Amino acid dipepetide frequency for Weissella cibaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.392AlaAla: 10.392 ± 0.294
0.124AlaCys: 0.124 ± 0.015
7.26AlaAsp: 7.26 ± 0.19
5.8AlaGlu: 5.8 ± 0.115
3.733AlaPhe: 3.733 ± 0.087
7.779AlaGly: 7.779 ± 0.128
1.727AlaHis: 1.727 ± 0.055
6.323AlaIle: 6.323 ± 0.123
5.543AlaLys: 5.543 ± 0.153
9.469AlaLeu: 9.469 ± 0.167
2.845AlaMet: 2.845 ± 0.073
4.515AlaAsn: 4.515 ± 0.111
3.011AlaPro: 3.011 ± 0.085
4.422AlaGln: 4.422 ± 0.147
3.576AlaArg: 3.576 ± 0.081
5.391AlaSer: 5.391 ± 0.134
7.935AlaThr: 7.935 ± 0.211
8.063AlaVal: 8.063 ± 0.146
1.131AlaTrp: 1.131 ± 0.038
2.999AlaTyr: 2.999 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.1CysAla: 0.1 ± 0.015
0.014CysCys: 0.014 ± 0.005
0.074CysAsp: 0.074 ± 0.011
0.06CysGlu: 0.06 ± 0.012
0.05CysPhe: 0.05 ± 0.008
0.142CysGly: 0.142 ± 0.016
0.034CysHis: 0.034 ± 0.006
0.063CysIle: 0.063 ± 0.01
0.044CysLys: 0.044 ± 0.008
0.116CysLeu: 0.116 ± 0.013
0.027CysMet: 0.027 ± 0.006
0.051CysAsn: 0.051 ± 0.009
0.067CysPro: 0.067 ± 0.013
0.057CysGln: 0.057 ± 0.01
0.069CysArg: 0.069 ± 0.011
0.066CysSer: 0.066 ± 0.011
0.066CysThr: 0.066 ± 0.01
0.067CysVal: 0.067 ± 0.012
0.03CysTrp: 0.03 ± 0.007
0.039CysTyr: 0.039 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
6.617AspAla: 6.617 ± 0.238
0.074AspCys: 0.074 ± 0.011
4.063AspAsp: 4.063 ± 0.115
4.122AspGlu: 4.122 ± 0.093
2.718AspPhe: 2.718 ± 0.063
4.392AspGly: 4.392 ± 0.112
1.031AspHis: 1.031 ± 0.039
3.71AspIle: 3.71 ± 0.091
3.234AspLys: 3.234 ± 0.088
5.702AspLeu: 5.702 ± 0.113
1.854AspMet: 1.854 ± 0.053
2.535AspAsn: 2.535 ± 0.082
2.11AspPro: 2.11 ± 0.1
2.496AspGln: 2.496 ± 0.081
2.415AspArg: 2.415 ± 0.064
2.798AspSer: 2.798 ± 0.076
3.544AspThr: 3.544 ± 0.092
4.899AspVal: 4.899 ± 0.108
0.826AspTrp: 0.826 ± 0.038
2.379AspTyr: 2.379 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
5.384GluAla: 5.384 ± 0.116
0.046GluCys: 0.046 ± 0.009
2.701GluAsp: 2.701 ± 0.065
3.009GluGlu: 3.009 ± 0.083
2.09GluPhe: 2.09 ± 0.053
2.526GluGly: 2.526 ± 0.08
1.121GluHis: 1.121 ± 0.04
3.401GluIle: 3.401 ± 0.079
3.15GluLys: 3.15 ± 0.066
5.526GluLeu: 5.526 ± 0.118
1.837GluMet: 1.837 ± 0.05
2.628GluAsn: 2.628 ± 0.06
1.83GluPro: 1.83 ± 0.057
2.808GluGln: 2.808 ± 0.076
2.894GluArg: 2.894 ± 0.074
2.588GluSer: 2.588 ± 0.078
3.7GluThr: 3.7 ± 0.078
3.862GluVal: 3.862 ± 0.093
0.599GluTrp: 0.599 ± 0.029
1.445GluTyr: 1.445 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.866PheAla: 3.866 ± 0.086
0.051PheCys: 0.051 ± 0.008
2.879PheAsp: 2.879 ± 0.076
2.333PheGlu: 2.333 ± 0.061
1.849PhePhe: 1.849 ± 0.068
3.691PheGly: 3.691 ± 0.089
0.625PheHis: 0.625 ± 0.031
2.686PheIle: 2.686 ± 0.081
2.024PheLys: 2.024 ± 0.066
3.23PheLeu: 3.23 ± 0.087
1.29PheMet: 1.29 ± 0.044
1.947PheAsn: 1.947 ± 0.054
1.302PhePro: 1.302 ± 0.045
1.302PheGln: 1.302 ± 0.044
1.328PheArg: 1.328 ± 0.05
2.418PheSer: 2.418 ± 0.071
2.595PheThr: 2.595 ± 0.071
3.363PheVal: 3.363 ± 0.085
0.548PheTrp: 0.548 ± 0.03
1.344PheTyr: 1.344 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.12GlyAla: 6.12 ± 0.105
0.089GlyCys: 0.089 ± 0.013
3.932GlyAsp: 3.932 ± 0.086
3.703GlyGlu: 3.703 ± 0.088
3.049GlyPhe: 3.049 ± 0.074
4.709GlyGly: 4.709 ± 0.105
1.443GlyHis: 1.443 ± 0.049
4.812GlyIle: 4.812 ± 0.102
3.684GlyLys: 3.684 ± 0.083
6.964GlyLeu: 6.964 ± 0.132
2.262GlyMet: 2.262 ± 0.065
2.711GlyAsn: 2.711 ± 0.071
1.578GlyPro: 1.578 ± 0.053
3.152GlyGln: 3.152 ± 0.067
2.978GlyArg: 2.978 ± 0.08
3.721GlySer: 3.721 ± 0.081
4.744GlyThr: 4.744 ± 0.094
6.122GlyVal: 6.122 ± 0.099
0.946GlyTrp: 0.946 ± 0.047
2.885GlyTyr: 2.885 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
1.668HisAla: 1.668 ± 0.056
0.037HisCys: 0.037 ± 0.009
1.37HisAsp: 1.37 ± 0.053
1.207HisGlu: 1.207 ± 0.04
0.881HisPhe: 0.881 ± 0.033
1.4HisGly: 1.4 ± 0.053
0.519HisHis: 0.519 ± 0.031
1.104HisIle: 1.104 ± 0.045
0.741HisLys: 0.741 ± 0.031
1.75HisLeu: 1.75 ± 0.054
0.543HisMet: 0.543 ± 0.025
0.801HisAsn: 0.801 ± 0.03
0.876HisPro: 0.876 ± 0.036
0.924HisGln: 0.924 ± 0.042
0.841HisArg: 0.841 ± 0.033
0.803HisSer: 0.803 ± 0.031
1.075HisThr: 1.075 ± 0.042
1.463HisVal: 1.463 ± 0.045
0.264HisTrp: 0.264 ± 0.019
0.779HisTyr: 0.779 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.978IleAla: 6.978 ± 0.115
0.086IleCys: 0.086 ± 0.012
3.913IleAsp: 3.913 ± 0.083
3.025IleGlu: 3.025 ± 0.066
2.536IlePhe: 2.536 ± 0.07
4.909IleGly: 4.909 ± 0.101
0.998IleHis: 0.998 ± 0.04
3.769IleIle: 3.769 ± 0.095
3.104IleLys: 3.104 ± 0.06
5.44IleLeu: 5.44 ± 0.126
1.663IleMet: 1.663 ± 0.055
2.855IleAsn: 2.855 ± 0.062
2.159IlePro: 2.159 ± 0.059
2.277IleGln: 2.277 ± 0.06
2.259IleArg: 2.259 ± 0.068
3.547IleSer: 3.547 ± 0.081
4.113IleThr: 4.113 ± 0.074
5.074IleVal: 5.074 ± 0.106
0.722IleTrp: 0.722 ± 0.036
1.733IleTyr: 1.733 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.699LysAla: 4.699 ± 0.115
0.033LysCys: 0.033 ± 0.008
2.679LysAsp: 2.679 ± 0.073
2.545LysGlu: 2.545 ± 0.072
1.714LysPhe: 1.714 ± 0.049
2.576LysGly: 2.576 ± 0.073
0.951LysHis: 0.951 ± 0.04
3.005LysIle: 3.005 ± 0.069
3.045LysLys: 3.045 ± 0.081
4.649LysLeu: 4.649 ± 0.099
1.956LysMet: 1.956 ± 0.058
2.355LysAsn: 2.355 ± 0.085
1.82LysPro: 1.82 ± 0.051
2.779LysGln: 2.779 ± 0.067
2.608LysArg: 2.608 ± 0.064
2.998LysSer: 2.998 ± 0.09
3.759LysThr: 3.759 ± 0.09
3.64LysVal: 3.64 ± 0.082
0.582LysTrp: 0.582 ± 0.027
1.697LysTyr: 1.697 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.662LeuAla: 10.662 ± 0.168
0.104LeuCys: 0.104 ± 0.012
5.141LeuAsp: 5.141 ± 0.093
3.979LeuGlu: 3.979 ± 0.084
3.753LeuPhe: 3.753 ± 0.099
6.551LeuGly: 6.551 ± 0.118
1.799LeuHis: 1.799 ± 0.051
5.742LeuIle: 5.742 ± 0.126
4.232LeuLys: 4.232 ± 0.088
8.777LeuLeu: 8.777 ± 0.204
2.752LeuMet: 2.752 ± 0.084
4.009LeuAsn: 4.009 ± 0.092
4.302LeuPro: 4.302 ± 0.088
4.383LeuGln: 4.383 ± 0.102
4.086LeuArg: 4.086 ± 0.084
5.609LeuSer: 5.609 ± 0.108
7.511LeuThr: 7.511 ± 0.129
7.349LeuVal: 7.349 ± 0.126
0.936LeuTrp: 0.936 ± 0.042
2.483LeuTyr: 2.483 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
3.451MetAla: 3.451 ± 0.081
0.04MetCys: 0.04 ± 0.008
1.408MetAsp: 1.408 ± 0.052
0.955MetGlu: 0.955 ± 0.041
1.061MetPhe: 1.061 ± 0.046
1.949MetGly: 1.949 ± 0.063
0.48MetHis: 0.48 ± 0.027
1.909MetIle: 1.909 ± 0.065
1.538MetLys: 1.538 ± 0.054
2.691MetLeu: 2.691 ± 0.068
1.079MetMet: 1.079 ± 0.039
1.358MetAsn: 1.358 ± 0.044
1.347MetPro: 1.347 ± 0.044
1.374MetGln: 1.374 ± 0.05
1.284MetArg: 1.284 ± 0.044
1.774MetSer: 1.774 ± 0.047
2.682MetThr: 2.682 ± 0.057
2.196MetVal: 2.196 ± 0.063
0.262MetTrp: 0.262 ± 0.021
0.751MetTyr: 0.751 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
4.067AsnAla: 4.067 ± 0.102
0.056AsnCys: 0.056 ± 0.01
2.739AsnAsp: 2.739 ± 0.068
2.469AsnGlu: 2.469 ± 0.065
1.69AsnPhe: 1.69 ± 0.047
3.623AsnGly: 3.623 ± 0.1
0.954AsnHis: 0.954 ± 0.041
2.309AsnIle: 2.309 ± 0.059
2.24AsnLys: 2.24 ± 0.075
3.6AsnLeu: 3.6 ± 0.068
1.268AsnMet: 1.268 ± 0.043
1.972AsnAsn: 1.972 ± 0.069
2.23AsnPro: 2.23 ± 0.07
2.237AsnGln: 2.237 ± 0.066
1.95AsnArg: 1.95 ± 0.057
1.976AsnSer: 1.976 ± 0.076
2.44AsnThr: 2.44 ± 0.066
3.344AsnVal: 3.344 ± 0.076
0.602AsnTrp: 0.602 ± 0.031
1.578AsnTyr: 1.578 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.966ProAla: 3.966 ± 0.086
0.04ProCys: 0.04 ± 0.008
2.479ProAsp: 2.479 ± 0.077
2.742ProGlu: 2.742 ± 0.072
1.57ProPhe: 1.57 ± 0.055
2.479ProGly: 2.479 ± 0.073
0.565ProHis: 0.565 ± 0.028
2.226ProIle: 2.226 ± 0.065
1.927ProLys: 1.927 ± 0.06
3.067ProLeu: 3.067 ± 0.079
0.968ProMet: 0.968 ± 0.043
1.727ProAsn: 1.727 ± 0.057
0.462ProPro: 0.462 ± 0.03
1.327ProGln: 1.327 ± 0.04
1.212ProArg: 1.212 ± 0.043
1.919ProSer: 1.919 ± 0.068
2.805ProThr: 2.805 ± 0.097
3.468ProVal: 3.468 ± 0.081
0.397ProTrp: 0.397 ± 0.025
1.222ProTyr: 1.222 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.107GlnAla: 5.107 ± 0.152
0.043GlnCys: 0.043 ± 0.007
2.247GlnAsp: 2.247 ± 0.083
2.089GlnGlu: 2.089 ± 0.063
1.673GlnPhe: 1.673 ± 0.052
2.486GlnGly: 2.486 ± 0.066
1.021GlnHis: 1.021 ± 0.04
2.563GlnIle: 2.563 ± 0.073
2.06GlnLys: 2.06 ± 0.061
4.817GlnLeu: 4.817 ± 0.116
1.262GlnMet: 1.262 ± 0.045
1.896GlnAsn: 1.896 ± 0.053
1.844GlnPro: 1.844 ± 0.049
2.786GlnGln: 2.786 ± 0.093
2.217GlnArg: 2.217 ± 0.063
2.333GlnSer: 2.333 ± 0.075
3.444GlnThr: 3.444 ± 0.105
3.551GlnVal: 3.551 ± 0.085
0.46GlnTrp: 0.46 ± 0.028
1.423GlnTyr: 1.423 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.371ArgAla: 3.371 ± 0.076
0.073ArgCys: 0.073 ± 0.011
2.681ArgAsp: 2.681 ± 0.077
2.892ArgGlu: 2.892 ± 0.07
2.003ArgPhe: 2.003 ± 0.054
2.538ArgGly: 2.538 ± 0.073
1.035ArgHis: 1.035 ± 0.038
2.408ArgIle: 2.408 ± 0.063
1.933ArgLys: 1.933 ± 0.052
4.385ArgLeu: 4.385 ± 0.092
1.248ArgMet: 1.248 ± 0.04
1.647ArgAsn: 1.647 ± 0.058
1.415ArgPro: 1.415 ± 0.046
2.349ArgGln: 2.349 ± 0.06
2.392ArgArg: 2.392 ± 0.069
1.944ArgSer: 1.944 ± 0.054
2.33ArgThr: 2.33 ± 0.056
3.124ArgVal: 3.124 ± 0.076
0.556ArgTrp: 0.556 ± 0.031
1.726ArgTyr: 1.726 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.418SerAla: 5.418 ± 0.164
0.059SerCys: 0.059 ± 0.01
3.58SerAsp: 3.58 ± 0.087
3.032SerGlu: 3.032 ± 0.077
2.383SerPhe: 2.383 ± 0.066
4.302SerGly: 4.302 ± 0.087
1.105SerHis: 1.105 ± 0.041
3.049SerIle: 3.049 ± 0.069
2.449SerLys: 2.449 ± 0.078
5.221SerLeu: 5.221 ± 0.106
1.408SerMet: 1.408 ± 0.05
2.246SerAsn: 2.246 ± 0.066
1.75SerPro: 1.75 ± 0.063
2.297SerGln: 2.297 ± 0.072
2.152SerArg: 2.152 ± 0.067
3.428SerSer: 3.428 ± 0.137
3.321SerThr: 3.321 ± 0.087
4.455SerVal: 4.455 ± 0.094
0.659SerTrp: 0.659 ± 0.035
1.903SerTyr: 1.903 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
7.344ThrAla: 7.344 ± 0.217
0.094ThrCys: 0.094 ± 0.014
4.834ThrAsp: 4.834 ± 0.154
3.314ThrGlu: 3.314 ± 0.074
2.796ThrPhe: 2.796 ± 0.079
5.143ThrGly: 5.143 ± 0.115
1.248ThrHis: 1.248 ± 0.043
4.459ThrIle: 4.459 ± 0.088
3.347ThrLys: 3.347 ± 0.072
6.545ThrLeu: 6.545 ± 0.119
1.73ThrMet: 1.73 ± 0.052
2.914ThrAsn: 2.914 ± 0.09
3.368ThrPro: 3.368 ± 0.096
2.778ThrGln: 2.778 ± 0.077
2.33ThrArg: 2.33 ± 0.064
3.883ThrSer: 3.883 ± 0.098
5.614ThrThr: 5.614 ± 0.174
6.162ThrVal: 6.162 ± 0.176
0.732ThrTrp: 0.732 ± 0.034
2.519ThrTyr: 2.519 ± 0.098
0.0ThrXaa: 0.0 ± 0.0
Val
9.181ValAla: 9.181 ± 0.171
0.119ValCys: 0.119 ± 0.014
4.857ValAsp: 4.857 ± 0.101
3.573ValGlu: 3.573 ± 0.097
2.949ValPhe: 2.949 ± 0.076
5.27ValGly: 5.27 ± 0.103
1.281ValHis: 1.281 ± 0.043
5.285ValIle: 5.285 ± 0.092
4.035ValLys: 4.035 ± 0.096
7.377ValLeu: 7.377 ± 0.135
2.362ValMet: 2.362 ± 0.069
3.361ValAsn: 3.361 ± 0.079
3.42ValPro: 3.42 ± 0.09
3.018ValGln: 3.018 ± 0.07
3.039ValArg: 3.039 ± 0.063
4.742ValSer: 4.742 ± 0.101
6.505ValThr: 6.505 ± 0.179
6.865ValVal: 6.865 ± 0.129
0.823ValTrp: 0.823 ± 0.039
2.333ValTyr: 2.333 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.826TrpAla: 0.826 ± 0.037
0.017TrpCys: 0.017 ± 0.005
0.526TrpAsp: 0.526 ± 0.03
0.435TrpGlu: 0.435 ± 0.023
0.608TrpPhe: 0.608 ± 0.035
0.791TrpGly: 0.791 ± 0.035
0.397TrpHis: 0.397 ± 0.023
0.643TrpIle: 0.643 ± 0.031
0.264TrpLys: 0.264 ± 0.021
1.511TrpLeu: 1.511 ± 0.061
0.36TrpMet: 0.36 ± 0.022
0.419TrpAsn: 0.419 ± 0.024
0.415TrpPro: 0.415 ± 0.028
0.879TrpGln: 0.879 ± 0.041
0.738TrpArg: 0.738 ± 0.038
0.726TrpSer: 0.726 ± 0.032
0.683TrpThr: 0.683 ± 0.033
0.872TrpVal: 0.872 ± 0.043
0.204TrpTrp: 0.204 ± 0.017
0.4TrpTyr: 0.4 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.818TyrAla: 2.818 ± 0.071
0.037TyrCys: 0.037 ± 0.008
2.156TyrAsp: 2.156 ± 0.057
1.86TyrGlu: 1.86 ± 0.053
1.565TyrPhe: 1.565 ± 0.053
2.35TyrGly: 2.35 ± 0.058
0.712TyrHis: 0.712 ± 0.033
1.693TyrIle: 1.693 ± 0.047
1.495TyrLys: 1.495 ± 0.047
3.327TyrLeu: 3.327 ± 0.078
0.872TyrMet: 0.872 ± 0.036
1.4TyrAsn: 1.4 ± 0.049
1.261TyrPro: 1.261 ± 0.056
1.676TyrGln: 1.676 ± 0.062
1.683TyrArg: 1.683 ± 0.054
1.554TyrSer: 1.554 ± 0.063
2.287TyrThr: 2.287 ± 0.115
2.458TyrVal: 2.458 ± 0.07
0.435TyrTrp: 0.435 ± 0.027
1.334TyrTyr: 1.334 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2282 proteins (699463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski