Amino acid dipepetide frequency for Wheat leaf yellowing-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.995AlaAla: 4.995 ± 0.821
0.333AlaCys: 0.333 ± 0.25
3.663AlaAsp: 3.663 ± 0.536
2.664AlaGlu: 2.664 ± 1.248
2.664AlaPhe: 2.664 ± 0.408
3.996AlaGly: 3.996 ± 1.043
0.666AlaHis: 0.666 ± 0.377
1.665AlaIle: 1.665 ± 0.847
3.996AlaLys: 3.996 ± 0.989
6.66AlaLeu: 6.66 ± 0.885
0.999AlaMet: 0.999 ± 0.408
2.664AlaAsn: 2.664 ± 1.269
6.66AlaPro: 6.66 ± 1.14
1.665AlaGln: 1.665 ± 0.645
3.996AlaArg: 3.996 ± 0.697
5.994AlaSer: 5.994 ± 1.012
4.662AlaThr: 4.662 ± 0.967
4.662AlaVal: 4.662 ± 0.421
0.333AlaTrp: 0.333 ± 0.25
3.996AlaTyr: 3.996 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
2.331CysAla: 2.331 ± 0.823
0.666CysCys: 0.666 ± 0.269
0.666CysAsp: 0.666 ± 0.5
0.666CysGlu: 0.666 ± 0.455
0.0CysPhe: 0.0 ± 0.0
1.998CysGly: 1.998 ± 0.857
0.0CysHis: 0.0 ± 0.0
0.333CysIle: 0.333 ± 0.25
0.999CysLys: 0.999 ± 0.408
1.998CysLeu: 1.998 ± 0.676
0.0CysMet: 0.0 ± 0.0
0.666CysAsn: 0.666 ± 0.299
0.0CysPro: 0.0 ± 0.0
0.999CysGln: 0.999 ± 0.434
0.666CysArg: 0.666 ± 0.518
3.663CysSer: 3.663 ± 0.762
0.999CysThr: 0.999 ± 0.459
0.666CysVal: 0.666 ± 0.269
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.331AspAla: 2.331 ± 0.623
0.333AspCys: 0.333 ± 0.25
2.997AspAsp: 2.997 ± 0.945
2.664AspGlu: 2.664 ± 1.25
1.332AspPhe: 1.332 ± 0.625
3.996AspGly: 3.996 ± 0.962
1.665AspHis: 1.665 ± 0.558
1.665AspIle: 1.665 ± 0.737
2.331AspLys: 2.331 ± 0.955
3.996AspLeu: 3.996 ± 0.736
1.332AspMet: 1.332 ± 0.538
0.666AspAsn: 0.666 ± 0.683
2.331AspPro: 2.331 ± 0.953
2.664AspGln: 2.664 ± 0.746
0.999AspArg: 0.999 ± 0.75
4.329AspSer: 4.329 ± 0.834
1.998AspThr: 1.998 ± 0.589
1.665AspVal: 1.665 ± 0.689
1.665AspTrp: 1.665 ± 1.25
0.333AspTyr: 0.333 ± 0.484
0.0AspXaa: 0.0 ± 0.0
Glu
1.665GluAla: 1.665 ± 0.364
1.665GluCys: 1.665 ± 0.618
3.996GluAsp: 3.996 ± 0.705
7.326GluGlu: 7.326 ± 2.317
2.331GluPhe: 2.331 ± 1.022
3.663GluGly: 3.663 ± 0.993
1.665GluHis: 1.665 ± 0.81
4.329GluIle: 4.329 ± 1.521
3.663GluLys: 3.663 ± 1.095
4.995GluLeu: 4.995 ± 1.57
1.665GluMet: 1.665 ± 0.377
0.333GluAsn: 0.333 ± 0.32
1.998GluPro: 1.998 ± 0.897
3.33GluGln: 3.33 ± 1.468
1.998GluArg: 1.998 ± 0.991
5.661GluSer: 5.661 ± 0.782
1.332GluThr: 1.332 ± 0.555
4.329GluVal: 4.329 ± 1.178
1.332GluTrp: 1.332 ± 0.271
3.663GluTyr: 3.663 ± 1.243
0.0GluXaa: 0.0 ± 0.0
Phe
0.333PheAla: 0.333 ± 0.305
0.999PheCys: 0.999 ± 0.408
0.666PheAsp: 0.666 ± 0.405
1.998PheGlu: 1.998 ± 0.347
0.666PhePhe: 0.666 ± 0.299
3.996PheGly: 3.996 ± 0.469
0.666PheHis: 0.666 ± 0.402
1.665PheIle: 1.665 ± 0.618
2.331PheLys: 2.331 ± 1.121
2.331PheLeu: 2.331 ± 0.691
0.999PheMet: 0.999 ± 0.398
1.332PheAsn: 1.332 ± 0.397
1.332PhePro: 1.332 ± 1.035
2.997PheGln: 2.997 ± 0.426
0.666PheArg: 0.666 ± 0.405
1.665PheSer: 1.665 ± 0.648
4.662PheThr: 4.662 ± 0.746
2.664PheVal: 2.664 ± 1.009
0.999PheTrp: 0.999 ± 0.732
0.999PheTyr: 0.999 ± 0.68
0.0PheXaa: 0.0 ± 0.0
Gly
5.661GlyAla: 5.661 ± 0.759
1.332GlyCys: 1.332 ± 0.555
3.33GlyAsp: 3.33 ± 0.478
4.329GlyGlu: 4.329 ± 1.595
4.329GlyPhe: 4.329 ± 1.187
7.659GlyGly: 7.659 ± 4.084
0.999GlyHis: 0.999 ± 0.213
2.331GlyIle: 2.331 ± 0.847
4.662GlyLys: 4.662 ± 0.446
2.664GlyLeu: 2.664 ± 1.021
1.665GlyMet: 1.665 ± 0.588
3.663GlyAsn: 3.663 ± 1.341
3.996GlyPro: 3.996 ± 0.752
1.998GlyGln: 1.998 ± 0.809
2.997GlyArg: 2.997 ± 0.97
7.326GlySer: 7.326 ± 2.097
1.998GlyThr: 1.998 ± 0.452
3.33GlyVal: 3.33 ± 0.864
2.331GlyTrp: 2.331 ± 0.443
3.996GlyTyr: 3.996 ± 0.715
0.0GlyXaa: 0.0 ± 0.0
His
1.665HisAla: 1.665 ± 0.648
0.999HisCys: 0.999 ± 0.408
0.666HisAsp: 0.666 ± 0.5
1.332HisGlu: 1.332 ± 0.782
0.333HisPhe: 0.333 ± 0.341
0.333HisGly: 0.333 ± 0.305
0.666HisHis: 0.666 ± 0.455
0.0HisIle: 0.0 ± 0.0
2.664HisLys: 2.664 ± 1.383
1.998HisLeu: 1.998 ± 0.427
0.666HisMet: 0.666 ± 0.269
0.999HisAsn: 0.999 ± 0.213
1.332HisPro: 1.332 ± 0.492
0.999HisGln: 0.999 ± 0.532
0.666HisArg: 0.666 ± 0.5
2.331HisSer: 2.331 ± 1.331
0.666HisThr: 0.666 ± 0.5
0.666HisVal: 0.666 ± 0.269
0.666HisTrp: 0.666 ± 0.269
0.666HisTyr: 0.666 ± 0.405
0.0HisXaa: 0.0 ± 0.0
Ile
3.663IleAla: 3.663 ± 0.449
1.665IleCys: 1.665 ± 0.588
1.332IleAsp: 1.332 ± 0.452
1.665IleGlu: 1.665 ± 0.742
0.333IlePhe: 0.333 ± 0.341
1.665IleGly: 1.665 ± 0.734
1.665IleHis: 1.665 ± 1.069
1.998IleIle: 1.998 ± 0.857
2.331IleLys: 2.331 ± 0.899
5.328IleLeu: 5.328 ± 1.289
1.332IleMet: 1.332 ± 0.519
1.665IleAsn: 1.665 ± 0.59
4.662IlePro: 4.662 ± 1.076
1.998IleGln: 1.998 ± 0.63
3.663IleArg: 3.663 ± 0.681
3.996IleSer: 3.996 ± 0.825
4.329IleThr: 4.329 ± 0.837
1.332IleVal: 1.332 ± 0.738
0.333IleTrp: 0.333 ± 0.341
2.331IleTyr: 2.331 ± 0.856
0.0IleXaa: 0.0 ± 0.0
Lys
3.663LysAla: 3.663 ± 0.842
0.666LysCys: 0.666 ± 0.5
3.33LysAsp: 3.33 ± 1.058
3.663LysGlu: 3.663 ± 1.45
1.332LysPhe: 1.332 ± 0.544
3.996LysGly: 3.996 ± 1.078
0.666LysHis: 0.666 ± 0.269
5.328LysIle: 5.328 ± 0.531
1.665LysLys: 1.665 ± 0.757
3.996LysLeu: 3.996 ± 1.094
1.998LysMet: 1.998 ± 0.42
1.998LysAsn: 1.998 ± 1.07
6.327LysPro: 6.327 ± 1.229
2.997LysGln: 2.997 ± 0.988
1.665LysArg: 1.665 ± 0.666
5.328LysSer: 5.328 ± 1.072
4.662LysThr: 4.662 ± 0.793
3.996LysVal: 3.996 ± 1.111
0.999LysTrp: 0.999 ± 0.612
1.998LysTyr: 1.998 ± 0.377
0.333LysXaa: 0.333 ± 0.305
Leu
4.662LeuAla: 4.662 ± 1.004
2.331LeuCys: 2.331 ± 0.884
3.996LeuAsp: 3.996 ± 1.19
6.66LeuGlu: 6.66 ± 1.164
2.664LeuPhe: 2.664 ± 0.977
2.997LeuGly: 2.997 ± 0.541
0.999LeuHis: 0.999 ± 0.213
4.662LeuIle: 4.662 ± 1.279
6.327LeuLys: 6.327 ± 1.295
7.659LeuLeu: 7.659 ± 1.952
2.331LeuMet: 2.331 ± 0.619
2.997LeuAsn: 2.997 ± 0.547
3.33LeuPro: 3.33 ± 0.746
3.663LeuGln: 3.663 ± 0.776
5.661LeuArg: 5.661 ± 1.127
7.326LeuSer: 7.326 ± 0.792
4.662LeuThr: 4.662 ± 1.179
6.327LeuVal: 6.327 ± 1.408
2.997LeuTrp: 2.997 ± 1.032
4.995LeuTyr: 4.995 ± 1.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.664MetAla: 2.664 ± 0.578
0.0MetCys: 0.0 ± 0.0
1.332MetAsp: 1.332 ± 0.505
0.666MetGlu: 0.666 ± 0.423
0.666MetPhe: 0.666 ± 0.269
2.664MetGly: 2.664 ± 0.689
0.666MetHis: 0.666 ± 0.269
2.664MetIle: 2.664 ± 1.075
0.666MetLys: 0.666 ± 0.269
1.998MetLeu: 1.998 ± 0.676
0.666MetMet: 0.666 ± 0.269
0.666MetAsn: 0.666 ± 0.518
0.0MetPro: 0.0 ± 0.0
0.333MetGln: 0.333 ± 0.396
0.999MetArg: 0.999 ± 0.398
1.998MetSer: 1.998 ± 0.495
1.332MetThr: 1.332 ± 0.454
1.998MetVal: 1.998 ± 0.676
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.329AsnAla: 4.329 ± 0.637
0.0AsnCys: 0.0 ± 0.0
2.997AsnAsp: 2.997 ± 0.684
1.332AsnGlu: 1.332 ± 0.533
0.999AsnPhe: 0.999 ± 0.55
4.995AsnGly: 4.995 ± 1.115
0.0AsnHis: 0.0 ± 0.0
1.332AsnIle: 1.332 ± 0.454
1.665AsnLys: 1.665 ± 0.476
2.997AsnLeu: 2.997 ± 0.714
0.0AsnMet: 0.0 ± 0.0
2.331AsnAsn: 2.331 ± 0.624
2.331AsnPro: 2.331 ± 0.428
1.332AsnGln: 1.332 ± 0.622
3.663AsnArg: 3.663 ± 1.762
4.995AsnSer: 4.995 ± 1.298
3.33AsnThr: 3.33 ± 0.848
1.332AsnVal: 1.332 ± 0.838
0.333AsnTrp: 0.333 ± 0.305
2.664AsnTyr: 2.664 ± 0.578
0.0AsnXaa: 0.0 ± 0.0
Pro
4.662ProAla: 4.662 ± 0.968
0.666ProCys: 0.666 ± 0.5
1.998ProAsp: 1.998 ± 0.535
3.33ProGlu: 3.33 ± 0.674
1.332ProPhe: 1.332 ± 0.692
3.33ProGly: 3.33 ± 0.801
1.332ProHis: 1.332 ± 0.772
3.663ProIle: 3.663 ± 0.787
4.662ProLys: 4.662 ± 1.779
3.33ProLeu: 3.33 ± 0.733
1.665ProMet: 1.665 ± 0.398
1.332ProAsn: 1.332 ± 0.738
5.994ProPro: 5.994 ± 2.048
1.998ProGln: 1.998 ± 0.795
3.33ProArg: 3.33 ± 1.074
4.329ProSer: 4.329 ± 1.011
4.662ProThr: 4.662 ± 2.179
4.329ProVal: 4.329 ± 0.925
0.0ProTrp: 0.0 ± 0.0
1.332ProTyr: 1.332 ± 0.271
0.0ProXaa: 0.0 ± 0.0
Gln
3.663GlnAla: 3.663 ± 0.665
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.664GlnGlu: 2.664 ± 1.095
1.998GlnPhe: 1.998 ± 1.553
2.664GlnGly: 2.664 ± 0.687
0.999GlnHis: 0.999 ± 0.398
0.999GlnIle: 0.999 ± 0.398
1.665GlnLys: 1.665 ± 0.717
4.662GlnLeu: 4.662 ± 1.097
1.332GlnMet: 1.332 ± 0.601
3.996GlnAsn: 3.996 ± 1.211
1.332GlnPro: 1.332 ± 0.289
2.331GlnGln: 2.331 ± 1.57
2.331GlnArg: 2.331 ± 0.498
2.997GlnSer: 2.997 ± 1.095
1.665GlnThr: 1.665 ± 0.509
1.332GlnVal: 1.332 ± 0.538
0.666GlnTrp: 0.666 ± 0.51
1.332GlnTyr: 1.332 ± 1.035
0.0GlnXaa: 0.0 ± 0.0
Arg
5.328ArgAla: 5.328 ± 2.362
0.666ArgCys: 0.666 ± 0.405
2.331ArgAsp: 2.331 ± 0.55
3.663ArgGlu: 3.663 ± 0.962
1.998ArgPhe: 1.998 ± 0.664
4.329ArgGly: 4.329 ± 1.688
0.999ArgHis: 0.999 ± 0.75
1.332ArgIle: 1.332 ± 1.033
4.329ArgLys: 4.329 ± 0.907
3.996ArgLeu: 3.996 ± 1.509
0.333ArgMet: 0.333 ± 0.522
2.997ArgAsn: 2.997 ± 0.89
3.33ArgPro: 3.33 ± 0.846
0.999ArgGln: 0.999 ± 0.213
8.991ArgArg: 8.991 ± 4.616
4.662ArgSer: 4.662 ± 1.577
0.999ArgThr: 0.999 ± 0.645
3.33ArgVal: 3.33 ± 0.781
0.999ArgTrp: 0.999 ± 0.408
0.666ArgTyr: 0.666 ± 0.269
0.0ArgXaa: 0.0 ± 0.0
Ser
3.663SerAla: 3.663 ± 0.91
2.664SerCys: 2.664 ± 0.794
1.998SerAsp: 1.998 ± 0.504
3.33SerGlu: 3.33 ± 0.52
5.661SerPhe: 5.661 ± 1.196
7.326SerGly: 7.326 ± 1.117
1.998SerHis: 1.998 ± 0.93
4.329SerIle: 4.329 ± 1.536
4.662SerLys: 4.662 ± 0.838
12.987SerLeu: 12.987 ± 1.502
0.999SerMet: 0.999 ± 0.616
5.661SerAsn: 5.661 ± 0.798
5.994SerPro: 5.994 ± 0.812
5.328SerGln: 5.328 ± 1.564
2.664SerArg: 2.664 ± 1.232
12.321SerSer: 12.321 ± 1.62
8.991SerThr: 8.991 ± 0.97
5.328SerVal: 5.328 ± 0.982
1.332SerTrp: 1.332 ± 0.449
1.998SerTyr: 1.998 ± 0.45
0.0SerXaa: 0.0 ± 0.0
Thr
3.663ThrAla: 3.663 ± 0.91
0.666ThrCys: 0.666 ± 0.269
1.332ThrAsp: 1.332 ± 0.598
3.33ThrGlu: 3.33 ± 0.537
2.331ThrPhe: 2.331 ± 1.05
3.33ThrGly: 3.33 ± 1.068
1.998ThrHis: 1.998 ± 0.787
5.328ThrIle: 5.328 ± 1.225
1.998ThrLys: 1.998 ± 0.817
3.663ThrLeu: 3.663 ± 0.647
1.665ThrMet: 1.665 ± 0.648
1.665ThrAsn: 1.665 ± 0.476
3.996ThrPro: 3.996 ± 0.992
0.999ThrGln: 0.999 ± 0.79
4.329ThrArg: 4.329 ± 1.804
8.325ThrSer: 8.325 ± 1.517
5.328ThrThr: 5.328 ± 2.365
2.331ThrVal: 2.331 ± 0.492
0.999ThrTrp: 0.999 ± 0.408
4.662ThrTyr: 4.662 ± 0.81
0.0ThrXaa: 0.0 ± 0.0
Val
4.329ValAla: 4.329 ± 1.42
1.332ValCys: 1.332 ± 0.397
2.997ValAsp: 2.997 ± 1.237
5.661ValGlu: 5.661 ± 1.343
1.998ValPhe: 1.998 ± 0.347
2.997ValGly: 2.997 ± 0.761
0.999ValHis: 0.999 ± 0.398
1.998ValIle: 1.998 ± 0.857
3.996ValLys: 3.996 ± 0.663
4.329ValLeu: 4.329 ± 1.087
0.333ValMet: 0.333 ± 0.29
3.33ValAsn: 3.33 ± 0.642
0.999ValPro: 0.999 ± 0.459
0.999ValGln: 0.999 ± 0.465
3.663ValArg: 3.663 ± 1.861
6.66ValSer: 6.66 ± 1.027
1.665ValThr: 1.665 ± 0.893
4.995ValVal: 4.995 ± 1.32
1.665ValTrp: 1.665 ± 0.737
1.665ValTyr: 1.665 ± 0.408
0.0ValXaa: 0.0 ± 0.0
Trp
0.666TrpAla: 0.666 ± 0.405
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.999TrpGlu: 0.999 ± 0.408
0.0TrpPhe: 0.0 ± 0.0
1.332TrpGly: 1.332 ± 0.656
0.0TrpHis: 0.0 ± 0.0
0.666TrpIle: 0.666 ± 0.51
2.664TrpLys: 2.664 ± 0.689
4.662TrpLeu: 4.662 ± 0.655
1.332TrpMet: 1.332 ± 0.271
1.332TrpAsn: 1.332 ± 0.622
0.333TrpPro: 0.333 ± 0.25
0.0TrpGln: 0.0 ± 0.0
1.665TrpArg: 1.665 ± 0.737
1.665TrpSer: 1.665 ± 0.758
0.666TrpThr: 0.666 ± 0.269
0.666TrpVal: 0.666 ± 0.269
1.332TrpTrp: 1.332 ± 0.538
0.333TrpTyr: 0.333 ± 0.341
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.997TyrAla: 2.997 ± 0.535
0.333TyrCys: 0.333 ± 0.305
1.665TyrAsp: 1.665 ± 1.069
2.997TyrGlu: 2.997 ± 0.573
0.999TyrPhe: 0.999 ± 0.916
3.33TyrGly: 3.33 ± 0.733
1.665TyrHis: 1.665 ± 0.568
0.999TyrIle: 0.999 ± 0.213
3.33TyrLys: 3.33 ± 0.862
2.997TyrLeu: 2.997 ± 0.631
0.333TyrMet: 0.333 ± 0.305
2.664TyrAsn: 2.664 ± 0.609
0.999TyrPro: 0.999 ± 0.459
0.999TyrGln: 0.999 ± 0.549
1.998TyrArg: 1.998 ± 0.86
3.663TyrSer: 3.663 ± 0.833
3.33TyrThr: 3.33 ± 0.753
0.999TyrVal: 0.999 ± 0.398
1.332TyrTrp: 1.332 ± 0.538
0.333TyrTyr: 0.333 ± 0.25
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.333XaaVal: 0.333 ± 0.305
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski