Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-4513 (FW-928)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.121AlaAla: 10.121 ± 0.094	1.038AlaCys: 1.038 ± 0.017	4.513AlaAsp: 4.513 ± 0.031	5.567AlaGlu: 5.567 ± 0.06	3.112AlaPhe: 3.112 ± 0.029	6.215AlaGly: 6.215 ± 0.044	1.709AlaHis: 1.709 ± 0.017	4.494AlaIle: 4.494 ± 0.036	4.494AlaLys: 4.494 ± 0.043	7.788AlaLeu: 7.788 ± 0.049	2.004AlaMet: 2.004 ± 0.019	3.128AlaAsn: 3.128 ± 0.028	5.183AlaPro: 5.183 ± 0.058	3.414AlaGln: 3.414 ± 0.036	4.839AlaArg: 4.839 ± 0.04	7.246AlaSer: 7.246 ± 0.049	5.65AlaThr: 5.65 ± 0.033	5.636AlaVal: 5.636 ± 0.041	1.137AlaTrp: 1.137 ± 0.018	2.182AlaTyr: 2.182 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.92CysAla: 0.92 ± 0.015	0.225CysCys: 0.225 ± 0.009	0.649CysAsp: 0.649 ± 0.014	0.583CysGlu: 0.583 ± 0.012	0.494CysPhe: 0.494 ± 0.011	0.968CysGly: 0.968 ± 0.018	0.294CysHis: 0.294 ± 0.008	0.669CysIle: 0.669 ± 0.012	0.496CysLys: 0.496 ± 0.012	1.129CysLeu: 1.129 ± 0.018	0.267CysMet: 0.267 ± 0.007	0.409CysAsn: 0.409 ± 0.01	0.602CysPro: 0.602 ± 0.013	0.399CysGln: 0.399 ± 0.011	0.651CysArg: 0.651 ± 0.013	0.828CysSer: 0.828 ± 0.016	0.676CysThr: 0.676 ± 0.014	0.722CysVal: 0.722 ± 0.012	0.189CysTrp: 0.189 ± 0.007	0.338CysTyr: 0.338 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.976AspAla: 4.976 ± 0.039	0.583AspCys: 0.583 ± 0.013	4.329AspAsp: 4.329 ± 0.039	4.728AspGlu: 4.728 ± 0.045	2.209AspPhe: 2.209 ± 0.023	4.4AspGly: 4.4 ± 0.04	1.119AspHis: 1.119 ± 0.016	3.209AspIle: 3.209 ± 0.028	2.527AspLys: 2.527 ± 0.031	4.936AspLeu: 4.936 ± 0.044	1.258AspMet: 1.258 ± 0.016	2.061AspAsn: 2.061 ± 0.03	3.093AspPro: 3.093 ± 0.023	1.727AspGln: 1.727 ± 0.022	2.849AspArg: 2.849 ± 0.03	4.227AspSer: 4.227 ± 0.038	3.036AspThr: 3.036 ± 0.029	3.813AspVal: 3.813 ± 0.03	0.83AspTrp: 0.83 ± 0.016	1.641AspTyr: 1.641 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.877GluAla: 5.877 ± 0.048	0.605GluCys: 0.605 ± 0.013	4.338GluAsp: 4.338 ± 0.046	5.972GluGlu: 5.972 ± 0.071	2.001GluPhe: 2.001 ± 0.022	4.395GluGly: 4.395 ± 0.036	1.276GluHis: 1.276 ± 0.017	3.188GluIle: 3.188 ± 0.033	3.954GluLys: 3.954 ± 0.041	5.211GluLeu: 5.211 ± 0.04	1.543GluMet: 1.543 ± 0.019	2.33GluAsn: 2.33 ± 0.026	2.768GluPro: 2.768 ± 0.048	2.327GluGln: 2.327 ± 0.03	3.943GluArg: 3.943 ± 0.04	4.391GluSer: 4.391 ± 0.035	3.505GluThr: 3.505 ± 0.031	3.887GluVal: 3.887 ± 0.039	0.886GluTrp: 0.886 ± 0.015	1.708GluTyr: 1.708 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.04PheAla: 3.04 ± 0.031	0.515PheCys: 0.515 ± 0.011	2.201PheAsp: 2.201 ± 0.024	2.162PheGlu: 2.162 ± 0.022	1.513PhePhe: 1.513 ± 0.022	2.932PheGly: 2.932 ± 0.034	0.815PheHis: 0.815 ± 0.015	1.802PheIle: 1.802 ± 0.022	1.594PheLys: 1.594 ± 0.017	3.22PheLeu: 3.22 ± 0.032	0.794PheMet: 0.794 ± 0.015	1.41PheAsn: 1.41 ± 0.021	1.839PhePro: 1.839 ± 0.024	1.346PheGln: 1.346 ± 0.018	1.773PheArg: 1.773 ± 0.019	2.862PheSer: 2.862 ± 0.027	2.142PheThr: 2.142 ± 0.024	2.35PheVal: 2.35 ± 0.024	0.6PheTrp: 0.6 ± 0.013	1.084PheTyr: 1.084 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.979GlyAla: 5.979 ± 0.042	0.89GlyCys: 0.89 ± 0.016	3.973GlyAsp: 3.973 ± 0.036	4.251GlyGlu: 4.251 ± 0.039	2.838GlyPhe: 2.838 ± 0.028	6.766GlyGly: 6.766 ± 0.07	1.691GlyHis: 1.691 ± 0.024	3.662GlyIle: 3.662 ± 0.035	3.896GlyLys: 3.896 ± 0.034	6.08GlyLeu: 6.08 ± 0.044	1.685GlyMet: 1.685 ± 0.024	2.75GlyAsn: 2.75 ± 0.031	3.352GlyPro: 3.352 ± 0.032	2.612GlyGln: 2.612 ± 0.029	4.184GlyArg: 4.184 ± 0.039	5.882GlySer: 5.882 ± 0.046	4.112GlyThr: 4.112 ± 0.036	4.735GlyVal: 4.735 ± 0.041	1.189GlyTrp: 1.189 ± 0.021	2.164GlyTyr: 2.164 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.74HisAla: 1.74 ± 0.021	0.289HisCys: 0.289 ± 0.008	1.228HisAsp: 1.228 ± 0.017	1.235HisGlu: 1.235 ± 0.017	0.864HisPhe: 0.864 ± 0.015	1.671HisGly: 1.671 ± 0.018	0.713HisHis: 0.713 ± 0.015	1.203HisIle: 1.203 ± 0.017	0.923HisLys: 0.923 ± 0.017	2.035HisLeu: 2.035 ± 0.022	0.443HisMet: 0.443 ± 0.012	0.848HisAsn: 0.848 ± 0.015	1.508HisPro: 1.508 ± 0.021	0.882HisGln: 0.882 ± 0.016	1.337HisArg: 1.337 ± 0.02	1.682HisSer: 1.682 ± 0.022	1.235HisThr: 1.235 ± 0.02	1.336HisVal: 1.336 ± 0.019	0.307HisTrp: 0.307 ± 0.008	0.662HisTyr: 0.662 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.402IleAla: 4.402 ± 0.039	0.722IleCys: 0.722 ± 0.014	2.983IleAsp: 2.983 ± 0.026	3.017IleGlu: 3.017 ± 0.025	1.994IlePhe: 1.994 ± 0.025	3.356IleGly: 3.356 ± 0.034	1.119IleHis: 1.119 ± 0.016	2.651IleIle: 2.651 ± 0.027	2.366IleLys: 2.366 ± 0.024	4.477IleLeu: 4.477 ± 0.036	1.05IleMet: 1.05 ± 0.017	1.894IleAsn: 1.894 ± 0.022	3.014IlePro: 3.014 ± 0.023	1.837IleGln: 1.837 ± 0.021	2.731IleArg: 2.731 ± 0.027	3.989IleSer: 3.989 ± 0.032	2.994IleThr: 2.994 ± 0.027	3.227IleVal: 3.227 ± 0.033	0.702IleTrp: 0.702 ± 0.012	1.436IleTyr: 1.436 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.686LysAla: 4.686 ± 0.045	0.501LysCys: 0.501 ± 0.011	2.951LysAsp: 2.951 ± 0.033	3.696LysGlu: 3.696 ± 0.041	1.553LysPhe: 1.553 ± 0.019	3.352LysGly: 3.352 ± 0.031	1.111LysHis: 1.111 ± 0.017	2.393LysIle: 2.393 ± 0.024	3.581LysLys: 3.581 ± 0.056	4.275LysLeu: 4.275 ± 0.035	1.062LysMet: 1.062 ± 0.019	1.874LysAsn: 1.874 ± 0.023	2.814LysPro: 2.814 ± 0.029	1.809LysGln: 1.809 ± 0.021	3.415LysArg: 3.415 ± 0.032	3.762LysSer: 3.762 ± 0.034	3.006LysThr: 3.006 ± 0.03	3.078LysVal: 3.078 ± 0.027	0.708LysTrp: 0.708 ± 0.013	1.434LysTyr: 1.434 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.779LeuAla: 7.779 ± 0.048	1.107LeuCys: 1.107 ± 0.017	5.043LeuAsp: 5.043 ± 0.041	5.451LeuGlu: 5.451 ± 0.043	3.157LeuPhe: 3.157 ± 0.029	5.968LeuGly: 5.968 ± 0.045	2.05LeuHis: 2.05 ± 0.021	3.926LeuIle: 3.926 ± 0.036	4.403LeuLys: 4.403 ± 0.033	8.169LeuLeu: 8.169 ± 0.07	1.71LeuMet: 1.71 ± 0.022	3.122LeuAsn: 3.122 ± 0.03	5.291LeuPro: 5.291 ± 0.042	3.613LeuGln: 3.613 ± 0.036	5.363LeuArg: 5.363 ± 0.039	7.112LeuSer: 7.112 ± 0.044	4.762LeuThr: 4.762 ± 0.034	5.259LeuVal: 5.259 ± 0.043	1.164LeuTrp: 1.164 ± 0.018	2.294LeuTyr: 2.294 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.235MetAla: 2.235 ± 0.025	0.232MetCys: 0.232 ± 0.007	1.279MetAsp: 1.279 ± 0.021	1.362MetGlu: 1.362 ± 0.018	0.734MetPhe: 0.734 ± 0.012	1.571MetGly: 1.571 ± 0.022	0.463MetHis: 0.463 ± 0.011	0.951MetIle: 0.951 ± 0.015	1.068MetLys: 1.068 ± 0.018	1.821MetLeu: 1.821 ± 0.021	0.566MetMet: 0.566 ± 0.013	0.79MetAsn: 0.79 ± 0.014	1.2MetPro: 1.2 ± 0.018	0.812MetGln: 0.812 ± 0.014	1.256MetArg: 1.256 ± 0.02	1.859MetSer: 1.859 ± 0.023	1.214MetThr: 1.214 ± 0.017	1.339MetVal: 1.339 ± 0.017	0.256MetTrp: 0.256 ± 0.007	0.522MetTyr: 0.522 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.263AsnAla: 3.263 ± 0.03	0.441AsnCys: 0.441 ± 0.01	2.043AsnAsp: 2.043 ± 0.031	2.086AsnGlu: 2.086 ± 0.023	1.421AsnPhe: 1.421 ± 0.019	3.228AsnGly: 3.228 ± 0.035	0.812AsnHis: 0.812 ± 0.014	2.159AsnIle: 2.159 ± 0.02	1.669AsnLys: 1.669 ± 0.02	3.211AsnLeu: 3.211 ± 0.025	0.857AsnMet: 0.857 ± 0.014	1.587AsnAsn: 1.587 ± 0.023	2.413AsnPro: 2.413 ± 0.024	1.303AsnGln: 1.303 ± 0.02	1.899AsnArg: 1.899 ± 0.02	2.893AsnSer: 2.893 ± 0.029	2.238AsnThr: 2.238 ± 0.024	2.336AsnVal: 2.336 ± 0.026	0.564AsnTrp: 0.564 ± 0.012	1.103AsnTyr: 1.103 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.292ProAla: 5.292 ± 0.05	0.457ProCys: 0.457 ± 0.011	3.021ProAsp: 3.021 ± 0.031	3.728ProGlu: 3.728 ± 0.042	1.908ProPhe: 1.908 ± 0.022	3.886ProGly: 3.886 ± 0.037	1.236ProHis: 1.236 ± 0.019	2.595ProIle: 2.595 ± 0.027	2.843ProLys: 2.843 ± 0.029	4.63ProLeu: 4.63 ± 0.036	1.025ProMet: 1.025 ± 0.016	2.2ProAsn: 2.2 ± 0.022	4.85ProPro: 4.85 ± 0.078	2.422ProGln: 2.422 ± 0.037	3.251ProArg: 3.251 ± 0.037	5.649ProSer: 5.649 ± 0.054	4.12ProThr: 4.12 ± 0.042	3.541ProVal: 3.541 ± 0.036	0.688ProTrp: 0.688 ± 0.014	1.478ProTyr: 1.478 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.326GlnAla: 3.326 ± 0.034	0.398GlnCys: 0.398 ± 0.01	1.949GlnAsp: 1.949 ± 0.022	2.279GlnGlu: 2.279 ± 0.027	1.248GlnPhe: 1.248 ± 0.019	2.487GlnGly: 2.487 ± 0.029	0.953GlnHis: 0.953 ± 0.016	1.831GlnIle: 1.831 ± 0.018	1.987GlnLys: 1.987 ± 0.022	3.311GlnLeu: 3.311 ± 0.03	0.84GlnMet: 0.84 ± 0.016	1.562GlnAsn: 1.562 ± 0.023	2.391GlnPro: 2.391 ± 0.035	2.412GlnGln: 2.412 ± 0.069	2.466GlnArg: 2.466 ± 0.027	2.944GlnSer: 2.944 ± 0.031	2.226GlnThr: 2.226 ± 0.024	2.075GlnVal: 2.075 ± 0.022	0.535GlnTrp: 0.535 ± 0.01	1.166GlnTyr: 1.166 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.66ArgAla: 4.66 ± 0.038	0.649ArgCys: 0.649 ± 0.011	3.306ArgAsp: 3.306 ± 0.036	3.834ArgGlu: 3.834 ± 0.038	1.912ArgPhe: 1.912 ± 0.025	3.904ArgGly: 3.904 ± 0.039	1.43ArgHis: 1.43 ± 0.019	2.808ArgIle: 2.808 ± 0.026	3.357ArgLys: 3.357 ± 0.03	5.047ArgLeu: 5.047 ± 0.04	1.245ArgMet: 1.245 ± 0.016	2.215ArgAsn: 2.215 ± 0.024	3.232ArgPro: 3.232 ± 0.036	2.474ArgGln: 2.474 ± 0.031	4.753ArgArg: 4.753 ± 0.045	4.435ArgSer: 4.435 ± 0.038	3.134ArgThr: 3.134 ± 0.024	3.27ArgVal: 3.27 ± 0.027	0.847ArgTrp: 0.847 ± 0.019	1.51ArgTyr: 1.51 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.738SerAla: 6.738 ± 0.048	0.817SerCys: 0.817 ± 0.017	4.32SerAsp: 4.32 ± 0.037	4.192SerGlu: 4.192 ± 0.036	2.867SerPhe: 2.867 ± 0.027	5.833SerGly: 5.833 ± 0.046	1.802SerHis: 1.802 ± 0.02	4.079SerIle: 4.079 ± 0.034	3.959SerLys: 3.959 ± 0.037	6.965SerLeu: 6.965 ± 0.042	1.696SerMet: 1.696 ± 0.024	3.094SerAsn: 3.094 ± 0.028	5.358SerPro: 5.358 ± 0.052	3.114SerGln: 3.114 ± 0.034	4.68SerArg: 4.68 ± 0.04	8.168SerSer: 8.168 ± 0.072	5.493SerThr: 5.493 ± 0.044	4.527SerVal: 4.527 ± 0.036	1.059SerTrp: 1.059 ± 0.018	2.096SerTyr: 2.096 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.377ThrAla: 5.377 ± 0.041	0.708ThrCys: 0.708 ± 0.015	2.936ThrAsp: 2.936 ± 0.026	3.282ThrGlu: 3.282 ± 0.026	2.181ThrPhe: 2.181 ± 0.028	4.333ThrGly: 4.333 ± 0.036	1.256ThrHis: 1.256 ± 0.019	3.185ThrIle: 3.185 ± 0.031	2.835ThrLys: 2.835 ± 0.03	5.162ThrLeu: 5.162 ± 0.044	1.218ThrMet: 1.218 ± 0.017	2.193ThrAsn: 2.193 ± 0.025	4.396ThrPro: 4.396 ± 0.051	2.059ThrGln: 2.059 ± 0.026	2.973ThrArg: 2.973 ± 0.028	5.272ThrSer: 5.272 ± 0.039	4.48ThrThr: 4.48 ± 0.047	3.805ThrVal: 3.805 ± 0.036	0.827ThrTrp: 0.827 ± 0.014	1.653ThrTyr: 1.653 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.726ValAla: 5.726 ± 0.04	0.766ValCys: 0.766 ± 0.013	3.9ValAsp: 3.9 ± 0.029	4.245ValGlu: 4.245 ± 0.033	2.325ValPhe: 2.325 ± 0.026	4.326ValGly: 4.326 ± 0.039	1.281ValHis: 1.281 ± 0.018	2.984ValIle: 2.984 ± 0.03	3.142ValLys: 3.142 ± 0.028	5.475ValLeu: 5.475 ± 0.044	1.328ValMet: 1.328 ± 0.018	2.259ValAsn: 2.259 ± 0.024	3.496ValPro: 3.496 ± 0.031	2.263ValGln: 2.263 ± 0.024	3.287ValArg: 3.287 ± 0.028	4.538ValSer: 4.538 ± 0.032	3.544ValThr: 3.544 ± 0.031	4.575ValVal: 4.575 ± 0.038	0.845ValTrp: 0.845 ± 0.014	1.691ValTyr: 1.691 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.185TrpAla: 1.185 ± 0.017	0.175TrpCys: 0.175 ± 0.007	0.905TrpAsp: 0.905 ± 0.016	0.864TrpGlu: 0.864 ± 0.015	0.499TrpPhe: 0.499 ± 0.012	0.975TrpGly: 0.975 ± 0.019	0.322TrpHis: 0.322 ± 0.01	0.72TrpIle: 0.72 ± 0.013	0.774TrpLys: 0.774 ± 0.015	1.237TrpLeu: 1.237 ± 0.016	0.352TrpMet: 0.352 ± 0.008	0.6TrpAsn: 0.6 ± 0.012	0.579TrpPro: 0.579 ± 0.012	0.506TrpGln: 0.506 ± 0.012	0.862TrpArg: 0.862 ± 0.016	1.006TrpSer: 1.006 ± 0.016	0.891TrpThr: 0.891 ± 0.017	0.895TrpVal: 0.895 ± 0.014	0.263TrpTrp: 0.263 ± 0.008	0.406TrpTyr: 0.406 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.147TyrAla: 2.147 ± 0.026	0.392TyrCys: 0.392 ± 0.01	1.686TyrAsp: 1.686 ± 0.02	1.573TyrGlu: 1.573 ± 0.02	1.166TyrPhe: 1.166 ± 0.019	2.125TyrGly: 2.125 ± 0.024	0.69TyrHis: 0.69 ± 0.013	1.452TyrIle: 1.452 ± 0.017	1.195TyrLys: 1.195 ± 0.016	2.56TyrLeu: 2.56 ± 0.026	0.586TyrMet: 0.586 ± 0.012	1.2TyrAsn: 1.2 ± 0.015	1.438TyrPro: 1.438 ± 0.019	1.056TyrGln: 1.056 ± 0.016	1.512TyrArg: 1.512 ± 0.018	2.109TyrSer: 2.109 ± 0.027	1.672TyrThr: 1.672 ± 0.018	1.592TyrVal: 1.592 ± 0.021	0.419TyrTrp: 0.419 ± 0.01	0.927TyrTyr: 0.927 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8667 proteins (4433224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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