Amino acid dipepetide frequency for Rhizobium sp. KAs_5_22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.106AlaAla: 16.106 ± 0.152	0.99AlaCys: 0.99 ± 0.028	6.903AlaAsp: 6.903 ± 0.081	8.062AlaGlu: 8.062 ± 0.095	4.6AlaPhe: 4.6 ± 0.06	10.458AlaGly: 10.458 ± 0.087	2.142AlaHis: 2.142 ± 0.041	6.787AlaIle: 6.787 ± 0.064	4.375AlaLys: 4.375 ± 0.067	12.79AlaLeu: 12.79 ± 0.114	3.576AlaMet: 3.576 ± 0.05	2.964AlaAsn: 2.964 ± 0.048	4.85AlaPro: 4.85 ± 0.078	3.324AlaGln: 3.324 ± 0.051	8.1AlaArg: 8.1 ± 0.085	6.403AlaSer: 6.403 ± 0.064	5.821AlaThr: 5.821 ± 0.068	8.805AlaVal: 8.805 ± 0.091	1.26AlaTrp: 1.26 ± 0.031	2.605AlaTyr: 2.605 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.027	0.108CysCys: 0.108 ± 0.008	0.559CysAsp: 0.559 ± 0.02	0.441CysGlu: 0.441 ± 0.016	0.327CysPhe: 0.327 ± 0.015	0.92CysGly: 0.92 ± 0.03	0.249CysHis: 0.249 ± 0.014	0.354CysIle: 0.354 ± 0.017	0.185CysLys: 0.185 ± 0.012	0.792CysLeu: 0.792 ± 0.025	0.152CysMet: 0.152 ± 0.009	0.21CysAsn: 0.21 ± 0.012	0.436CysPro: 0.436 ± 0.018	0.214CysGln: 0.214 ± 0.012	0.638CysArg: 0.638 ± 0.023	0.447CysSer: 0.447 ± 0.016	0.4CysThr: 0.4 ± 0.016	0.569CysVal: 0.569 ± 0.018	0.108CysTrp: 0.108 ± 0.009	0.194CysTyr: 0.194 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.39AspAla: 6.39 ± 0.07	0.516AspCys: 0.516 ± 0.024	3.074AspAsp: 3.074 ± 0.057	3.643AspGlu: 3.643 ± 0.057	2.393AspPhe: 2.393 ± 0.043	5.107AspGly: 5.107 ± 0.065	1.273AspHis: 1.273 ± 0.034	3.341AspIle: 3.341 ± 0.047	2.017AspLys: 2.017 ± 0.044	5.986AspLeu: 5.986 ± 0.06	1.495AspMet: 1.495 ± 0.034	1.447AspAsn: 1.447 ± 0.034	3.366AspPro: 3.366 ± 0.049	1.71AspGln: 1.71 ± 0.035	4.191AspArg: 4.191 ± 0.067	2.195AspSer: 2.195 ± 0.042	2.622AspThr: 2.622 ± 0.049	4.03AspVal: 4.03 ± 0.051	0.923AspTrp: 0.923 ± 0.027	1.62AspTyr: 1.62 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.752GluAla: 7.752 ± 0.087	0.366GluCys: 0.366 ± 0.016	2.956GluAsp: 2.956 ± 0.051	3.571GluGlu: 3.571 ± 0.06	1.927GluPhe: 1.927 ± 0.03	4.452GluGly: 4.452 ± 0.055	1.174GluHis: 1.174 ± 0.028	4.005GluIle: 4.005 ± 0.06	2.768GluLys: 2.768 ± 0.055	5.453GluLeu: 5.453 ± 0.059	1.636GluMet: 1.636 ± 0.033	1.854GluAsn: 1.854 ± 0.035	2.687GluPro: 2.687 ± 0.055	2.168GluGln: 2.168 ± 0.043	4.906GluArg: 4.906 ± 0.069	2.419GluSer: 2.419 ± 0.044	3.815GluThr: 3.815 ± 0.057	3.867GluVal: 3.867 ± 0.051	0.678GluTrp: 0.678 ± 0.022	1.057GluTyr: 1.057 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.718PheAla: 4.718 ± 0.057	0.424PheCys: 0.424 ± 0.016	2.79PheAsp: 2.79 ± 0.045	2.281PheGlu: 2.281 ± 0.04	1.655PhePhe: 1.655 ± 0.041	3.803PheGly: 3.803 ± 0.05	0.822PheHis: 0.822 ± 0.023	1.906PheIle: 1.906 ± 0.036	1.189PheLys: 1.189 ± 0.027	3.594PheLeu: 3.594 ± 0.065	0.892PheMet: 0.892 ± 0.026	1.12PheAsn: 1.12 ± 0.027	1.56PhePro: 1.56 ± 0.033	1.059PheGln: 1.059 ± 0.023	2.277PheArg: 2.277 ± 0.035	2.586PheSer: 2.586 ± 0.041	1.951PheThr: 1.951 ± 0.038	2.997PheVal: 2.997 ± 0.042	0.512PheTrp: 0.512 ± 0.02	1.014PheTyr: 1.014 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.735GlyAla: 8.735 ± 0.081	0.814GlyCys: 0.814 ± 0.024	4.335GlyAsp: 4.335 ± 0.065	5.078GlyGlu: 5.078 ± 0.067	3.695GlyPhe: 3.695 ± 0.054	6.982GlyGly: 6.982 ± 0.083	1.971GlyHis: 1.971 ± 0.048	4.899GlyIle: 4.899 ± 0.056	3.64GlyLys: 3.64 ± 0.057	8.876GlyLeu: 8.876 ± 0.097	2.368GlyMet: 2.368 ± 0.037	2.348GlyAsn: 2.348 ± 0.057	3.149GlyPro: 3.149 ± 0.053	2.675GlyGln: 2.675 ± 0.045	5.784GlyArg: 5.784 ± 0.063	4.617GlySer: 4.617 ± 0.057	4.53GlyThr: 4.53 ± 0.064	5.752GlyVal: 5.752 ± 0.066	1.228GlyTrp: 1.228 ± 0.028	2.413GlyTyr: 2.413 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.192HisAla: 2.192 ± 0.045	0.222HisCys: 0.222 ± 0.012	1.25HisAsp: 1.25 ± 0.034	1.065HisGlu: 1.065 ± 0.028	0.95HisPhe: 0.95 ± 0.025	1.943HisGly: 1.943 ± 0.037	0.609HisHis: 0.609 ± 0.024	1.012HisIle: 1.012 ± 0.028	0.549HisLys: 0.549 ± 0.019	2.097HisLeu: 2.097 ± 0.042	0.529HisMet: 0.529 ± 0.019	0.467HisAsn: 0.467 ± 0.018	1.296HisPro: 1.296 ± 0.028	0.578HisGln: 0.578 ± 0.021	1.398HisArg: 1.398 ± 0.033	1.01HisSer: 1.01 ± 0.027	0.823HisThr: 0.823 ± 0.024	1.545HisVal: 1.545 ± 0.028	0.291HisTrp: 0.291 ± 0.013	0.548HisTyr: 0.548 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.832IleAla: 7.832 ± 0.085	0.554IleCys: 0.554 ± 0.02	3.917IleAsp: 3.917 ± 0.051	3.891IleGlu: 3.891 ± 0.053	1.918IlePhe: 1.918 ± 0.037	5.35IleGly: 5.35 ± 0.074	0.99IleHis: 0.99 ± 0.029	2.616IleIle: 2.616 ± 0.05	1.683IleLys: 1.683 ± 0.036	4.997IleLeu: 4.997 ± 0.068	1.083IleMet: 1.083 ± 0.03	1.626IleAsn: 1.626 ± 0.036	2.34IlePro: 2.34 ± 0.035	1.241IleGln: 1.241 ± 0.03	3.526IleArg: 3.526 ± 0.053	3.233IleSer: 3.233 ± 0.05	2.826IleThr: 2.826 ± 0.047	4.466IleVal: 4.466 ± 0.054	0.581IleTrp: 0.581 ± 0.022	1.215IleTyr: 1.215 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.888LysAla: 4.888 ± 0.06	0.167LysCys: 0.167 ± 0.009	2.061LysAsp: 2.061 ± 0.043	1.839LysGlu: 1.839 ± 0.043	1.023LysPhe: 1.023 ± 0.03	2.937LysGly: 2.937 ± 0.045	0.656LysHis: 0.656 ± 0.02	2.164LysIle: 2.164 ± 0.044	1.627LysLys: 1.627 ± 0.038	3.627LysLeu: 3.627 ± 0.049	0.91LysMet: 0.91 ± 0.027	1.082LysAsn: 1.082 ± 0.029	2.273LysPro: 2.273 ± 0.048	1.077LysGln: 1.077 ± 0.029	2.495LysArg: 2.495 ± 0.043	2.065LysSer: 2.065 ± 0.04	2.269LysThr: 2.269 ± 0.046	2.721LysVal: 2.721 ± 0.052	0.385LysTrp: 0.385 ± 0.014	0.681LysTyr: 0.681 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.013LeuAla: 13.013 ± 0.122	0.856LeuCys: 0.856 ± 0.026	6.039LeuAsp: 6.039 ± 0.071	5.569LeuGlu: 5.569 ± 0.066	3.81LeuPhe: 3.81 ± 0.065	8.07LeuGly: 8.07 ± 0.09	1.761LeuHis: 1.761 ± 0.033	5.241LeuIle: 5.241 ± 0.063	4.366LeuLys: 4.366 ± 0.069	9.51LeuLeu: 9.51 ± 0.107	2.48LeuMet: 2.48 ± 0.038	2.666LeuAsn: 2.666 ± 0.043	5.315LeuPro: 5.315 ± 0.068	2.645LeuGln: 2.645 ± 0.041	6.085LeuArg: 6.085 ± 0.069	7.127LeuSer: 7.127 ± 0.077	5.594LeuThr: 5.594 ± 0.07	7.521LeuVal: 7.521 ± 0.079	1.088LeuTrp: 1.088 ± 0.03	2.124LeuTyr: 2.124 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.25MetAla: 3.25 ± 0.051	0.153MetCys: 0.153 ± 0.01	1.193MetAsp: 1.193 ± 0.027	1.248MetGlu: 1.248 ± 0.028	0.709MetPhe: 0.709 ± 0.024	1.789MetGly: 1.789 ± 0.034	0.459MetHis: 0.459 ± 0.016	1.509MetIle: 1.509 ± 0.035	1.11MetLys: 1.11 ± 0.027	2.575MetLeu: 2.575 ± 0.038	0.722MetMet: 0.722 ± 0.021	0.833MetAsn: 0.833 ± 0.022	1.554MetPro: 1.554 ± 0.036	0.919MetGln: 0.919 ± 0.029	1.816MetArg: 1.816 ± 0.032	1.699MetSer: 1.699 ± 0.03	1.993MetThr: 1.993 ± 0.04	1.873MetVal: 1.873 ± 0.034	0.204MetTrp: 0.204 ± 0.012	0.322MetTyr: 0.322 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.292AsnAla: 3.292 ± 0.046	0.226AsnCys: 0.226 ± 0.012	1.558AsnAsp: 1.558 ± 0.04	1.391AsnGlu: 1.391 ± 0.034	1.051AsnPhe: 1.051 ± 0.031	2.517AsnGly: 2.517 ± 0.051	0.554AsnHis: 0.554 ± 0.018	1.494AsnIle: 1.494 ± 0.039	0.832AsnLys: 0.832 ± 0.026	2.644AsnLeu: 2.644 ± 0.042	0.652AsnMet: 0.652 ± 0.023	0.757AsnAsn: 0.757 ± 0.025	1.857AsnPro: 1.857 ± 0.036	0.783AsnGln: 0.783 ± 0.026	1.929AsnArg: 1.929 ± 0.033	1.418AsnSer: 1.418 ± 0.038	1.288AsnThr: 1.288 ± 0.032	1.973AsnVal: 1.973 ± 0.04	0.439AsnTrp: 0.439 ± 0.017	0.7AsnTyr: 0.7 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.936ProAla: 5.936 ± 0.082	0.289ProCys: 0.289 ± 0.015	3.363ProAsp: 3.363 ± 0.047	3.618ProGlu: 3.618 ± 0.048	2.023ProPhe: 2.023 ± 0.036	4.056ProGly: 4.056 ± 0.062	1.043ProHis: 1.043 ± 0.03	2.332ProIle: 2.332 ± 0.042	1.814ProLys: 1.814 ± 0.035	4.737ProLeu: 4.737 ± 0.066	1.179ProMet: 1.179 ± 0.028	1.276ProAsn: 1.276 ± 0.029	2.112ProPro: 2.112 ± 0.058	1.561ProGln: 1.561 ± 0.029	2.521ProArg: 2.521 ± 0.042	2.662ProSer: 2.662 ± 0.044	2.314ProThr: 2.314 ± 0.044	4.142ProVal: 4.142 ± 0.058	0.587ProTrp: 0.587 ± 0.019	1.15ProTyr: 1.15 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.781GlnAla: 3.781 ± 0.05	0.194GlnCys: 0.194 ± 0.014	1.359GlnAsp: 1.359 ± 0.033	1.515GlnGlu: 1.515 ± 0.034	1.075GlnPhe: 1.075 ± 0.023	2.158GlnGly: 2.158 ± 0.043	0.583GlnHis: 0.583 ± 0.02	1.888GlnIle: 1.888 ± 0.042	1.219GlnLys: 1.219 ± 0.027	2.795GlnLeu: 2.795 ± 0.045	0.935GlnMet: 0.935 ± 0.024	0.846GlnAsn: 0.846 ± 0.023	1.626GlnPro: 1.626 ± 0.037	1.181GlnGln: 1.181 ± 0.046	2.089GlnArg: 2.089 ± 0.043	1.806GlnSer: 1.806 ± 0.032	1.696GlnThr: 1.696 ± 0.035	2.111GlnVal: 2.111 ± 0.037	0.364GlnTrp: 0.364 ± 0.015	0.578GlnTyr: 0.578 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.071ArgAla: 7.071 ± 0.078	0.462ArgCys: 0.462 ± 0.018	3.923ArgAsp: 3.923 ± 0.051	3.87ArgGlu: 3.87 ± 0.058	3.016ArgPhe: 3.016 ± 0.044	4.304ArgGly: 4.304 ± 0.057	1.716ArgHis: 1.716 ± 0.041	4.223ArgIle: 4.223 ± 0.054	2.397ArgLys: 2.397 ± 0.039	7.549ArgLeu: 7.549 ± 0.073	1.875ArgMet: 1.875 ± 0.034	1.941ArgAsn: 1.941 ± 0.04	3.238ArgPro: 3.238 ± 0.055	2.559ArgGln: 2.559 ± 0.044	5.188ArgArg: 5.188 ± 0.069	3.731ArgSer: 3.731 ± 0.054	3.201ArgThr: 3.201 ± 0.051	4.29ArgVal: 4.29 ± 0.063	0.817ArgTrp: 0.817 ± 0.023	1.688ArgTyr: 1.688 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.392SerAla: 6.392 ± 0.068	0.423SerCys: 0.423 ± 0.019	3.108SerAsp: 3.108 ± 0.051	3.059SerGlu: 3.059 ± 0.051	2.493SerPhe: 2.493 ± 0.037	5.734SerGly: 5.734 ± 0.071	1.168SerHis: 1.168 ± 0.03	3.088SerIle: 3.088 ± 0.043	1.753SerLys: 1.753 ± 0.04	5.853SerLeu: 5.853 ± 0.067	1.386SerMet: 1.386 ± 0.033	1.43SerAsn: 1.43 ± 0.036	2.762SerPro: 2.762 ± 0.044	1.66SerGln: 1.66 ± 0.03	3.686SerArg: 3.686 ± 0.059	3.146SerSer: 3.146 ± 0.054	2.858SerThr: 2.858 ± 0.046	4.131SerVal: 4.131 ± 0.056	0.7SerTrp: 0.7 ± 0.022	1.337SerTyr: 1.337 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.277ThrAla: 6.277 ± 0.072	0.424ThrCys: 0.424 ± 0.018	2.853ThrAsp: 2.853 ± 0.045	2.856ThrGlu: 2.856 ± 0.04	2.028ThrPhe: 2.028 ± 0.039	5.097ThrGly: 5.097 ± 0.076	1.029ThrHis: 1.029 ± 0.028	3.177ThrIle: 3.177 ± 0.054	1.61ThrLys: 1.61 ± 0.039	5.709ThrLeu: 5.709 ± 0.064	1.253ThrMet: 1.253 ± 0.028	1.349ThrAsn: 1.349 ± 0.035	2.975ThrPro: 2.975 ± 0.05	1.345ThrGln: 1.345 ± 0.031	3.202ThrArg: 3.202 ± 0.048	2.847ThrSer: 2.847 ± 0.042	2.876ThrThr: 2.876 ± 0.051	4.519ThrVal: 4.519 ± 0.062	0.575ThrTrp: 0.575 ± 0.021	1.264ThrTyr: 1.264 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.915ValAla: 8.915 ± 0.098	0.607ValCys: 0.607 ± 0.022	4.05ValAsp: 4.05 ± 0.053	4.677ValGlu: 4.677 ± 0.064	2.914ValPhe: 2.914 ± 0.043	5.335ValGly: 5.335 ± 0.07	1.361ValHis: 1.361 ± 0.033	4.231ValIle: 4.231 ± 0.058	2.569ValLys: 2.569 ± 0.046	7.403ValLeu: 7.403 ± 0.089	1.983ValMet: 1.983 ± 0.042	2.064ValAsn: 2.064 ± 0.037	3.572ValPro: 3.572 ± 0.05	1.826ValGln: 1.826 ± 0.031	4.493ValArg: 4.493 ± 0.049	4.737ValSer: 4.737 ± 0.059	4.558ValThr: 4.558 ± 0.057	5.863ValVal: 5.863 ± 0.064	0.846ValTrp: 0.846 ± 0.026	1.556ValTyr: 1.556 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.085TrpAla: 1.085 ± 0.031	0.117TrpCys: 0.117 ± 0.01	0.565TrpAsp: 0.565 ± 0.021	0.546TrpGlu: 0.546 ± 0.018	0.535TrpPhe: 0.535 ± 0.018	0.765TrpGly: 0.765 ± 0.025	0.29TrpHis: 0.29 ± 0.012	0.624TrpIle: 0.624 ± 0.023	0.524TrpLys: 0.524 ± 0.019	1.521TrpLeu: 1.521 ± 0.035	0.348TrpMet: 0.348 ± 0.015	0.446TrpAsn: 0.446 ± 0.018	0.621TrpPro: 0.621 ± 0.02	0.52TrpGln: 0.52 ± 0.018	0.966TrpArg: 0.966 ± 0.026	0.774TrpSer: 0.774 ± 0.027	0.7TrpThr: 0.7 ± 0.021	0.689TrpVal: 0.689 ± 0.021	0.186TrpTrp: 0.186 ± 0.012	0.285TrpTyr: 0.285 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.434TyrAla: 2.434 ± 0.043	0.256TyrCys: 0.256 ± 0.013	1.479TyrAsp: 1.479 ± 0.03	1.289TyrGlu: 1.289 ± 0.028	1.006TyrPhe: 1.006 ± 0.028	2.115TyrGly: 2.115 ± 0.038	0.522TyrHis: 0.522 ± 0.017	0.995TyrIle: 0.995 ± 0.023	0.723TyrLys: 0.723 ± 0.028	2.375TyrLeu: 2.375 ± 0.042	0.474TyrMet: 0.474 ± 0.015	0.627TyrAsn: 0.627 ± 0.019	1.124TyrPro: 1.124 ± 0.028	0.756TyrGln: 0.756 ± 0.021	1.77TyrArg: 1.77 ± 0.037	1.244TyrSer: 1.244 ± 0.034	1.128TyrThr: 1.128 ± 0.032	1.695TyrVal: 1.695 ± 0.037	0.337TyrTrp: 0.337 ± 0.016	0.636TyrTyr: 0.636 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5237 proteins (1493378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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