Amino acid dipepetide frequency for Vibrio phage Vp_R1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.353AlaAla: 4.353 ± 0.683
0.747AlaCys: 0.747 ± 0.158
3.93AlaAsp: 3.93 ± 0.425
4.58AlaGlu: 4.58 ± 0.673
2.566AlaPhe: 2.566 ± 0.272
4.678AlaGly: 4.678 ± 0.367
0.747AlaHis: 0.747 ± 0.188
3.346AlaIle: 3.346 ± 0.392
3.995AlaLys: 3.995 ± 0.59
4.97AlaLeu: 4.97 ± 0.678
1.689AlaMet: 1.689 ± 0.255
2.761AlaAsn: 2.761 ± 0.376
2.176AlaPro: 2.176 ± 0.261
1.884AlaGln: 1.884 ± 0.271
2.794AlaArg: 2.794 ± 0.297
4.158AlaSer: 4.158 ± 0.337
3.898AlaThr: 3.898 ± 0.418
4.158AlaVal: 4.158 ± 0.351
0.617AlaTrp: 0.617 ± 0.154
2.501AlaTyr: 2.501 ± 0.394
0.0AlaXaa: 0.0 ± 0.0
Cys
0.455CysAla: 0.455 ± 0.136
0.162CysCys: 0.162 ± 0.066
1.072CysAsp: 1.072 ± 0.21
0.747CysGlu: 0.747 ± 0.166
0.455CysPhe: 0.455 ± 0.137
1.429CysGly: 1.429 ± 0.312
0.325CysHis: 0.325 ± 0.093
0.78CysIle: 0.78 ± 0.191
0.877CysLys: 0.877 ± 0.175
0.455CysLeu: 0.455 ± 0.13
0.325CysMet: 0.325 ± 0.126
0.617CysAsn: 0.617 ± 0.133
0.585CysPro: 0.585 ± 0.128
0.292CysGln: 0.292 ± 0.086
0.552CysArg: 0.552 ± 0.141
0.682CysSer: 0.682 ± 0.142
0.39CysThr: 0.39 ± 0.108
0.552CysVal: 0.552 ± 0.132
0.162CysTrp: 0.162 ± 0.07
0.422CysTyr: 0.422 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
4.288AspAla: 4.288 ± 0.452
0.65AspCys: 0.65 ± 0.152
3.606AspAsp: 3.606 ± 0.441
4.288AspGlu: 4.288 ± 0.407
2.924AspPhe: 2.924 ± 0.342
6.432AspGly: 6.432 ± 0.584
0.91AspHis: 0.91 ± 0.189
4.97AspIle: 4.97 ± 0.347
3.833AspLys: 3.833 ± 0.338
5.815AspLeu: 5.815 ± 0.521
2.501AspMet: 2.501 ± 0.267
3.898AspAsn: 3.898 ± 0.373
2.956AspPro: 2.956 ± 0.314
1.332AspGln: 1.332 ± 0.211
2.859AspArg: 2.859 ± 0.259
4.905AspSer: 4.905 ± 0.497
4.158AspThr: 4.158 ± 0.388
5.067AspVal: 5.067 ± 0.404
1.072AspTrp: 1.072 ± 0.219
3.053AspTyr: 3.053 ± 0.327
0.0AspXaa: 0.0 ± 0.0
Glu
5.685GluAla: 5.685 ± 0.562
0.52GluCys: 0.52 ± 0.12
5.879GluAsp: 5.879 ± 0.621
7.991GluGlu: 7.991 ± 0.703
3.995GluPhe: 3.995 ± 0.408
4.873GluGly: 4.873 ± 0.436
1.559GluHis: 1.559 ± 0.22
5.1GluIle: 5.1 ± 0.493
4.548GluLys: 4.548 ± 0.538
7.179GluLeu: 7.179 ± 0.511
2.274GluMet: 2.274 ± 0.268
3.411GluAsn: 3.411 ± 0.351
2.469GluPro: 2.469 ± 0.343
2.534GluGln: 2.534 ± 0.305
3.248GluArg: 3.248 ± 0.374
5.815GluSer: 5.815 ± 0.696
3.995GluThr: 3.995 ± 0.426
6.984GluVal: 6.984 ± 0.544
1.364GluTrp: 1.364 ± 0.229
3.411GluTyr: 3.411 ± 0.366
0.0GluXaa: 0.0 ± 0.0
Phe
1.819PheAla: 1.819 ± 0.295
0.552PheCys: 0.552 ± 0.127
3.411PheAsp: 3.411 ± 0.448
3.898PheGlu: 3.898 ± 0.344
1.884PhePhe: 1.884 ± 0.308
2.729PheGly: 2.729 ± 0.338
0.812PheHis: 0.812 ± 0.156
2.436PheIle: 2.436 ± 0.377
2.924PheLys: 2.924 ± 0.385
2.924PheLeu: 2.924 ± 0.473
1.072PheMet: 1.072 ± 0.178
2.209PheAsn: 2.209 ± 0.222
1.429PhePro: 1.429 ± 0.245
1.072PheGln: 1.072 ± 0.186
1.722PheArg: 1.722 ± 0.24
3.183PheSer: 3.183 ± 0.287
2.501PheThr: 2.501 ± 0.285
2.761PheVal: 2.761 ± 0.341
0.747PheTrp: 0.747 ± 0.173
1.494PheTyr: 1.494 ± 0.216
0.0PheXaa: 0.0 ± 0.0
Gly
4.028GlyAla: 4.028 ± 0.402
1.007GlyCys: 1.007 ± 0.225
5.36GlyAsp: 5.36 ± 0.533
6.042GlyGlu: 6.042 ± 0.424
3.118GlyPhe: 3.118 ± 0.257
4.808GlyGly: 4.808 ± 0.451
1.527GlyHis: 1.527 ± 0.206
3.866GlyIle: 3.866 ± 0.337
5.392GlyLys: 5.392 ± 0.483
5.002GlyLeu: 5.002 ± 0.418
2.144GlyMet: 2.144 ± 0.28
4.125GlyAsn: 4.125 ± 0.481
1.332GlyPro: 1.332 ± 0.253
2.371GlyGln: 2.371 ± 0.306
3.248GlyArg: 3.248 ± 0.359
5.392GlySer: 5.392 ± 0.541
4.873GlyThr: 4.873 ± 0.425
5.392GlyVal: 5.392 ± 0.405
1.364GlyTrp: 1.364 ± 0.21
3.313GlyTyr: 3.313 ± 0.362
0.0GlyXaa: 0.0 ± 0.0
His
1.104HisAla: 1.104 ± 0.226
0.292HisCys: 0.292 ± 0.095
1.429HisAsp: 1.429 ± 0.227
1.397HisGlu: 1.397 ± 0.255
0.65HisPhe: 0.65 ± 0.16
1.364HisGly: 1.364 ± 0.219
0.487HisHis: 0.487 ± 0.119
1.234HisIle: 1.234 ± 0.239
1.104HisLys: 1.104 ± 0.186
2.209HisLeu: 2.209 ± 0.299
0.65HisMet: 0.65 ± 0.155
1.104HisAsn: 1.104 ± 0.21
0.78HisPro: 0.78 ± 0.168
0.585HisGln: 0.585 ± 0.143
1.039HisArg: 1.039 ± 0.206
1.429HisSer: 1.429 ± 0.189
0.812HisThr: 0.812 ± 0.164
1.202HisVal: 1.202 ± 0.195
0.39HisTrp: 0.39 ± 0.113
0.942HisTyr: 0.942 ± 0.205
0.0HisXaa: 0.0 ± 0.0
Ile
3.443IleAla: 3.443 ± 0.312
0.877IleCys: 0.877 ± 0.194
4.158IleAsp: 4.158 ± 0.408
5.132IleGlu: 5.132 ± 0.429
2.079IlePhe: 2.079 ± 0.287
3.93IleGly: 3.93 ± 0.329
1.332IleHis: 1.332 ± 0.208
2.859IleIle: 2.859 ± 0.333
3.508IleLys: 3.508 ± 0.314
4.028IleLeu: 4.028 ± 0.398
1.267IleMet: 1.267 ± 0.228
3.443IleAsn: 3.443 ± 0.443
3.118IlePro: 3.118 ± 0.38
1.299IleGln: 1.299 ± 0.213
2.664IleArg: 2.664 ± 0.316
4.678IleSer: 4.678 ± 0.397
3.866IleThr: 3.866 ± 0.341
4.093IleVal: 4.093 ± 0.347
0.65IleTrp: 0.65 ± 0.159
2.209IleTyr: 2.209 ± 0.338
0.0IleXaa: 0.0 ± 0.0
Lys
5.002LysAla: 5.002 ± 0.562
0.845LysCys: 0.845 ± 0.179
4.84LysAsp: 4.84 ± 0.458
6.237LysGlu: 6.237 ± 0.678
2.241LysPhe: 2.241 ± 0.291
4.385LysGly: 4.385 ± 0.391
1.527LysHis: 1.527 ± 0.27
4.028LysIle: 4.028 ± 0.338
4.71LysLys: 4.71 ± 0.502
5.23LysLeu: 5.23 ± 0.511
1.981LysMet: 1.981 ± 0.269
2.501LysAsn: 2.501 ± 0.311
2.209LysPro: 2.209 ± 0.365
2.209LysGln: 2.209 ± 0.418
3.053LysArg: 3.053 ± 0.356
3.963LysSer: 3.963 ± 0.477
3.313LysThr: 3.313 ± 0.309
5.295LysVal: 5.295 ± 0.609
0.877LysTrp: 0.877 ± 0.189
2.826LysTyr: 2.826 ± 0.342
0.0LysXaa: 0.0 ± 0.0
Leu
4.84LeuAla: 4.84 ± 0.55
1.039LeuCys: 1.039 ± 0.167
5.035LeuAsp: 5.035 ± 0.292
7.471LeuGlu: 7.471 ± 0.586
2.729LeuPhe: 2.729 ± 0.393
5.165LeuGly: 5.165 ± 0.419
1.657LeuHis: 1.657 ± 0.229
3.995LeuIle: 3.995 ± 0.371
5.165LeuLys: 5.165 ± 0.445
5.62LeuLeu: 5.62 ± 0.529
2.404LeuMet: 2.404 ± 0.283
3.768LeuAsn: 3.768 ± 0.369
2.891LeuPro: 2.891 ± 0.296
2.014LeuGln: 2.014 ± 0.262
4.125LeuArg: 4.125 ± 0.426
5.977LeuSer: 5.977 ± 0.491
3.93LeuThr: 3.93 ± 0.35
4.743LeuVal: 4.743 ± 0.459
0.682LeuTrp: 0.682 ± 0.143
2.436LeuTyr: 2.436 ± 0.364
0.0LeuXaa: 0.0 ± 0.0
Met
1.624MetAla: 1.624 ± 0.221
0.357MetCys: 0.357 ± 0.132
1.689MetAsp: 1.689 ± 0.285
2.046MetGlu: 2.046 ± 0.278
0.942MetPhe: 0.942 ± 0.164
1.657MetGly: 1.657 ± 0.22
0.65MetHis: 0.65 ± 0.155
1.624MetIle: 1.624 ± 0.207
2.079MetLys: 2.079 ± 0.252
2.339MetLeu: 2.339 ± 0.331
0.845MetMet: 0.845 ± 0.182
1.104MetAsn: 1.104 ± 0.198
1.234MetPro: 1.234 ± 0.183
0.552MetGln: 0.552 ± 0.135
1.592MetArg: 1.592 ± 0.282
2.209MetSer: 2.209 ± 0.295
1.397MetThr: 1.397 ± 0.205
1.819MetVal: 1.819 ± 0.231
0.195MetTrp: 0.195 ± 0.082
0.975MetTyr: 0.975 ± 0.172
0.0MetXaa: 0.0 ± 0.0
Asn
3.118AsnAla: 3.118 ± 0.308
0.422AsnCys: 0.422 ± 0.12
2.371AsnAsp: 2.371 ± 0.325
3.053AsnGlu: 3.053 ± 0.33
2.339AsnPhe: 2.339 ± 0.282
4.84AsnGly: 4.84 ± 0.6
0.65AsnHis: 0.65 ± 0.166
3.216AsnIle: 3.216 ± 0.305
3.086AsnLys: 3.086 ± 0.329
3.281AsnLeu: 3.281 ± 0.307
1.007AsnMet: 1.007 ± 0.205
2.306AsnAsn: 2.306 ± 0.256
2.956AsnPro: 2.956 ± 0.371
1.657AsnGln: 1.657 ± 0.216
2.404AsnArg: 2.404 ± 0.262
3.508AsnSer: 3.508 ± 0.312
2.469AsnThr: 2.469 ± 0.293
3.833AsnVal: 3.833 ± 0.402
0.78AsnTrp: 0.78 ± 0.193
1.949AsnTyr: 1.949 ± 0.257
0.0AsnXaa: 0.0 ± 0.0
Pro
2.371ProAla: 2.371 ± 0.323
0.39ProCys: 0.39 ± 0.127
3.151ProAsp: 3.151 ± 0.342
3.833ProGlu: 3.833 ± 0.496
2.046ProPhe: 2.046 ± 0.263
2.404ProGly: 2.404 ± 0.331
1.104ProHis: 1.104 ± 0.204
2.306ProIle: 2.306 ± 0.301
2.111ProLys: 2.111 ± 0.309
1.884ProLeu: 1.884 ± 0.223
0.812ProMet: 0.812 ± 0.149
1.852ProAsn: 1.852 ± 0.273
0.975ProPro: 0.975 ± 0.23
1.267ProGln: 1.267 ± 0.258
1.689ProArg: 1.689 ± 0.262
2.924ProSer: 2.924 ± 0.377
2.339ProThr: 2.339 ± 0.358
2.826ProVal: 2.826 ± 0.363
0.422ProTrp: 0.422 ± 0.118
1.527ProTyr: 1.527 ± 0.227
0.0ProXaa: 0.0 ± 0.0
Gln
1.949GlnAla: 1.949 ± 0.331
0.455GlnCys: 0.455 ± 0.124
1.884GlnAsp: 1.884 ± 0.252
2.794GlnGlu: 2.794 ± 0.297
1.039GlnPhe: 1.039 ± 0.143
2.306GlnGly: 2.306 ± 0.348
0.682GlnHis: 0.682 ± 0.15
2.014GlnIle: 2.014 ± 0.223
1.852GlnLys: 1.852 ± 0.29
2.631GlnLeu: 2.631 ± 0.31
0.877GlnMet: 0.877 ± 0.186
1.039GlnAsn: 1.039 ± 0.245
1.039GlnPro: 1.039 ± 0.217
0.78GlnGln: 0.78 ± 0.189
1.624GlnArg: 1.624 ± 0.269
1.527GlnSer: 1.527 ± 0.223
1.072GlnThr: 1.072 ± 0.183
1.624GlnVal: 1.624 ± 0.224
0.52GlnTrp: 0.52 ± 0.132
1.169GlnTyr: 1.169 ± 0.183
0.0GlnXaa: 0.0 ± 0.0
Arg
2.761ArgAla: 2.761 ± 0.313
0.422ArgCys: 0.422 ± 0.118
3.346ArgAsp: 3.346 ± 0.348
3.281ArgGlu: 3.281 ± 0.303
2.306ArgPhe: 2.306 ± 0.283
2.534ArgGly: 2.534 ± 0.283
1.072ArgHis: 1.072 ± 0.19
2.306ArgIle: 2.306 ± 0.24
3.866ArgLys: 3.866 ± 0.388
3.508ArgLeu: 3.508 ± 0.328
1.462ArgMet: 1.462 ± 0.198
2.664ArgAsn: 2.664 ± 0.415
1.332ArgPro: 1.332 ± 0.214
1.202ArgGln: 1.202 ± 0.176
1.949ArgArg: 1.949 ± 0.255
2.729ArgSer: 2.729 ± 0.284
2.209ArgThr: 2.209 ± 0.29
3.313ArgVal: 3.313 ± 0.431
0.682ArgTrp: 0.682 ± 0.144
1.657ArgTyr: 1.657 ± 0.234
0.0ArgXaa: 0.0 ± 0.0
Ser
4.158SerAla: 4.158 ± 0.367
0.845SerCys: 0.845 ± 0.177
5.262SerAsp: 5.262 ± 0.389
6.529SerGlu: 6.529 ± 0.376
2.826SerPhe: 2.826 ± 0.263
5.717SerGly: 5.717 ± 0.506
1.202SerHis: 1.202 ± 0.213
3.671SerIle: 3.671 ± 0.323
5.36SerLys: 5.36 ± 0.659
5.425SerLeu: 5.425 ± 0.378
1.234SerMet: 1.234 ± 0.184
3.995SerAsn: 3.995 ± 0.41
2.566SerPro: 2.566 ± 0.285
2.111SerGln: 2.111 ± 0.262
2.924SerArg: 2.924 ± 0.271
5.002SerSer: 5.002 ± 0.507
3.508SerThr: 3.508 ± 0.295
4.645SerVal: 4.645 ± 0.356
1.332SerTrp: 1.332 ± 0.255
2.664SerTyr: 2.664 ± 0.32
0.0SerXaa: 0.0 ± 0.0
Thr
3.151ThrAla: 3.151 ± 0.425
0.52ThrCys: 0.52 ± 0.131
3.801ThrAsp: 3.801 ± 0.421
3.703ThrGlu: 3.703 ± 0.444
2.534ThrPhe: 2.534 ± 0.31
5.49ThrGly: 5.49 ± 0.443
1.007ThrHis: 1.007 ± 0.171
3.508ThrIle: 3.508 ± 0.44
2.859ThrLys: 2.859 ± 0.352
4.288ThrLeu: 4.288 ± 0.407
0.91ThrMet: 0.91 ± 0.142
2.469ThrAsn: 2.469 ± 0.265
3.638ThrPro: 3.638 ± 0.36
1.657ThrGln: 1.657 ± 0.248
2.274ThrArg: 2.274 ± 0.261
3.833ThrSer: 3.833 ± 0.411
3.151ThrThr: 3.151 ± 0.349
4.028ThrVal: 4.028 ± 0.369
0.52ThrTrp: 0.52 ± 0.134
2.014ThrTyr: 2.014 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
3.898ValAla: 3.898 ± 0.368
0.747ValCys: 0.747 ± 0.149
5.425ValAsp: 5.425 ± 0.404
5.717ValGlu: 5.717 ± 0.376
2.469ValPhe: 2.469 ± 0.389
4.808ValGly: 4.808 ± 0.443
1.559ValHis: 1.559 ± 0.222
4.32ValIle: 4.32 ± 0.485
5.652ValLys: 5.652 ± 0.541
5.002ValLeu: 5.002 ± 0.35
1.722ValMet: 1.722 ± 0.222
3.508ValAsn: 3.508 ± 0.382
2.891ValPro: 2.891 ± 0.353
2.079ValGln: 2.079 ± 0.223
2.696ValArg: 2.696 ± 0.319
4.905ValSer: 4.905 ± 0.498
4.905ValThr: 4.905 ± 0.425
5.295ValVal: 5.295 ± 0.554
0.65ValTrp: 0.65 ± 0.173
2.794ValTyr: 2.794 ± 0.358
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.139
0.065TrpCys: 0.065 ± 0.056
1.299TrpAsp: 1.299 ± 0.2
1.429TrpGlu: 1.429 ± 0.241
0.552TrpPhe: 0.552 ± 0.165
0.942TrpGly: 0.942 ± 0.2
0.455TrpHis: 0.455 ± 0.13
0.747TrpIle: 0.747 ± 0.164
1.039TrpLys: 1.039 ± 0.161
0.65TrpLeu: 0.65 ± 0.143
0.422TrpMet: 0.422 ± 0.121
0.78TrpAsn: 0.78 ± 0.185
0.162TrpPro: 0.162 ± 0.078
0.715TrpGln: 0.715 ± 0.17
0.52TrpArg: 0.52 ± 0.114
1.007TrpSer: 1.007 ± 0.171
0.715TrpThr: 0.715 ± 0.183
1.202TrpVal: 1.202 ± 0.211
0.357TrpTrp: 0.357 ± 0.149
0.325TrpTyr: 0.325 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.917TyrAla: 1.917 ± 0.236
0.422TyrCys: 0.422 ± 0.123
2.599TyrAsp: 2.599 ± 0.281
2.664TyrGlu: 2.664 ± 0.303
1.884TyrPhe: 1.884 ± 0.267
3.216TyrGly: 3.216 ± 0.393
0.942TyrHis: 0.942 ± 0.21
2.306TyrIle: 2.306 ± 0.324
3.313TyrLys: 3.313 ± 0.355
3.248TyrLeu: 3.248 ± 0.381
1.299TyrMet: 1.299 ± 0.2
1.689TyrAsn: 1.689 ± 0.271
1.494TyrPro: 1.494 ± 0.27
1.267TyrGln: 1.267 ± 0.26
1.624TyrArg: 1.624 ± 0.284
3.151TyrSer: 3.151 ± 0.47
1.852TyrThr: 1.852 ± 0.21
2.209TyrVal: 2.209 ± 0.384
0.585TyrTrp: 0.585 ± 0.137
1.787TyrTyr: 1.787 ± 0.266
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 147 proteins (30786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski