Amino acid dipepetide frequency for Burkholderia phage vB_BmuP_KL4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.105AlaAla: 20.105 ± 2.345
1.238AlaCys: 1.238 ± 0.332
7.867AlaAsp: 7.867 ± 0.951
7.212AlaGlu: 7.212 ± 0.95
3.205AlaPhe: 3.205 ± 0.546
10.927AlaGly: 10.927 ± 1.114
2.258AlaHis: 2.258 ± 0.404
5.609AlaIle: 5.609 ± 0.643
5.536AlaLys: 5.536 ± 0.698
11.436AlaLeu: 11.436 ± 0.847
4.735AlaMet: 4.735 ± 0.636
3.351AlaAsn: 3.351 ± 0.531
6.046AlaPro: 6.046 ± 0.625
5.973AlaGln: 5.973 ± 0.905
9.251AlaArg: 9.251 ± 0.9
7.357AlaSer: 7.357 ± 0.841
6.483AlaThr: 6.483 ± 0.625
8.013AlaVal: 8.013 ± 0.913
2.112AlaTrp: 2.112 ± 0.449
2.55AlaTyr: 2.55 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.319
0.146CysCys: 0.146 ± 0.102
0.583CysAsp: 0.583 ± 0.228
0.728CysGlu: 0.728 ± 0.204
0.364CysPhe: 0.364 ± 0.168
1.238CysGly: 1.238 ± 0.33
0.364CysHis: 0.364 ± 0.184
0.364CysIle: 0.364 ± 0.166
0.219CysLys: 0.219 ± 0.13
0.656CysLeu: 0.656 ± 0.224
0.583CysMet: 0.583 ± 0.216
0.364CysAsn: 0.364 ± 0.151
0.219CysPro: 0.219 ± 0.136
0.219CysGln: 0.219 ± 0.124
1.166CysArg: 1.166 ± 0.292
0.728CysSer: 0.728 ± 0.273
0.656CysThr: 0.656 ± 0.216
0.656CysVal: 0.656 ± 0.19
0.146CysTrp: 0.146 ± 0.086
0.364CysTyr: 0.364 ± 0.192
0.0CysXaa: 0.0 ± 0.0
Asp
9.178AspAla: 9.178 ± 0.918
0.728AspCys: 0.728 ± 0.228
4.225AspAsp: 4.225 ± 0.559
3.934AspGlu: 3.934 ± 0.696
1.53AspPhe: 1.53 ± 0.353
4.808AspGly: 4.808 ± 0.702
0.947AspHis: 0.947 ± 0.269
1.384AspIle: 1.384 ± 0.345
2.112AspLys: 2.112 ± 0.472
5.536AspLeu: 5.536 ± 0.532
1.748AspMet: 1.748 ± 0.303
1.675AspAsn: 1.675 ± 0.373
3.497AspPro: 3.497 ± 0.552
1.894AspGln: 1.894 ± 0.446
4.079AspArg: 4.079 ± 0.657
3.424AspSer: 3.424 ± 0.507
2.987AspThr: 2.987 ± 0.55
4.881AspVal: 4.881 ± 0.518
1.311AspTrp: 1.311 ± 0.27
1.603AspTyr: 1.603 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
5.828GluAla: 5.828 ± 0.771
0.728GluCys: 0.728 ± 0.229
2.04GluAsp: 2.04 ± 0.328
1.457GluGlu: 1.457 ± 0.296
2.185GluPhe: 2.185 ± 0.421
3.278GluGly: 3.278 ± 0.448
2.185GluHis: 2.185 ± 0.433
2.768GluIle: 2.768 ± 0.539
2.185GluLys: 2.185 ± 0.505
4.953GluLeu: 4.953 ± 0.73
1.311GluMet: 1.311 ± 0.338
2.55GluAsn: 2.55 ± 0.409
2.841GluPro: 2.841 ± 0.4
2.695GluGln: 2.695 ± 0.466
3.351GluArg: 3.351 ± 0.572
3.278GluSer: 3.278 ± 0.512
2.914GluThr: 2.914 ± 0.432
2.622GluVal: 2.622 ± 0.465
1.311GluTrp: 1.311 ± 0.353
1.311GluTyr: 1.311 ± 0.375
0.0GluXaa: 0.0 ± 0.0
Phe
4.152PheAla: 4.152 ± 0.61
0.801PheCys: 0.801 ± 0.279
2.258PheAsp: 2.258 ± 0.454
2.331PheGlu: 2.331 ± 0.467
0.874PhePhe: 0.874 ± 0.232
3.059PheGly: 3.059 ± 0.578
0.656PheHis: 0.656 ± 0.188
1.384PheIle: 1.384 ± 0.283
1.166PheLys: 1.166 ± 0.211
2.04PheLeu: 2.04 ± 0.472
0.146PheMet: 0.146 ± 0.088
0.874PheAsn: 0.874 ± 0.243
1.384PhePro: 1.384 ± 0.278
0.656PheGln: 0.656 ± 0.163
2.477PheArg: 2.477 ± 0.445
1.821PheSer: 1.821 ± 0.381
1.748PheThr: 1.748 ± 0.407
2.768PheVal: 2.768 ± 0.413
0.728PheTrp: 0.728 ± 0.262
1.457PheTyr: 1.457 ± 0.297
0.0PheXaa: 0.0 ± 0.0
Gly
9.688GlyAla: 9.688 ± 1.128
0.728GlyCys: 0.728 ± 0.267
4.443GlyAsp: 4.443 ± 0.623
4.371GlyGlu: 4.371 ± 0.558
4.079GlyPhe: 4.079 ± 0.576
7.649GlyGly: 7.649 ± 0.728
1.093GlyHis: 1.093 ± 0.225
3.788GlyIle: 3.788 ± 0.474
3.278GlyLys: 3.278 ± 0.498
5.9GlyLeu: 5.9 ± 0.559
2.258GlyMet: 2.258 ± 0.391
3.132GlyAsn: 3.132 ± 0.671
2.404GlyPro: 2.404 ± 0.368
3.642GlyGln: 3.642 ± 0.553
5.609GlyArg: 5.609 ± 0.62
5.463GlySer: 5.463 ± 1.045
4.953GlyThr: 4.953 ± 1.059
6.046GlyVal: 6.046 ± 0.552
2.112GlyTrp: 2.112 ± 0.396
2.331GlyTyr: 2.331 ± 0.442
0.0GlyXaa: 0.0 ± 0.0
His
1.675HisAla: 1.675 ± 0.376
0.364HisCys: 0.364 ± 0.164
1.166HisAsp: 1.166 ± 0.241
0.947HisGlu: 0.947 ± 0.208
1.02HisPhe: 1.02 ± 0.243
1.603HisGly: 1.603 ± 0.265
0.437HisHis: 0.437 ± 0.181
0.801HisIle: 0.801 ± 0.24
0.656HisLys: 0.656 ± 0.187
1.311HisLeu: 1.311 ± 0.284
0.364HisMet: 0.364 ± 0.15
0.291HisAsn: 0.291 ± 0.129
1.238HisPro: 1.238 ± 0.323
0.656HisGln: 0.656 ± 0.218
1.53HisArg: 1.53 ± 0.351
1.02HisSer: 1.02 ± 0.247
0.947HisThr: 0.947 ± 0.309
1.166HisVal: 1.166 ± 0.248
0.219HisTrp: 0.219 ± 0.112
0.583HisTyr: 0.583 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
5.973IleAla: 5.973 ± 0.674
0.947IleCys: 0.947 ± 0.318
4.152IleAsp: 4.152 ± 0.589
3.205IleGlu: 3.205 ± 0.478
0.874IlePhe: 0.874 ± 0.337
5.682IleGly: 5.682 ± 0.541
0.364IleHis: 0.364 ± 0.145
1.166IleIle: 1.166 ± 0.275
1.457IleLys: 1.457 ± 0.377
2.914IleLeu: 2.914 ± 0.479
0.874IleMet: 0.874 ± 0.268
1.457IleAsn: 1.457 ± 0.246
2.04IlePro: 2.04 ± 0.405
1.311IleGln: 1.311 ± 0.295
2.55IleArg: 2.55 ± 0.393
2.55IleSer: 2.55 ± 0.585
2.695IleThr: 2.695 ± 0.499
3.278IleVal: 3.278 ± 0.487
0.583IleTrp: 0.583 ± 0.203
1.238IleTyr: 1.238 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
4.516LysAla: 4.516 ± 0.523
0.51LysCys: 0.51 ± 0.18
2.258LysAsp: 2.258 ± 0.343
1.821LysGlu: 1.821 ± 0.385
1.166LysPhe: 1.166 ± 0.282
2.112LysGly: 2.112 ± 0.399
0.801LysHis: 0.801 ± 0.236
1.894LysIle: 1.894 ± 0.357
1.603LysLys: 1.603 ± 0.415
3.569LysLeu: 3.569 ± 0.512
0.51LysMet: 0.51 ± 0.189
0.801LysAsn: 0.801 ± 0.235
1.967LysPro: 1.967 ± 0.473
2.622LysGln: 2.622 ± 0.384
3.132LysArg: 3.132 ± 0.476
2.185LysSer: 2.185 ± 0.35
2.987LysThr: 2.987 ± 0.426
2.04LysVal: 2.04 ± 0.396
0.437LysTrp: 0.437 ± 0.182
1.53LysTyr: 1.53 ± 0.39
0.0LysXaa: 0.0 ± 0.0
Leu
10.927LeuAla: 10.927 ± 0.984
0.51LeuCys: 0.51 ± 0.223
5.9LeuAsp: 5.9 ± 0.693
3.497LeuGlu: 3.497 ± 0.617
3.132LeuPhe: 3.132 ± 0.516
6.483LeuGly: 6.483 ± 0.507
1.311LeuHis: 1.311 ± 0.279
4.516LeuIle: 4.516 ± 0.568
2.695LeuLys: 2.695 ± 0.328
6.556LeuLeu: 6.556 ± 0.76
1.457LeuMet: 1.457 ± 0.4
3.788LeuAsn: 3.788 ± 0.545
3.424LeuPro: 3.424 ± 0.568
3.205LeuGln: 3.205 ± 0.615
6.192LeuArg: 6.192 ± 0.614
5.536LeuSer: 5.536 ± 0.711
5.755LeuThr: 5.755 ± 0.561
4.808LeuVal: 4.808 ± 0.617
0.947LeuTrp: 0.947 ± 0.258
1.457LeuTyr: 1.457 ± 0.32
0.0LeuXaa: 0.0 ± 0.0
Met
2.841MetAla: 2.841 ± 0.458
0.291MetCys: 0.291 ± 0.134
0.656MetAsp: 0.656 ± 0.189
0.874MetGlu: 0.874 ± 0.299
0.801MetPhe: 0.801 ± 0.248
2.04MetGly: 2.04 ± 0.403
0.364MetHis: 0.364 ± 0.142
1.093MetIle: 1.093 ± 0.226
1.457MetLys: 1.457 ± 0.357
2.477MetLeu: 2.477 ± 0.385
0.801MetMet: 0.801 ± 0.23
1.53MetAsn: 1.53 ± 0.405
1.894MetPro: 1.894 ± 0.364
1.457MetGln: 1.457 ± 0.301
2.768MetArg: 2.768 ± 0.498
1.457MetSer: 1.457 ± 0.319
1.894MetThr: 1.894 ± 0.337
1.02MetVal: 1.02 ± 0.233
0.219MetTrp: 0.219 ± 0.119
0.364MetTyr: 0.364 ± 0.15
0.0MetXaa: 0.0 ± 0.0
Asn
4.808AsnAla: 4.808 ± 0.526
0.219AsnCys: 0.219 ± 0.123
2.258AsnAsp: 2.258 ± 0.483
1.894AsnGlu: 1.894 ± 0.387
0.728AsnPhe: 0.728 ± 0.229
2.987AsnGly: 2.987 ± 0.446
0.51AsnHis: 0.51 ± 0.219
1.821AsnIle: 1.821 ± 0.39
0.801AsnLys: 0.801 ± 0.266
2.768AsnLeu: 2.768 ± 0.435
0.656AsnMet: 0.656 ± 0.218
0.947AsnAsn: 0.947 ± 0.424
2.04AsnPro: 2.04 ± 0.505
1.093AsnGln: 1.093 ± 0.255
2.55AsnArg: 2.55 ± 0.52
1.967AsnSer: 1.967 ± 0.394
2.331AsnThr: 2.331 ± 0.493
1.967AsnVal: 1.967 ± 0.468
0.437AsnTrp: 0.437 ± 0.195
0.728AsnTyr: 0.728 ± 0.249
0.0AsnXaa: 0.0 ± 0.0
Pro
6.483ProAla: 6.483 ± 0.777
0.364ProCys: 0.364 ± 0.176
3.861ProAsp: 3.861 ± 0.554
3.642ProGlu: 3.642 ± 0.613
1.748ProPhe: 1.748 ± 0.311
3.715ProGly: 3.715 ± 0.58
0.728ProHis: 0.728 ± 0.217
1.894ProIle: 1.894 ± 0.347
1.384ProLys: 1.384 ± 0.285
3.934ProLeu: 3.934 ± 0.54
1.166ProMet: 1.166 ± 0.266
1.675ProAsn: 1.675 ± 0.323
1.53ProPro: 1.53 ± 0.383
1.384ProGln: 1.384 ± 0.266
2.695ProArg: 2.695 ± 0.481
2.477ProSer: 2.477 ± 0.373
3.424ProThr: 3.424 ± 0.585
4.006ProVal: 4.006 ± 0.592
0.656ProTrp: 0.656 ± 0.232
0.728ProTyr: 0.728 ± 0.211
0.0ProXaa: 0.0 ± 0.0
Gln
5.755GlnAla: 5.755 ± 0.996
0.291GlnCys: 0.291 ± 0.152
1.894GlnAsp: 1.894 ± 0.299
1.675GlnGlu: 1.675 ± 0.292
0.874GlnPhe: 0.874 ± 0.215
2.622GlnGly: 2.622 ± 0.45
0.728GlnHis: 0.728 ± 0.243
2.987GlnIle: 2.987 ± 0.406
1.457GlnLys: 1.457 ± 0.309
3.642GlnLeu: 3.642 ± 0.538
1.384GlnMet: 1.384 ± 0.277
1.311GlnAsn: 1.311 ± 0.284
2.185GlnPro: 2.185 ± 0.447
2.841GlnGln: 2.841 ± 0.65
3.278GlnArg: 3.278 ± 0.586
1.821GlnSer: 1.821 ± 0.335
2.477GlnThr: 2.477 ± 0.378
2.695GlnVal: 2.695 ± 0.44
0.728GlnTrp: 0.728 ± 0.228
1.384GlnTyr: 1.384 ± 0.358
0.0GlnXaa: 0.0 ± 0.0
Arg
10.708ArgAla: 10.708 ± 0.871
0.728ArgCys: 0.728 ± 0.239
4.443ArgAsp: 4.443 ± 0.754
4.662ArgGlu: 4.662 ± 0.596
2.768ArgPhe: 2.768 ± 0.484
4.225ArgGly: 4.225 ± 0.505
1.384ArgHis: 1.384 ± 0.285
3.132ArgIle: 3.132 ± 0.384
3.861ArgLys: 3.861 ± 0.583
4.589ArgLeu: 4.589 ± 0.602
2.622ArgMet: 2.622 ± 0.535
2.622ArgAsn: 2.622 ± 0.491
3.278ArgPro: 3.278 ± 0.596
3.351ArgGln: 3.351 ± 0.405
4.808ArgArg: 4.808 ± 0.839
3.059ArgSer: 3.059 ± 0.539
3.497ArgThr: 3.497 ± 0.526
4.225ArgVal: 4.225 ± 0.555
1.093ArgTrp: 1.093 ± 0.246
2.112ArgTyr: 2.112 ± 0.41
0.0ArgXaa: 0.0 ± 0.0
Ser
7.284SerAla: 7.284 ± 0.928
0.437SerCys: 0.437 ± 0.158
2.987SerAsp: 2.987 ± 0.534
1.821SerGlu: 1.821 ± 0.392
1.603SerPhe: 1.603 ± 0.368
6.629SerGly: 6.629 ± 0.825
0.874SerHis: 0.874 ± 0.244
3.497SerIle: 3.497 ± 0.522
1.967SerLys: 1.967 ± 0.388
4.371SerLeu: 4.371 ± 0.536
2.112SerMet: 2.112 ± 0.51
1.53SerAsn: 1.53 ± 0.334
3.351SerPro: 3.351 ± 0.47
2.477SerGln: 2.477 ± 0.466
4.225SerArg: 4.225 ± 0.461
3.642SerSer: 3.642 ± 0.931
3.642SerThr: 3.642 ± 0.63
3.278SerVal: 3.278 ± 0.645
0.801SerTrp: 0.801 ± 0.272
1.675SerTyr: 1.675 ± 0.37
0.0SerXaa: 0.0 ± 0.0
Thr
7.576ThrAla: 7.576 ± 0.936
0.364ThrCys: 0.364 ± 0.163
3.861ThrAsp: 3.861 ± 0.482
2.477ThrGlu: 2.477 ± 0.444
2.331ThrPhe: 2.331 ± 0.447
5.245ThrGly: 5.245 ± 0.766
0.874ThrHis: 0.874 ± 0.239
2.695ThrIle: 2.695 ± 0.404
2.331ThrLys: 2.331 ± 0.543
5.39ThrLeu: 5.39 ± 0.546
1.311ThrMet: 1.311 ± 0.322
1.967ThrAsn: 1.967 ± 0.36
3.205ThrPro: 3.205 ± 0.501
2.55ThrGln: 2.55 ± 0.384
3.132ThrArg: 3.132 ± 0.551
3.642ThrSer: 3.642 ± 0.762
4.079ThrThr: 4.079 ± 0.879
3.934ThrVal: 3.934 ± 0.611
0.947ThrTrp: 0.947 ± 0.224
1.603ThrTyr: 1.603 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
7.867ValAla: 7.867 ± 0.748
0.656ValCys: 0.656 ± 0.215
4.152ValAsp: 4.152 ± 0.659
3.059ValGlu: 3.059 ± 0.511
1.821ValPhe: 1.821 ± 0.398
4.953ValGly: 4.953 ± 0.575
1.311ValHis: 1.311 ± 0.314
2.768ValIle: 2.768 ± 0.443
2.55ValLys: 2.55 ± 0.449
5.536ValLeu: 5.536 ± 0.703
1.384ValMet: 1.384 ± 0.295
2.112ValAsn: 2.112 ± 0.312
3.424ValPro: 3.424 ± 0.519
2.112ValGln: 2.112 ± 0.498
4.516ValArg: 4.516 ± 0.518
4.371ValSer: 4.371 ± 0.619
4.516ValThr: 4.516 ± 0.877
3.715ValVal: 3.715 ± 0.388
1.894ValTrp: 1.894 ± 0.382
1.238ValTyr: 1.238 ± 0.235
0.0ValXaa: 0.0 ± 0.0
Trp
1.748TrpAla: 1.748 ± 0.382
0.364TrpCys: 0.364 ± 0.139
0.874TrpAsp: 0.874 ± 0.26
0.874TrpGlu: 0.874 ± 0.225
0.874TrpPhe: 0.874 ± 0.243
1.093TrpGly: 1.093 ± 0.277
0.364TrpHis: 0.364 ± 0.14
0.874TrpIle: 0.874 ± 0.244
1.02TrpLys: 1.02 ± 0.291
1.748TrpLeu: 1.748 ± 0.391
0.437TrpMet: 0.437 ± 0.17
0.656TrpAsn: 0.656 ± 0.243
0.437TrpPro: 0.437 ± 0.154
0.583TrpGln: 0.583 ± 0.205
1.675TrpArg: 1.675 ± 0.309
1.238TrpSer: 1.238 ± 0.301
0.947TrpThr: 0.947 ± 0.233
0.801TrpVal: 0.801 ± 0.258
0.291TrpTrp: 0.291 ± 0.154
0.51TrpTyr: 0.51 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.059TyrAla: 3.059 ± 0.536
0.437TyrCys: 0.437 ± 0.18
1.603TyrAsp: 1.603 ± 0.344
1.311TyrGlu: 1.311 ± 0.298
0.801TyrPhe: 0.801 ± 0.262
2.622TyrGly: 2.622 ± 0.462
0.437TyrHis: 0.437 ± 0.152
0.874TyrIle: 0.874 ± 0.224
0.728TyrLys: 0.728 ± 0.246
2.768TyrLeu: 2.768 ± 0.37
0.364TyrMet: 0.364 ± 0.193
0.874TyrAsn: 0.874 ± 0.203
1.093TyrPro: 1.093 ± 0.3
1.311TyrGln: 1.311 ± 0.289
2.185TyrArg: 2.185 ± 0.335
1.238TyrSer: 1.238 ± 0.438
0.583TyrThr: 0.583 ± 0.191
2.04TyrVal: 2.04 ± 0.422
0.437TyrTrp: 0.437 ± 0.149
0.656TyrTyr: 0.656 ± 0.193
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (13729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski