Amino acid dipepetide frequency for Pedobacter xixiisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.147AlaAla: 6.147 ± 0.093
0.609AlaCys: 0.609 ± 0.022
4.225AlaAsp: 4.225 ± 0.059
4.488AlaGlu: 4.488 ± 0.06
3.592AlaPhe: 3.592 ± 0.055
5.143AlaGly: 5.143 ± 0.085
1.164AlaHis: 1.164 ± 0.03
5.743AlaIle: 5.743 ± 0.077
5.629AlaLys: 5.629 ± 0.07
6.965AlaLeu: 6.965 ± 0.08
1.643AlaMet: 1.643 ± 0.037
4.557AlaAsn: 4.557 ± 0.071
2.197AlaPro: 2.197 ± 0.04
3.057AlaGln: 3.057 ± 0.046
2.193AlaArg: 2.193 ± 0.042
4.722AlaSer: 4.722 ± 0.077
4.469AlaThr: 4.469 ± 0.08
4.787AlaVal: 4.787 ± 0.068
0.746AlaTrp: 0.746 ± 0.025
2.942AlaTyr: 2.942 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.465CysAla: 0.465 ± 0.02
0.115CysCys: 0.115 ± 0.01
0.341CysAsp: 0.341 ± 0.016
0.39CysGlu: 0.39 ± 0.018
0.376CysPhe: 0.376 ± 0.017
0.594CysGly: 0.594 ± 0.025
0.156CysHis: 0.156 ± 0.013
0.541CysIle: 0.541 ± 0.02
0.505CysLys: 0.505 ± 0.02
0.698CysLeu: 0.698 ± 0.022
0.141CysMet: 0.141 ± 0.009
0.393CysAsn: 0.393 ± 0.017
0.262CysPro: 0.262 ± 0.015
0.185CysGln: 0.185 ± 0.012
0.252CysArg: 0.252 ± 0.014
0.473CysSer: 0.473 ± 0.02
0.382CysThr: 0.382 ± 0.017
0.44CysVal: 0.44 ± 0.017
0.063CysTrp: 0.063 ± 0.007
0.298CysTyr: 0.298 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.896AspAla: 3.896 ± 0.056
0.343AspCys: 0.343 ± 0.017
2.502AspAsp: 2.502 ± 0.041
3.442AspGlu: 3.442 ± 0.059
3.272AspPhe: 3.272 ± 0.048
3.924AspGly: 3.924 ± 0.063
0.849AspHis: 0.849 ± 0.026
3.952AspIle: 3.952 ± 0.057
4.006AspLys: 4.006 ± 0.059
4.935AspLeu: 4.935 ± 0.054
1.099AspMet: 1.099 ± 0.03
2.67AspAsn: 2.67 ± 0.048
1.723AspPro: 1.723 ± 0.038
1.679AspGln: 1.679 ± 0.037
2.101AspArg: 2.101 ± 0.044
2.56AspSer: 2.56 ± 0.047
2.394AspThr: 2.394 ± 0.049
3.477AspVal: 3.477 ± 0.055
0.723AspTrp: 0.723 ± 0.021
2.398AspTyr: 2.398 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
4.27GluAla: 4.27 ± 0.071
0.284GluCys: 0.284 ± 0.014
2.885GluAsp: 2.885 ± 0.047
4.194GluGlu: 4.194 ± 0.071
2.495GluPhe: 2.495 ± 0.047
3.276GluGly: 3.276 ± 0.049
1.029GluHis: 1.029 ± 0.028
4.864GluIle: 4.864 ± 0.07
5.286GluLys: 5.286 ± 0.079
5.966GluLeu: 5.966 ± 0.071
1.405GluMet: 1.405 ± 0.034
3.701GluAsn: 3.701 ± 0.053
1.525GluPro: 1.525 ± 0.034
2.614GluGln: 2.614 ± 0.048
2.512GluArg: 2.512 ± 0.046
2.686GluSer: 2.686 ± 0.047
3.22GluThr: 3.22 ± 0.041
4.125GluVal: 4.125 ± 0.055
0.588GluTrp: 0.588 ± 0.022
1.954GluTyr: 1.954 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.677PheAla: 3.677 ± 0.05
0.466PheCys: 0.466 ± 0.02
2.935PheAsp: 2.935 ± 0.052
3.045PheGlu: 3.045 ± 0.046
2.57PhePhe: 2.57 ± 0.049
3.66PheGly: 3.66 ± 0.058
0.755PheHis: 0.755 ± 0.026
3.421PheIle: 3.421 ± 0.053
3.527PheLys: 3.527 ± 0.051
4.495PheLeu: 4.495 ± 0.071
1.012PheMet: 1.012 ± 0.027
3.24PheAsn: 3.24 ± 0.054
1.635PhePro: 1.635 ± 0.037
1.294PheGln: 1.294 ± 0.03
1.759PheArg: 1.759 ± 0.031
3.852PheSer: 3.852 ± 0.052
3.157PheThr: 3.157 ± 0.052
3.158PheVal: 3.158 ± 0.044
0.578PheTrp: 0.578 ± 0.023
2.146PheTyr: 2.146 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.871GlyAla: 4.871 ± 0.094
0.535GlyCys: 0.535 ± 0.021
3.215GlyAsp: 3.215 ± 0.054
3.359GlyGlu: 3.359 ± 0.044
3.703GlyPhe: 3.703 ± 0.062
4.932GlyGly: 4.932 ± 0.117
1.063GlyHis: 1.063 ± 0.034
5.139GlyIle: 5.139 ± 0.076
5.406GlyLys: 5.406 ± 0.078
6.177GlyLeu: 6.177 ± 0.071
1.587GlyMet: 1.587 ± 0.033
3.987GlyAsn: 3.987 ± 0.071
1.366GlyPro: 1.366 ± 0.034
2.121GlyGln: 2.121 ± 0.04
2.362GlyArg: 2.362 ± 0.047
4.327GlySer: 4.327 ± 0.083
4.405GlyThr: 4.405 ± 0.085
4.458GlyVal: 4.458 ± 0.065
0.825GlyTrp: 0.825 ± 0.027
3.082GlyTyr: 3.082 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
0.995HisAla: 0.995 ± 0.03
0.173HisCys: 0.173 ± 0.012
0.725HisAsp: 0.725 ± 0.022
0.866HisGlu: 0.866 ± 0.023
1.099HisPhe: 1.099 ± 0.029
1.029HisGly: 1.029 ± 0.031
0.473HisHis: 0.473 ± 0.02
1.298HisIle: 1.298 ± 0.031
0.995HisLys: 0.995 ± 0.03
1.773HisLeu: 1.773 ± 0.038
0.308HisMet: 0.308 ± 0.015
0.862HisAsn: 0.862 ± 0.027
0.868HisPro: 0.868 ± 0.027
0.854HisGln: 0.854 ± 0.027
0.715HisArg: 0.715 ± 0.023
0.976HisSer: 0.976 ± 0.029
0.893HisThr: 0.893 ± 0.025
0.884HisVal: 0.884 ± 0.026
0.193HisTrp: 0.193 ± 0.012
0.787HisTyr: 0.787 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.011IleAla: 6.011 ± 0.075
0.644IleCys: 0.644 ± 0.019
4.432IleAsp: 4.432 ± 0.062
4.521IleGlu: 4.521 ± 0.06
3.308IlePhe: 3.308 ± 0.059
4.963IleGly: 4.963 ± 0.068
1.175IleHis: 1.175 ± 0.027
5.045IleIle: 5.045 ± 0.078
5.553IleLys: 5.553 ± 0.076
6.275IleLeu: 6.275 ± 0.082
1.269IleMet: 1.269 ± 0.032
4.659IleAsn: 4.659 ± 0.068
2.863IlePro: 2.863 ± 0.046
2.193IleGln: 2.193 ± 0.043
2.569IleArg: 2.569 ± 0.043
5.392IleSer: 5.392 ± 0.061
4.495IleThr: 4.495 ± 0.066
4.425IleVal: 4.425 ± 0.059
0.701IleTrp: 0.701 ± 0.023
2.815IleTyr: 2.815 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.549LysAla: 5.549 ± 0.081
0.329LysCys: 0.329 ± 0.016
4.302LysAsp: 4.302 ± 0.061
5.068LysGlu: 5.068 ± 0.076
2.965LysPhe: 2.965 ± 0.047
4.681LysGly: 4.681 ± 0.058
1.34LysHis: 1.34 ± 0.032
5.599LysIle: 5.599 ± 0.074
6.075LysLys: 6.075 ± 0.087
6.865LysLeu: 6.865 ± 0.084
1.953LysMet: 1.953 ± 0.037
4.765LysAsn: 4.765 ± 0.065
2.685LysPro: 2.685 ± 0.049
3.095LysGln: 3.095 ± 0.054
2.705LysArg: 2.705 ± 0.05
4.393LysSer: 4.393 ± 0.062
4.459LysThr: 4.459 ± 0.053
4.881LysVal: 4.881 ± 0.063
0.85LysTrp: 0.85 ± 0.022
2.988LysTyr: 2.988 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
7.326LeuAla: 7.326 ± 0.082
0.725LeuCys: 0.725 ± 0.025
4.677LeuAsp: 4.677 ± 0.053
5.114LeuGlu: 5.114 ± 0.076
4.69LeuPhe: 4.69 ± 0.071
5.775LeuGly: 5.775 ± 0.064
1.538LeuHis: 1.538 ± 0.036
6.5LeuIle: 6.5 ± 0.078
7.585LeuLys: 7.585 ± 0.089
9.373LeuLeu: 9.373 ± 0.104
2.107LeuMet: 2.107 ± 0.041
5.952LeuAsn: 5.952 ± 0.078
3.865LeuPro: 3.865 ± 0.055
3.473LeuGln: 3.473 ± 0.047
3.512LeuArg: 3.512 ± 0.056
7.037LeuSer: 7.037 ± 0.07
5.649LeuThr: 5.649 ± 0.074
5.699LeuVal: 5.699 ± 0.066
0.87LeuTrp: 0.87 ± 0.026
3.185LeuTyr: 3.185 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.689MetAla: 1.689 ± 0.036
0.121MetCys: 0.121 ± 0.009
1.076MetAsp: 1.076 ± 0.025
1.303MetGlu: 1.303 ± 0.031
0.81MetPhe: 0.81 ± 0.024
1.461MetGly: 1.461 ± 0.033
0.363MetHis: 0.363 ± 0.015
1.41MetIle: 1.41 ± 0.03
1.962MetLys: 1.962 ± 0.035
2.033MetLeu: 2.033 ± 0.038
0.605MetMet: 0.605 ± 0.021
1.205MetAsn: 1.205 ± 0.029
0.997MetPro: 0.997 ± 0.022
0.91MetGln: 0.91 ± 0.028
0.847MetArg: 0.847 ± 0.024
1.351MetSer: 1.351 ± 0.032
0.953MetThr: 0.953 ± 0.024
1.408MetVal: 1.408 ± 0.03
0.163MetTrp: 0.163 ± 0.011
0.662MetTyr: 0.662 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.484AsnAla: 4.484 ± 0.056
0.406AsnCys: 0.406 ± 0.019
2.862AsnAsp: 2.862 ± 0.046
3.374AsnGlu: 3.374 ± 0.056
3.027AsnPhe: 3.027 ± 0.047
4.542AsnGly: 4.542 ± 0.082
1.025AsnHis: 1.025 ± 0.033
4.525AsnIle: 4.525 ± 0.059
4.104AsnLys: 4.104 ± 0.052
5.543AsnLeu: 5.543 ± 0.072
1.201AsnMet: 1.201 ± 0.034
3.76AsnAsn: 3.76 ± 0.073
2.716AsnPro: 2.716 ± 0.047
2.325AsnGln: 2.325 ± 0.042
2.27AsnArg: 2.27 ± 0.045
3.708AsnSer: 3.708 ± 0.061
3.653AsnThr: 3.653 ± 0.065
3.727AsnVal: 3.727 ± 0.062
0.808AsnTrp: 0.808 ± 0.025
2.921AsnTyr: 2.921 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.614ProAla: 2.614 ± 0.055
0.193ProCys: 0.193 ± 0.013
1.952ProAsp: 1.952 ± 0.036
2.473ProGlu: 2.473 ± 0.045
1.824ProPhe: 1.824 ± 0.04
1.984ProGly: 1.984 ± 0.042
0.561ProHis: 0.561 ± 0.021
2.641ProIle: 2.641 ± 0.046
2.476ProLys: 2.476 ± 0.045
3.107ProLeu: 3.107 ± 0.05
0.739ProMet: 0.739 ± 0.023
2.256ProAsn: 2.256 ± 0.044
0.839ProPro: 0.839 ± 0.029
1.348ProGln: 1.348 ± 0.033
0.987ProArg: 0.987 ± 0.029
2.401ProSer: 2.401 ± 0.041
2.172ProThr: 2.172 ± 0.045
2.561ProVal: 2.561 ± 0.043
0.333ProTrp: 0.333 ± 0.015
1.395ProTyr: 1.395 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.514GlnAla: 2.514 ± 0.044
0.159GlnCys: 0.159 ± 0.011
1.572GlnAsp: 1.572 ± 0.035
2.099GlnGlu: 2.099 ± 0.039
1.696GlnPhe: 1.696 ± 0.035
2.018GlnGly: 2.018 ± 0.041
0.752GlnHis: 0.752 ± 0.023
2.772GlnIle: 2.772 ± 0.048
2.942GlnLys: 2.942 ± 0.049
3.956GlnLeu: 3.956 ± 0.062
0.86GlnMet: 0.86 ± 0.025
2.218GlnAsn: 2.218 ± 0.042
1.31GlnPro: 1.31 ± 0.033
2.07GlnGln: 2.07 ± 0.045
1.449GlnArg: 1.449 ± 0.032
2.155GlnSer: 2.155 ± 0.038
2.31GlnThr: 2.31 ± 0.044
2.191GlnVal: 2.191 ± 0.041
0.395GlnTrp: 0.395 ± 0.015
1.36GlnTyr: 1.36 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.282ArgAla: 2.282 ± 0.045
0.22ArgCys: 0.22 ± 0.012
1.744ArgAsp: 1.744 ± 0.039
2.108ArgGlu: 2.108 ± 0.043
1.974ArgPhe: 1.974 ± 0.036
2.028ArgGly: 2.028 ± 0.044
0.555ArgHis: 0.555 ± 0.019
2.863ArgIle: 2.863 ± 0.041
2.826ArgLys: 2.826 ± 0.044
3.65ArgLeu: 3.65 ± 0.06
0.922ArgMet: 0.922 ± 0.023
2.372ArgAsn: 2.372 ± 0.045
1.233ArgPro: 1.233 ± 0.032
1.253ArgGln: 1.253 ± 0.031
1.426ArgArg: 1.426 ± 0.037
2.115ArgSer: 2.115 ± 0.042
2.051ArgThr: 2.051 ± 0.035
2.208ArgVal: 2.208 ± 0.047
0.469ArgTrp: 0.469 ± 0.02
1.733ArgTyr: 1.733 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.79SerAla: 4.79 ± 0.073
0.53SerCys: 0.53 ± 0.02
2.99SerAsp: 2.99 ± 0.044
3.276SerGlu: 3.276 ± 0.047
3.847SerPhe: 3.847 ± 0.054
4.69SerGly: 4.69 ± 0.087
1.023SerHis: 1.023 ± 0.03
4.854SerIle: 4.854 ± 0.062
4.424SerLys: 4.424 ± 0.062
6.234SerLeu: 6.234 ± 0.076
1.187SerMet: 1.187 ± 0.029
3.766SerAsn: 3.766 ± 0.068
2.182SerPro: 2.182 ± 0.038
1.978SerGln: 1.978 ± 0.037
2.187SerArg: 2.187 ± 0.044
4.481SerSer: 4.481 ± 0.078
3.867SerThr: 3.867 ± 0.069
4.303SerVal: 4.303 ± 0.062
0.681SerTrp: 0.681 ± 0.024
2.925SerTyr: 2.925 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.819ThrAla: 4.819 ± 0.079
0.301ThrCys: 0.301 ± 0.015
3.265ThrAsp: 3.265 ± 0.049
3.331ThrGlu: 3.331 ± 0.048
2.984ThrPhe: 2.984 ± 0.052
4.536ThrGly: 4.536 ± 0.082
0.954ThrHis: 0.954 ± 0.03
4.409ThrIle: 4.409 ± 0.067
3.761ThrLys: 3.761 ± 0.056
5.567ThrLeu: 5.567 ± 0.068
0.923ThrMet: 0.923 ± 0.024
3.372ThrAsn: 3.372 ± 0.061
2.439ThrPro: 2.439 ± 0.046
1.919ThrGln: 1.919 ± 0.035
1.705ThrArg: 1.705 ± 0.039
3.859ThrSer: 3.859 ± 0.072
3.765ThrThr: 3.765 ± 0.069
4.103ThrVal: 4.103 ± 0.076
0.638ThrTrp: 0.638 ± 0.023
2.543ThrTyr: 2.543 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.984ValAla: 4.984 ± 0.061
0.514ValCys: 0.514 ± 0.021
3.493ValAsp: 3.493 ± 0.049
3.66ValGlu: 3.66 ± 0.066
3.293ValPhe: 3.293 ± 0.052
4.141ValGly: 4.141 ± 0.067
0.928ValHis: 0.928 ± 0.028
4.456ValIle: 4.456 ± 0.059
4.91ValLys: 4.91 ± 0.06
6.067ValLeu: 6.067 ± 0.074
1.356ValMet: 1.356 ± 0.034
4.008ValAsn: 4.008 ± 0.061
2.302ValPro: 2.302 ± 0.041
1.956ValGln: 1.956 ± 0.035
2.235ValArg: 2.235 ± 0.041
4.498ValSer: 4.498 ± 0.067
3.779ValThr: 3.779 ± 0.079
4.571ValVal: 4.571 ± 0.073
0.683ValTrp: 0.683 ± 0.021
2.454ValTyr: 2.454 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.735TrpAla: 0.735 ± 0.027
0.099TrpCys: 0.099 ± 0.008
0.609TrpAsp: 0.609 ± 0.023
0.625TrpGlu: 0.625 ± 0.022
0.551TrpPhe: 0.551 ± 0.021
0.757TrpGly: 0.757 ± 0.026
0.213TrpHis: 0.213 ± 0.012
0.711TrpIle: 0.711 ± 0.024
0.836TrpLys: 0.836 ± 0.024
1.049TrpLeu: 1.049 ± 0.03
0.3TrpMet: 0.3 ± 0.016
0.679TrpAsn: 0.679 ± 0.022
0.306TrpPro: 0.306 ± 0.018
0.514TrpGln: 0.514 ± 0.021
0.448TrpArg: 0.448 ± 0.015
0.643TrpSer: 0.643 ± 0.019
0.602TrpThr: 0.602 ± 0.023
0.651TrpVal: 0.651 ± 0.02
0.16TrpTrp: 0.16 ± 0.013
0.452TrpTyr: 0.452 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.901TyrAla: 2.901 ± 0.048
0.303TyrCys: 0.303 ± 0.015
2.142TyrAsp: 2.142 ± 0.044
2.144TyrGlu: 2.144 ± 0.038
2.308TyrPhe: 2.308 ± 0.045
2.787TyrGly: 2.787 ± 0.049
0.849TyrHis: 0.849 ± 0.028
2.566TyrIle: 2.566 ± 0.042
2.737TyrLys: 2.737 ± 0.05
3.92TyrLeu: 3.92 ± 0.06
0.71TyrMet: 0.71 ± 0.022
2.562TyrAsn: 2.562 ± 0.045
1.542TyrPro: 1.542 ± 0.035
1.962TyrGln: 1.962 ± 0.042
1.797TyrArg: 1.797 ± 0.039
2.587TyrSer: 2.587 ± 0.047
2.517TyrThr: 2.517 ± 0.054
2.233TyrVal: 2.233 ± 0.039
0.472TyrTrp: 0.472 ± 0.018
1.848TyrTyr: 1.848 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4166 proteins (1461943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski