Amino acid dipepetide frequency for Salmonella phage vB_SalS_SA001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.747AlaAla: 6.747 ± 1.107
0.521AlaCys: 0.521 ± 0.132
3.813AlaAsp: 3.813 ± 0.392
5.247AlaGlu: 5.247 ± 0.52
3.324AlaPhe: 3.324 ± 0.359
4.954AlaGly: 4.954 ± 0.556
1.499AlaHis: 1.499 ± 0.266
4.628AlaIle: 4.628 ± 0.369
5.704AlaLys: 5.704 ± 0.483
6.29AlaLeu: 6.29 ± 0.485
2.119AlaMet: 2.119 ± 0.329
3.324AlaAsn: 3.324 ± 0.328
2.379AlaPro: 2.379 ± 0.337
3.161AlaGln: 3.161 ± 0.419
3.357AlaArg: 3.357 ± 0.353
4.498AlaSer: 4.498 ± 0.591
3.422AlaThr: 3.422 ± 0.334
4.335AlaVal: 4.335 ± 0.431
0.88AlaTrp: 0.88 ± 0.174
2.314AlaTyr: 2.314 ± 0.304
0.0AlaXaa: 0.0 ± 0.0
Cys
0.652CysAla: 0.652 ± 0.123
0.261CysCys: 0.261 ± 0.098
0.424CysAsp: 0.424 ± 0.105
0.717CysGlu: 0.717 ± 0.148
0.424CysPhe: 0.424 ± 0.124
0.782CysGly: 0.782 ± 0.172
0.196CysHis: 0.196 ± 0.073
0.554CysIle: 0.554 ± 0.132
0.913CysLys: 0.913 ± 0.172
1.043CysLeu: 1.043 ± 0.168
0.293CysMet: 0.293 ± 0.117
0.521CysAsn: 0.521 ± 0.144
0.554CysPro: 0.554 ± 0.139
0.554CysGln: 0.554 ± 0.144
0.619CysArg: 0.619 ± 0.142
1.076CysSer: 1.076 ± 0.173
0.684CysThr: 0.684 ± 0.17
0.652CysVal: 0.652 ± 0.138
0.13CysTrp: 0.13 ± 0.073
0.326CysTyr: 0.326 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
4.433AspAla: 4.433 ± 0.425
0.587AspCys: 0.587 ± 0.136
2.901AspAsp: 2.901 ± 0.376
4.628AspGlu: 4.628 ± 0.42
2.966AspPhe: 2.966 ± 0.355
3.944AspGly: 3.944 ± 0.455
1.239AspHis: 1.239 ± 0.196
4.498AspIle: 4.498 ± 0.432
4.009AspLys: 4.009 ± 0.394
5.508AspLeu: 5.508 ± 0.471
2.119AspMet: 2.119 ± 0.224
2.542AspAsn: 2.542 ± 0.28
2.966AspPro: 2.966 ± 0.285
1.597AspGln: 1.597 ± 0.218
2.77AspArg: 2.77 ± 0.286
3.585AspSer: 3.585 ± 0.338
3.39AspThr: 3.39 ± 0.316
3.813AspVal: 3.813 ± 0.414
0.782AspTrp: 0.782 ± 0.184
2.803AspTyr: 2.803 ± 0.323
0.0AspXaa: 0.0 ± 0.0
Glu
5.736GluAla: 5.736 ± 0.405
0.619GluCys: 0.619 ± 0.172
3.553GluAsp: 3.553 ± 0.287
5.28GluGlu: 5.28 ± 0.474
2.542GluPhe: 2.542 ± 0.301
3.944GluGly: 3.944 ± 0.387
1.434GluHis: 1.434 ± 0.198
5.019GluIle: 5.019 ± 0.455
5.084GluLys: 5.084 ± 0.518
7.79GluLeu: 7.79 ± 0.482
2.086GluMet: 2.086 ± 0.24
2.803GluAsn: 2.803 ± 0.302
1.597GluPro: 1.597 ± 0.289
3.194GluGln: 3.194 ± 0.444
3.194GluArg: 3.194 ± 0.398
3.422GluSer: 3.422 ± 0.346
3.716GluThr: 3.716 ± 0.384
4.563GluVal: 4.563 ± 0.382
1.108GluTrp: 1.108 ± 0.18
3.39GluTyr: 3.39 ± 0.294
0.0GluXaa: 0.0 ± 0.0
Phe
2.51PheAla: 2.51 ± 0.296
0.424PheCys: 0.424 ± 0.138
2.868PheAsp: 2.868 ± 0.29
2.379PheGlu: 2.379 ± 0.334
1.499PhePhe: 1.499 ± 0.211
3.031PheGly: 3.031 ± 0.343
1.271PheHis: 1.271 ± 0.202
2.836PheIle: 2.836 ± 0.337
3.357PheLys: 3.357 ± 0.332
3.096PheLeu: 3.096 ± 0.306
0.782PheMet: 0.782 ± 0.191
2.444PheAsn: 2.444 ± 0.31
1.89PhePro: 1.89 ± 0.286
1.141PheGln: 1.141 ± 0.221
1.825PheArg: 1.825 ± 0.283
2.999PheSer: 2.999 ± 0.278
2.053PheThr: 2.053 ± 0.232
2.868PheVal: 2.868 ± 0.292
0.521PheTrp: 0.521 ± 0.143
1.63PheTyr: 1.63 ± 0.226
0.0PheXaa: 0.0 ± 0.0
Gly
4.009GlyAla: 4.009 ± 0.458
1.173GlyCys: 1.173 ± 0.225
3.748GlyAsp: 3.748 ± 0.372
4.498GlyGlu: 4.498 ± 0.346
3.031GlyPhe: 3.031 ± 0.275
3.129GlyGly: 3.129 ± 0.373
1.271GlyHis: 1.271 ± 0.243
5.084GlyIle: 5.084 ± 0.44
5.313GlyLys: 5.313 ± 0.422
4.367GlyLeu: 4.367 ± 0.365
1.793GlyMet: 1.793 ± 0.249
3.781GlyAsn: 3.781 ± 0.544
0.945GlyPro: 0.945 ± 0.166
2.216GlyGln: 2.216 ± 0.282
2.575GlyArg: 2.575 ± 0.251
3.911GlySer: 3.911 ± 0.425
3.422GlyThr: 3.422 ± 0.357
4.563GlyVal: 4.563 ± 0.408
1.043GlyTrp: 1.043 ± 0.207
2.933GlyTyr: 2.933 ± 0.331
0.0GlyXaa: 0.0 ± 0.0
His
1.206HisAla: 1.206 ± 0.229
0.261HisCys: 0.261 ± 0.091
1.434HisAsp: 1.434 ± 0.231
1.141HisGlu: 1.141 ± 0.182
0.554HisPhe: 0.554 ± 0.159
1.304HisGly: 1.304 ± 0.198
0.717HisHis: 0.717 ± 0.168
1.499HisIle: 1.499 ± 0.251
1.271HisLys: 1.271 ± 0.217
1.727HisLeu: 1.727 ± 0.246
0.359HisMet: 0.359 ± 0.118
1.01HisAsn: 1.01 ± 0.224
1.043HisPro: 1.043 ± 0.185
0.684HisGln: 0.684 ± 0.158
1.141HisArg: 1.141 ± 0.186
1.173HisSer: 1.173 ± 0.184
0.945HisThr: 0.945 ± 0.186
0.913HisVal: 0.913 ± 0.166
0.293HisTrp: 0.293 ± 0.117
0.815HisTyr: 0.815 ± 0.154
0.0HisXaa: 0.0 ± 0.0
Ile
4.693IleAla: 4.693 ± 0.419
0.75IleCys: 0.75 ± 0.151
5.215IleAsp: 5.215 ± 0.403
4.791IleGlu: 4.791 ± 0.366
2.281IlePhe: 2.281 ± 0.277
3.944IleGly: 3.944 ± 0.347
1.043IleHis: 1.043 ± 0.17
4.237IleIle: 4.237 ± 0.386
4.693IleLys: 4.693 ± 0.43
5.638IleLeu: 5.638 ± 0.452
1.825IleMet: 1.825 ± 0.28
4.107IleAsn: 4.107 ± 0.455
2.673IlePro: 2.673 ± 0.334
2.51IleGln: 2.51 ± 0.278
3.39IleArg: 3.39 ± 0.295
4.726IleSer: 4.726 ± 0.422
4.661IleThr: 4.661 ± 0.432
3.813IleVal: 3.813 ± 0.364
0.619IleTrp: 0.619 ± 0.141
2.379IleTyr: 2.379 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
5.899LysAla: 5.899 ± 0.573
0.815LysCys: 0.815 ± 0.172
5.117LysAsp: 5.117 ± 0.373
5.378LysGlu: 5.378 ± 0.466
3.357LysPhe: 3.357 ± 0.278
3.292LysGly: 3.292 ± 0.36
1.239LysHis: 1.239 ± 0.228
3.944LysIle: 3.944 ± 0.384
4.433LysLys: 4.433 ± 0.477
7.594LysLeu: 7.594 ± 0.64
2.444LysMet: 2.444 ± 0.339
3.683LysAsn: 3.683 ± 0.438
2.51LysPro: 2.51 ± 0.334
3.194LysGln: 3.194 ± 0.338
3.553LysArg: 3.553 ± 0.299
4.139LysSer: 4.139 ± 0.414
4.041LysThr: 4.041 ± 0.409
4.563LysVal: 4.563 ± 0.451
0.847LysTrp: 0.847 ± 0.181
3.422LysTyr: 3.422 ± 0.33
0.0LysXaa: 0.0 ± 0.0
Leu
7.236LeuAla: 7.236 ± 0.51
0.945LeuCys: 0.945 ± 0.173
6.03LeuAsp: 6.03 ± 0.445
7.464LeuGlu: 7.464 ± 0.469
2.705LeuPhe: 2.705 ± 0.325
5.443LeuGly: 5.443 ± 0.453
1.923LeuHis: 1.923 ± 0.26
5.345LeuIle: 5.345 ± 0.502
6.16LeuLys: 6.16 ± 0.452
7.04LeuLeu: 7.04 ± 0.695
2.314LeuMet: 2.314 ± 0.409
4.921LeuAsn: 4.921 ± 0.439
3.553LeuPro: 3.553 ± 0.334
3.194LeuGln: 3.194 ± 0.383
3.813LeuArg: 3.813 ± 0.324
4.889LeuSer: 4.889 ± 0.371
4.465LeuThr: 4.465 ± 0.338
5.736LeuVal: 5.736 ± 0.556
0.717LeuTrp: 0.717 ± 0.176
2.836LeuTyr: 2.836 ± 0.307
0.0LeuXaa: 0.0 ± 0.0
Met
1.727MetAla: 1.727 ± 0.302
0.228MetCys: 0.228 ± 0.086
1.304MetAsp: 1.304 ± 0.207
2.151MetGlu: 2.151 ± 0.31
0.913MetPhe: 0.913 ± 0.173
1.63MetGly: 1.63 ± 0.261
0.521MetHis: 0.521 ± 0.13
2.184MetIle: 2.184 ± 0.275
2.347MetLys: 2.347 ± 0.294
2.575MetLeu: 2.575 ± 0.31
0.456MetMet: 0.456 ± 0.112
0.88MetAsn: 0.88 ± 0.179
0.815MetPro: 0.815 ± 0.153
1.271MetGln: 1.271 ± 0.287
1.206MetArg: 1.206 ± 0.179
2.347MetSer: 2.347 ± 0.309
1.923MetThr: 1.923 ± 0.21
1.108MetVal: 1.108 ± 0.21
0.163MetTrp: 0.163 ± 0.07
0.945MetTyr: 0.945 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
3.292AsnAla: 3.292 ± 0.386
0.652AsnCys: 0.652 ± 0.171
2.575AsnAsp: 2.575 ± 0.32
2.575AsnGlu: 2.575 ± 0.313
2.216AsnPhe: 2.216 ± 0.298
4.367AsnGly: 4.367 ± 0.486
0.75AsnHis: 0.75 ± 0.189
3.976AsnIle: 3.976 ± 0.411
4.107AsnLys: 4.107 ± 0.396
4.237AsnLeu: 4.237 ± 0.412
1.108AsnMet: 1.108 ± 0.183
2.966AsnAsn: 2.966 ± 0.392
2.477AsnPro: 2.477 ± 0.298
1.564AsnGln: 1.564 ± 0.225
2.77AsnArg: 2.77 ± 0.336
3.65AsnSer: 3.65 ± 0.399
3.227AsnThr: 3.227 ± 0.3
3.422AsnVal: 3.422 ± 0.324
0.587AsnTrp: 0.587 ± 0.155
1.825AsnTyr: 1.825 ± 0.252
0.0AsnXaa: 0.0 ± 0.0
Pro
2.64ProAla: 2.64 ± 0.314
0.424ProCys: 0.424 ± 0.112
2.705ProAsp: 2.705 ± 0.264
3.227ProGlu: 3.227 ± 0.353
1.564ProPhe: 1.564 ± 0.198
2.281ProGly: 2.281 ± 0.307
0.684ProHis: 0.684 ± 0.147
2.216ProIle: 2.216 ± 0.314
1.988ProLys: 1.988 ± 0.269
2.379ProLeu: 2.379 ± 0.29
0.521ProMet: 0.521 ± 0.13
2.053ProAsn: 2.053 ± 0.292
1.304ProPro: 1.304 ± 0.282
0.945ProGln: 0.945 ± 0.17
1.564ProArg: 1.564 ± 0.225
2.216ProSer: 2.216 ± 0.298
1.76ProThr: 1.76 ± 0.219
2.803ProVal: 2.803 ± 0.285
0.424ProTrp: 0.424 ± 0.123
1.695ProTyr: 1.695 ± 0.24
0.0ProXaa: 0.0 ± 0.0
Gln
3.129GlnAla: 3.129 ± 0.504
0.489GlnCys: 0.489 ± 0.096
2.021GlnAsp: 2.021 ± 0.251
2.868GlnGlu: 2.868 ± 0.364
1.63GlnPhe: 1.63 ± 0.249
1.597GlnGly: 1.597 ± 0.198
0.587GlnHis: 0.587 ± 0.15
2.314GlnIle: 2.314 ± 0.266
2.868GlnLys: 2.868 ± 0.492
3.813GlnLeu: 3.813 ± 0.421
0.847GlnMet: 0.847 ± 0.165
1.597GlnAsn: 1.597 ± 0.222
0.619GlnPro: 0.619 ± 0.144
1.988GlnGln: 1.988 ± 0.312
2.184GlnArg: 2.184 ± 0.29
2.119GlnSer: 2.119 ± 0.245
1.956GlnThr: 1.956 ± 0.262
2.77GlnVal: 2.77 ± 0.313
0.554GlnTrp: 0.554 ± 0.167
1.434GlnTyr: 1.434 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
3.324ArgAla: 3.324 ± 0.371
0.326ArgCys: 0.326 ± 0.096
2.868ArgAsp: 2.868 ± 0.345
3.422ArgGlu: 3.422 ± 0.392
1.727ArgPhe: 1.727 ± 0.25
3.422ArgGly: 3.422 ± 0.288
0.684ArgHis: 0.684 ± 0.172
3.259ArgIle: 3.259 ± 0.406
3.65ArgLys: 3.65 ± 0.466
4.4ArgLeu: 4.4 ± 0.455
1.499ArgMet: 1.499 ± 0.259
2.738ArgAsn: 2.738 ± 0.278
1.173ArgPro: 1.173 ± 0.215
1.793ArgGln: 1.793 ± 0.279
2.412ArgArg: 2.412 ± 0.328
2.216ArgSer: 2.216 ± 0.248
2.542ArgThr: 2.542 ± 0.291
3.031ArgVal: 3.031 ± 0.3
0.391ArgTrp: 0.391 ± 0.11
1.923ArgTyr: 1.923 ± 0.253
0.0ArgXaa: 0.0 ± 0.0
Ser
3.976SerAla: 3.976 ± 0.507
0.815SerCys: 0.815 ± 0.172
2.933SerAsp: 2.933 ± 0.306
3.422SerGlu: 3.422 ± 0.369
2.933SerPhe: 2.933 ± 0.292
4.335SerGly: 4.335 ± 0.373
0.945SerHis: 0.945 ± 0.167
4.563SerIle: 4.563 ± 0.49
4.856SerLys: 4.856 ± 0.392
5.997SerLeu: 5.997 ± 0.397
1.662SerMet: 1.662 ± 0.243
3.976SerAsn: 3.976 ± 0.391
2.021SerPro: 2.021 ± 0.292
1.956SerGln: 1.956 ± 0.227
3.292SerArg: 3.292 ± 0.328
4.335SerSer: 4.335 ± 0.414
3.618SerThr: 3.618 ± 0.304
3.618SerVal: 3.618 ± 0.323
1.108SerTrp: 1.108 ± 0.172
2.607SerTyr: 2.607 ± 0.302
0.0SerXaa: 0.0 ± 0.0
Thr
3.976ThrAla: 3.976 ± 0.479
0.587ThrCys: 0.587 ± 0.134
3.031ThrAsp: 3.031 ± 0.283
3.455ThrGlu: 3.455 ± 0.331
2.673ThrPhe: 2.673 ± 0.258
4.563ThrGly: 4.563 ± 0.463
0.945ThrHis: 0.945 ± 0.186
3.813ThrIle: 3.813 ± 0.346
3.878ThrLys: 3.878 ± 0.421
4.433ThrLeu: 4.433 ± 0.396
1.336ThrMet: 1.336 ± 0.234
3.194ThrAsn: 3.194 ± 0.361
2.347ThrPro: 2.347 ± 0.268
2.086ThrGln: 2.086 ± 0.255
2.119ThrArg: 2.119 ± 0.259
3.52ThrSer: 3.52 ± 0.361
2.803ThrThr: 2.803 ± 0.31
4.107ThrVal: 4.107 ± 0.4
0.652ThrTrp: 0.652 ± 0.171
1.956ThrTyr: 1.956 ± 0.226
0.0ThrXaa: 0.0 ± 0.0
Val
4.791ValAla: 4.791 ± 0.378
0.619ValCys: 0.619 ± 0.153
4.335ValAsp: 4.335 ± 0.491
4.27ValGlu: 4.27 ± 0.415
2.575ValPhe: 2.575 ± 0.313
3.748ValGly: 3.748 ± 0.356
1.173ValHis: 1.173 ± 0.195
4.791ValIle: 4.791 ± 0.392
4.889ValLys: 4.889 ± 0.416
4.791ValLeu: 4.791 ± 0.376
1.564ValMet: 1.564 ± 0.182
2.836ValAsn: 2.836 ± 0.375
2.705ValPro: 2.705 ± 0.314
2.314ValGln: 2.314 ± 0.311
2.77ValArg: 2.77 ± 0.281
4.53ValSer: 4.53 ± 0.42
3.813ValThr: 3.813 ± 0.425
4.465ValVal: 4.465 ± 0.447
0.619ValTrp: 0.619 ± 0.159
2.477ValTyr: 2.477 ± 0.31
0.0ValXaa: 0.0 ± 0.0
Trp
0.456TrpAla: 0.456 ± 0.125
0.196TrpCys: 0.196 ± 0.078
1.173TrpAsp: 1.173 ± 0.213
1.01TrpGlu: 1.01 ± 0.195
0.619TrpPhe: 0.619 ± 0.162
0.847TrpGly: 0.847 ± 0.208
0.098TrpHis: 0.098 ± 0.062
0.652TrpIle: 0.652 ± 0.168
1.043TrpLys: 1.043 ± 0.174
1.141TrpLeu: 1.141 ± 0.223
0.391TrpMet: 0.391 ± 0.123
0.456TrpAsn: 0.456 ± 0.125
0.326TrpPro: 0.326 ± 0.097
0.554TrpGln: 0.554 ± 0.125
0.554TrpArg: 0.554 ± 0.12
0.815TrpSer: 0.815 ± 0.19
0.717TrpThr: 0.717 ± 0.149
0.587TrpVal: 0.587 ± 0.127
0.228TrpTrp: 0.228 ± 0.104
0.424TrpTyr: 0.424 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.086TyrAla: 2.086 ± 0.269
0.684TyrCys: 0.684 ± 0.143
3.031TyrAsp: 3.031 ± 0.275
2.151TyrGlu: 2.151 ± 0.251
1.89TyrPhe: 1.89 ± 0.266
2.281TyrGly: 2.281 ± 0.276
1.271TyrHis: 1.271 ± 0.167
2.575TyrIle: 2.575 ± 0.319
2.901TyrLys: 2.901 ± 0.293
2.868TyrLeu: 2.868 ± 0.273
1.141TyrMet: 1.141 ± 0.18
2.51TyrAsn: 2.51 ± 0.263
1.499TyrPro: 1.499 ± 0.201
1.467TyrGln: 1.467 ± 0.202
1.695TyrArg: 1.695 ± 0.271
2.803TyrSer: 2.803 ± 0.309
2.314TyrThr: 2.314 ± 0.261
2.347TyrVal: 2.347 ± 0.284
0.619TyrTrp: 0.619 ± 0.137
1.499TyrTyr: 1.499 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 157 proteins (30683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski