Amino acid dipepetide frequency for Gillisia mitskevichiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.352AlaAla: 4.352 ± 0.082	0.496AlaCys: 0.496 ± 0.021	3.197AlaAsp: 3.197 ± 0.061	4.272AlaGlu: 4.272 ± 0.066	3.142AlaPhe: 3.142 ± 0.052	4.265AlaGly: 4.265 ± 0.082	1.067AlaHis: 1.067 ± 0.034	5.483AlaIle: 5.483 ± 0.076	4.538AlaLys: 4.538 ± 0.081	6.023AlaLeu: 6.023 ± 0.095	1.6AlaMet: 1.6 ± 0.045	3.318AlaAsn: 3.318 ± 0.065	1.857AlaPro: 1.857 ± 0.048	2.276AlaGln: 2.276 ± 0.043	2.045AlaArg: 2.045 ± 0.052	4.258AlaSer: 4.258 ± 0.07	3.539AlaThr: 3.539 ± 0.075	3.963AlaVal: 3.963 ± 0.068	0.566AlaTrp: 0.566 ± 0.024	2.267AlaTyr: 2.267 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.402CysAla: 0.402 ± 0.021	0.087CysCys: 0.087 ± 0.009	0.391CysAsp: 0.391 ± 0.021	0.49CysGlu: 0.49 ± 0.025	0.361CysPhe: 0.361 ± 0.019	0.604CysGly: 0.604 ± 0.027	0.154CysHis: 0.154 ± 0.012	0.571CysIle: 0.571 ± 0.026	0.452CysLys: 0.452 ± 0.019	0.578CysLeu: 0.578 ± 0.021	0.127CysMet: 0.127 ± 0.01	0.399CysAsn: 0.399 ± 0.021	0.327CysPro: 0.327 ± 0.023	0.195CysGln: 0.195 ± 0.015	0.199CysArg: 0.199 ± 0.014	0.56CysSer: 0.56 ± 0.031	0.38CysThr: 0.38 ± 0.023	0.389CysVal: 0.389 ± 0.021	0.052CysTrp: 0.052 ± 0.007	0.275CysTyr: 0.275 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.552AspAla: 3.552 ± 0.074	0.363AspCys: 0.363 ± 0.018	2.731AspAsp: 2.731 ± 0.068	3.789AspGlu: 3.789 ± 0.06	3.549AspPhe: 3.549 ± 0.066	3.454AspGly: 3.454 ± 0.068	1.033AspHis: 1.033 ± 0.032	4.326AspIle: 4.326 ± 0.073	4.119AspLys: 4.119 ± 0.069	5.751AspLeu: 5.751 ± 0.075	1.087AspMet: 1.087 ± 0.032	2.998AspAsn: 2.998 ± 0.062	1.959AspPro: 1.959 ± 0.05	1.628AspGln: 1.628 ± 0.04	1.962AspArg: 1.962 ± 0.041	3.419AspSer: 3.419 ± 0.065	2.521AspThr: 2.521 ± 0.053	3.312AspVal: 3.312 ± 0.065	0.701AspTrp: 0.701 ± 0.028	2.593AspTyr: 2.593 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.515GluAla: 4.515 ± 0.079	0.377GluCys: 0.377 ± 0.021	4.16GluAsp: 4.16 ± 0.067	5.785GluGlu: 5.785 ± 0.083	3.345GluPhe: 3.345 ± 0.062	3.864GluGly: 3.864 ± 0.063	1.177GluHis: 1.177 ± 0.034	6.544GluIle: 6.544 ± 0.081	6.266GluLys: 6.266 ± 0.097	6.867GluLeu: 6.867 ± 0.095	1.756GluMet: 1.756 ± 0.041	5.113GluAsn: 5.113 ± 0.07	1.591GluPro: 1.591 ± 0.037	2.254GluGln: 2.254 ± 0.046	2.629GluArg: 2.629 ± 0.054	3.58GluSer: 3.58 ± 0.06	3.548GluThr: 3.548 ± 0.06	4.713GluVal: 4.713 ± 0.075	0.597GluTrp: 0.597 ± 0.026	2.465GluTyr: 2.465 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.907PheAla: 2.907 ± 0.062	0.401PheCys: 0.401 ± 0.02	2.982PheAsp: 2.982 ± 0.058	3.56PheGlu: 3.56 ± 0.063	2.713PhePhe: 2.713 ± 0.061	3.63PheGly: 3.63 ± 0.069	0.877PheHis: 0.877 ± 0.025	4.158PheIle: 4.158 ± 0.082	4.037PheLys: 4.037 ± 0.071	4.992PheLeu: 4.992 ± 0.075	1.123PheMet: 1.123 ± 0.032	3.324PheAsn: 3.324 ± 0.059	1.823PhePro: 1.823 ± 0.04	1.742PheGln: 1.742 ± 0.043	1.634PheArg: 1.634 ± 0.043	4.21PheSer: 4.21 ± 0.076	3.01PheThr: 3.01 ± 0.053	2.823PheVal: 2.823 ± 0.061	0.596PheTrp: 0.596 ± 0.027	2.15PheTyr: 2.15 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.1GlyAla: 4.1 ± 0.073	0.555GlyCys: 0.555 ± 0.024	3.348GlyAsp: 3.348 ± 0.068	4.014GlyGlu: 4.014 ± 0.068	3.739GlyPhe: 3.739 ± 0.074	4.433GlyGly: 4.433 ± 0.092	1.081GlyHis: 1.081 ± 0.034	5.639GlyIle: 5.639 ± 0.077	4.886GlyLys: 4.886 ± 0.076	5.794GlyLeu: 5.794 ± 0.075	1.638GlyMet: 1.638 ± 0.045	3.642GlyAsn: 3.642 ± 0.082	1.311GlyPro: 1.311 ± 0.041	1.694GlyGln: 1.694 ± 0.048	2.014GlyArg: 2.014 ± 0.053	4.152GlySer: 4.152 ± 0.079	3.719GlyThr: 3.719 ± 0.095	4.172GlyVal: 4.172 ± 0.069	0.712GlyTrp: 0.712 ± 0.03	2.635GlyTyr: 2.635 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.858HisAla: 0.858 ± 0.03	0.178HisCys: 0.178 ± 0.014	0.76HisAsp: 0.76 ± 0.025	0.98HisGlu: 0.98 ± 0.029	1.105HisPhe: 1.105 ± 0.037	1.033HisGly: 1.033 ± 0.035	0.438HisHis: 0.438 ± 0.021	1.389HisIle: 1.389 ± 0.045	1.174HisLys: 1.174 ± 0.036	1.802HisLeu: 1.802 ± 0.043	0.305HisMet: 0.305 ± 0.019	0.902HisAsn: 0.902 ± 0.032	0.895HisPro: 0.895 ± 0.032	0.682HisGln: 0.682 ± 0.029	0.636HisArg: 0.636 ± 0.024	1.113HisSer: 1.113 ± 0.032	0.879HisThr: 0.879 ± 0.028	0.84HisVal: 0.84 ± 0.031	0.224HisTrp: 0.224 ± 0.014	0.761HisTyr: 0.761 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.773IleAla: 5.773 ± 0.076	0.626IleCys: 0.626 ± 0.026	4.774IleAsp: 4.774 ± 0.068	5.686IleGlu: 5.686 ± 0.07	4.007IlePhe: 4.007 ± 0.071	5.292IleGly: 5.292 ± 0.083	1.342IleHis: 1.342 ± 0.04	6.569IleIle: 6.569 ± 0.101	6.026IleLys: 6.026 ± 0.082	8.109IleLeu: 8.109 ± 0.105	1.507IleMet: 1.507 ± 0.041	4.767IleAsn: 4.767 ± 0.084	3.464IlePro: 3.464 ± 0.058	2.647IleGln: 2.647 ± 0.053	2.642IleArg: 2.642 ± 0.052	6.429IleSer: 6.429 ± 0.079	4.809IleThr: 4.809 ± 0.088	4.68IleVal: 4.68 ± 0.065	0.721IleTrp: 0.721 ± 0.028	2.998IleTyr: 2.998 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.751LysAla: 4.751 ± 0.074	0.351LysCys: 0.351 ± 0.016	4.694LysAsp: 4.694 ± 0.081	6.654LysGlu: 6.654 ± 0.101	3.386LysPhe: 3.386 ± 0.061	4.279LysGly: 4.279 ± 0.071	1.309LysHis: 1.309 ± 0.036	6.637LysIle: 6.637 ± 0.098	6.742LysLys: 6.742 ± 0.102	7.102LysLeu: 7.102 ± 0.098	2.128LysMet: 2.128 ± 0.052	5.303LysAsn: 5.303 ± 0.076	2.339LysPro: 2.339 ± 0.045	2.525LysGln: 2.525 ± 0.054	2.845LysArg: 2.845 ± 0.048	4.721LysSer: 4.721 ± 0.078	4.256LysThr: 4.256 ± 0.063	4.557LysVal: 4.557 ± 0.077	0.814LysTrp: 0.814 ± 0.026	3.02LysTyr: 3.02 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.749LeuAla: 5.749 ± 0.085	0.631LeuCys: 0.631 ± 0.025	5.409LeuAsp: 5.409 ± 0.077	6.85LeuGlu: 6.85 ± 0.097	4.984LeuPhe: 4.984 ± 0.087	5.982LeuGly: 5.982 ± 0.084	1.565LeuHis: 1.565 ± 0.043	7.835LeuIle: 7.835 ± 0.11	8.139LeuLys: 8.139 ± 0.107	9.194LeuLeu: 9.194 ± 0.125	2.114LeuMet: 2.114 ± 0.046	6.012LeuAsn: 6.012 ± 0.084	3.578LeuPro: 3.578 ± 0.066	3.313LeuGln: 3.313 ± 0.052	3.369LeuArg: 3.369 ± 0.056	6.851LeuSer: 6.851 ± 0.077	4.904LeuThr: 4.904 ± 0.076	5.478LeuVal: 5.478 ± 0.078	0.8LeuTrp: 0.8 ± 0.029	3.104LeuTyr: 3.104 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.646MetAla: 1.646 ± 0.037	0.118MetCys: 0.118 ± 0.011	1.261MetAsp: 1.261 ± 0.038	1.629MetGlu: 1.629 ± 0.044	0.873MetPhe: 0.873 ± 0.029	1.47MetGly: 1.47 ± 0.037	0.425MetHis: 0.425 ± 0.022	1.634MetIle: 1.634 ± 0.043	2.204MetLys: 2.204 ± 0.046	1.976MetLeu: 1.976 ± 0.054	0.63MetMet: 0.63 ± 0.033	1.314MetAsn: 1.314 ± 0.038	0.827MetPro: 0.827 ± 0.029	0.833MetGln: 0.833 ± 0.027	0.902MetArg: 0.902 ± 0.031	1.412MetSer: 1.412 ± 0.039	1.001MetThr: 1.001 ± 0.034	1.395MetVal: 1.395 ± 0.039	0.165MetTrp: 0.165 ± 0.013	0.668MetTyr: 0.668 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.662AsnAla: 3.662 ± 0.063	0.459AsnCys: 0.459 ± 0.028	3.069AsnAsp: 3.069 ± 0.059	3.968AsnGlu: 3.968 ± 0.068	3.337AsnPhe: 3.337 ± 0.057	3.737AsnGly: 3.737 ± 0.086	0.953AsnHis: 0.953 ± 0.03	4.997AsnIle: 4.997 ± 0.065	4.675AsnLys: 4.675 ± 0.072	5.835AsnLeu: 5.835 ± 0.082	1.369AsnMet: 1.369 ± 0.041	3.796AsnAsn: 3.796 ± 0.074	2.625AsnPro: 2.625 ± 0.054	1.914AsnGln: 1.914 ± 0.047	2.167AsnArg: 2.167 ± 0.046	4.361AsnSer: 4.361 ± 0.078	3.367AsnThr: 3.367 ± 0.064	3.311AsnVal: 3.311 ± 0.06	0.774AsnTrp: 0.774 ± 0.03	2.81AsnTyr: 2.81 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.934ProAla: 1.934 ± 0.051	0.19ProCys: 0.19 ± 0.015	1.991ProAsp: 1.991 ± 0.049	3.006ProGlu: 3.006 ± 0.055	1.86ProPhe: 1.86 ± 0.043	1.955ProGly: 1.955 ± 0.049	0.588ProHis: 0.588 ± 0.026	2.797ProIle: 2.797 ± 0.054	2.48ProLys: 2.48 ± 0.047	2.968ProLeu: 2.968 ± 0.057	0.708ProMet: 0.708 ± 0.028	2.099ProAsn: 2.099 ± 0.051	0.798ProPro: 0.798 ± 0.03	1.154ProGln: 1.154 ± 0.032	0.953ProArg: 0.953 ± 0.028	2.266ProSer: 2.266 ± 0.05	1.867ProThr: 1.867 ± 0.049	2.411ProVal: 2.411 ± 0.052	0.328ProTrp: 0.328 ± 0.017	1.293ProTyr: 1.293 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.987GlnAla: 1.987 ± 0.048	0.142GlnCys: 0.142 ± 0.013	1.707GlnAsp: 1.707 ± 0.043	2.596GlnGlu: 2.596 ± 0.057	1.64GlnPhe: 1.64 ± 0.047	1.772GlnGly: 1.772 ± 0.042	0.537GlnHis: 0.537 ± 0.025	2.689GlnIle: 2.689 ± 0.051	2.666GlnLys: 2.666 ± 0.056	3.49GlnLeu: 3.49 ± 0.054	0.724GlnMet: 0.724 ± 0.028	2.123GlnAsn: 2.123 ± 0.051	1.044GlnPro: 1.044 ± 0.035	1.37GlnGln: 1.37 ± 0.038	1.192GlnArg: 1.192 ± 0.036	1.822GlnSer: 1.822 ± 0.042	1.662GlnThr: 1.662 ± 0.044	1.906GlnVal: 1.906 ± 0.044	0.299GlnTrp: 0.299 ± 0.016	1.22GlnTyr: 1.22 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.096ArgAla: 2.096 ± 0.042	0.196ArgCys: 0.196 ± 0.015	1.948ArgAsp: 1.948 ± 0.039	2.501ArgGlu: 2.501 ± 0.052	1.821ArgPhe: 1.821 ± 0.039	1.895ArgGly: 1.895 ± 0.046	0.566ArgHis: 0.566 ± 0.023	2.981ArgIle: 2.981 ± 0.051	2.897ArgLys: 2.897 ± 0.06	3.22ArgLeu: 3.22 ± 0.063	0.909ArgMet: 0.909 ± 0.028	2.188ArgAsn: 2.188 ± 0.045	1.032ArgPro: 1.032 ± 0.035	0.974ArgGln: 0.974 ± 0.032	1.309ArgArg: 1.309 ± 0.038	2.19ArgSer: 2.19 ± 0.055	1.798ArgThr: 1.798 ± 0.041	2.057ArgVal: 2.057 ± 0.045	0.329ArgTrp: 0.329 ± 0.016	1.467ArgTyr: 1.467 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.843SerAla: 3.843 ± 0.055	0.601SerCys: 0.601 ± 0.026	3.414SerAsp: 3.414 ± 0.063	4.922SerGlu: 4.922 ± 0.072	3.839SerPhe: 3.839 ± 0.067	4.68SerGly: 4.68 ± 0.093	1.109SerHis: 1.109 ± 0.038	5.587SerIle: 5.587 ± 0.083	5.297SerLys: 5.297 ± 0.077	6.63SerLeu: 6.63 ± 0.085	1.332SerMet: 1.332 ± 0.038	4.035SerAsn: 4.035 ± 0.066	2.154SerPro: 2.154 ± 0.038	2.129SerGln: 2.129 ± 0.045	2.347SerArg: 2.347 ± 0.05	4.731SerSer: 4.731 ± 0.088	3.61SerThr: 3.61 ± 0.072	3.928SerVal: 3.928 ± 0.057	0.681SerTrp: 0.681 ± 0.027	2.767SerTyr: 2.767 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.566ThrAla: 3.566 ± 0.073	0.377ThrCys: 0.377 ± 0.025	2.89ThrAsp: 2.89 ± 0.057	3.462ThrGlu: 3.462 ± 0.057	2.829ThrPhe: 2.829 ± 0.061	4.099ThrGly: 4.099 ± 0.088	0.901ThrHis: 0.901 ± 0.032	4.391ThrIle: 4.391 ± 0.076	3.62ThrLys: 3.62 ± 0.06	4.86ThrLeu: 4.86 ± 0.076	0.976ThrMet: 0.976 ± 0.027	3.182ThrAsn: 3.182 ± 0.06	2.289ThrPro: 2.289 ± 0.056	1.764ThrGln: 1.764 ± 0.045	1.66ThrArg: 1.66 ± 0.042	3.869ThrSer: 3.869 ± 0.075	3.079ThrThr: 3.079 ± 0.068	3.322ThrVal: 3.322 ± 0.09	0.515ThrTrp: 0.515 ± 0.026	2.179ThrTyr: 2.179 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.082ValAla: 4.082 ± 0.064	0.452ValCys: 0.452 ± 0.023	3.42ValAsp: 3.42 ± 0.063	4.022ValGlu: 4.022 ± 0.069	3.114ValPhe: 3.114 ± 0.055	3.753ValGly: 3.753 ± 0.072	0.911ValHis: 0.911 ± 0.03	5.074ValIle: 5.074 ± 0.079	4.348ValLys: 4.348 ± 0.079	5.853ValLeu: 5.853 ± 0.082	1.35ValMet: 1.35 ± 0.039	3.421ValAsn: 3.421 ± 0.058	2.068ValPro: 2.068 ± 0.047	1.752ValGln: 1.752 ± 0.045	1.965ValArg: 1.965 ± 0.043	4.285ValSer: 4.285 ± 0.077	3.267ValThr: 3.267 ± 0.079	3.934ValVal: 3.934 ± 0.071	0.563ValTrp: 0.563 ± 0.023	2.144ValTyr: 2.144 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.571TrpAla: 0.571 ± 0.024	0.08TrpCys: 0.08 ± 0.009	0.594TrpAsp: 0.594 ± 0.022	0.718TrpGlu: 0.718 ± 0.026	0.566TrpPhe: 0.566 ± 0.025	0.584TrpGly: 0.584 ± 0.026	0.206TrpHis: 0.206 ± 0.016	0.801TrpIle: 0.801 ± 0.03	0.806TrpLys: 0.806 ± 0.03	0.932TrpLeu: 0.932 ± 0.031	0.309TrpMet: 0.309 ± 0.019	0.681TrpAsn: 0.681 ± 0.029	0.237TrpPro: 0.237 ± 0.016	0.334TrpGln: 0.334 ± 0.019	0.391TrpArg: 0.391 ± 0.021	0.6TrpSer: 0.6 ± 0.029	0.48TrpThr: 0.48 ± 0.025	0.589TrpVal: 0.589 ± 0.025	0.154TrpTrp: 0.154 ± 0.016	0.411TrpTyr: 0.411 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.18TyrAla: 2.18 ± 0.05	0.314TyrCys: 0.314 ± 0.018	2.106TyrAsp: 2.106 ± 0.049	2.244TyrGlu: 2.244 ± 0.048	2.481TyrPhe: 2.481 ± 0.055	2.496TyrGly: 2.496 ± 0.059	0.715TyrHis: 0.715 ± 0.026	2.766TyrIle: 2.766 ± 0.054	3.041TyrLys: 3.041 ± 0.053	3.885TyrLeu: 3.885 ± 0.072	0.69TyrMet: 0.69 ± 0.022	2.566TyrAsn: 2.566 ± 0.052	1.427TyrPro: 1.427 ± 0.039	1.406TyrGln: 1.406 ± 0.039	1.515TyrArg: 1.515 ± 0.041	2.806TyrSer: 2.806 ± 0.055	2.133TyrThr: 2.133 ± 0.052	1.999TyrVal: 1.999 ± 0.044	0.454TyrTrp: 0.454 ± 0.024	1.73TyrTyr: 1.73 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3228 proteins (1068363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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