArgVal: 4.734 ± 1.516
1.114ArgTrp: 1.114 ± 0.621
2.228ArgTyr: 2.228 ± 0.498
0.0ArgXaa: 0.0 ± 0.0
Ser
3.342SerAla: 3.342 ± 1.419
1.392SerCys: 1.392 ± 0.776
6.126SerAsp: 6.126 ± 1.103
7.797SerGlu: 7.797 ± 1.867
5.569SerPhe: 5.569 ± 0.688
5.291SerGly: 5.291 ± 0.75
3.62SerHis: 3.62 ± 1.166
4.456SerIle: 4.456 ± 0.802
5.013SerLys: 5.013 ± 0.756
10.582SerLeu: 10.582 ± 2.618
1.114SerMet: 1.114 ± 0.394
2.228SerAsn: 2.228 ± 0.498
3.899SerPro: 3.899 ± 1.272
2.785SerGln: 2.785 ± 0.574
6.683SerArg: 6.683 ± 0.794
8.354SerSer: 8.354 ± 1.114
5.291SerThr: 5.291 ± 1.038
6.405SerVal: 6.405 ± 0.24
2.228SerTrp: 2.228 ± 0.552
3.342SerTyr: 3.342 ± 0.901
0.0SerXaa: 0.0 ± 0.0
Thr
3.62ThrAla: 3.62 ± 1.59
1.114ThrCys: 1.114 ± 0.692
3.063ThrAsp: 3.063 ± 0.381
1.114ThrGlu: 1.114 ± 0.61
1.671ThrPhe: 1.671 ± 0.343
3.342ThrGly: 3.342 ± 0.701
1.392ThrHis: 1.392 ± 0.501
3.063ThrIle: 3.063 ± 1.1
3.62ThrLys: 3.62 ± 1.24
5.848ThrLeu: 5.848 ± 0.984
2.506ThrMet: 2.506 ± 0.821
2.228ThrAsn: 2.228 ± 0.773
2.228ThrPro: 2.228 ± 1.306
2.228ThrGln: 2.228 ± 0.553
3.62ThrArg: 3.62 ± 1.354
3.899ThrSer: 3.899 ± 0.502
2.785ThrThr: 2.785 ± 1.04
2.785ThrVal: 2.785 ± 1.05
1.671ThrTrp: 1.671 ± 0.441
3.342ThrTyr: 3.342 ± 0.554
0.0ThrXaa: 0.0 ± 0.0
Val
2.228ValAla: 2.228 ± 0.848
1.392ValCys: 1.392 ± 0.591
2.228ValAsp: 2.228 ± 0.492
1.949ValGlu: 1.949 ± 1.061
4.177ValPhe: 4.177 ± 0.919
3.342ValGly: 3.342 ± 1.443
1.671ValHis: 1.671 ± 0.343
3.62ValIle: 3.62 ± 0.434
3.342ValLys: 3.342 ± 1.294
4.456ValLeu: 4.456 ± 0.349
0.557ValMet: 0.557 ± 0.505
3.063ValAsn: 3.063 ± 0.565
3.063ValPro: 3.063 ± 1.101
1.671ValGln: 1.671 ± 0.644
1.671ValArg: 1.671 ± 0.613
6.405ValSer: 6.405 ± 1.293
4.456ValThr: 4.456 ± 1.125
3.063ValVal: 3.063 ± 0.761
0.557ValTrp: 0.557 ± 0.31
2.228ValTyr: 2.228 ± 0.734
0.0ValXaa: 0.0 ± 0.0
Trp
1.392TrpAla: 1.392 ± 0.94
0.278TrpCys: 0.278 ± 0.523
0.835TrpAsp: 0.835 ± 0.466
1.392TrpGlu: 1.392 ± 0.426
0.278TrpPhe: 0.278 ± 0.155
1.392TrpGly: 1.392 ± 0.776
0.557TrpHis: 0.557 ± 0.31
1.671TrpIle: 1.671 ± 0.607
0.835TrpLys: 0.835 ± 0.615
1.114TrpLeu: 1.114 ± 0.355
0.557TrpMet: 0.557 ± 0.658
1.114TrpAsn: 1.114 ± 0.42
0.557TrpPro: 0.557 ± 0.362
0.0TrpGln: 0.0 ± 0.0
0.835TrpArg: 0.835 ± 0.278
1.949TrpSer: 1.949 ± 0.582
1.114TrpThr: 1.114 ± 0.3
1.114TrpVal: 1.114 ± 0.355
0.0TrpTrp: 0.0 ± 0.0
0.278TrpTyr: 0.278 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.278TyrAla: 0.278 ± 0.155
0.278TyrCys: 0.278 ± 0.353
1.392TyrAsp: 1.392 ± 0.283
2.506TyrGlu: 2.506 ± 0.831
1.671TyrPhe: 1.671 ± 0.564
1.671TyrGly: 1.671 ± 0.564
0.557TyrHis: 0.557 ± 0.31
1.114TyrIle: 1.114 ± 0.621
3.063TyrLys: 3.063 ± 0.744
3.62TyrLeu: 3.62 ± 1.049
1.392TyrMet: 1.392 ± 0.501
1.949TyrAsn: 1.949 ± 0.619
1.949TyrPro: 1.949 ± 0.483
1.671TyrGln: 1.671 ± 0.868
3.063TyrArg: 3.063 ± 0.455
5.013TyrSer: 5.013 ± 1.082
1.114TyrThr: 1.114 ± 1.146
1.671TyrVal: 1.671 ± 0.533
0.0TyrTrp: 0.0 ± 0.0
0.557TyrTyr: 0.557 ± 0.31
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski