Amino acid dipepetide frequency for Caviibacterium pharyngocola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.8AlaAla: 7.8 ± 0.13
0.983AlaCys: 0.983 ± 0.038
4.796AlaAsp: 4.796 ± 0.089
6.68AlaGlu: 6.68 ± 0.12
3.449AlaPhe: 3.449 ± 0.082
5.86AlaGly: 5.86 ± 0.124
1.408AlaHis: 1.408 ± 0.053
5.663AlaIle: 5.663 ± 0.118
5.556AlaLys: 5.556 ± 0.106
10.637AlaLeu: 10.637 ± 0.141
2.33AlaMet: 2.33 ± 0.065
3.554AlaAsn: 3.554 ± 0.08
2.661AlaPro: 2.661 ± 0.06
4.833AlaGln: 4.833 ± 0.102
3.73AlaArg: 3.73 ± 0.086
3.956AlaSer: 3.956 ± 0.097
4.308AlaThr: 4.308 ± 0.111
6.799AlaVal: 6.799 ± 0.104
0.821AlaTrp: 0.821 ± 0.032
2.574AlaTyr: 2.574 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.957CysAla: 0.957 ± 0.044
0.193CysCys: 0.193 ± 0.018
0.603CysAsp: 0.603 ± 0.031
0.644CysGlu: 0.644 ± 0.029
0.518CysPhe: 0.518 ± 0.025
1.136CysGly: 1.136 ± 0.045
0.326CysHis: 0.326 ± 0.025
0.621CysIle: 0.621 ± 0.03
0.465CysLys: 0.465 ± 0.026
1.084CysLeu: 1.084 ± 0.043
0.177CysMet: 0.177 ± 0.018
0.367CysAsn: 0.367 ± 0.024
0.499CysPro: 0.499 ± 0.031
0.433CysGln: 0.433 ± 0.03
0.559CysArg: 0.559 ± 0.029
0.622CysSer: 0.622 ± 0.028
0.485CysThr: 0.485 ± 0.028
0.707CysVal: 0.707 ± 0.033
0.117CysTrp: 0.117 ± 0.012
0.414CysTyr: 0.414 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.767AspAla: 3.767 ± 0.074
0.583AspCys: 0.583 ± 0.032
2.581AspAsp: 2.581 ± 0.074
3.742AspGlu: 3.742 ± 0.07
2.569AspPhe: 2.569 ± 0.063
3.315AspGly: 3.315 ± 0.091
0.928AspHis: 0.928 ± 0.04
3.848AspIle: 3.848 ± 0.072
3.463AspLys: 3.463 ± 0.079
5.256AspLeu: 5.256 ± 0.101
1.151AspMet: 1.151 ± 0.037
2.541AspAsn: 2.541 ± 0.071
2.07AspPro: 2.07 ± 0.052
1.77AspGln: 1.77 ± 0.055
2.204AspArg: 2.204 ± 0.06
2.452AspSer: 2.452 ± 0.053
2.297AspThr: 2.297 ± 0.057
3.402AspVal: 3.402 ± 0.076
0.798AspTrp: 0.798 ± 0.036
2.365AspTyr: 2.365 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.304GluAla: 4.304 ± 0.084
0.477GluCys: 0.477 ± 0.029
2.557GluAsp: 2.557 ± 0.061
3.857GluGlu: 3.857 ± 0.092
2.532GluPhe: 2.532 ± 0.061
3.149GluGly: 3.149 ± 0.072
1.3GluHis: 1.3 ± 0.041
4.798GluIle: 4.798 ± 0.092
5.175GluLys: 5.175 ± 0.097
6.569GluLeu: 6.569 ± 0.117
1.822GluMet: 1.822 ± 0.049
3.922GluAsn: 3.922 ± 0.071
1.827GluPro: 1.827 ± 0.051
4.221GluGln: 4.221 ± 0.092
3.48GluArg: 3.48 ± 0.078
2.968GluSer: 2.968 ± 0.066
3.356GluThr: 3.356 ± 0.083
3.703GluVal: 3.703 ± 0.083
0.709GluTrp: 0.709 ± 0.031
1.724GluTyr: 1.724 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
4.033PheAla: 4.033 ± 0.084
0.659PheCys: 0.659 ± 0.027
2.801PheAsp: 2.801 ± 0.078
2.435PheGlu: 2.435 ± 0.066
2.119PhePhe: 2.119 ± 0.068
3.504PheGly: 3.504 ± 0.078
0.851PheHis: 0.851 ± 0.033
3.164PheIle: 3.164 ± 0.088
2.012PheLys: 2.012 ± 0.052
4.049PheLeu: 4.049 ± 0.09
0.953PheMet: 0.953 ± 0.039
2.299PheAsn: 2.299 ± 0.054
1.461PhePro: 1.461 ± 0.046
1.338PheGln: 1.338 ± 0.042
1.661PheArg: 1.661 ± 0.05
3.284PheSer: 3.284 ± 0.072
2.336PheThr: 2.336 ± 0.056
2.932PheVal: 2.932 ± 0.074
0.574PheTrp: 0.574 ± 0.032
1.626PheTyr: 1.626 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
5.478GlyAla: 5.478 ± 0.127
0.838GlyCys: 0.838 ± 0.039
3.238GlyAsp: 3.238 ± 0.073
4.496GlyGlu: 4.496 ± 0.089
3.294GlyPhe: 3.294 ± 0.075
4.768GlyGly: 4.768 ± 0.108
1.261GlyHis: 1.261 ± 0.041
5.28GlyIle: 5.28 ± 0.1
4.803GlyLys: 4.803 ± 0.086
7.038GlyLeu: 7.038 ± 0.117
1.811GlyMet: 1.811 ± 0.047
2.829GlyAsn: 2.829 ± 0.076
1.231GlyPro: 1.231 ± 0.052
2.473GlyGln: 2.473 ± 0.061
2.925GlyArg: 2.925 ± 0.067
3.572GlySer: 3.572 ± 0.085
3.452GlyThr: 3.452 ± 0.085
5.167GlyVal: 5.167 ± 0.09
0.875GlyTrp: 0.875 ± 0.038
2.536GlyTyr: 2.536 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.182HisAla: 1.182 ± 0.037
0.4HisCys: 0.4 ± 0.026
0.739HisAsp: 0.739 ± 0.036
0.796HisGlu: 0.796 ± 0.035
1.221HisPhe: 1.221 ± 0.043
1.158HisGly: 1.158 ± 0.039
0.603HisHis: 0.603 ± 0.036
1.663HisIle: 1.663 ± 0.052
1.082HisLys: 1.082 ± 0.043
2.254HisLeu: 2.254 ± 0.064
0.329HisMet: 0.329 ± 0.02
1.013HisAsn: 1.013 ± 0.041
1.02HisPro: 1.02 ± 0.041
1.083HisGln: 1.083 ± 0.039
1.116HisArg: 1.116 ± 0.043
1.39HisSer: 1.39 ± 0.046
0.957HisThr: 0.957 ± 0.041
0.698HisVal: 0.698 ± 0.032
0.35HisTrp: 0.35 ± 0.022
0.833HisTyr: 0.833 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
7.116IleAla: 7.116 ± 0.103
0.835IleCys: 0.835 ± 0.034
3.927IleAsp: 3.927 ± 0.087
4.531IleGlu: 4.531 ± 0.095
2.95IlePhe: 2.95 ± 0.079
5.309IleGly: 5.309 ± 0.115
1.247IleHis: 1.247 ± 0.041
4.504IleIle: 4.504 ± 0.103
3.694IleLys: 3.694 ± 0.079
6.48IleLeu: 6.48 ± 0.12
1.321IleMet: 1.321 ± 0.043
3.21IleAsn: 3.21 ± 0.084
2.743IlePro: 2.743 ± 0.065
2.537IleGln: 2.537 ± 0.062
3.188IleArg: 3.188 ± 0.071
4.408IleSer: 4.408 ± 0.084
3.74IleThr: 3.74 ± 0.062
4.251IleVal: 4.251 ± 0.084
0.677IleTrp: 0.677 ± 0.029
2.062IleTyr: 2.062 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
5.221LysAla: 5.221 ± 0.111
0.443LysCys: 0.443 ± 0.024
2.976LysAsp: 2.976 ± 0.082
3.65LysGlu: 3.65 ± 0.084
1.91LysPhe: 1.91 ± 0.049
3.69LysGly: 3.69 ± 0.074
1.161LysHis: 1.161 ± 0.04
4.177LysIle: 4.177 ± 0.078
3.681LysLys: 3.681 ± 0.085
6.004LysLeu: 6.004 ± 0.086
1.792LysMet: 1.792 ± 0.053
3.249LysAsn: 3.249 ± 0.08
2.381LysPro: 2.381 ± 0.058
3.254LysGln: 3.254 ± 0.079
2.892LysArg: 2.892 ± 0.064
3.202LysSer: 3.202 ± 0.07
3.393LysThr: 3.393 ± 0.064
3.698LysVal: 3.698 ± 0.081
0.594LysTrp: 0.594 ± 0.03
1.656LysTyr: 1.656 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
9.885LeuAla: 9.885 ± 0.125
1.302LeuCys: 1.302 ± 0.047
5.56LeuAsp: 5.56 ± 0.103
5.597LeuGlu: 5.597 ± 0.084
4.858LeuPhe: 4.858 ± 0.1
7.128LeuGly: 7.128 ± 0.109
1.973LeuHis: 1.973 ± 0.054
6.897LeuIle: 6.897 ± 0.116
5.748LeuLys: 5.748 ± 0.095
11.109LeuLeu: 11.109 ± 0.168
2.392LeuMet: 2.392 ± 0.056
5.29LeuAsn: 5.29 ± 0.095
4.731LeuPro: 4.731 ± 0.095
4.572LeuGln: 4.572 ± 0.085
4.972LeuArg: 4.972 ± 0.09
7.496LeuSer: 7.496 ± 0.116
6.138LeuThr: 6.138 ± 0.097
6.324LeuVal: 6.324 ± 0.101
1.121LeuTrp: 1.121 ± 0.041
2.785LeuTyr: 2.785 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.229MetAla: 2.229 ± 0.057
0.211MetCys: 0.211 ± 0.018
0.946MetAsp: 0.946 ± 0.046
1.12MetGlu: 1.12 ± 0.04
0.875MetPhe: 0.875 ± 0.038
1.469MetGly: 1.469 ± 0.048
0.424MetHis: 0.424 ± 0.025
1.519MetIle: 1.519 ± 0.049
1.613MetLys: 1.613 ± 0.045
2.592MetLeu: 2.592 ± 0.055
0.598MetMet: 0.598 ± 0.032
1.153MetAsn: 1.153 ± 0.041
1.065MetPro: 1.065 ± 0.037
1.247MetGln: 1.247 ± 0.041
1.084MetArg: 1.084 ± 0.038
1.471MetSer: 1.471 ± 0.051
1.544MetThr: 1.544 ± 0.045
1.294MetVal: 1.294 ± 0.046
0.211MetTrp: 0.211 ± 0.018
0.5MetTyr: 0.5 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.322AsnAla: 4.322 ± 0.096
0.408AsnCys: 0.408 ± 0.024
2.286AsnAsp: 2.286 ± 0.065
2.832AsnGlu: 2.832 ± 0.071
1.812AsnPhe: 1.812 ± 0.048
3.505AsnGly: 3.505 ± 0.075
0.972AsnHis: 0.972 ± 0.042
3.234AsnIle: 3.234 ± 0.082
2.676AsnLys: 2.676 ± 0.063
4.754AsnLeu: 4.754 ± 0.093
0.949AsnMet: 0.949 ± 0.039
2.307AsnAsn: 2.307 ± 0.081
2.413AsnPro: 2.413 ± 0.062
2.328AsnGln: 2.328 ± 0.062
2.402AsnArg: 2.402 ± 0.057
2.451AsnSer: 2.451 ± 0.069
2.345AsnThr: 2.345 ± 0.065
3.131AsnVal: 3.131 ± 0.09
0.665AsnTrp: 0.665 ± 0.032
1.571AsnTyr: 1.571 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.929ProAla: 2.929 ± 0.073
0.351ProCys: 0.351 ± 0.023
1.971ProAsp: 1.971 ± 0.057
2.803ProGlu: 2.803 ± 0.062
1.818ProPhe: 1.818 ± 0.055
1.49ProGly: 1.49 ± 0.05
0.975ProHis: 0.975 ± 0.04
2.65ProIle: 2.65 ± 0.063
2.185ProLys: 2.185 ± 0.051
3.995ProLeu: 3.995 ± 0.078
0.918ProMet: 0.918 ± 0.032
2.095ProAsn: 2.095 ± 0.056
1.117ProPro: 1.117 ± 0.041
2.07ProGln: 2.07 ± 0.053
1.287ProArg: 1.287 ± 0.05
2.056ProSer: 2.056 ± 0.047
2.289ProThr: 2.289 ± 0.048
2.621ProVal: 2.621 ± 0.055
0.363ProTrp: 0.363 ± 0.023
1.353ProTyr: 1.353 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.663GlnAla: 4.663 ± 0.098
0.418GlnCys: 0.418 ± 0.026
2.296GlnAsp: 2.296 ± 0.054
2.761GlnGlu: 2.761 ± 0.067
1.923GlnPhe: 1.923 ± 0.057
3.474GlnGly: 3.474 ± 0.08
1.031GlnHis: 1.031 ± 0.04
3.208GlnIle: 3.208 ± 0.082
2.833GlnLys: 2.833 ± 0.063
4.829GlnLeu: 4.829 ± 0.097
0.958GlnMet: 0.958 ± 0.036
2.271GlnAsn: 2.271 ± 0.06
1.742GlnPro: 1.742 ± 0.049
3.338GlnGln: 3.338 ± 0.102
2.47GlnArg: 2.47 ± 0.069
2.699GlnSer: 2.699 ± 0.069
2.48GlnThr: 2.48 ± 0.064
2.862GlnVal: 2.862 ± 0.069
0.684GlnTrp: 0.684 ± 0.033
1.545GlnTyr: 1.545 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.43ArgAla: 3.43 ± 0.079
0.496ArgCys: 0.496 ± 0.026
2.325ArgAsp: 2.325 ± 0.062
3.161ArgGlu: 3.161 ± 0.075
2.398ArgPhe: 2.398 ± 0.06
2.666ArgGly: 2.666 ± 0.061
1.117ArgHis: 1.117 ± 0.041
3.376ArgIle: 3.376 ± 0.062
2.639ArgLys: 2.639 ± 0.069
5.489ArgLeu: 5.489 ± 0.1
1.006ArgMet: 1.006 ± 0.032
2.037ArgAsn: 2.037 ± 0.05
1.6ArgPro: 1.6 ± 0.049
2.569ArgGln: 2.569 ± 0.069
2.658ArgArg: 2.658 ± 0.063
2.378ArgSer: 2.378 ± 0.056
2.399ArgThr: 2.399 ± 0.055
2.876ArgVal: 2.876 ± 0.066
0.574ArgTrp: 0.574 ± 0.027
1.918ArgTyr: 1.918 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
6.092SerAla: 6.092 ± 0.1
0.537SerCys: 0.537 ± 0.03
3.017SerAsp: 3.017 ± 0.063
3.309SerGlu: 3.309 ± 0.066
2.514SerPhe: 2.514 ± 0.062
4.558SerGly: 4.558 ± 0.086
1.162SerHis: 1.162 ± 0.041
3.469SerIle: 3.469 ± 0.071
2.694SerLys: 2.694 ± 0.072
6.056SerLeu: 6.056 ± 0.094
1.201SerMet: 1.201 ± 0.047
2.199SerAsn: 2.199 ± 0.064
2.159SerPro: 2.159 ± 0.063
2.444SerGln: 2.444 ± 0.073
2.679SerArg: 2.679 ± 0.058
3.198SerSer: 3.198 ± 0.08
2.766SerThr: 2.766 ± 0.076
4.189SerVal: 4.189 ± 0.082
0.654SerTrp: 0.654 ± 0.03
1.766SerTyr: 1.766 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
5.546ThrAla: 5.546 ± 0.102
0.446ThrCys: 0.446 ± 0.03
2.999ThrAsp: 2.999 ± 0.086
3.564ThrGlu: 3.564 ± 0.081
2.278ThrPhe: 2.278 ± 0.061
3.786ThrGly: 3.786 ± 0.079
1.024ThrHis: 1.024 ± 0.036
3.154ThrIle: 3.154 ± 0.077
2.529ThrLys: 2.529 ± 0.066
5.952ThrLeu: 5.952 ± 0.105
1.003ThrMet: 1.003 ± 0.038
2.21ThrAsn: 2.21 ± 0.072
2.506ThrPro: 2.506 ± 0.063
2.536ThrGln: 2.536 ± 0.065
2.071ThrArg: 2.071 ± 0.057
2.559ThrSer: 2.559 ± 0.065
2.783ThrThr: 2.783 ± 0.089
3.744ThrVal: 3.744 ± 0.096
0.515ThrTrp: 0.515 ± 0.028
1.486ThrTyr: 1.486 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
5.853ValAla: 5.853 ± 0.108
0.707ValCys: 0.707 ± 0.031
3.271ValAsp: 3.271 ± 0.08
4.393ValGlu: 4.393 ± 0.083
2.777ValPhe: 2.777 ± 0.075
4.559ValGly: 4.559 ± 0.105
1.032ValHis: 1.032 ± 0.04
4.854ValIle: 4.854 ± 0.106
4.089ValLys: 4.089 ± 0.072
6.584ValLeu: 6.584 ± 0.104
1.601ValMet: 1.601 ± 0.05
3.054ValAsn: 3.054 ± 0.072
2.461ValPro: 2.461 ± 0.064
2.509ValGln: 2.509 ± 0.057
3.079ValArg: 3.079 ± 0.068
4.088ValSer: 4.088 ± 0.078
3.608ValThr: 3.608 ± 0.089
4.663ValVal: 4.663 ± 0.096
0.633ValTrp: 0.633 ± 0.03
1.878ValTyr: 1.878 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.88TrpAla: 0.88 ± 0.034
0.158TrpCys: 0.158 ± 0.015
0.54TrpAsp: 0.54 ± 0.03
0.521TrpGlu: 0.521 ± 0.027
0.592TrpPhe: 0.592 ± 0.027
0.687TrpGly: 0.687 ± 0.037
0.284TrpHis: 0.284 ± 0.021
0.75TrpIle: 0.75 ± 0.033
0.665TrpLys: 0.665 ± 0.032
1.613TrpLeu: 1.613 ± 0.048
0.232TrpMet: 0.232 ± 0.017
0.52TrpAsn: 0.52 ± 0.03
0.164TrpPro: 0.164 ± 0.015
0.96TrpGln: 0.96 ± 0.042
0.711TrpArg: 0.711 ± 0.032
0.559TrpSer: 0.559 ± 0.029
0.509TrpThr: 0.509 ± 0.028
0.699TrpVal: 0.699 ± 0.03
0.181TrpTrp: 0.181 ± 0.017
0.35TrpTyr: 0.35 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.713TyrAla: 2.713 ± 0.062
0.484TyrCys: 0.484 ± 0.026
1.672TyrAsp: 1.672 ± 0.06
1.554TyrGlu: 1.554 ± 0.045
1.685TyrPhe: 1.685 ± 0.057
2.152TyrGly: 2.152 ± 0.06
0.807TyrHis: 0.807 ± 0.036
1.904TyrIle: 1.904 ± 0.056
1.424TyrLys: 1.424 ± 0.048
3.533TyrLeu: 3.533 ± 0.08
0.62TyrMet: 0.62 ± 0.031
1.242TyrAsn: 1.242 ± 0.046
1.486TyrPro: 1.486 ± 0.05
1.973TyrGln: 1.973 ± 0.05
1.941TyrArg: 1.941 ± 0.05
1.852TyrSer: 1.852 ± 0.055
1.508TyrThr: 1.508 ± 0.049
1.934TyrVal: 1.934 ± 0.056
0.458TyrTrp: 0.458 ± 0.032
1.117TyrTyr: 1.117 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2334 proteins (729501 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski