Amino acid dipepetide frequency for Infectious laryngotracheitis virus (ILTV) (Gallid herpesvirus 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.848AlaAla: 7.848 ± 0.555
1.943AlaCys: 1.943 ± 0.203
3.23AlaAsp: 3.23 ± 0.228
4.365AlaGlu: 4.365 ± 0.376
3.684AlaPhe: 3.684 ± 0.271
4.012AlaGly: 4.012 ± 0.249
1.741AlaHis: 1.741 ± 0.231
4.618AlaIle: 4.618 ± 0.335
3.078AlaLys: 3.078 ± 0.399
8.579AlaLeu: 8.579 ± 0.521
1.716AlaMet: 1.716 ± 0.234
2.422AlaAsn: 2.422 ± 0.274
4.441AlaPro: 4.441 ± 0.357
2.523AlaGln: 2.523 ± 0.268
5.678AlaArg: 5.678 ± 0.457
6.838AlaSer: 6.838 ± 0.425
4.416AlaThr: 4.416 ± 0.323
5.425AlaVal: 5.425 ± 0.392
0.908AlaTrp: 0.908 ± 0.17
2.321AlaTyr: 2.321 ± 0.216
0.0AlaXaa: 0.0 ± 0.0
Cys
1.539CysAla: 1.539 ± 0.207
0.479CysCys: 0.479 ± 0.132
1.262CysAsp: 1.262 ± 0.151
1.337CysGlu: 1.337 ± 0.203
0.656CysPhe: 0.656 ± 0.147
1.262CysGly: 1.262 ± 0.255
0.631CysHis: 0.631 ± 0.119
1.388CysIle: 1.388 ± 0.233
1.035CysLys: 1.035 ± 0.176
2.195CysLeu: 2.195 ± 0.298
0.505CysMet: 0.505 ± 0.143
0.833CysAsn: 0.833 ± 0.116
1.262CysPro: 1.262 ± 0.289
0.454CysGln: 0.454 ± 0.108
1.363CysArg: 1.363 ± 0.211
2.094CysSer: 2.094 ± 0.217
0.934CysThr: 0.934 ± 0.139
1.388CysVal: 1.388 ± 0.205
0.278CysTrp: 0.278 ± 0.085
0.732CysTyr: 0.732 ± 0.158
0.0CysXaa: 0.0 ± 0.0
Asp
3.104AspAla: 3.104 ± 0.296
1.136AspCys: 1.136 ± 0.155
2.877AspAsp: 2.877 ± 0.347
3.533AspGlu: 3.533 ± 0.294
2.321AspPhe: 2.321 ± 0.248
3.533AspGly: 3.533 ± 0.25
1.186AspHis: 1.186 ± 0.15
3.356AspIle: 3.356 ± 0.306
1.993AspLys: 1.993 ± 0.207
4.567AspLeu: 4.567 ± 0.408
1.337AspMet: 1.337 ± 0.167
1.691AspAsn: 1.691 ± 0.185
3.634AspPro: 3.634 ± 0.375
1.312AspGln: 1.312 ± 0.205
3.154AspArg: 3.154 ± 0.3
4.769AspSer: 4.769 ± 0.412
3.154AspThr: 3.154 ± 0.28
3.154AspVal: 3.154 ± 0.306
0.656AspTrp: 0.656 ± 0.17
1.438AspTyr: 1.438 ± 0.225
0.0AspXaa: 0.0 ± 0.0
Glu
4.365GluAla: 4.365 ± 0.328
1.262GluCys: 1.262 ± 0.17
4.214GluAsp: 4.214 ± 0.327
5.173GluGlu: 5.173 ± 0.537
2.347GluPhe: 2.347 ± 0.256
2.927GluGly: 2.927 ± 0.258
1.388GluHis: 1.388 ± 0.208
3.936GluIle: 3.936 ± 0.355
3.634GluLys: 3.634 ± 0.373
6.106GluLeu: 6.106 ± 0.463
1.287GluMet: 1.287 ± 0.199
3.331GluAsn: 3.331 ± 0.356
3.078GluPro: 3.078 ± 0.344
2.094GluGln: 2.094 ± 0.238
3.785GluArg: 3.785 ± 0.279
4.744GluSer: 4.744 ± 0.36
4.542GluThr: 4.542 ± 0.456
3.028GluVal: 3.028 ± 0.26
0.782GluTrp: 0.782 ± 0.107
1.968GluTyr: 1.968 ± 0.158
0.0GluXaa: 0.0 ± 0.0
Phe
3.154PheAla: 3.154 ± 0.324
1.186PheCys: 1.186 ± 0.181
2.397PheAsp: 2.397 ± 0.275
3.255PheGlu: 3.255 ± 0.333
2.372PhePhe: 2.372 ± 0.312
2.523PheGly: 2.523 ± 0.245
0.883PheHis: 0.883 ± 0.16
2.296PheIle: 2.296 ± 0.221
1.842PheLys: 1.842 ± 0.194
4.643PheLeu: 4.643 ± 0.352
1.009PheMet: 1.009 ± 0.186
1.388PheAsn: 1.388 ± 0.253
2.195PhePro: 2.195 ± 0.229
1.236PheGln: 1.236 ± 0.179
1.968PheArg: 1.968 ± 0.235
4.264PheSer: 4.264 ± 0.325
2.473PheThr: 2.473 ± 0.361
2.902PheVal: 2.902 ± 0.27
0.479PheTrp: 0.479 ± 0.131
1.539PheTyr: 1.539 ± 0.21
0.0PheXaa: 0.0 ± 0.0
Gly
4.365GlyAla: 4.365 ± 0.359
1.035GlyCys: 1.035 ± 0.187
2.826GlyAsp: 2.826 ± 0.289
3.785GlyGlu: 3.785 ± 0.321
2.599GlyPhe: 2.599 ± 0.249
3.558GlyGly: 3.558 ± 0.48
1.085GlyHis: 1.085 ± 0.195
3.053GlyIle: 3.053 ± 0.246
3.028GlyLys: 3.028 ± 0.278
5.148GlyLeu: 5.148 ± 0.325
1.514GlyMet: 1.514 ± 0.2
2.372GlyAsn: 2.372 ± 0.244
3.23GlyPro: 3.23 ± 0.342
1.817GlyGln: 1.817 ± 0.204
3.861GlyArg: 3.861 ± 0.399
3.936GlySer: 3.936 ± 0.372
3.583GlyThr: 3.583 ± 0.32
2.851GlyVal: 2.851 ± 0.312
0.858GlyTrp: 0.858 ± 0.129
1.665GlyTyr: 1.665 ± 0.24
0.0GlyXaa: 0.0 ± 0.0
His
1.615HisAla: 1.615 ± 0.232
0.454HisCys: 0.454 ± 0.092
1.085HisAsp: 1.085 ± 0.162
1.539HisGlu: 1.539 ± 0.21
0.833HisPhe: 0.833 ± 0.119
1.691HisGly: 1.691 ± 0.147
0.606HisHis: 0.606 ± 0.122
0.984HisIle: 0.984 ± 0.141
0.707HisLys: 0.707 ± 0.158
2.448HisLeu: 2.448 ± 0.251
0.353HisMet: 0.353 ± 0.082
0.757HisAsn: 0.757 ± 0.145
1.489HisPro: 1.489 ± 0.196
0.858HisGln: 0.858 ± 0.13
1.236HisArg: 1.236 ± 0.183
2.044HisSer: 2.044 ± 0.199
1.035HisThr: 1.035 ± 0.156
1.691HisVal: 1.691 ± 0.241
0.177HisTrp: 0.177 ± 0.071
0.732HisTyr: 0.732 ± 0.142
0.0HisXaa: 0.0 ± 0.0
Ile
4.517IleAla: 4.517 ± 0.405
1.211IleCys: 1.211 ± 0.177
3.407IleAsp: 3.407 ± 0.336
2.902IleGlu: 2.902 ± 0.419
2.7IlePhe: 2.7 ± 0.289
2.624IleGly: 2.624 ± 0.273
1.363IleHis: 1.363 ± 0.209
3.053IleIle: 3.053 ± 0.356
2.12IleLys: 2.12 ± 0.239
6.006IleLeu: 6.006 ± 0.486
1.136IleMet: 1.136 ± 0.199
2.145IleAsn: 2.145 ± 0.283
3.078IlePro: 3.078 ± 0.261
1.867IleGln: 1.867 ± 0.161
3.078IleArg: 3.078 ± 0.249
4.996IleSer: 4.996 ± 0.413
3.936IleThr: 3.936 ± 0.281
2.675IleVal: 2.675 ± 0.348
0.404IleTrp: 0.404 ± 0.087
2.044IleTyr: 2.044 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
3.028LysAla: 3.028 ± 0.389
1.009LysCys: 1.009 ± 0.153
2.221LysAsp: 2.221 ± 0.203
3.078LysGlu: 3.078 ± 0.285
1.716LysPhe: 1.716 ± 0.227
1.665LysGly: 1.665 ± 0.206
1.085LysHis: 1.085 ± 0.223
3.003LysIle: 3.003 ± 0.364
2.574LysLys: 2.574 ± 0.374
4.441LysLeu: 4.441 ± 0.332
0.934LysMet: 0.934 ± 0.157
2.321LysAsn: 2.321 ± 0.256
1.867LysPro: 1.867 ± 0.228
1.186LysGln: 1.186 ± 0.207
3.129LysArg: 3.129 ± 0.313
3.104LysSer: 3.104 ± 0.274
3.23LysThr: 3.23 ± 0.308
2.448LysVal: 2.448 ± 0.319
0.681LysTrp: 0.681 ± 0.139
1.918LysTyr: 1.918 ± 0.202
0.0LysXaa: 0.0 ± 0.0
Leu
7.898LeuAla: 7.898 ± 0.48
2.271LeuCys: 2.271 ± 0.219
4.719LeuAsp: 4.719 ± 0.349
6.233LeuGlu: 6.233 ± 0.41
4.744LeuPhe: 4.744 ± 0.314
5.854LeuGly: 5.854 ± 0.408
1.716LeuHis: 1.716 ± 0.186
4.693LeuIle: 4.693 ± 0.369
4.971LeuLys: 4.971 ± 0.398
9.109LeuLeu: 9.109 ± 0.556
2.296LeuMet: 2.296 ± 0.233
3.684LeuAsn: 3.684 ± 0.304
5.4LeuPro: 5.4 ± 0.421
3.23LeuGln: 3.23 ± 0.285
6.308LeuArg: 6.308 ± 0.414
8.68LeuSer: 8.68 ± 0.559
5.425LeuThr: 5.425 ± 0.324
5.652LeuVal: 5.652 ± 0.392
1.161LeuTrp: 1.161 ± 0.178
2.978LeuTyr: 2.978 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
1.993MetAla: 1.993 ± 0.22
0.404MetCys: 0.404 ± 0.095
1.035MetAsp: 1.035 ± 0.169
1.136MetGlu: 1.136 ± 0.169
0.631MetPhe: 0.631 ± 0.128
1.363MetGly: 1.363 ± 0.198
0.429MetHis: 0.429 ± 0.103
1.085MetIle: 1.085 ± 0.188
0.807MetLys: 0.807 ± 0.155
2.321MetLeu: 2.321 ± 0.245
0.429MetMet: 0.429 ± 0.124
1.085MetAsn: 1.085 ± 0.176
1.161MetPro: 1.161 ± 0.176
1.035MetGln: 1.035 ± 0.16
1.413MetArg: 1.413 ± 0.197
1.665MetSer: 1.665 ± 0.214
1.489MetThr: 1.489 ± 0.213
1.161MetVal: 1.161 ± 0.173
0.227MetTrp: 0.227 ± 0.074
0.757MetTyr: 0.757 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
2.978AsnAla: 2.978 ± 0.258
0.757AsnCys: 0.757 ± 0.144
1.918AsnAsp: 1.918 ± 0.241
1.943AsnGlu: 1.943 ± 0.21
2.12AsnPhe: 2.12 ± 0.247
2.347AsnGly: 2.347 ± 0.238
0.782AsnHis: 0.782 ± 0.147
2.372AsnIle: 2.372 ± 0.23
1.438AsnLys: 1.438 ± 0.182
3.407AsnLeu: 3.407 ± 0.311
0.984AsnMet: 0.984 ± 0.16
1.489AsnAsn: 1.489 ± 0.217
2.271AsnPro: 2.271 ± 0.233
0.858AsnGln: 0.858 ± 0.118
1.918AsnArg: 1.918 ± 0.218
3.129AsnSer: 3.129 ± 0.294
2.523AsnThr: 2.523 ± 0.232
2.473AsnVal: 2.473 ± 0.253
0.328AsnTrp: 0.328 ± 0.098
1.363AsnTyr: 1.363 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
4.264ProAla: 4.264 ± 0.386
1.388ProCys: 1.388 ± 0.255
3.003ProAsp: 3.003 ± 0.309
4.189ProGlu: 4.189 ± 0.403
2.372ProPhe: 2.372 ± 0.266
3.205ProGly: 3.205 ± 0.371
1.262ProHis: 1.262 ± 0.168
3.003ProIle: 3.003 ± 0.277
2.145ProLys: 2.145 ± 0.256
4.063ProLeu: 4.063 ± 0.402
1.186ProMet: 1.186 ± 0.194
1.59ProAsn: 1.59 ± 0.242
4.845ProPro: 4.845 ± 0.528
2.044ProGln: 2.044 ± 0.28
3.356ProArg: 3.356 ± 0.314
5.577ProSer: 5.577 ± 0.47
3.407ProThr: 3.407 ± 0.276
3.709ProVal: 3.709 ± 0.301
0.732ProTrp: 0.732 ± 0.133
1.741ProTyr: 1.741 ± 0.226
0.0ProXaa: 0.0 ± 0.0
Gln
2.296GlnAla: 2.296 ± 0.185
0.555GlnCys: 0.555 ± 0.145
1.514GlnAsp: 1.514 ± 0.173
2.145GlnGlu: 2.145 ± 0.226
1.413GlnPhe: 1.413 ± 0.228
1.413GlnGly: 1.413 ± 0.173
0.883GlnHis: 0.883 ± 0.148
1.766GlnIle: 1.766 ± 0.246
1.716GlnLys: 1.716 ± 0.227
3.078GlnLeu: 3.078 ± 0.262
0.707GlnMet: 0.707 ± 0.137
1.211GlnAsn: 1.211 ± 0.213
1.464GlnPro: 1.464 ± 0.18
1.136GlnGln: 1.136 ± 0.237
1.817GlnArg: 1.817 ± 0.211
2.7GlnSer: 2.7 ± 0.317
2.498GlnThr: 2.498 ± 0.429
1.363GlnVal: 1.363 ± 0.173
0.151GlnTrp: 0.151 ± 0.06
1.186GlnTyr: 1.186 ± 0.179
0.0GlnXaa: 0.0 ± 0.0
Arg
5.905ArgAla: 5.905 ± 0.497
1.035ArgCys: 1.035 ± 0.188
3.785ArgAsp: 3.785 ± 0.314
3.684ArgGlu: 3.684 ± 0.359
2.65ArgPhe: 2.65 ± 0.317
4.391ArgGly: 4.391 ± 0.383
1.842ArgHis: 1.842 ± 0.234
3.129ArgIle: 3.129 ± 0.27
2.978ArgLys: 2.978 ± 0.323
6.031ArgLeu: 6.031 ± 0.338
1.085ArgMet: 1.085 ± 0.172
2.574ArgAsn: 2.574 ± 0.247
3.381ArgPro: 3.381 ± 0.3
1.968ArgGln: 1.968 ± 0.26
6.207ArgArg: 6.207 ± 0.603
4.946ArgSer: 4.946 ± 0.379
3.583ArgThr: 3.583 ± 0.322
3.533ArgVal: 3.533 ± 0.315
0.782ArgTrp: 0.782 ± 0.138
1.943ArgTyr: 1.943 ± 0.236
0.0ArgXaa: 0.0 ± 0.0
Ser
7.419SerAla: 7.419 ± 0.543
1.64SerCys: 1.64 ± 0.185
4.214SerAsp: 4.214 ± 0.324
5.778SerGlu: 5.778 ± 0.402
3.407SerPhe: 3.407 ± 0.263
5.45SerGly: 5.45 ± 0.515
1.993SerHis: 1.993 ± 0.286
3.709SerIle: 3.709 ± 0.292
3.634SerLys: 3.634 ± 0.343
7.822SerLeu: 7.822 ± 0.377
1.514SerMet: 1.514 ± 0.192
3.432SerAsn: 3.432 ± 0.256
4.996SerPro: 4.996 ± 0.452
2.473SerGln: 2.473 ± 0.269
5.879SerArg: 5.879 ± 0.482
8.68SerSer: 8.68 ± 0.729
5.476SerThr: 5.476 ± 0.523
4.996SerVal: 4.996 ± 0.291
1.136SerTrp: 1.136 ± 0.151
2.019SerTyr: 2.019 ± 0.233
0.0SerXaa: 0.0 ± 0.0
Thr
5.778ThrAla: 5.778 ± 0.412
1.337ThrCys: 1.337 ± 0.181
2.65ThrAsp: 2.65 ± 0.263
3.835ThrGlu: 3.835 ± 0.446
2.574ThrPhe: 2.574 ± 0.259
3.331ThrGly: 3.331 ± 0.32
1.438ThrHis: 1.438 ± 0.159
3.785ThrIle: 3.785 ± 0.318
2.221ThrLys: 2.221 ± 0.248
6.006ThrLeu: 6.006 ± 0.473
1.413ThrMet: 1.413 ± 0.202
1.842ThrAsn: 1.842 ± 0.228
3.457ThrPro: 3.457 ± 0.502
1.918ThrGln: 1.918 ± 0.497
4.618ThrArg: 4.618 ± 0.318
4.794ThrSer: 4.794 ± 0.336
3.533ThrThr: 3.533 ± 0.379
4.82ThrVal: 4.82 ± 0.409
0.631ThrTrp: 0.631 ± 0.109
1.943ThrTyr: 1.943 ± 0.178
0.0ThrXaa: 0.0 ± 0.0
Val
4.845ValAla: 4.845 ± 0.383
1.337ValCys: 1.337 ± 0.192
3.078ValAsp: 3.078 ± 0.224
3.583ValGlu: 3.583 ± 0.326
2.75ValPhe: 2.75 ± 0.307
2.801ValGly: 2.801 ± 0.253
1.035ValHis: 1.035 ± 0.163
3.659ValIle: 3.659 ± 0.365
2.624ValLys: 2.624 ± 0.292
6.384ValLeu: 6.384 ± 0.516
1.161ValMet: 1.161 ± 0.157
2.094ValAsn: 2.094 ± 0.212
3.381ValPro: 3.381 ± 0.32
1.867ValGln: 1.867 ± 0.248
3.81ValArg: 3.81 ± 0.368
4.643ValSer: 4.643 ± 0.428
3.861ValThr: 3.861 ± 0.316
3.659ValVal: 3.659 ± 0.37
0.606ValTrp: 0.606 ± 0.151
2.372ValTyr: 2.372 ± 0.243
0.0ValXaa: 0.0 ± 0.0
Trp
0.757TrpAla: 0.757 ± 0.161
0.252TrpCys: 0.252 ± 0.084
0.681TrpAsp: 0.681 ± 0.123
0.606TrpGlu: 0.606 ± 0.151
0.555TrpPhe: 0.555 ± 0.105
0.53TrpGly: 0.53 ± 0.1
0.278TrpHis: 0.278 ± 0.076
0.656TrpIle: 0.656 ± 0.115
0.858TrpLys: 0.858 ± 0.176
1.211TrpLeu: 1.211 ± 0.144
0.429TrpMet: 0.429 ± 0.095
0.353TrpAsn: 0.353 ± 0.099
0.858TrpPro: 0.858 ± 0.149
0.227TrpGln: 0.227 ± 0.07
0.681TrpArg: 0.681 ± 0.136
0.782TrpSer: 0.782 ± 0.118
0.959TrpThr: 0.959 ± 0.169
0.505TrpVal: 0.505 ± 0.11
0.151TrpTrp: 0.151 ± 0.061
0.202TrpTyr: 0.202 ± 0.058
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.12TyrAla: 2.12 ± 0.249
0.934TyrCys: 0.934 ± 0.137
1.792TyrAsp: 1.792 ± 0.209
1.893TyrGlu: 1.893 ± 0.203
1.564TyrPhe: 1.564 ± 0.236
1.691TyrGly: 1.691 ± 0.222
0.707TyrHis: 0.707 ± 0.134
1.716TyrIle: 1.716 ± 0.206
1.236TyrLys: 1.236 ± 0.175
3.457TyrLeu: 3.457 ± 0.301
0.606TyrMet: 0.606 ± 0.128
0.782TyrAsn: 0.782 ± 0.139
1.59TyrPro: 1.59 ± 0.211
0.908TyrGln: 0.908 ± 0.148
2.17TyrArg: 2.17 ± 0.231
3.28TyrSer: 3.28 ± 0.309
1.867TyrThr: 1.867 ± 0.237
2.12TyrVal: 2.12 ± 0.234
0.404TyrTrp: 0.404 ± 0.101
1.211TyrTyr: 1.211 ± 0.179
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (39631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski