Amino acid dipepetide frequency for Streptococcus phage Javan465

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.667AlaAla: 4.667 ± 0.996
0.255AlaCys: 0.255 ± 0.114
5.261AlaAsp: 5.261 ± 0.771
7.043AlaGlu: 7.043 ± 0.781
2.97AlaPhe: 2.97 ± 0.812
4.582AlaGly: 4.582 ± 0.856
0.339AlaHis: 0.339 ± 0.219
6.788AlaIle: 6.788 ± 0.788
7.043AlaLys: 7.043 ± 0.873
7.552AlaLeu: 7.552 ± 0.93
2.376AlaMet: 2.376 ± 0.498
5.77AlaAsn: 5.77 ± 1.062
1.527AlaPro: 1.527 ± 0.347
4.073AlaGln: 4.073 ± 0.721
2.885AlaArg: 2.885 ± 0.558
4.667AlaSer: 4.667 ± 1.108
5.855AlaThr: 5.855 ± 1.074
4.752AlaVal: 4.752 ± 0.862
0.424AlaTrp: 0.424 ± 0.191
3.564AlaTyr: 3.564 ± 0.733
0.0AlaXaa: 0.0 ± 0.0
Cys
0.17CysAla: 0.17 ± 0.121
0.085CysCys: 0.085 ± 0.082
0.085CysAsp: 0.085 ± 0.082
0.424CysGlu: 0.424 ± 0.219
0.085CysPhe: 0.085 ± 0.089
0.255CysGly: 0.255 ± 0.154
0.085CysHis: 0.085 ± 0.08
0.339CysIle: 0.339 ± 0.163
0.339CysLys: 0.339 ± 0.2
0.509CysLeu: 0.509 ± 0.27
0.17CysMet: 0.17 ± 0.121
0.085CysAsn: 0.085 ± 0.079
0.085CysPro: 0.085 ± 0.086
0.509CysGln: 0.509 ± 0.176
0.339CysArg: 0.339 ± 0.202
0.085CysSer: 0.085 ± 0.082
0.255CysThr: 0.255 ± 0.193
0.17CysVal: 0.17 ± 0.116
0.17CysTrp: 0.17 ± 0.11
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.564AspAla: 3.564 ± 0.57
0.17AspCys: 0.17 ± 0.123
3.224AspAsp: 3.224 ± 0.589
5.006AspGlu: 5.006 ± 0.86
3.649AspPhe: 3.649 ± 0.608
4.243AspGly: 4.243 ± 0.671
0.509AspHis: 0.509 ± 0.208
4.752AspIle: 4.752 ± 0.65
6.194AspLys: 6.194 ± 0.881
5.855AspLeu: 5.855 ± 0.912
1.952AspMet: 1.952 ± 0.424
3.224AspAsn: 3.224 ± 0.626
1.612AspPro: 1.612 ± 0.404
1.103AspGln: 1.103 ± 0.296
2.715AspArg: 2.715 ± 0.451
3.479AspSer: 3.479 ± 0.508
3.055AspThr: 3.055 ± 0.537
2.97AspVal: 2.97 ± 0.601
0.679AspTrp: 0.679 ± 0.228
3.564AspTyr: 3.564 ± 0.77
0.0AspXaa: 0.0 ± 0.0
Glu
6.279GluAla: 6.279 ± 0.923
0.255GluCys: 0.255 ± 0.179
3.394GluAsp: 3.394 ± 0.731
5.94GluGlu: 5.94 ± 1.04
2.291GluPhe: 2.291 ± 0.355
3.818GluGly: 3.818 ± 0.598
1.358GluHis: 1.358 ± 0.417
5.091GluIle: 5.091 ± 0.788
6.534GluLys: 6.534 ± 1.008
7.891GluLeu: 7.891 ± 0.974
2.036GluMet: 2.036 ± 0.393
3.818GluAsn: 3.818 ± 0.739
2.376GluPro: 2.376 ± 0.414
2.121GluGln: 2.121 ± 0.458
4.073GluArg: 4.073 ± 1.02
3.564GluSer: 3.564 ± 0.511
3.903GluThr: 3.903 ± 0.601
3.988GluVal: 3.988 ± 0.765
1.018GluTrp: 1.018 ± 0.271
3.394GluTyr: 3.394 ± 0.69
0.0GluXaa: 0.0 ± 0.0
Phe
3.394PheAla: 3.394 ± 0.844
0.17PheCys: 0.17 ± 0.099
2.63PheAsp: 2.63 ± 0.514
2.546PheGlu: 2.546 ± 0.494
1.103PhePhe: 1.103 ± 0.376
2.291PheGly: 2.291 ± 0.629
0.17PheHis: 0.17 ± 0.124
2.63PheIle: 2.63 ± 0.507
3.818PheLys: 3.818 ± 0.744
2.715PheLeu: 2.715 ± 0.586
0.933PheMet: 0.933 ± 0.275
2.63PheAsn: 2.63 ± 0.369
0.594PhePro: 0.594 ± 0.192
0.509PheGln: 0.509 ± 0.173
1.612PheArg: 1.612 ± 0.298
2.461PheSer: 2.461 ± 0.424
2.546PheThr: 2.546 ± 0.432
2.206PheVal: 2.206 ± 0.417
0.679PheTrp: 0.679 ± 0.247
1.103PheTyr: 1.103 ± 0.353
0.0PheXaa: 0.0 ± 0.0
Gly
5.431GlyAla: 5.431 ± 0.69
0.085GlyCys: 0.085 ± 0.086
3.479GlyAsp: 3.479 ± 0.67
3.394GlyGlu: 3.394 ± 0.533
2.8GlyPhe: 2.8 ± 0.632
3.903GlyGly: 3.903 ± 0.541
1.103GlyHis: 1.103 ± 0.334
4.412GlyIle: 4.412 ± 1.222
6.109GlyLys: 6.109 ± 0.736
6.449GlyLeu: 6.449 ± 0.881
2.036GlyMet: 2.036 ± 0.442
1.867GlyAsn: 1.867 ± 0.35
0.679GlyPro: 0.679 ± 0.21
2.036GlyGln: 2.036 ± 0.35
3.224GlyArg: 3.224 ± 0.58
2.97GlySer: 2.97 ± 0.377
4.158GlyThr: 4.158 ± 0.757
4.412GlyVal: 4.412 ± 0.602
0.679GlyTrp: 0.679 ± 0.256
2.715GlyTyr: 2.715 ± 0.582
0.0GlyXaa: 0.0 ± 0.0
His
0.933HisAla: 0.933 ± 0.28
0.085HisCys: 0.085 ± 0.084
0.424HisAsp: 0.424 ± 0.223
0.933HisGlu: 0.933 ± 0.256
0.594HisPhe: 0.594 ± 0.243
0.679HisGly: 0.679 ± 0.269
0.424HisHis: 0.424 ± 0.18
0.849HisIle: 0.849 ± 0.305
1.018HisLys: 1.018 ± 0.258
0.849HisLeu: 0.849 ± 0.274
0.0HisMet: 0.0 ± 0.0
0.424HisAsn: 0.424 ± 0.182
0.764HisPro: 0.764 ± 0.298
0.339HisGln: 0.339 ± 0.153
0.679HisArg: 0.679 ± 0.237
0.764HisSer: 0.764 ± 0.312
0.849HisThr: 0.849 ± 0.345
0.849HisVal: 0.849 ± 0.285
0.0HisTrp: 0.0 ± 0.0
0.255HisTyr: 0.255 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
5.6IleAla: 5.6 ± 0.936
0.17IleCys: 0.17 ± 0.117
7.297IleAsp: 7.297 ± 0.849
4.412IleGlu: 4.412 ± 0.844
1.952IlePhe: 1.952 ± 0.418
3.903IleGly: 3.903 ± 0.673
0.594IleHis: 0.594 ± 0.187
5.261IleIle: 5.261 ± 0.833
7.552IleLys: 7.552 ± 1.023
4.922IleLeu: 4.922 ± 0.609
1.358IleMet: 1.358 ± 0.215
4.412IleAsn: 4.412 ± 0.744
2.121IlePro: 2.121 ± 0.375
2.63IleGln: 2.63 ± 0.737
2.206IleArg: 2.206 ± 0.47
4.328IleSer: 4.328 ± 0.707
4.497IleThr: 4.497 ± 0.635
3.734IleVal: 3.734 ± 0.571
0.679IleTrp: 0.679 ± 0.277
3.649IleTyr: 3.649 ± 0.651
0.0IleXaa: 0.0 ± 0.0
Lys
6.788LysAla: 6.788 ± 0.611
0.17LysCys: 0.17 ± 0.115
5.431LysAsp: 5.431 ± 0.849
6.279LysGlu: 6.279 ± 0.871
2.121LysPhe: 2.121 ± 0.427
5.091LysGly: 5.091 ± 0.663
1.103LysHis: 1.103 ± 0.423
8.231LysIle: 8.231 ± 0.843
7.637LysLys: 7.637 ± 1.447
6.109LysLeu: 6.109 ± 0.609
2.63LysMet: 2.63 ± 0.534
5.091LysAsn: 5.091 ± 0.725
3.224LysPro: 3.224 ± 0.535
3.903LysGln: 3.903 ± 0.725
4.412LysArg: 4.412 ± 0.757
4.243LysSer: 4.243 ± 0.561
4.922LysThr: 4.922 ± 0.572
5.431LysVal: 5.431 ± 0.707
1.273LysTrp: 1.273 ± 0.394
3.309LysTyr: 3.309 ± 0.587
0.0LysXaa: 0.0 ± 0.0
Leu
6.788LeuAla: 6.788 ± 0.792
0.255LeuCys: 0.255 ± 0.158
5.94LeuAsp: 5.94 ± 0.546
7.128LeuGlu: 7.128 ± 1.202
2.63LeuPhe: 2.63 ± 0.461
5.346LeuGly: 5.346 ± 0.832
0.679LeuHis: 0.679 ± 0.225
4.412LeuIle: 4.412 ± 0.685
8.401LeuLys: 8.401 ± 1.155
6.109LeuLeu: 6.109 ± 0.688
2.121LeuMet: 2.121 ± 0.477
5.77LeuAsn: 5.77 ± 0.504
3.818LeuPro: 3.818 ± 0.805
3.479LeuGln: 3.479 ± 0.404
4.073LeuArg: 4.073 ± 0.646
7.128LeuSer: 7.128 ± 1.131
5.006LeuThr: 5.006 ± 0.595
5.6LeuVal: 5.6 ± 0.541
0.679LeuTrp: 0.679 ± 0.228
1.782LeuTyr: 1.782 ± 0.422
0.0LeuXaa: 0.0 ± 0.0
Met
3.309MetAla: 3.309 ± 0.751
0.085MetCys: 0.085 ± 0.082
1.443MetAsp: 1.443 ± 0.269
1.867MetGlu: 1.867 ± 0.37
0.849MetPhe: 0.849 ± 0.263
1.273MetGly: 1.273 ± 0.308
0.255MetHis: 0.255 ± 0.124
1.443MetIle: 1.443 ± 0.295
1.018MetLys: 1.018 ± 0.298
2.121MetLeu: 2.121 ± 0.342
0.594MetMet: 0.594 ± 0.237
1.612MetAsn: 1.612 ± 0.369
1.018MetPro: 1.018 ± 0.233
0.849MetGln: 0.849 ± 0.258
1.697MetArg: 1.697 ± 0.4
2.8MetSer: 2.8 ± 0.643
1.103MetThr: 1.103 ± 0.268
0.764MetVal: 0.764 ± 0.263
0.085MetTrp: 0.085 ± 0.068
0.424MetTyr: 0.424 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
5.431AsnAla: 5.431 ± 0.66
0.17AsnCys: 0.17 ± 0.119
2.546AsnAsp: 2.546 ± 0.455
3.479AsnGlu: 3.479 ± 0.842
1.782AsnPhe: 1.782 ± 0.5
4.158AsnGly: 4.158 ± 0.605
0.764AsnHis: 0.764 ± 0.232
4.243AsnIle: 4.243 ± 0.5
3.988AsnLys: 3.988 ± 0.587
5.006AsnLeu: 5.006 ± 0.688
0.933AsnMet: 0.933 ± 0.235
2.546AsnAsn: 2.546 ± 0.472
2.206AsnPro: 2.206 ± 0.488
1.697AsnGln: 1.697 ± 0.453
2.206AsnArg: 2.206 ± 0.367
4.582AsnSer: 4.582 ± 0.959
2.885AsnThr: 2.885 ± 0.539
2.63AsnVal: 2.63 ± 0.479
0.764AsnTrp: 0.764 ± 0.238
2.206AsnTyr: 2.206 ± 0.473
0.0AsnXaa: 0.0 ± 0.0
Pro
1.527ProAla: 1.527 ± 0.382
0.255ProCys: 0.255 ± 0.183
1.527ProAsp: 1.527 ± 0.378
2.546ProGlu: 2.546 ± 0.622
1.103ProPhe: 1.103 ± 0.31
1.867ProGly: 1.867 ± 0.38
0.085ProHis: 0.085 ± 0.09
1.443ProIle: 1.443 ± 0.319
2.546ProLys: 2.546 ± 0.524
2.036ProLeu: 2.036 ± 0.461
0.339ProMet: 0.339 ± 0.179
2.121ProAsn: 2.121 ± 0.529
0.255ProPro: 0.255 ± 0.138
1.952ProGln: 1.952 ± 0.438
1.273ProArg: 1.273 ± 0.357
1.867ProSer: 1.867 ± 0.424
1.867ProThr: 1.867 ± 0.434
2.546ProVal: 2.546 ± 0.494
0.17ProTrp: 0.17 ± 0.12
0.933ProTyr: 0.933 ± 0.429
0.0ProXaa: 0.0 ± 0.0
Gln
3.649GlnAla: 3.649 ± 0.751
0.17GlnCys: 0.17 ± 0.124
2.206GlnAsp: 2.206 ± 0.418
2.8GlnGlu: 2.8 ± 0.562
1.697GlnPhe: 1.697 ± 0.39
2.461GlnGly: 2.461 ± 0.474
0.17GlnHis: 0.17 ± 0.115
3.564GlnIle: 3.564 ± 0.679
3.055GlnLys: 3.055 ± 0.526
3.988GlnLeu: 3.988 ± 0.662
0.933GlnMet: 0.933 ± 0.315
1.952GlnAsn: 1.952 ± 0.488
0.339GlnPro: 0.339 ± 0.18
1.697GlnGln: 1.697 ± 0.472
1.697GlnArg: 1.697 ± 0.358
2.885GlnSer: 2.885 ± 0.591
2.206GlnThr: 2.206 ± 0.379
1.188GlnVal: 1.188 ± 0.3
0.339GlnTrp: 0.339 ± 0.203
0.849GlnTyr: 0.849 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
3.564ArgAla: 3.564 ± 0.601
0.424ArgCys: 0.424 ± 0.224
2.291ArgAsp: 2.291 ± 0.471
3.309ArgGlu: 3.309 ± 0.615
2.291ArgPhe: 2.291 ± 0.477
1.612ArgGly: 1.612 ± 0.368
0.933ArgHis: 0.933 ± 0.254
3.564ArgIle: 3.564 ± 0.537
3.224ArgLys: 3.224 ± 0.682
5.94ArgLeu: 5.94 ± 1.073
1.443ArgMet: 1.443 ± 0.361
2.546ArgAsn: 2.546 ± 0.605
1.103ArgPro: 1.103 ± 0.27
1.443ArgGln: 1.443 ± 0.305
1.443ArgArg: 1.443 ± 0.452
2.036ArgSer: 2.036 ± 0.368
2.885ArgThr: 2.885 ± 0.641
2.461ArgVal: 2.461 ± 0.512
0.594ArgTrp: 0.594 ± 0.261
1.527ArgTyr: 1.527 ± 0.437
0.0ArgXaa: 0.0 ± 0.0
Ser
6.788SerAla: 6.788 ± 1.689
0.339SerCys: 0.339 ± 0.182
3.649SerAsp: 3.649 ± 0.61
4.073SerGlu: 4.073 ± 0.551
1.697SerPhe: 1.697 ± 0.486
5.515SerGly: 5.515 ± 0.95
0.849SerHis: 0.849 ± 0.359
4.328SerIle: 4.328 ± 0.702
5.346SerLys: 5.346 ± 0.559
5.091SerLeu: 5.091 ± 1.5
1.612SerMet: 1.612 ± 0.507
3.394SerAsn: 3.394 ± 0.72
1.612SerPro: 1.612 ± 0.329
2.206SerGln: 2.206 ± 0.432
3.14SerArg: 3.14 ± 0.537
5.261SerSer: 5.261 ± 1.624
3.309SerThr: 3.309 ± 0.717
5.006SerVal: 5.006 ± 0.708
0.509SerTrp: 0.509 ± 0.193
2.206SerTyr: 2.206 ± 0.43
0.0SerXaa: 0.0 ± 0.0
Thr
5.176ThrAla: 5.176 ± 0.886
0.339ThrCys: 0.339 ± 0.192
3.394ThrAsp: 3.394 ± 0.597
2.715ThrGlu: 2.715 ± 0.521
2.63ThrPhe: 2.63 ± 0.474
4.752ThrGly: 4.752 ± 0.738
0.933ThrHis: 0.933 ± 0.294
3.564ThrIle: 3.564 ± 0.448
5.091ThrLys: 5.091 ± 0.536
4.752ThrLeu: 4.752 ± 0.562
1.018ThrMet: 1.018 ± 0.328
2.036ThrAsn: 2.036 ± 0.398
1.867ThrPro: 1.867 ± 0.382
2.546ThrGln: 2.546 ± 0.503
2.121ThrArg: 2.121 ± 0.512
5.091ThrSer: 5.091 ± 1.542
4.328ThrThr: 4.328 ± 0.788
4.158ThrVal: 4.158 ± 0.484
0.679ThrTrp: 0.679 ± 0.349
2.121ThrTyr: 2.121 ± 0.507
0.0ThrXaa: 0.0 ± 0.0
Val
5.346ValAla: 5.346 ± 0.675
0.255ValCys: 0.255 ± 0.149
3.649ValAsp: 3.649 ± 0.534
4.667ValGlu: 4.667 ± 0.747
2.036ValPhe: 2.036 ± 0.422
3.818ValGly: 3.818 ± 0.508
0.933ValHis: 0.933 ± 0.245
4.243ValIle: 4.243 ± 0.553
4.752ValLys: 4.752 ± 0.413
4.667ValLeu: 4.667 ± 0.647
1.782ValMet: 1.782 ± 0.412
2.8ValAsn: 2.8 ± 0.397
1.443ValPro: 1.443 ± 0.377
2.206ValGln: 2.206 ± 0.596
2.291ValArg: 2.291 ± 0.44
4.328ValSer: 4.328 ± 0.737
3.479ValThr: 3.479 ± 0.423
3.903ValVal: 3.903 ± 0.443
0.509ValTrp: 0.509 ± 0.182
2.291ValTyr: 2.291 ± 0.488
0.0ValXaa: 0.0 ± 0.0
Trp
0.849TrpAla: 0.849 ± 0.243
0.0TrpCys: 0.0 ± 0.0
0.849TrpAsp: 0.849 ± 0.2
1.273TrpGlu: 1.273 ± 0.293
0.764TrpPhe: 0.764 ± 0.215
0.594TrpGly: 0.594 ± 0.201
0.085TrpHis: 0.085 ± 0.08
0.509TrpIle: 0.509 ± 0.179
0.594TrpLys: 0.594 ± 0.18
1.018TrpLeu: 1.018 ± 0.294
0.0TrpMet: 0.0 ± 0.0
0.509TrpAsn: 0.509 ± 0.202
0.594TrpPro: 0.594 ± 0.248
0.509TrpGln: 0.509 ± 0.239
0.594TrpArg: 0.594 ± 0.261
0.679TrpSer: 0.679 ± 0.221
0.085TrpThr: 0.085 ± 0.079
0.679TrpVal: 0.679 ± 0.289
0.17TrpTrp: 0.17 ± 0.114
0.085TrpTyr: 0.085 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.14TyrAla: 3.14 ± 0.475
0.509TyrCys: 0.509 ± 0.2
2.8TyrAsp: 2.8 ± 0.65
3.309TyrGlu: 3.309 ± 0.749
1.697TyrPhe: 1.697 ± 0.362
1.782TyrGly: 1.782 ± 0.467
0.339TyrHis: 0.339 ± 0.16
1.612TyrIle: 1.612 ± 0.397
3.224TyrLys: 3.224 ± 0.591
3.564TyrLeu: 3.564 ± 0.653
0.255TyrMet: 0.255 ± 0.133
1.612TyrAsn: 1.612 ± 0.357
1.018TyrPro: 1.018 ± 0.359
2.036TyrGln: 2.036 ± 0.465
1.952TyrArg: 1.952 ± 0.54
2.715TyrSer: 2.715 ± 0.49
2.121TyrThr: 2.121 ± 0.468
1.952TyrVal: 1.952 ± 0.436
0.339TyrTrp: 0.339 ± 0.152
1.867TyrTyr: 1.867 ± 0.514
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski