Amino acid dipepetide frequency for Streptosporangium subroseum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.031AlaAla: 18.031 ± 0.099
1.009AlaCys: 1.009 ± 0.019
7.514AlaAsp: 7.514 ± 0.045
8.206AlaGlu: 8.206 ± 0.062
3.619AlaPhe: 3.619 ± 0.034
12.425AlaGly: 12.425 ± 0.076
2.444AlaHis: 2.444 ± 0.03
4.583AlaIle: 4.583 ± 0.04
2.775AlaLys: 2.775 ± 0.037
13.473AlaLeu: 13.473 ± 0.081
2.678AlaMet: 2.678 ± 0.033
2.168AlaAsn: 2.168 ± 0.034
6.079AlaPro: 6.079 ± 0.05
3.574AlaGln: 3.574 ± 0.037
9.128AlaArg: 9.128 ± 0.069
6.241AlaSer: 6.241 ± 0.051
7.116AlaThr: 7.116 ± 0.065
11.265AlaVal: 11.265 ± 0.072
1.825AlaTrp: 1.825 ± 0.027
2.613AlaTyr: 2.613 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
0.907CysAla: 0.907 ± 0.017
0.095CysCys: 0.095 ± 0.006
0.494CysAsp: 0.494 ± 0.012
0.414CysGlu: 0.414 ± 0.012
0.22CysPhe: 0.22 ± 0.009
0.91CysGly: 0.91 ± 0.02
0.207CysHis: 0.207 ± 0.008
0.15CysIle: 0.15 ± 0.007
0.117CysLys: 0.117 ± 0.006
0.725CysLeu: 0.725 ± 0.015
0.119CysMet: 0.119 ± 0.006
0.119CysAsn: 0.119 ± 0.007
0.482CysPro: 0.482 ± 0.017
0.167CysGln: 0.167 ± 0.008
0.559CysArg: 0.559 ± 0.016
0.449CysSer: 0.449 ± 0.014
0.434CysThr: 0.434 ± 0.018
0.648CysVal: 0.648 ± 0.015
0.107CysTrp: 0.107 ± 0.006
0.165CysTyr: 0.165 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
6.731AspAla: 6.731 ± 0.054
0.369AspCys: 0.369 ± 0.011
3.572AspAsp: 3.572 ± 0.038
3.621AspGlu: 3.621 ± 0.036
1.648AspPhe: 1.648 ± 0.024
5.889AspGly: 5.889 ± 0.051
1.421AspHis: 1.421 ± 0.022
1.979AspIle: 1.979 ± 0.025
1.074AspLys: 1.074 ± 0.023
6.659AspLeu: 6.659 ± 0.051
0.883AspMet: 0.883 ± 0.016
1.016AspAsn: 1.016 ± 0.02
4.408AspPro: 4.408 ± 0.044
1.661AspGln: 1.661 ± 0.029
4.776AspArg: 4.776 ± 0.049
2.473AspSer: 2.473 ± 0.033
2.717AspThr: 2.717 ± 0.033
4.81AspVal: 4.81 ± 0.041
0.968AspTrp: 0.968 ± 0.016
1.254AspTyr: 1.254 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
6.827GluAla: 6.827 ± 0.061
0.358GluCys: 0.358 ± 0.01
2.619GluAsp: 2.619 ± 0.033
3.465GluGlu: 3.465 ± 0.043
1.562GluPhe: 1.562 ± 0.021
4.057GluGly: 4.057 ± 0.039
1.494GluHis: 1.494 ± 0.025
2.756GluIle: 2.756 ± 0.031
1.353GluLys: 1.353 ± 0.027
6.68GluLeu: 6.68 ± 0.054
1.037GluMet: 1.037 ± 0.019
1.123GluAsn: 1.123 ± 0.018
3.276GluPro: 3.276 ± 0.038
2.104GluGln: 2.104 ± 0.028
5.325GluArg: 5.325 ± 0.051
2.738GluSer: 2.738 ± 0.029
3.076GluThr: 3.076 ± 0.034
4.624GluVal: 4.624 ± 0.04
0.838GluTrp: 0.838 ± 0.019
1.053GluTyr: 1.053 ± 0.017
0.0GluXaa: 0.0 ± 0.0
Phe
3.781PheAla: 3.781 ± 0.035
0.267PheCys: 0.267 ± 0.009
2.102PheAsp: 2.102 ± 0.028
1.49PheGlu: 1.49 ± 0.022
0.963PhePhe: 0.963 ± 0.021
3.175PheGly: 3.175 ± 0.038
0.643PheHis: 0.643 ± 0.015
0.903PheIle: 0.903 ± 0.019
0.532PheLys: 0.532 ± 0.016
2.714PheLeu: 2.714 ± 0.032
0.486PheMet: 0.486 ± 0.013
0.68PheAsn: 0.68 ± 0.015
1.443PhePro: 1.443 ± 0.02
0.773PheGln: 0.773 ± 0.015
1.878PheArg: 1.878 ± 0.027
1.667PheSer: 1.667 ± 0.025
2.089PheThr: 2.089 ± 0.027
2.404PheVal: 2.404 ± 0.03
0.466PheTrp: 0.466 ± 0.014
0.65PheTyr: 0.65 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
10.11GlyAla: 10.11 ± 0.069
0.759GlyCys: 0.759 ± 0.015
5.159GlyAsp: 5.159 ± 0.044
5.148GlyGlu: 5.148 ± 0.045
3.002GlyPhe: 3.002 ± 0.033
8.443GlyGly: 8.443 ± 0.067
2.221GlyHis: 2.221 ± 0.03
3.719GlyIle: 3.719 ± 0.035
2.465GlyLys: 2.465 ± 0.031
9.556GlyLeu: 9.556 ± 0.066
2.093GlyMet: 2.093 ± 0.028
1.922GlyAsn: 1.922 ± 0.034
4.846GlyPro: 4.846 ± 0.049
2.804GlyGln: 2.804 ± 0.031
7.349GlyArg: 7.349 ± 0.063
5.449GlySer: 5.449 ± 0.049
5.977GlyThr: 5.977 ± 0.068
7.79GlyVal: 7.79 ± 0.051
1.746GlyTrp: 1.746 ± 0.026
2.355GlyTyr: 2.355 ± 0.027
0.0GlyXaa: 0.0 ± 0.0
His
2.488HisAla: 2.488 ± 0.031
0.179HisCys: 0.179 ± 0.008
1.345HisAsp: 1.345 ± 0.025
1.158HisGlu: 1.158 ± 0.019
0.622HisPhe: 0.622 ± 0.015
2.158HisGly: 2.158 ± 0.026
0.649HisHis: 0.649 ± 0.017
0.76HisIle: 0.76 ± 0.017
0.285HisLys: 0.285 ± 0.01
2.436HisLeu: 2.436 ± 0.03
0.354HisMet: 0.354 ± 0.011
0.387HisAsn: 0.387 ± 0.011
1.697HisPro: 1.697 ± 0.027
0.57HisGln: 0.57 ± 0.015
1.974HisArg: 1.974 ± 0.028
1.015HisSer: 1.015 ± 0.019
1.138HisThr: 1.138 ± 0.018
1.727HisVal: 1.727 ± 0.023
0.334HisTrp: 0.334 ± 0.01
0.477HisTyr: 0.477 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
5.491IleAla: 5.491 ± 0.051
0.342IleCys: 0.342 ± 0.011
2.648IleAsp: 2.648 ± 0.03
2.405IleGlu: 2.405 ± 0.032
1.034IlePhe: 1.034 ± 0.02
4.18IleGly: 4.18 ± 0.043
0.755IleHis: 0.755 ± 0.016
1.352IleIle: 1.352 ± 0.024
0.927IleLys: 0.927 ± 0.021
3.156IleLeu: 3.156 ± 0.035
0.659IleMet: 0.659 ± 0.016
0.906IleAsn: 0.906 ± 0.018
2.151IlePro: 2.151 ± 0.028
0.926IleGln: 0.926 ± 0.019
2.782IleArg: 2.782 ± 0.03
2.274IleSer: 2.274 ± 0.028
2.759IleThr: 2.759 ± 0.035
3.536IleVal: 3.536 ± 0.039
0.528IleTrp: 0.528 ± 0.013
0.745IleTyr: 0.745 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
2.648LysAla: 2.648 ± 0.032
0.128LysCys: 0.128 ± 0.007
1.22LysAsp: 1.22 ± 0.023
1.096LysGlu: 1.096 ± 0.02
0.487LysPhe: 0.487 ± 0.014
1.703LysGly: 1.703 ± 0.029
0.446LysHis: 0.446 ± 0.012
1.174LysIle: 1.174 ± 0.021
0.747LysLys: 0.747 ± 0.023
2.117LysLeu: 2.117 ± 0.029
0.417LysMet: 0.417 ± 0.013
0.534LysAsn: 0.534 ± 0.014
1.409LysPro: 1.409 ± 0.028
0.688LysGln: 0.688 ± 0.017
1.441LysArg: 1.441 ± 0.025
1.158LysSer: 1.158 ± 0.022
1.373LysThr: 1.373 ± 0.026
1.993LysVal: 1.993 ± 0.028
0.286LysTrp: 0.286 ± 0.01
0.461LysTyr: 0.461 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
14.727LeuAla: 14.727 ± 0.091
0.759LeuCys: 0.759 ± 0.014
6.503LeuAsp: 6.503 ± 0.053
4.856LeuGlu: 4.856 ± 0.049
2.794LeuPhe: 2.794 ± 0.033
9.158LeuGly: 9.158 ± 0.07
2.11LeuHis: 2.11 ± 0.03
4.296LeuIle: 4.296 ± 0.044
1.969LeuLys: 1.969 ± 0.026
10.988LeuLeu: 10.988 ± 0.077
1.786LeuMet: 1.786 ± 0.026
1.996LeuAsn: 1.996 ± 0.027
6.285LeuPro: 6.285 ± 0.046
2.211LeuGln: 2.211 ± 0.029
8.648LeuArg: 8.648 ± 0.065
6.021LeuSer: 6.021 ± 0.044
6.894LeuThr: 6.894 ± 0.055
8.639LeuVal: 8.639 ± 0.062
1.321LeuTrp: 1.321 ± 0.025
1.927LeuTyr: 1.927 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
2.38MetAla: 2.38 ± 0.031
0.132MetCys: 0.132 ± 0.008
0.955MetAsp: 0.955 ± 0.018
0.824MetGlu: 0.824 ± 0.018
0.545MetPhe: 0.545 ± 0.015
1.4MetGly: 1.4 ± 0.024
0.37MetHis: 0.37 ± 0.011
1.003MetIle: 1.003 ± 0.017
0.474MetLys: 0.474 ± 0.012
2.013MetLeu: 2.013 ± 0.027
0.358MetMet: 0.358 ± 0.011
0.507MetAsn: 0.507 ± 0.012
1.212MetPro: 1.212 ± 0.024
0.434MetGln: 0.434 ± 0.014
1.618MetArg: 1.618 ± 0.024
1.451MetSer: 1.451 ± 0.021
1.634MetThr: 1.634 ± 0.021
1.511MetVal: 1.511 ± 0.024
0.24MetTrp: 0.24 ± 0.008
0.306MetTyr: 0.306 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
2.419AsnAla: 2.419 ± 0.035
0.173AsnCys: 0.173 ± 0.009
1.106AsnAsp: 1.106 ± 0.021
0.906AsnGlu: 0.906 ± 0.017
0.529AsnPhe: 0.529 ± 0.015
2.17AsnGly: 2.17 ± 0.039
0.436AsnHis: 0.436 ± 0.012
0.711AsnIle: 0.711 ± 0.015
0.428AsnLys: 0.428 ± 0.014
2.041AsnLeu: 2.041 ± 0.03
0.337AsnMet: 0.337 ± 0.011
0.589AsnAsn: 0.589 ± 0.027
1.609AsnPro: 1.609 ± 0.025
0.592AsnGln: 0.592 ± 0.016
1.449AsnArg: 1.449 ± 0.02
0.982AsnSer: 0.982 ± 0.022
1.223AsnThr: 1.223 ± 0.029
1.63AsnVal: 1.63 ± 0.025
0.321AsnTrp: 0.321 ± 0.01
0.468AsnTyr: 0.468 ± 0.012
0.0AsnXaa: 0.0 ± 0.0
Pro
7.808ProAla: 7.808 ± 0.061
0.33ProCys: 0.33 ± 0.011
4.136ProAsp: 4.136 ± 0.041
4.169ProGlu: 4.169 ± 0.047
1.582ProPhe: 1.582 ± 0.022
6.456ProGly: 6.456 ± 0.05
1.19ProHis: 1.19 ± 0.023
2.038ProIle: 2.038 ± 0.024
1.222ProLys: 1.222 ± 0.021
5.169ProLeu: 5.169 ± 0.041
1.17ProMet: 1.17 ± 0.021
1.066ProAsn: 1.066 ± 0.022
3.552ProPro: 3.552 ± 0.052
1.679ProGln: 1.679 ± 0.029
3.669ProArg: 3.669 ± 0.036
3.521ProSer: 3.521 ± 0.044
3.22ProThr: 3.22 ± 0.04
5.13ProVal: 5.13 ± 0.046
0.913ProTrp: 0.913 ± 0.019
1.428ProTyr: 1.428 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.956GlnAla: 3.956 ± 0.045
0.156GlnCys: 0.156 ± 0.006
1.349GlnAsp: 1.349 ± 0.022
1.479GlnGlu: 1.479 ± 0.027
0.693GlnPhe: 0.693 ± 0.014
2.221GlnGly: 2.221 ± 0.032
0.577GlnHis: 0.577 ± 0.015
1.361GlnIle: 1.361 ± 0.021
0.602GlnLys: 0.602 ± 0.016
2.769GlnLeu: 2.769 ± 0.033
0.546GlnMet: 0.546 ± 0.014
0.589GlnAsn: 0.589 ± 0.014
1.668GlnPro: 1.668 ± 0.032
1.031GlnGln: 1.031 ± 0.026
2.34GlnArg: 2.34 ± 0.028
1.31GlnSer: 1.31 ± 0.025
1.467GlnThr: 1.467 ± 0.025
2.622GlnVal: 2.622 ± 0.035
0.452GlnTrp: 0.452 ± 0.013
0.524GlnTyr: 0.524 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.683ArgAla: 8.683 ± 0.067
0.56ArgCys: 0.56 ± 0.014
4.236ArgAsp: 4.236 ± 0.037
4.653ArgGlu: 4.653 ± 0.046
2.525ArgPhe: 2.525 ± 0.031
5.601ArgGly: 5.601 ± 0.051
1.964ArgHis: 1.964 ± 0.027
3.462ArgIle: 3.462 ± 0.035
1.636ArgLys: 1.636 ± 0.027
9.109ArgLeu: 9.109 ± 0.069
1.875ArgMet: 1.875 ± 0.023
1.451ArgAsn: 1.451 ± 0.024
4.598ArgPro: 4.598 ± 0.048
2.374ArgGln: 2.374 ± 0.032
7.477ArgArg: 7.477 ± 0.07
4.299ArgSer: 4.299 ± 0.038
4.634ArgThr: 4.634 ± 0.051
5.862ArgVal: 5.862 ± 0.048
1.357ArgTrp: 1.357 ± 0.023
1.8ArgTyr: 1.8 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
6.797SerAla: 6.797 ± 0.052
0.408SerCys: 0.408 ± 0.014
2.739SerAsp: 2.739 ± 0.031
2.676SerGlu: 2.676 ± 0.031
1.735SerPhe: 1.735 ± 0.023
6.292SerGly: 6.292 ± 0.059
1.109SerHis: 1.109 ± 0.016
2.019SerIle: 2.019 ± 0.028
1.117SerLys: 1.117 ± 0.023
5.142SerLeu: 5.142 ± 0.043
1.26SerMet: 1.26 ± 0.022
1.036SerAsn: 1.036 ± 0.022
3.623SerPro: 3.623 ± 0.039
1.452SerGln: 1.452 ± 0.026
4.04SerArg: 4.04 ± 0.036
3.279SerSer: 3.279 ± 0.047
3.344SerThr: 3.344 ± 0.041
4.388SerVal: 4.388 ± 0.042
0.989SerTrp: 0.989 ± 0.021
1.288SerTyr: 1.288 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
8.102ThrAla: 8.102 ± 0.071
0.475ThrCys: 0.475 ± 0.022
3.212ThrAsp: 3.212 ± 0.036
2.976ThrGlu: 2.976 ± 0.034
1.802ThrPhe: 1.802 ± 0.026
6.672ThrGly: 6.672 ± 0.065
1.123ThrHis: 1.123 ± 0.019
2.301ThrIle: 2.301 ± 0.035
1.165ThrLys: 1.165 ± 0.022
5.954ThrLeu: 5.954 ± 0.05
1.093ThrMet: 1.093 ± 0.017
1.152ThrAsn: 1.152 ± 0.021
4.147ThrPro: 4.147 ± 0.049
1.429ThrGln: 1.429 ± 0.021
3.96ThrArg: 3.96 ± 0.045
3.429ThrSer: 3.429 ± 0.039
3.776ThrThr: 3.776 ± 0.051
6.032ThrVal: 6.032 ± 0.064
0.984ThrTrp: 0.984 ± 0.021
1.362ThrTyr: 1.362 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.728ValAla: 10.728 ± 0.074
0.671ValCys: 0.671 ± 0.015
4.863ValAsp: 4.863 ± 0.044
4.874ValGlu: 4.874 ± 0.04
2.543ValPhe: 2.543 ± 0.029
6.561ValGly: 6.561 ± 0.043
1.766ValHis: 1.766 ± 0.027
3.728ValIle: 3.728 ± 0.039
1.864ValLys: 1.864 ± 0.028
9.14ValLeu: 9.14 ± 0.066
1.572ValMet: 1.572 ± 0.025
1.952ValAsn: 1.952 ± 0.034
5.004ValPro: 5.004 ± 0.052
2.013ValGln: 2.013 ± 0.026
6.522ValArg: 6.522 ± 0.049
4.842ValSer: 4.842 ± 0.041
6.045ValThr: 6.045 ± 0.074
7.809ValVal: 7.809 ± 0.064
1.083ValTrp: 1.083 ± 0.02
1.626ValTyr: 1.626 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
1.621TrpAla: 1.621 ± 0.026
0.138TrpCys: 0.138 ± 0.008
0.79TrpAsp: 0.79 ± 0.016
0.773TrpGlu: 0.773 ± 0.016
0.521TrpPhe: 0.521 ± 0.014
1.06TrpGly: 1.06 ± 0.018
0.394TrpHis: 0.394 ± 0.013
0.653TrpIle: 0.653 ± 0.014
0.398TrpLys: 0.398 ± 0.014
1.803TrpLeu: 1.803 ± 0.027
0.34TrpMet: 0.34 ± 0.014
0.457TrpAsn: 0.457 ± 0.014
0.851TrpPro: 0.851 ± 0.017
0.567TrpGln: 0.567 ± 0.013
1.331TrpArg: 1.331 ± 0.02
1.025TrpSer: 1.025 ± 0.018
1.028TrpThr: 1.028 ± 0.021
1.03TrpVal: 1.03 ± 0.019
0.328TrpTrp: 0.328 ± 0.01
0.357TrpTyr: 0.357 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.029
0.179TyrCys: 0.179 ± 0.008
1.366TyrAsp: 1.366 ± 0.024
1.179TyrGlu: 1.179 ± 0.02
0.68TyrPhe: 0.68 ± 0.015
2.382TyrGly: 2.382 ± 0.031
0.433TyrHis: 0.433 ± 0.013
0.61TyrIle: 0.61 ± 0.016
0.375TyrLys: 0.375 ± 0.012
2.241TyrLeu: 2.241 ± 0.028
0.303TyrMet: 0.303 ± 0.011
0.469TyrAsn: 0.469 ± 0.015
1.107TyrPro: 1.107 ± 0.018
0.664TyrGln: 0.664 ± 0.014
1.889TyrArg: 1.889 ± 0.028
1.109TyrSer: 1.109 ± 0.022
1.203TyrThr: 1.203 ± 0.023
1.759TyrVal: 1.759 ± 0.025
0.378TyrTrp: 0.378 ± 0.013
0.491TyrTyr: 0.491 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.001
Statistics based on 9643 proteins (3066309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski