Amino acid dipepetide frequency for Nipponia nippon (Crested ibis) (Ibis nippon)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.933AlaAla: 5.933 ± 0.048	1.383AlaCys: 1.383 ± 0.02	3.04AlaAsp: 3.04 ± 0.023	4.624AlaGlu: 4.624 ± 0.032	2.656AlaPhe: 2.656 ± 0.023	4.075AlaGly: 4.075 ± 0.034	1.397AlaHis: 1.397 ± 0.016	3.11AlaIle: 3.11 ± 0.022	3.717AlaLys: 3.717 ± 0.029	6.622AlaLeu: 6.622 ± 0.04	1.515AlaMet: 1.515 ± 0.017	2.247AlaAsn: 2.247 ± 0.022	3.091AlaPro: 3.091 ± 0.025	2.783AlaGln: 2.783 ± 0.027	3.161AlaArg: 3.161 ± 0.025	5.21AlaSer: 5.21 ± 0.037	3.382AlaThr: 3.382 ± 0.028	5.01AlaVal: 5.01 ± 0.037	0.737AlaTrp: 0.737 ± 0.011	1.653AlaTyr: 1.653 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.211CysAla: 1.211 ± 0.019	0.661CysCys: 0.661 ± 0.015	1.077CysAsp: 1.077 ± 0.017	1.34CysGlu: 1.34 ± 0.023	0.921CysPhe: 0.921 ± 0.013	1.525CysGly: 1.525 ± 0.025	0.632CysHis: 0.632 ± 0.013	1.174CysIle: 1.174 ± 0.018	1.342CysLys: 1.342 ± 0.021	2.184CysLeu: 2.184 ± 0.025	0.458CysMet: 0.458 ± 0.01	0.942CysAsn: 0.942 ± 0.016	1.309CysPro: 1.309 ± 0.025	1.072CysGln: 1.072 ± 0.018	1.263CysArg: 1.263 ± 0.017	2.022CysSer: 2.022 ± 0.025	1.217CysThr: 1.217 ± 0.018	1.375CysVal: 1.375 ± 0.022	0.298CysTrp: 0.298 ± 0.007	0.683CysTyr: 0.683 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.033AspAla: 3.033 ± 0.021	1.121AspCys: 1.121 ± 0.02	2.822AspAsp: 2.822 ± 0.028	3.644AspGlu: 3.644 ± 0.033	2.267AspPhe: 2.267 ± 0.022	3.426AspGly: 3.426 ± 0.032	1.154AspHis: 1.154 ± 0.014	3.02AspIle: 3.02 ± 0.022	2.751AspLys: 2.751 ± 0.024	4.989AspLeu: 4.989 ± 0.032	1.163AspMet: 1.163 ± 0.013	1.931AspAsn: 1.931 ± 0.02	2.662AspPro: 2.662 ± 0.023	1.83AspGln: 1.83 ± 0.019	2.399AspArg: 2.399 ± 0.024	4.013AspSer: 4.013 ± 0.029	2.502AspThr: 2.502 ± 0.018	3.244AspVal: 3.244 ± 0.026	0.669AspTrp: 0.669 ± 0.011	1.652AspTyr: 1.652 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.702GluAla: 4.702 ± 0.032	1.344GluCys: 1.344 ± 0.027	4.478GluAsp: 4.478 ± 0.032	7.84GluGlu: 7.84 ± 0.066	2.199GluPhe: 2.199 ± 0.022	3.988GluGly: 3.988 ± 0.031	1.552GluHis: 1.552 ± 0.015	3.495GluIle: 3.495 ± 0.027	5.674GluLys: 5.674 ± 0.052	6.324GluLeu: 6.324 ± 0.055	1.779GluMet: 1.779 ± 0.016	3.391GluAsn: 3.391 ± 0.029	2.584GluPro: 2.584 ± 0.024	3.189GluGln: 3.189 ± 0.027	3.887GluArg: 3.887 ± 0.036	4.398GluSer: 4.398 ± 0.03	3.546GluThr: 3.546 ± 0.027	4.382GluVal: 4.382 ± 0.031	0.747GluTrp: 0.747 ± 0.013	1.834GluTyr: 1.834 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.201PheAla: 2.201 ± 0.021	0.996PheCys: 0.996 ± 0.014	1.845PheAsp: 1.845 ± 0.017	2.155PheGlu: 2.155 ± 0.021	1.92PhePhe: 1.92 ± 0.024	2.33PheGly: 2.33 ± 0.027	1.09PheHis: 1.09 ± 0.014	2.113PheIle: 2.113 ± 0.02	2.205PheLys: 2.205 ± 0.022	4.181PheLeu: 4.181 ± 0.034	0.795PheMet: 0.795 ± 0.012	1.516PheAsn: 1.516 ± 0.016	1.956PhePro: 1.956 ± 0.022	1.844PheGln: 1.844 ± 0.018	2.014PheArg: 2.014 ± 0.019	3.442PheSer: 3.442 ± 0.026	2.337PheThr: 2.337 ± 0.02	2.393PheVal: 2.393 ± 0.023	0.518PheTrp: 0.518 ± 0.01	1.338PheTyr: 1.338 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	3.717GlyAla: 3.717 ± 0.034	1.272GlyCys: 1.272 ± 0.02	2.999GlyAsp: 2.999 ± 0.026	3.818GlyGlu: 3.818 ± 0.035	2.588GlyPhe: 2.588 ± 0.029	4.057GlyGly: 4.057 ± 0.042	1.513GlyHis: 1.513 ± 0.016	3.094GlyIle: 3.094 ± 0.029	4.015GlyLys: 4.015 ± 0.035	5.206GlyLeu: 5.206 ± 0.037	1.388GlyMet: 1.388 ± 0.019	2.589GlyAsn: 2.589 ± 0.025	2.783GlyPro: 2.783 ± 0.05	2.54GlyGln: 2.54 ± 0.024	3.327GlyArg: 3.327 ± 0.029	5.04GlySer: 5.04 ± 0.043	3.511GlyThr: 3.511 ± 0.031	3.509GlyVal: 3.509 ± 0.028	0.793GlyTrp: 0.793 ± 0.014	1.932GlyTyr: 1.932 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.376HisAla: 1.376 ± 0.017	0.72HisCys: 0.72 ± 0.014	0.934HisAsp: 0.934 ± 0.014	1.349HisGlu: 1.349 ± 0.016	1.09HisPhe: 1.09 ± 0.014	1.508HisGly: 1.508 ± 0.016	0.871HisHis: 0.871 ± 0.016	1.342HisIle: 1.342 ± 0.016	1.352HisLys: 1.352 ± 0.015	2.811HisLeu: 2.811 ± 0.026	0.588HisMet: 0.588 ± 0.01	0.964HisAsn: 0.964 ± 0.012	1.509HisPro: 1.509 ± 0.017	1.193HisGln: 1.193 ± 0.015	1.468HisArg: 1.468 ± 0.018	2.136HisSer: 2.136 ± 0.023	1.326HisThr: 1.326 ± 0.018	1.539HisVal: 1.539 ± 0.016	0.445HisTrp: 0.445 ± 0.008	0.865HisTyr: 0.865 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.052IleAla: 3.052 ± 0.026	1.244IleCys: 1.244 ± 0.017	2.33IleAsp: 2.33 ± 0.023	2.887IleGlu: 2.887 ± 0.023	2.185IlePhe: 2.185 ± 0.02	2.494IleGly: 2.494 ± 0.028	1.388IleHis: 1.388 ± 0.015	2.734IleIle: 2.734 ± 0.025	3.0IleLys: 3.0 ± 0.024	4.966IleLeu: 4.966 ± 0.036	1.072IleMet: 1.072 ± 0.014	2.174IleAsn: 2.174 ± 0.022	2.842IlePro: 2.842 ± 0.026	2.444IleGln: 2.444 ± 0.023	2.639IleArg: 2.639 ± 0.022	4.045IleSer: 4.045 ± 0.026	2.866IleThr: 2.866 ± 0.026	2.933IleVal: 2.933 ± 0.024	0.586IleTrp: 0.586 ± 0.01	1.607IleTyr: 1.607 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.2LysAla: 4.2 ± 0.034	1.237LysCys: 1.237 ± 0.019	3.447LysAsp: 3.447 ± 0.03	5.65LysGlu: 5.65 ± 0.05	1.99LysPhe: 1.99 ± 0.021	3.441LysGly: 3.441 ± 0.036	1.604LysHis: 1.604 ± 0.018	3.161LysIle: 3.161 ± 0.027	5.356LysLys: 5.356 ± 0.047	5.752LysLeu: 5.752 ± 0.039	1.546LysMet: 1.546 ± 0.018	2.737LysAsn: 2.737 ± 0.026	3.037LysPro: 3.037 ± 0.031	2.94LysGln: 2.94 ± 0.029	3.536LysArg: 3.536 ± 0.027	4.177LysSer: 4.177 ± 0.033	3.354LysThr: 3.354 ± 0.025	3.734LysVal: 3.734 ± 0.027	0.682LysTrp: 0.682 ± 0.01	1.879LysTyr: 1.879 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.4LeuAla: 6.4 ± 0.041	2.217LeuCys: 2.217 ± 0.023	4.957LeuAsp: 4.957 ± 0.03	7.041LeuGlu: 7.041 ± 0.055	3.585LeuPhe: 3.585 ± 0.032	5.231LeuGly: 5.231 ± 0.035	2.682LeuHis: 2.682 ± 0.028	4.275LeuIle: 4.275 ± 0.029	6.398LeuLys: 6.398 ± 0.045	10.153LeuLeu: 10.153 ± 0.07	2.034LeuMet: 2.034 ± 0.022	3.856LeuAsn: 3.856 ± 0.026	5.485LeuPro: 5.485 ± 0.035	5.61LeuGln: 5.61 ± 0.047	5.253LeuArg: 5.253 ± 0.037	7.804LeuSer: 7.804 ± 0.038	4.993LeuThr: 4.993 ± 0.036	5.551LeuVal: 5.551 ± 0.039	1.091LeuTrp: 1.091 ± 0.016	2.819LeuTyr: 2.819 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.646MetAla: 1.646 ± 0.016	0.438MetCys: 0.438 ± 0.009	1.275MetAsp: 1.275 ± 0.016	1.875MetGlu: 1.875 ± 0.016	0.831MetPhe: 0.831 ± 0.011	1.28MetGly: 1.28 ± 0.019	0.52MetHis: 0.52 ± 0.01	0.979MetIle: 0.979 ± 0.014	1.584MetLys: 1.584 ± 0.017	2.05MetLeu: 2.05 ± 0.022	0.603MetMet: 0.603 ± 0.01	1.0MetAsn: 1.0 ± 0.012	1.025MetPro: 1.025 ± 0.014	1.017MetGln: 1.017 ± 0.013	1.128MetArg: 1.128 ± 0.014	1.527MetSer: 1.527 ± 0.016	1.147MetThr: 1.147 ± 0.014	1.432MetVal: 1.432 ± 0.015	0.248MetTrp: 0.248 ± 0.007	0.669MetTyr: 0.669 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.367AsnAla: 2.367 ± 0.025	0.981AsnCys: 0.981 ± 0.017	1.706AsnAsp: 1.706 ± 0.019	2.549AsnGlu: 2.549 ± 0.023	1.614AsnPhe: 1.614 ± 0.016	2.853AsnGly: 2.853 ± 0.032	0.993AsnHis: 0.993 ± 0.011	2.483AsnIle: 2.483 ± 0.024	2.558AsnLys: 2.558 ± 0.023	4.12AsnLeu: 4.12 ± 0.029	0.996AsnMet: 0.996 ± 0.013	1.819AsnAsn: 1.819 ± 0.021	2.257AsnPro: 2.257 ± 0.022	1.697AsnGln: 1.697 ± 0.02	2.084AsnArg: 2.084 ± 0.019	3.349AsnSer: 3.349 ± 0.03	2.217AsnThr: 2.217 ± 0.022	2.5AsnVal: 2.5 ± 0.023	0.502AsnTrp: 0.502 ± 0.01	1.314AsnTyr: 1.314 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	3.847ProAla: 3.847 ± 0.033	1.105ProCys: 1.105 ± 0.02	2.613ProAsp: 2.613 ± 0.022	3.839ProGlu: 3.839 ± 0.028	1.926ProPhe: 1.926 ± 0.019	3.771ProGly: 3.771 ± 0.075	1.249ProHis: 1.249 ± 0.016	1.954ProIle: 1.954 ± 0.02	2.727ProLys: 2.727 ± 0.024	4.667ProLeu: 4.667 ± 0.029	0.927ProMet: 0.927 ± 0.013	1.896ProAsn: 1.896 ± 0.02	4.371ProPro: 4.371 ± 0.058	2.298ProGln: 2.298 ± 0.027	2.641ProArg: 2.641 ± 0.027	4.923ProSer: 4.923 ± 0.041	2.649ProThr: 2.649 ± 0.024	3.732ProVal: 3.732 ± 0.029	0.578ProTrp: 0.578 ± 0.011	1.485ProTyr: 1.485 ± 0.015	0.001ProXaa: 0.001 ± 0.0
Gln	3.068GlnAla: 3.068 ± 0.026	1.0GlnCys: 1.0 ± 0.017	2.208GlnAsp: 2.208 ± 0.022	3.631GlnGlu: 3.631 ± 0.033	1.463GlnPhe: 1.463 ± 0.018	2.494GlnGly: 2.494 ± 0.025	1.294GlnHis: 1.294 ± 0.017	2.226GlnIle: 2.226 ± 0.022	3.132GlnLys: 3.132 ± 0.029	4.614GlnLeu: 4.614 ± 0.036	1.084GlnMet: 1.084 ± 0.015	2.017GlnAsn: 2.017 ± 0.023	2.355GlnPro: 2.355 ± 0.028	3.001GlnGln: 3.001 ± 0.043	2.671GlnArg: 2.671 ± 0.026	3.145GlnSer: 3.145 ± 0.032	2.333GlnThr: 2.333 ± 0.021	2.751GlnVal: 2.751 ± 0.025	0.539GlnTrp: 0.539 ± 0.01	1.31GlnTyr: 1.31 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.221ArgAla: 3.221 ± 0.027	1.187ArgCys: 1.187 ± 0.02	2.603ArgAsp: 2.603 ± 0.023	3.814ArgGlu: 3.814 ± 0.033	2.008ArgPhe: 2.008 ± 0.019	2.945ArgGly: 2.945 ± 0.034	1.498ArgHis: 1.498 ± 0.019	2.594ArgIle: 2.594 ± 0.021	3.95ArgLys: 3.95 ± 0.031	5.188ArgLeu: 5.188 ± 0.037	1.183ArgMet: 1.183 ± 0.014	2.251ArgAsn: 2.251 ± 0.021	2.456ArgPro: 2.456 ± 0.025	2.515ArgGln: 2.515 ± 0.026	3.773ArgArg: 3.773 ± 0.036	3.955ArgSer: 3.955 ± 0.042	2.696ArgThr: 2.696 ± 0.022	3.051ArgVal: 3.051 ± 0.025	0.648ArgTrp: 0.648 ± 0.012	1.64ArgTyr: 1.64 ± 0.018	0.001ArgXaa: 0.001 ± 0.0
Ser	5.084SerAla: 5.084 ± 0.035	1.846SerCys: 1.846 ± 0.022	3.957SerAsp: 3.957 ± 0.034	4.993SerGlu: 4.993 ± 0.034	3.114SerPhe: 3.114 ± 0.025	4.914SerGly: 4.914 ± 0.038	2.005SerHis: 2.005 ± 0.022	3.577SerIle: 3.577 ± 0.025	4.391SerLys: 4.391 ± 0.032	7.949SerLeu: 7.949 ± 0.042	1.602SerMet: 1.602 ± 0.017	3.092SerAsn: 3.092 ± 0.028	5.086SerPro: 5.086 ± 0.044	3.564SerGln: 3.564 ± 0.028	4.078SerArg: 4.078 ± 0.038	8.864SerSer: 8.864 ± 0.08	4.458SerThr: 4.458 ± 0.034	5.042SerVal: 5.042 ± 0.035	0.975SerTrp: 0.975 ± 0.016	2.251SerTyr: 2.251 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	3.834ThrAla: 3.834 ± 0.029	1.351ThrCys: 1.351 ± 0.023	2.714ThrAsp: 2.714 ± 0.026	3.693ThrGlu: 3.693 ± 0.028	2.242ThrPhe: 2.242 ± 0.022	3.476ThrGly: 3.476 ± 0.029	1.224ThrHis: 1.224 ± 0.017	2.599ThrIle: 2.599 ± 0.024	2.851ThrLys: 2.851 ± 0.026	5.143ThrLeu: 5.143 ± 0.035	1.159ThrMet: 1.159 ± 0.014	1.958ThrAsn: 1.958 ± 0.022	3.081ThrPro: 3.081 ± 0.036	2.1ThrGln: 2.1 ± 0.023	2.335ThrArg: 2.335 ± 0.021	4.573ThrSer: 4.573 ± 0.042	2.987ThrThr: 2.987 ± 0.033	4.129ThrVal: 4.129 ± 0.031	0.674ThrTrp: 0.674 ± 0.013	1.578ThrTyr: 1.578 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.157ValAla: 4.157 ± 0.029	1.579ValCys: 1.579 ± 0.022	3.151ValAsp: 3.151 ± 0.021	3.955ValGlu: 3.955 ± 0.03	2.705ValPhe: 2.705 ± 0.024	3.381ValGly: 3.381 ± 0.028	1.597ValHis: 1.597 ± 0.017	3.286ValIle: 3.286 ± 0.026	3.846ValLys: 3.846 ± 0.031	6.354ValLeu: 6.354 ± 0.035	1.391ValMet: 1.391 ± 0.018	2.574ValAsn: 2.574 ± 0.024	3.486ValPro: 3.486 ± 0.025	2.812ValGln: 2.812 ± 0.025	3.096ValArg: 3.096 ± 0.024	4.928ValSer: 4.928 ± 0.037	3.87ValThr: 3.87 ± 0.033	4.427ValVal: 4.427 ± 0.035	0.738ValTrp: 0.738 ± 0.012	1.871ValTyr: 1.871 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.684TrpAla: 0.684 ± 0.011	0.247TrpCys: 0.247 ± 0.006	0.669TrpAsp: 0.669 ± 0.013	0.798TrpGlu: 0.798 ± 0.011	0.47TrpPhe: 0.47 ± 0.009	0.668TrpGly: 0.668 ± 0.013	0.316TrpHis: 0.316 ± 0.007	0.621TrpIle: 0.621 ± 0.01	0.902TrpLys: 0.902 ± 0.014	1.194TrpLeu: 1.194 ± 0.016	0.314TrpMet: 0.314 ± 0.008	0.693TrpAsn: 0.693 ± 0.012	0.45TrpPro: 0.45 ± 0.009	0.557TrpGln: 0.557 ± 0.009	0.675TrpArg: 0.675 ± 0.011	0.889TrpSer: 0.889 ± 0.014	0.659TrpThr: 0.659 ± 0.012	0.691TrpVal: 0.691 ± 0.012	0.2TrpTrp: 0.2 ± 0.006	0.383TrpTyr: 0.383 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.614TyrAla: 1.614 ± 0.017	0.776TyrCys: 0.776 ± 0.013	1.467TyrAsp: 1.467 ± 0.017	1.835TyrGlu: 1.835 ± 0.019	1.414TyrPhe: 1.414 ± 0.018	1.834TyrGly: 1.834 ± 0.02	0.805TyrHis: 0.805 ± 0.012	1.651TyrIle: 1.651 ± 0.019	1.713TyrLys: 1.713 ± 0.02	2.967TyrLeu: 2.967 ± 0.026	0.677TyrMet: 0.677 ± 0.011	1.311TyrAsn: 1.311 ± 0.016	1.373TyrPro: 1.373 ± 0.018	1.331TyrGln: 1.331 ± 0.015	1.751TyrArg: 1.751 ± 0.017	2.402TyrSer: 2.402 ± 0.024	1.649TyrThr: 1.649 ± 0.019	1.777TyrVal: 1.777 ± 0.018	0.413TyrTrp: 0.413 ± 0.013	1.116TyrTyr: 1.116 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.017XaaXaa: 0.017 ± 0.004

Statistics based on 14132 proteins (6146519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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