Amino acid dipepetide frequency for Candidatus Microthrix parvicella RN1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.623AlaAla: 17.623 ± 0.189	1.013AlaCys: 1.013 ± 0.031	8.519AlaAsp: 8.519 ± 0.094	7.942AlaGlu: 7.942 ± 0.097	3.265AlaPhe: 3.265 ± 0.051	11.848AlaGly: 11.848 ± 0.115	2.416AlaHis: 2.416 ± 0.05	4.819AlaIle: 4.819 ± 0.069	2.917AlaLys: 2.917 ± 0.06	12.385AlaLeu: 12.385 ± 0.111	2.915AlaMet: 2.915 ± 0.048	2.859AlaAsn: 2.859 ± 0.05	6.314AlaPro: 6.314 ± 0.106	3.674AlaGln: 3.674 ± 0.059	8.14AlaArg: 8.14 ± 0.098	6.683AlaSer: 6.683 ± 0.081	7.906AlaThr: 7.906 ± 0.087	10.498AlaVal: 10.498 ± 0.127	1.894AlaTrp: 1.894 ± 0.044	1.959AlaTyr: 1.959 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.957CysAla: 0.957 ± 0.033	0.132CysCys: 0.132 ± 0.011	0.614CysAsp: 0.614 ± 0.023	0.446CysGlu: 0.446 ± 0.019	0.279CysPhe: 0.279 ± 0.015	0.988CysGly: 0.988 ± 0.026	0.219CysHis: 0.219 ± 0.014	0.269CysIle: 0.269 ± 0.014	0.109CysLys: 0.109 ± 0.01	0.656CysLeu: 0.656 ± 0.022	0.136CysMet: 0.136 ± 0.011	0.186CysAsn: 0.186 ± 0.012	0.53CysPro: 0.53 ± 0.021	0.189CysGln: 0.189 ± 0.012	0.618CysArg: 0.618 ± 0.025	0.549CysSer: 0.549 ± 0.022	0.46CysThr: 0.46 ± 0.021	0.667CysVal: 0.667 ± 0.025	0.199CysTrp: 0.199 ± 0.021	0.149CysTyr: 0.149 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.003AspAla: 8.003 ± 0.099	0.408AspCys: 0.408 ± 0.019	4.888AspAsp: 4.888 ± 0.07	4.592AspGlu: 4.592 ± 0.067	1.61AspPhe: 1.61 ± 0.038	6.835AspGly: 6.835 ± 0.091	1.625AspHis: 1.625 ± 0.038	1.875AspIle: 1.875 ± 0.042	0.951AspLys: 0.951 ± 0.033	6.888AspLeu: 6.888 ± 0.085	0.845AspMet: 0.845 ± 0.03	1.086AspAsn: 1.086 ± 0.03	4.815AspPro: 4.815 ± 0.065	2.107AspGln: 2.107 ± 0.046	5.319AspArg: 5.319 ± 0.076	2.882AspSer: 2.882 ± 0.049	3.138AspThr: 3.138 ± 0.055	5.22AspVal: 5.22 ± 0.061	0.939AspTrp: 0.939 ± 0.028	1.089AspTyr: 1.089 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.607GluAla: 7.607 ± 0.09	0.376GluCys: 0.376 ± 0.018	2.566GluAsp: 2.566 ± 0.047	2.684GluGlu: 2.684 ± 0.06	1.636GluPhe: 1.636 ± 0.04	4.246GluGly: 4.246 ± 0.066	1.4GluHis: 1.4 ± 0.038	2.179GluIle: 2.179 ± 0.042	0.92GluLys: 0.92 ± 0.031	6.875GluLeu: 6.875 ± 0.079	1.119GluMet: 1.119 ± 0.032	0.909GluAsn: 0.909 ± 0.027	3.434GluPro: 3.434 ± 0.063	1.999GluGln: 1.999 ± 0.045	5.128GluArg: 5.128 ± 0.065	2.753GluSer: 2.753 ± 0.049	2.791GluThr: 2.791 ± 0.048	5.564GluVal: 5.564 ± 0.078	0.832GluTrp: 0.832 ± 0.027	0.877GluTyr: 0.877 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.457PheAla: 3.457 ± 0.056	0.321PheCys: 0.321 ± 0.018	2.37PheAsp: 2.37 ± 0.044	1.823PheGlu: 1.823 ± 0.037	0.929PhePhe: 0.929 ± 0.03	3.3PheGly: 3.3 ± 0.052	0.586PheHis: 0.586 ± 0.021	0.978PheIle: 0.978 ± 0.034	0.518PheLys: 0.518 ± 0.021	2.47PheLeu: 2.47 ± 0.047	0.457PheMet: 0.457 ± 0.022	0.739PheAsn: 0.739 ± 0.025	1.424PhePro: 1.424 ± 0.034	0.692PheGln: 0.692 ± 0.023	1.734PheArg: 1.734 ± 0.041	1.702PheSer: 1.702 ± 0.038	1.778PheThr: 1.778 ± 0.038	2.509PheVal: 2.509 ± 0.045	0.42PheTrp: 0.42 ± 0.019	0.544PheTyr: 0.544 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.798GlyAla: 10.798 ± 0.117	0.926GlyCys: 0.926 ± 0.026	5.929GlyAsp: 5.929 ± 0.079	4.942GlyGlu: 4.942 ± 0.068	3.044GlyPhe: 3.044 ± 0.053	8.732GlyGly: 8.732 ± 0.123	2.104GlyHis: 2.104 ± 0.044	3.747GlyIle: 3.747 ± 0.056	2.0GlyLys: 2.0 ± 0.049	9.036GlyLeu: 9.036 ± 0.1	2.206GlyMet: 2.206 ± 0.041	1.931GlyAsn: 1.931 ± 0.043	5.072GlyPro: 5.072 ± 0.096	2.665GlyGln: 2.665 ± 0.05	7.16GlyArg: 7.16 ± 0.087	6.249GlySer: 6.249 ± 0.081	5.736GlyThr: 5.736 ± 0.091	7.849GlyVal: 7.849 ± 0.09	1.913GlyTrp: 1.913 ± 0.043	1.94GlyTyr: 1.94 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.022HisAla: 2.022 ± 0.041	0.2HisCys: 0.2 ± 0.013	1.29HisAsp: 1.29 ± 0.032	1.067HisGlu: 1.067 ± 0.03	0.561HisPhe: 0.561 ± 0.021	1.997HisGly: 1.997 ± 0.048	0.791HisHis: 0.791 ± 0.028	0.634HisIle: 0.634 ± 0.025	0.307HisLys: 0.307 ± 0.016	2.591HisLeu: 2.591 ± 0.05	0.279HisMet: 0.279 ± 0.014	0.46HisAsn: 0.46 ± 0.021	1.712HisPro: 1.712 ± 0.039	0.813HisGln: 0.813 ± 0.027	2.077HisArg: 2.077 ± 0.046	1.118HisSer: 1.118 ± 0.037	1.152HisThr: 1.152 ± 0.032	1.504HisVal: 1.504 ± 0.04	0.322HisTrp: 0.322 ± 0.016	0.423HisTyr: 0.423 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.918IleAla: 4.918 ± 0.065	0.357IleCys: 0.357 ± 0.016	3.49IleAsp: 3.49 ± 0.058	2.761IleGlu: 2.761 ± 0.043	0.871IlePhe: 0.871 ± 0.03	4.096IleGly: 4.096 ± 0.063	0.715IleHis: 0.715 ± 0.026	1.361IleIle: 1.361 ± 0.035	0.696IleLys: 0.696 ± 0.026	2.656IleLeu: 2.656 ± 0.049	0.608IleMet: 0.608 ± 0.022	0.965IleAsn: 0.965 ± 0.028	2.037IlePro: 2.037 ± 0.042	0.865IleGln: 0.865 ± 0.029	2.336IleArg: 2.336 ± 0.046	2.179IleSer: 2.179 ± 0.045	2.47IleThr: 2.47 ± 0.05	3.206IleVal: 3.206 ± 0.056	0.473IleTrp: 0.473 ± 0.018	0.64IleTyr: 0.64 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.606LysAla: 2.606 ± 0.055	0.104LysCys: 0.104 ± 0.009	0.937LysAsp: 0.937 ± 0.029	0.904LysGlu: 0.904 ± 0.027	0.525LysPhe: 0.525 ± 0.018	1.598LysGly: 1.598 ± 0.043	0.395LysHis: 0.395 ± 0.017	0.748LysIle: 0.748 ± 0.026	0.613LysLys: 0.613 ± 0.033	2.066LysLeu: 2.066 ± 0.046	0.422LysMet: 0.422 ± 0.021	0.49LysAsn: 0.49 ± 0.019	1.287LysPro: 1.287 ± 0.036	0.631LysGln: 0.631 ± 0.025	1.681LysArg: 1.681 ± 0.037	1.079LysSer: 1.079 ± 0.027	1.14LysThr: 1.14 ± 0.028	2.022LysVal: 2.022 ± 0.039	0.28LysTrp: 0.28 ± 0.017	0.355LysTyr: 0.355 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.309LeuAla: 14.309 ± 0.125	0.804LeuCys: 0.804 ± 0.024	6.937LeuAsp: 6.937 ± 0.074	5.142LeuGlu: 5.142 ± 0.066	2.637LeuPhe: 2.637 ± 0.044	10.103LeuGly: 10.103 ± 0.1	1.808LeuHis: 1.808 ± 0.039	3.944LeuIle: 3.944 ± 0.056	1.75LeuLys: 1.75 ± 0.044	9.2LeuLeu: 9.2 ± 0.108	1.918LeuMet: 1.918 ± 0.042	2.204LeuAsn: 2.204 ± 0.037	5.389LeuPro: 5.389 ± 0.071	2.122LeuGln: 2.122 ± 0.044	6.798LeuArg: 6.798 ± 0.097	5.655LeuSer: 5.655 ± 0.067	6.086LeuThr: 6.086 ± 0.067	9.318LeuVal: 9.318 ± 0.095	1.394LeuTrp: 1.394 ± 0.036	1.416LeuTyr: 1.416 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.946MetAla: 2.946 ± 0.043	0.174MetCys: 0.174 ± 0.012	0.922MetAsp: 0.922 ± 0.03	0.904MetGlu: 0.904 ± 0.03	0.584MetPhe: 0.584 ± 0.019	1.741MetGly: 1.741 ± 0.037	0.363MetHis: 0.363 ± 0.017	0.828MetIle: 0.828 ± 0.025	0.472MetLys: 0.472 ± 0.02	1.966MetLeu: 1.966 ± 0.042	0.483MetMet: 0.483 ± 0.019	0.58MetAsn: 0.58 ± 0.02	1.105MetPro: 1.105 ± 0.031	0.426MetGln: 0.426 ± 0.018	1.313MetArg: 1.313 ± 0.033	1.594MetSer: 1.594 ± 0.038	1.515MetThr: 1.515 ± 0.038	1.915MetVal: 1.915 ± 0.041	0.282MetTrp: 0.282 ± 0.014	0.283MetTyr: 0.283 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.424AsnAla: 2.424 ± 0.043	0.211AsnCys: 0.211 ± 0.013	1.53AsnAsp: 1.53 ± 0.035	1.202AsnGlu: 1.202 ± 0.039	0.612AsnPhe: 0.612 ± 0.024	2.055AsnGly: 2.055 ± 0.046	0.574AsnHis: 0.574 ± 0.021	0.784AsnIle: 0.784 ± 0.027	0.481AsnLys: 0.481 ± 0.019	2.423AsnLeu: 2.423 ± 0.04	0.39AsnMet: 0.39 ± 0.019	0.586AsnAsn: 0.586 ± 0.026	1.873AsnPro: 1.873 ± 0.041	0.742AsnGln: 0.742 ± 0.022	1.737AsnArg: 1.737 ± 0.037	1.192AsnSer: 1.192 ± 0.03	1.255AsnThr: 1.255 ± 0.032	1.787AsnVal: 1.787 ± 0.038	0.318AsnTrp: 0.318 ± 0.015	0.447AsnTyr: 0.447 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.965ProAla: 6.965 ± 0.091	0.363ProCys: 0.363 ± 0.018	4.62ProAsp: 4.62 ± 0.069	3.931ProGlu: 3.931 ± 0.059	1.578ProPhe: 1.578 ± 0.035	5.912ProGly: 5.912 ± 0.08	1.192ProHis: 1.192 ± 0.032	2.077ProIle: 2.077 ± 0.045	1.487ProLys: 1.487 ± 0.034	4.841ProLeu: 4.841 ± 0.064	1.256ProMet: 1.256 ± 0.033	1.591ProAsn: 1.591 ± 0.039	3.892ProPro: 3.892 ± 0.08	1.691ProGln: 1.691 ± 0.039	3.227ProArg: 3.227 ± 0.053	3.885ProSer: 3.885 ± 0.066	4.37ProThr: 4.37 ± 0.069	4.879ProVal: 4.879 ± 0.067	0.958ProTrp: 0.958 ± 0.029	0.917ProTyr: 0.917 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.762GlnAla: 3.762 ± 0.064	0.186GlnCys: 0.186 ± 0.013	1.064GlnAsp: 1.064 ± 0.028	1.073GlnGlu: 1.073 ± 0.03	0.846GlnPhe: 0.846 ± 0.024	2.135GlnGly: 2.135 ± 0.043	0.642GlnHis: 0.642 ± 0.026	1.067GlnIle: 1.067 ± 0.029	0.522GlnLys: 0.522 ± 0.024	3.424GlnLeu: 3.424 ± 0.054	0.634GlnMet: 0.634 ± 0.02	0.545GlnAsn: 0.545 ± 0.022	1.97GlnPro: 1.97 ± 0.051	1.059GlnGln: 1.059 ± 0.039	2.766GlnArg: 2.766 ± 0.05	1.435GlnSer: 1.435 ± 0.036	1.386GlnThr: 1.386 ± 0.034	2.645GlnVal: 2.645 ± 0.04	0.427GlnTrp: 0.427 ± 0.02	0.438GlnTyr: 0.438 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.758ArgAla: 7.758 ± 0.094	0.691ArgCys: 0.691 ± 0.026	3.659ArgAsp: 3.659 ± 0.066	3.178ArgGlu: 3.178 ± 0.054	2.688ArgPhe: 2.688 ± 0.053	4.929ArgGly: 4.929 ± 0.066	1.875ArgHis: 1.875 ± 0.044	2.868ArgIle: 2.868 ± 0.051	1.357ArgLys: 1.357 ± 0.036	8.176ArgLeu: 8.176 ± 0.089	1.664ArgMet: 1.664 ± 0.035	1.705ArgAsn: 1.705 ± 0.037	4.573ArgPro: 4.573 ± 0.075	2.199ArgGln: 2.199 ± 0.045	7.467ArgArg: 7.467 ± 0.094	5.357ArgSer: 5.357 ± 0.068	4.132ArgThr: 4.132 ± 0.06	5.862ArgVal: 5.862 ± 0.076	1.607ArgTrp: 1.607 ± 0.041	1.586ArgTyr: 1.586 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.835SerAla: 6.835 ± 0.081	0.517SerCys: 0.517 ± 0.026	3.818SerAsp: 3.818 ± 0.051	3.071SerGlu: 3.071 ± 0.059	1.785SerPhe: 1.785 ± 0.036	6.337SerGly: 6.337 ± 0.075	1.122SerHis: 1.122 ± 0.03	2.357SerIle: 2.357 ± 0.039	1.262SerLys: 1.262 ± 0.035	5.397SerLeu: 5.397 ± 0.076	1.483SerMet: 1.483 ± 0.034	1.449SerAsn: 1.449 ± 0.033	3.676SerPro: 3.676 ± 0.059	1.614SerGln: 1.614 ± 0.036	3.577SerArg: 3.577 ± 0.055	3.773SerSer: 3.773 ± 0.065	3.988SerThr: 3.988 ± 0.079	4.92SerVal: 4.92 ± 0.061	0.957SerTrp: 0.957 ± 0.027	1.103SerTyr: 1.103 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.98ThrAla: 6.98 ± 0.08	0.462ThrCys: 0.462 ± 0.021	3.975ThrAsp: 3.975 ± 0.062	3.364ThrGlu: 3.364 ± 0.064	1.816ThrPhe: 1.816 ± 0.037	5.943ThrGly: 5.943 ± 0.099	1.235ThrHis: 1.235 ± 0.031	2.403ThrIle: 2.403 ± 0.052	1.396ThrLys: 1.396 ± 0.038	5.632ThrLeu: 5.632 ± 0.067	1.296ThrMet: 1.296 ± 0.031	1.568ThrAsn: 1.568 ± 0.043	3.951ThrPro: 3.951 ± 0.056	1.595ThrGln: 1.595 ± 0.039	3.76ThrArg: 3.76 ± 0.049	3.935ThrSer: 3.935 ± 0.062	4.343ThrThr: 4.343 ± 0.084	5.163ThrVal: 5.163 ± 0.07	0.972ThrTrp: 0.972 ± 0.029	1.198ThrTyr: 1.198 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	12.036ValAla: 12.036 ± 0.121	0.717ValCys: 0.717 ± 0.022	5.899ValAsp: 5.899 ± 0.07	5.126ValGlu: 5.126 ± 0.066	2.336ValPhe: 2.336 ± 0.044	8.34ValGly: 8.34 ± 0.086	1.558ValHis: 1.558 ± 0.035	3.666ValIle: 3.666 ± 0.06	1.47ValLys: 1.47 ± 0.036	8.467ValLeu: 8.467 ± 0.103	1.652ValMet: 1.652 ± 0.041	1.941ValAsn: 1.941 ± 0.039	4.741ValPro: 4.741 ± 0.065	1.883ValGln: 1.883 ± 0.041	5.691ValArg: 5.691 ± 0.075	4.875ValSer: 4.875 ± 0.067	5.553ValThr: 5.553 ± 0.073	8.906ValVal: 8.906 ± 0.118	1.132ValTrp: 1.132 ± 0.03	1.158ValTyr: 1.158 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.892TrpAla: 1.892 ± 0.033	0.209TrpCys: 0.209 ± 0.012	0.908TrpAsp: 0.908 ± 0.031	0.713TrpGlu: 0.713 ± 0.022	0.571TrpPhe: 0.571 ± 0.02	1.215TrpGly: 1.215 ± 0.04	0.305TrpHis: 0.305 ± 0.015	0.612TrpIle: 0.612 ± 0.022	0.333TrpLys: 0.333 ± 0.018	1.708TrpLeu: 1.708 ± 0.04	0.438TrpMet: 0.438 ± 0.019	0.425TrpAsn: 0.425 ± 0.019	0.858TrpPro: 0.858 ± 0.025	0.467TrpGln: 0.467 ± 0.022	1.293TrpArg: 1.293 ± 0.033	1.119TrpSer: 1.119 ± 0.038	0.895TrpThr: 0.895 ± 0.027	1.373TrpVal: 1.373 ± 0.032	0.445TrpTrp: 0.445 ± 0.024	0.306TrpTyr: 0.306 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.692TyrAla: 1.692 ± 0.037	0.181TyrCys: 0.181 ± 0.012	1.177TyrAsp: 1.177 ± 0.029	1.031TyrGlu: 1.031 ± 0.029	0.577TyrPhe: 0.577 ± 0.024	1.631TyrGly: 1.631 ± 0.032	0.396TyrHis: 0.396 ± 0.016	0.481TyrIle: 0.481 ± 0.018	0.32TyrLys: 0.32 ± 0.015	2.077TyrLeu: 2.077 ± 0.045	0.195TyrMet: 0.195 ± 0.012	0.404TyrAsn: 0.404 ± 0.018	0.979TyrPro: 0.979 ± 0.029	0.595TyrGln: 0.595 ± 0.022	1.51TyrArg: 1.51 ± 0.035	1.026TyrSer: 1.026 ± 0.035	0.893TyrThr: 0.893 ± 0.027	1.34TyrVal: 1.34 ± 0.033	0.321TyrTrp: 0.321 ± 0.015	0.388TyrTyr: 0.388 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4245 proteins (1298969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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