Amino acid dipepetide frequency for Ruminococcaceae bacterium YRB3002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.21AlaAla: 7.21 ± 0.137	1.163AlaCys: 1.163 ± 0.039	5.078AlaAsp: 5.078 ± 0.085	4.894AlaGlu: 4.894 ± 0.077	3.103AlaPhe: 3.103 ± 0.064	6.052AlaGly: 6.052 ± 0.108	1.097AlaHis: 1.097 ± 0.034	5.046AlaIle: 5.046 ± 0.082	3.961AlaLys: 3.961 ± 0.078	6.646AlaLeu: 6.646 ± 0.094	2.4AlaMet: 2.4 ± 0.052	2.555AlaAsn: 2.555 ± 0.058	2.446AlaPro: 2.446 ± 0.079	1.945AlaGln: 1.945 ± 0.05	3.428AlaArg: 3.428 ± 0.079	4.922AlaSer: 4.922 ± 0.082	3.49AlaThr: 3.49 ± 0.088	6.494AlaVal: 6.494 ± 0.105	0.547AlaTrp: 0.547 ± 0.028	2.701AlaTyr: 2.701 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.197CysAla: 1.197 ± 0.035	0.314CysCys: 0.314 ± 0.019	1.153CysAsp: 1.153 ± 0.04	0.967CysGlu: 0.967 ± 0.032	0.728CysPhe: 0.728 ± 0.032	1.636CysGly: 1.636 ± 0.048	0.277CysHis: 0.277 ± 0.019	1.085CysIle: 1.085 ± 0.036	0.755CysLys: 0.755 ± 0.026	1.189CysLeu: 1.189 ± 0.034	0.381CysMet: 0.381 ± 0.021	0.594CysAsn: 0.594 ± 0.024	0.659CysPro: 0.659 ± 0.033	0.295CysGln: 0.295 ± 0.015	0.73CysArg: 0.73 ± 0.031	1.035CysSer: 1.035 ± 0.038	0.766CysThr: 0.766 ± 0.032	1.068CysVal: 1.068 ± 0.03	0.162CysTrp: 0.162 ± 0.013	0.68CysTyr: 0.68 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.342AspAla: 4.342 ± 0.083	0.945AspCys: 0.945 ± 0.029	4.759AspAsp: 4.759 ± 0.097	5.349AspGlu: 5.349 ± 0.083	2.668AspPhe: 2.668 ± 0.053	5.225AspGly: 5.225 ± 0.108	1.113AspHis: 1.113 ± 0.039	5.353AspIle: 5.353 ± 0.077	3.973AspLys: 3.973 ± 0.07	5.172AspLeu: 5.172 ± 0.074	2.027AspMet: 2.027 ± 0.05	3.091AspAsn: 3.091 ± 0.061	2.75AspPro: 2.75 ± 0.058	1.404AspGln: 1.404 ± 0.035	3.373AspArg: 3.373 ± 0.066	4.175AspSer: 4.175 ± 0.078	3.5AspThr: 3.5 ± 0.062	4.357AspVal: 4.357 ± 0.08	0.606AspTrp: 0.606 ± 0.029	3.335AspTyr: 3.335 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	5.17GluAla: 5.17 ± 0.084	0.911GluCys: 0.911 ± 0.034	4.628GluAsp: 4.628 ± 0.077	5.737GluGlu: 5.737 ± 0.099	2.741GluPhe: 2.741 ± 0.062	4.39GluGly: 4.39 ± 0.073	1.177GluHis: 1.177 ± 0.038	4.96GluIle: 4.96 ± 0.071	3.723GluLys: 3.723 ± 0.08	6.053GluLeu: 6.053 ± 0.099	2.048GluMet: 2.048 ± 0.054	3.193GluAsn: 3.193 ± 0.065	2.119GluPro: 2.119 ± 0.066	2.193GluGln: 2.193 ± 0.048	2.996GluArg: 2.996 ± 0.069	3.435GluSer: 3.435 ± 0.063	3.335GluThr: 3.335 ± 0.072	3.964GluVal: 3.964 ± 0.078	0.627GluTrp: 0.627 ± 0.028	3.24GluTyr: 3.24 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.409PheAla: 3.409 ± 0.061	0.752PheCys: 0.752 ± 0.03	3.221PheAsp: 3.221 ± 0.058	2.707PheGlu: 2.707 ± 0.054	1.909PhePhe: 1.909 ± 0.052	3.076PheGly: 3.076 ± 0.056	0.563PheHis: 0.563 ± 0.025	3.155PheIle: 3.155 ± 0.062	2.047PheLys: 2.047 ± 0.054	3.412PheLeu: 3.412 ± 0.074	1.26PheMet: 1.26 ± 0.038	1.773PheAsn: 1.773 ± 0.05	1.332PhePro: 1.332 ± 0.041	0.695PheGln: 0.695 ± 0.028	1.86PheArg: 1.86 ± 0.048	2.622PheSer: 2.622 ± 0.063	2.667PheThr: 2.667 ± 0.065	3.313PheVal: 3.313 ± 0.077	0.465PheTrp: 0.465 ± 0.025	1.772PheTyr: 1.772 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.908GlyAla: 4.908 ± 0.097	1.259GlyCys: 1.259 ± 0.041	4.424GlyAsp: 4.424 ± 0.081	4.351GlyGlu: 4.351 ± 0.078	3.426GlyPhe: 3.426 ± 0.059	5.104GlyGly: 5.104 ± 0.133	1.272GlyHis: 1.272 ± 0.041	6.194GlyIle: 6.194 ± 0.084	4.949GlyLys: 4.949 ± 0.086	5.675GlyLeu: 5.675 ± 0.09	2.306GlyMet: 2.306 ± 0.058	3.186GlyAsn: 3.186 ± 0.072	1.382GlyPro: 1.382 ± 0.044	1.761GlyGln: 1.761 ± 0.045	3.552GlyArg: 3.552 ± 0.075	4.812GlySer: 4.812 ± 0.096	4.565GlyThr: 4.565 ± 0.101	5.272GlyVal: 5.272 ± 0.082	0.808GlyTrp: 0.808 ± 0.046	3.422GlyTyr: 3.422 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.911HisAla: 0.911 ± 0.029	0.283HisCys: 0.283 ± 0.017	1.092HisAsp: 1.092 ± 0.033	1.042HisGlu: 1.042 ± 0.041	0.699HisPhe: 0.699 ± 0.027	1.234HisGly: 1.234 ± 0.045	0.362HisHis: 0.362 ± 0.025	1.306HisIle: 1.306 ± 0.039	0.94HisLys: 0.94 ± 0.035	1.292HisLeu: 1.292 ± 0.04	0.464HisMet: 0.464 ± 0.024	0.704HisAsn: 0.704 ± 0.028	0.815HisPro: 0.815 ± 0.03	0.363HisGln: 0.363 ± 0.018	0.758HisArg: 0.758 ± 0.03	0.937HisSer: 0.937 ± 0.039	0.854HisThr: 0.854 ± 0.03	0.966HisVal: 0.966 ± 0.032	0.147HisTrp: 0.147 ± 0.014	0.773HisTyr: 0.773 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.043IleAla: 6.043 ± 0.085	1.378IleCys: 1.378 ± 0.042	5.201IleAsp: 5.201 ± 0.076	4.449IleGlu: 4.449 ± 0.074	2.897IlePhe: 2.897 ± 0.064	5.035IleGly: 5.035 ± 0.084	1.058IleHis: 1.058 ± 0.036	5.798IleIle: 5.798 ± 0.105	3.929IleLys: 3.929 ± 0.071	6.509IleLeu: 6.509 ± 0.097	2.127IleMet: 2.127 ± 0.046	3.485IleAsn: 3.485 ± 0.068	3.143IlePro: 3.143 ± 0.058	1.429IleGln: 1.429 ± 0.041	4.07IleArg: 4.07 ± 0.073	5.608IleSer: 5.608 ± 0.075	4.853IleThr: 4.853 ± 0.074	5.566IleVal: 5.566 ± 0.082	0.575IleTrp: 0.575 ± 0.025	2.929IleTyr: 2.929 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.694LysAla: 4.694 ± 0.09	0.761LysCys: 0.761 ± 0.033	3.857LysAsp: 3.857 ± 0.07	4.074LysGlu: 4.074 ± 0.077	1.784LysPhe: 1.784 ± 0.046	3.735LysGly: 3.735 ± 0.065	0.93LysHis: 0.93 ± 0.031	4.364LysIle: 4.364 ± 0.067	4.094LysLys: 4.094 ± 0.089	4.423LysLeu: 4.423 ± 0.072	1.812LysMet: 1.812 ± 0.046	2.567LysAsn: 2.567 ± 0.051	1.959LysPro: 1.959 ± 0.056	1.451LysGln: 1.451 ± 0.044	2.737LysArg: 2.737 ± 0.063	3.109LysSer: 3.109 ± 0.061	3.465LysThr: 3.465 ± 0.068	3.848LysVal: 3.848 ± 0.073	0.657LysTrp: 0.657 ± 0.033	2.614LysTyr: 2.614 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.305LeuAla: 6.305 ± 0.093	1.389LeuCys: 1.389 ± 0.042	5.051LeuAsp: 5.051 ± 0.077	4.76LeuGlu: 4.76 ± 0.078	3.793LeuPhe: 3.793 ± 0.077	5.503LeuGly: 5.503 ± 0.094	1.288LeuHis: 1.288 ± 0.041	6.581LeuIle: 6.581 ± 0.094	4.916LeuLys: 4.916 ± 0.08	7.265LeuLeu: 7.265 ± 0.126	2.733LeuMet: 2.733 ± 0.063	3.439LeuAsn: 3.439 ± 0.068	3.237LeuPro: 3.237 ± 0.059	1.845LeuGln: 1.845 ± 0.051	3.866LeuArg: 3.866 ± 0.066	6.07LeuSer: 6.07 ± 0.102	5.132LeuThr: 5.132 ± 0.087	5.779LeuVal: 5.779 ± 0.085	0.725LeuTrp: 0.725 ± 0.033	3.325LeuTyr: 3.325 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.439MetAla: 2.439 ± 0.05	0.439MetCys: 0.439 ± 0.021	1.766MetAsp: 1.766 ± 0.051	1.667MetGlu: 1.667 ± 0.042	1.164MetPhe: 1.164 ± 0.042	1.983MetGly: 1.983 ± 0.053	0.439MetHis: 0.439 ± 0.022	2.439MetIle: 2.439 ± 0.059	1.918MetLys: 1.918 ± 0.045	2.545MetLeu: 2.545 ± 0.049	1.015MetMet: 1.015 ± 0.035	1.549MetAsn: 1.549 ± 0.04	1.242MetPro: 1.242 ± 0.036	0.723MetGln: 0.723 ± 0.027	1.567MetArg: 1.567 ± 0.042	2.294MetSer: 2.294 ± 0.057	1.992MetThr: 1.992 ± 0.047	1.754MetVal: 1.754 ± 0.046	0.246MetTrp: 0.246 ± 0.016	1.015MetTyr: 1.015 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.063	0.749AsnCys: 0.749 ± 0.027	2.763AsnAsp: 2.763 ± 0.054	2.727AsnGlu: 2.727 ± 0.059	1.272AsnPhe: 1.272 ± 0.042	3.675AsnGly: 3.675 ± 0.068	0.652AsnHis: 0.652 ± 0.029	3.388AsnIle: 3.388 ± 0.068	2.441AsnLys: 2.441 ± 0.053	3.179AsnLeu: 3.179 ± 0.062	1.312AsnMet: 1.312 ± 0.041	2.271AsnAsn: 2.271 ± 0.059	1.921AsnPro: 1.921 ± 0.049	0.917AsnGln: 0.917 ± 0.032	2.219AsnArg: 2.219 ± 0.057	2.808AsnSer: 2.808 ± 0.059	2.574AsnThr: 2.574 ± 0.055	3.043AsnVal: 3.043 ± 0.07	0.403AsnTrp: 0.403 ± 0.02	1.952AsnTyr: 1.952 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.842ProAla: 2.842 ± 0.086	0.421ProCys: 0.421 ± 0.025	3.141ProAsp: 3.141 ± 0.071	3.36ProGlu: 3.36 ± 0.063	1.559ProPhe: 1.559 ± 0.05	2.558ProGly: 2.558 ± 0.059	0.55ProHis: 0.55 ± 0.025	1.894ProIle: 1.894 ± 0.045	1.67ProLys: 1.67 ± 0.051	2.705ProLeu: 2.705 ± 0.064	0.879ProMet: 0.879 ± 0.028	1.29ProAsn: 1.29 ± 0.034	0.854ProPro: 0.854 ± 0.036	1.026ProGln: 1.026 ± 0.041	1.123ProArg: 1.123 ± 0.038	2.323ProSer: 2.323 ± 0.055	1.64ProThr: 1.64 ± 0.066	3.505ProVal: 3.505 ± 0.074	0.313ProTrp: 0.313 ± 0.019	1.514ProTyr: 1.514 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.837GlnAla: 1.837 ± 0.047	0.281GlnCys: 0.281 ± 0.019	1.386GlnAsp: 1.386 ± 0.034	1.635GlnGlu: 1.635 ± 0.05	0.965GlnPhe: 0.965 ± 0.033	1.508GlnGly: 1.508 ± 0.043	0.378GlnHis: 0.378 ± 0.022	1.996GlnIle: 1.996 ± 0.046	1.579GlnLys: 1.579 ± 0.042	1.892GlnLeu: 1.892 ± 0.047	0.929GlnMet: 0.929 ± 0.035	1.067GlnAsn: 1.067 ± 0.031	0.776GlnPro: 0.776 ± 0.043	0.788GlnGln: 0.788 ± 0.041	1.11GlnArg: 1.11 ± 0.043	1.38GlnSer: 1.38 ± 0.038	1.336GlnThr: 1.336 ± 0.042	1.551GlnVal: 1.551 ± 0.04	0.228GlnTrp: 0.228 ± 0.015	1.13GlnTyr: 1.13 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.058ArgAla: 3.058 ± 0.063	0.636ArgCys: 0.636 ± 0.026	3.007ArgAsp: 3.007 ± 0.062	3.539ArgGlu: 3.539 ± 0.074	2.181ArgPhe: 2.181 ± 0.058	2.672ArgGly: 2.672 ± 0.059	0.86ArgHis: 0.86 ± 0.025	4.09ArgIle: 4.09 ± 0.081	3.231ArgLys: 3.231 ± 0.064	4.074ArgLeu: 4.074 ± 0.086	1.496ArgMet: 1.496 ± 0.048	2.189ArgAsn: 2.189 ± 0.052	1.544ArgPro: 1.544 ± 0.049	1.417ArgGln: 1.417 ± 0.041	2.726ArgArg: 2.726 ± 0.071	2.958ArgSer: 2.958 ± 0.055	2.506ArgThr: 2.506 ± 0.057	2.899ArgVal: 2.899 ± 0.059	0.411ArgTrp: 0.411 ± 0.022	2.197ArgTyr: 2.197 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.74SerAla: 4.74 ± 0.082	0.979SerCys: 0.979 ± 0.029	4.787SerAsp: 4.787 ± 0.08	4.366SerGlu: 4.366 ± 0.073	2.967SerPhe: 2.967 ± 0.059	6.042SerGly: 6.042 ± 0.111	1.027SerHis: 1.027 ± 0.034	4.388SerIle: 4.388 ± 0.076	3.255SerLys: 3.255 ± 0.064	5.441SerLeu: 5.441 ± 0.088	1.827SerMet: 1.827 ± 0.04	2.579SerAsn: 2.579 ± 0.06	1.928SerPro: 1.928 ± 0.047	1.547SerGln: 1.547 ± 0.044	3.125SerArg: 3.125 ± 0.062	4.907SerSer: 4.907 ± 0.107	3.243SerThr: 3.243 ± 0.074	5.136SerVal: 5.136 ± 0.085	0.557SerTrp: 0.557 ± 0.023	2.862SerTyr: 2.862 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.542ThrAla: 4.542 ± 0.097	0.844ThrCys: 0.844 ± 0.03	3.973ThrAsp: 3.973 ± 0.064	3.591ThrGlu: 3.591 ± 0.062	2.195ThrPhe: 2.195 ± 0.051	5.368ThrGly: 5.368 ± 0.095	0.87ThrHis: 0.87 ± 0.031	3.861ThrIle: 3.861 ± 0.064	2.752ThrLys: 2.752 ± 0.055	4.601ThrLeu: 4.601 ± 0.069	1.438ThrMet: 1.438 ± 0.039	1.985ThrAsn: 1.985 ± 0.048	2.538ThrPro: 2.538 ± 0.087	1.149ThrGln: 1.149 ± 0.039	2.29ThrArg: 2.29 ± 0.046	3.67ThrSer: 3.67 ± 0.081	3.37ThrThr: 3.37 ± 0.136	5.209ThrVal: 5.209 ± 0.101	0.509ThrTrp: 0.509 ± 0.026	2.347ThrTyr: 2.347 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.176ValAla: 5.176 ± 0.087	1.208ValCys: 1.208 ± 0.031	4.361ValAsp: 4.361 ± 0.076	4.013ValGlu: 4.013 ± 0.076	3.602ValPhe: 3.602 ± 0.07	4.017ValGly: 4.017 ± 0.076	1.051ValHis: 1.051 ± 0.035	6.362ValIle: 6.362 ± 0.094	3.936ValLys: 3.936 ± 0.064	6.535ValLeu: 6.535 ± 0.102	2.293ValMet: 2.293 ± 0.058	3.205ValAsn: 3.205 ± 0.066	2.872ValPro: 2.872 ± 0.06	1.451ValGln: 1.451 ± 0.047	3.473ValArg: 3.473 ± 0.065	5.155ValSer: 5.155 ± 0.077	4.943ValThr: 4.943 ± 0.105	5.322ValVal: 5.322 ± 0.1	0.664ValTrp: 0.664 ± 0.026	2.864ValTyr: 2.864 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.561TrpAla: 0.561 ± 0.025	0.146TrpCys: 0.146 ± 0.014	0.584TrpAsp: 0.584 ± 0.029	0.524TrpGlu: 0.524 ± 0.024	0.483TrpPhe: 0.483 ± 0.026	0.664TrpGly: 0.664 ± 0.032	0.214TrpHis: 0.214 ± 0.017	0.661TrpIle: 0.661 ± 0.03	0.624TrpLys: 0.624 ± 0.029	0.743TrpLeu: 0.743 ± 0.027	0.305TrpMet: 0.305 ± 0.019	0.48TrpAsn: 0.48 ± 0.02	0.233TrpPro: 0.233 ± 0.018	0.33TrpGln: 0.33 ± 0.02	0.419TrpArg: 0.419 ± 0.02	0.528TrpSer: 0.528 ± 0.024	0.441TrpThr: 0.441 ± 0.021	0.519TrpVal: 0.519 ± 0.028	0.127TrpTrp: 0.127 ± 0.012	0.632TrpTyr: 0.632 ± 0.041	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.766TyrAla: 2.766 ± 0.067	0.816TyrCys: 0.816 ± 0.028	3.287TyrAsp: 3.287 ± 0.069	2.888TyrGlu: 2.888 ± 0.06	1.874TyrPhe: 1.874 ± 0.054	3.152TyrGly: 3.152 ± 0.058	0.764TyrHis: 0.764 ± 0.034	3.161TyrIle: 3.161 ± 0.064	2.244TyrLys: 2.244 ± 0.047	3.648TyrLeu: 3.648 ± 0.06	1.142TyrMet: 1.142 ± 0.036	2.093TyrAsn: 2.093 ± 0.052	1.415TyrPro: 1.415 ± 0.043	1.025TyrGln: 1.025 ± 0.036	2.269TyrArg: 2.269 ± 0.056	2.957TyrSer: 2.957 ± 0.068	2.427TyrThr: 2.427 ± 0.067	2.936TyrVal: 2.936 ± 0.059	0.438TyrTrp: 0.438 ± 0.023	2.467TyrTyr: 2.467 ± 0.081	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2644 proteins (907111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---