Amino acid dipepetide frequency for Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.301AlaAla: 8.301 ± 0.059	0.988AlaCys: 0.988 ± 0.016	4.041AlaAsp: 4.041 ± 0.03	4.873AlaGlu: 4.873 ± 0.044	3.001AlaPhe: 3.001 ± 0.025	5.273AlaGly: 5.273 ± 0.038	1.669AlaHis: 1.669 ± 0.018	4.54AlaIle: 4.54 ± 0.034	3.852AlaLys: 3.852 ± 0.03	7.379AlaLeu: 7.379 ± 0.05	1.865AlaMet: 1.865 ± 0.019	3.052AlaAsn: 3.052 ± 0.024	4.164AlaPro: 4.164 ± 0.044	3.286AlaGln: 3.286 ± 0.028	4.48AlaArg: 4.48 ± 0.036	6.941AlaSer: 6.941 ± 0.042	5.247AlaThr: 5.247 ± 0.035	5.201AlaVal: 5.201 ± 0.034	1.107AlaTrp: 1.107 ± 0.016	2.229AlaTyr: 2.229 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.869CysAla: 0.869 ± 0.015	0.218CysCys: 0.218 ± 0.007	0.643CysAsp: 0.643 ± 0.011	0.588CysGlu: 0.588 ± 0.01	0.531CysPhe: 0.531 ± 0.01	0.841CysGly: 0.841 ± 0.015	0.328CysHis: 0.328 ± 0.009	0.707CysIle: 0.707 ± 0.013	0.479CysLys: 0.479 ± 0.01	1.225CysLeu: 1.225 ± 0.016	0.259CysMet: 0.259 ± 0.007	0.414CysAsn: 0.414 ± 0.009	0.586CysPro: 0.586 ± 0.012	0.457CysGln: 0.457 ± 0.011	0.691CysArg: 0.691 ± 0.013	0.822CysSer: 0.822 ± 0.015	0.652CysThr: 0.652 ± 0.012	0.753CysVal: 0.753 ± 0.014	0.191CysTrp: 0.191 ± 0.006	0.354CysTyr: 0.354 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.404AspAla: 4.404 ± 0.027	0.608AspCys: 0.608 ± 0.011	4.232AspAsp: 4.232 ± 0.05	4.508AspGlu: 4.508 ± 0.038	2.22AspPhe: 2.22 ± 0.023	3.755AspGly: 3.755 ± 0.026	1.25AspHis: 1.25 ± 0.015	3.489AspIle: 3.489 ± 0.029	2.425AspLys: 2.425 ± 0.022	5.068AspLeu: 5.068 ± 0.037	1.313AspMet: 1.313 ± 0.016	2.099AspAsn: 2.099 ± 0.02	3.075AspPro: 3.075 ± 0.029	1.938AspGln: 1.938 ± 0.021	3.009AspArg: 3.009 ± 0.03	4.218AspSer: 4.218 ± 0.033	3.054AspThr: 3.054 ± 0.024	3.698AspVal: 3.698 ± 0.031	0.861AspTrp: 0.861 ± 0.014	1.723AspTyr: 1.723 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.101GluAla: 5.101 ± 0.04	0.587GluCys: 0.587 ± 0.012	4.246GluAsp: 4.246 ± 0.038	5.549GluGlu: 5.549 ± 0.06	2.027GluPhe: 2.027 ± 0.019	3.488GluGly: 3.488 ± 0.03	1.38GluHis: 1.38 ± 0.014	3.437GluIle: 3.437 ± 0.026	3.9GluLys: 3.9 ± 0.036	5.204GluLeu: 5.204 ± 0.036	1.413GluMet: 1.413 ± 0.015	2.582GluAsn: 2.582 ± 0.026	2.617GluPro: 2.617 ± 0.045	2.619GluGln: 2.619 ± 0.029	3.84GluArg: 3.84 ± 0.039	4.447GluSer: 4.447 ± 0.036	3.669GluThr: 3.669 ± 0.029	3.495GluVal: 3.495 ± 0.029	0.875GluTrp: 0.875 ± 0.013	1.8GluTyr: 1.8 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.949PheAla: 2.949 ± 0.027	0.535PheCys: 0.535 ± 0.01	2.318PheAsp: 2.318 ± 0.021	2.206PheGlu: 2.206 ± 0.02	1.611PhePhe: 1.611 ± 0.021	2.748PheGly: 2.748 ± 0.027	0.907PheHis: 0.907 ± 0.013	1.981PheIle: 1.981 ± 0.022	1.525PheLys: 1.525 ± 0.016	3.582PheLeu: 3.582 ± 0.03	0.848PheMet: 0.848 ± 0.013	1.492PheAsn: 1.492 ± 0.016	1.902PhePro: 1.902 ± 0.017	1.44PheGln: 1.44 ± 0.016	1.942PheArg: 1.942 ± 0.02	3.065PheSer: 3.065 ± 0.026	2.21PheThr: 2.21 ± 0.021	2.425PheVal: 2.425 ± 0.024	0.613PheTrp: 0.613 ± 0.012	1.156PheTyr: 1.156 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.859GlyAla: 4.859 ± 0.038	0.779GlyCys: 0.779 ± 0.015	3.406GlyAsp: 3.406 ± 0.028	3.347GlyGlu: 3.347 ± 0.027	2.76GlyPhe: 2.76 ± 0.025	5.276GlyGly: 5.276 ± 0.048	1.635GlyHis: 1.635 ± 0.019	3.648GlyIle: 3.648 ± 0.028	3.308GlyLys: 3.308 ± 0.03	5.918GlyLeu: 5.918 ± 0.037	1.473GlyMet: 1.473 ± 0.017	2.558GlyAsn: 2.558 ± 0.025	2.974GlyPro: 2.974 ± 0.03	2.493GlyGln: 2.493 ± 0.024	3.799GlyArg: 3.799 ± 0.027	5.426GlySer: 5.426 ± 0.036	3.842GlyThr: 3.842 ± 0.032	4.166GlyVal: 4.166 ± 0.031	1.117GlyTrp: 1.117 ± 0.017	2.201GlyTyr: 2.201 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.729HisAla: 1.729 ± 0.017	0.297HisCys: 0.297 ± 0.007	1.327HisAsp: 1.327 ± 0.02	1.359HisGlu: 1.359 ± 0.02	0.918HisPhe: 0.918 ± 0.013	1.653HisGly: 1.653 ± 0.019	0.875HisHis: 0.875 ± 0.018	1.342HisIle: 1.342 ± 0.017	0.943HisLys: 0.943 ± 0.013	2.232HisLeu: 2.232 ± 0.023	0.479HisMet: 0.479 ± 0.01	0.911HisAsn: 0.911 ± 0.012	1.556HisPro: 1.556 ± 0.018	1.015HisGln: 1.015 ± 0.014	1.526HisArg: 1.526 ± 0.021	1.853HisSer: 1.853 ± 0.022	1.288HisThr: 1.288 ± 0.015	1.427HisVal: 1.427 ± 0.015	0.347HisTrp: 0.347 ± 0.008	0.724HisTyr: 0.724 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.403IleAla: 4.403 ± 0.033	0.807IleCys: 0.807 ± 0.013	3.269IleAsp: 3.269 ± 0.025	3.29IleGlu: 3.29 ± 0.028	2.199IlePhe: 2.199 ± 0.023	3.387IleGly: 3.387 ± 0.031	1.311IleHis: 1.311 ± 0.017	2.967IleIle: 2.967 ± 0.029	2.432IleLys: 2.432 ± 0.022	5.013IleLeu: 5.013 ± 0.034	1.095IleMet: 1.095 ± 0.014	2.136IleAsn: 2.136 ± 0.02	3.334IlePro: 3.334 ± 0.029	2.234IleGln: 2.234 ± 0.024	3.089IleArg: 3.089 ± 0.027	4.437IleSer: 4.437 ± 0.03	3.128IleThr: 3.128 ± 0.024	3.431IleVal: 3.431 ± 0.031	0.776IleTrp: 0.776 ± 0.012	1.638IleTyr: 1.638 ± 0.02	0.001IleXaa: 0.001 ± 0.0
Lys	4.097LysAla: 4.097 ± 0.035	0.486LysCys: 0.486 ± 0.008	2.851LysAsp: 2.851 ± 0.029	3.503LysGlu: 3.503 ± 0.035	1.514LysPhe: 1.514 ± 0.017	2.829LysGly: 2.829 ± 0.028	1.125LysHis: 1.125 ± 0.017	2.564LysIle: 2.564 ± 0.02	3.421LysLys: 3.421 ± 0.045	4.178LysLeu: 4.178 ± 0.032	1.015LysMet: 1.015 ± 0.014	1.948LysAsn: 1.948 ± 0.022	2.632LysPro: 2.632 ± 0.027	1.977LysGln: 1.977 ± 0.023	3.437LysArg: 3.437 ± 0.031	3.67LysSer: 3.67 ± 0.035	2.913LysThr: 2.913 ± 0.026	2.807LysVal: 2.807 ± 0.027	0.666LysTrp: 0.666 ± 0.012	1.518LysTyr: 1.518 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.382LeuAla: 7.382 ± 0.04	1.164LeuCys: 1.164 ± 0.02	5.224LeuAsp: 5.224 ± 0.034	5.542LeuGlu: 5.542 ± 0.042	3.358LeuPhe: 3.358 ± 0.029	5.702LeuGly: 5.702 ± 0.038	2.214LeuHis: 2.214 ± 0.022	4.413LeuIle: 4.413 ± 0.034	4.385LeuLys: 4.385 ± 0.037	8.445LeuLeu: 8.445 ± 0.056	1.778LeuMet: 1.778 ± 0.018	3.475LeuAsn: 3.475 ± 0.026	5.234LeuPro: 5.234 ± 0.034	4.051LeuGln: 4.051 ± 0.026	5.613LeuArg: 5.613 ± 0.041	7.5LeuSer: 7.5 ± 0.043	4.959LeuThr: 4.959 ± 0.034	5.358LeuVal: 5.358 ± 0.04	1.19LeuTrp: 1.19 ± 0.014	2.485LeuTyr: 2.485 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.12MetAla: 2.12 ± 0.02	0.231MetCys: 0.231 ± 0.007	1.209MetAsp: 1.209 ± 0.015	1.289MetGlu: 1.289 ± 0.017	0.731MetPhe: 0.731 ± 0.013	1.369MetGly: 1.369 ± 0.016	0.482MetHis: 0.482 ± 0.009	1.115MetIle: 1.115 ± 0.014	1.023MetLys: 1.023 ± 0.015	1.851MetLeu: 1.851 ± 0.022	0.562MetMet: 0.562 ± 0.01	0.856MetAsn: 0.856 ± 0.014	1.191MetPro: 1.191 ± 0.017	0.875MetGln: 0.875 ± 0.014	1.192MetArg: 1.192 ± 0.017	1.871MetSer: 1.871 ± 0.019	1.378MetThr: 1.378 ± 0.017	1.269MetVal: 1.269 ± 0.018	0.264MetTrp: 0.264 ± 0.008	0.522MetTyr: 0.522 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.221AsnAla: 3.221 ± 0.027	0.451AsnCys: 0.451 ± 0.01	2.225AsnAsp: 2.225 ± 0.024	2.293AsnGlu: 2.293 ± 0.021	1.437AsnPhe: 1.437 ± 0.015	3.096AsnGly: 3.096 ± 0.032	0.943AsnHis: 0.943 ± 0.014	2.446AsnIle: 2.446 ± 0.024	1.76AsnLys: 1.76 ± 0.023	3.435AsnLeu: 3.435 ± 0.029	0.887AsnMet: 0.887 ± 0.012	1.972AsnAsn: 1.972 ± 0.03	2.523AsnPro: 2.523 ± 0.025	1.512AsnGln: 1.512 ± 0.02	2.11AsnArg: 2.11 ± 0.018	2.985AsnSer: 2.985 ± 0.027	2.461AsnThr: 2.461 ± 0.027	2.475AsnVal: 2.475 ± 0.022	0.572AsnTrp: 0.572 ± 0.011	1.175AsnTyr: 1.175 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.599ProAla: 4.599 ± 0.04	0.48ProCys: 0.48 ± 0.01	3.02ProAsp: 3.02 ± 0.026	3.774ProGlu: 3.774 ± 0.045	2.024ProPhe: 2.024 ± 0.021	3.522ProGly: 3.522 ± 0.031	1.238ProHis: 1.238 ± 0.017	2.731ProIle: 2.731 ± 0.021	2.502ProLys: 2.502 ± 0.027	4.564ProLeu: 4.564 ± 0.033	0.981ProMet: 0.981 ± 0.013	2.221ProAsn: 2.221 ± 0.021	4.477ProPro: 4.477 ± 0.076	2.352ProGln: 2.352 ± 0.032	3.152ProArg: 3.152 ± 0.034	5.711ProSer: 5.711 ± 0.053	3.87ProThr: 3.87 ± 0.035	3.411ProVal: 3.411 ± 0.037	0.708ProTrp: 0.708 ± 0.012	1.56ProTyr: 1.56 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.386GlnAla: 3.386 ± 0.032	0.445GlnCys: 0.445 ± 0.011	2.061GlnAsp: 2.061 ± 0.022	2.545GlnGlu: 2.545 ± 0.024	1.365GlnPhe: 1.365 ± 0.016	2.319GlnGly: 2.319 ± 0.023	1.099GlnHis: 1.099 ± 0.016	2.147GlnIle: 2.147 ± 0.019	2.138GlnLys: 2.138 ± 0.02	3.575GlnLeu: 3.575 ± 0.029	0.875GlnMet: 0.875 ± 0.014	1.758GlnAsn: 1.758 ± 0.018	2.495GlnPro: 2.495 ± 0.031	2.693GlnGln: 2.693 ± 0.044	2.731GlnArg: 2.731 ± 0.026	3.322GlnSer: 3.322 ± 0.029	2.455GlnThr: 2.455 ± 0.023	2.177GlnVal: 2.177 ± 0.022	0.587GlnTrp: 0.587 ± 0.011	1.316GlnTyr: 1.316 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.305ArgAla: 4.305 ± 0.033	0.654ArgCys: 0.654 ± 0.012	3.28ArgAsp: 3.28 ± 0.034	3.741ArgGlu: 3.741 ± 0.035	2.214ArgPhe: 2.214 ± 0.025	3.486ArgGly: 3.486 ± 0.029	1.529ArgHis: 1.529 ± 0.019	3.18ArgIle: 3.18 ± 0.026	3.462ArgLys: 3.462 ± 0.035	5.515ArgLeu: 5.515 ± 0.041	1.257ArgMet: 1.257 ± 0.015	2.395ArgAsn: 2.395 ± 0.024	3.171ArgPro: 3.171 ± 0.034	2.647ArgGln: 2.647 ± 0.025	4.949ArgArg: 4.949 ± 0.048	4.642ArgSer: 4.642 ± 0.04	3.281ArgThr: 3.281 ± 0.029	3.193ArgVal: 3.193 ± 0.026	0.885ArgTrp: 0.885 ± 0.014	1.726ArgTyr: 1.726 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.357SerAla: 6.357 ± 0.042	0.803SerCys: 0.803 ± 0.015	4.258SerAsp: 4.258 ± 0.037	4.238SerGlu: 4.238 ± 0.035	3.124SerPhe: 3.124 ± 0.027	5.27SerGly: 5.27 ± 0.035	1.993SerHis: 1.993 ± 0.022	4.454SerIle: 4.454 ± 0.038	3.863SerLys: 3.863 ± 0.035	7.426SerLeu: 7.426 ± 0.046	1.741SerMet: 1.741 ± 0.021	3.347SerAsn: 3.347 ± 0.031	5.189SerPro: 5.189 ± 0.052	3.466SerGln: 3.466 ± 0.033	4.976SerArg: 4.976 ± 0.039	9.109SerSer: 9.109 ± 0.083	6.003SerThr: 6.003 ± 0.042	4.633SerVal: 4.633 ± 0.033	1.103SerTrp: 1.103 ± 0.017	2.215SerTyr: 2.215 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.155ThrAla: 5.155 ± 0.034	0.709ThrCys: 0.709 ± 0.013	2.979ThrAsp: 2.979 ± 0.027	3.35ThrGlu: 3.35 ± 0.028	2.256ThrPhe: 2.256 ± 0.021	4.177ThrGly: 4.177 ± 0.03	1.293ThrHis: 1.293 ± 0.016	3.449ThrIle: 3.449 ± 0.027	2.823ThrLys: 2.823 ± 0.029	5.259ThrLeu: 5.259 ± 0.035	1.212ThrMet: 1.212 ± 0.017	2.408ThrAsn: 2.408 ± 0.025	4.23ThrPro: 4.23 ± 0.041	2.228ThrGln: 2.228 ± 0.025	3.093ThrArg: 3.093 ± 0.026	5.594ThrSer: 5.594 ± 0.044	4.864ThrThr: 4.864 ± 0.044	3.847ThrVal: 3.847 ± 0.033	0.855ThrTrp: 0.855 ± 0.015	1.731ThrTyr: 1.731 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.981ValAla: 4.981 ± 0.035	0.762ValCys: 0.762 ± 0.013	3.726ValAsp: 3.726 ± 0.029	3.791ValGlu: 3.791 ± 0.034	2.395ValPhe: 2.395 ± 0.025	3.81ValGly: 3.81 ± 0.032	1.39ValHis: 1.39 ± 0.017	3.287ValIle: 3.287 ± 0.027	2.88ValLys: 2.88 ± 0.026	5.458ValLeu: 5.458 ± 0.042	1.307ValMet: 1.307 ± 0.015	2.406ValAsn: 2.406 ± 0.025	3.438ValPro: 3.438 ± 0.027	2.405ValGln: 2.405 ± 0.02	3.314ValArg: 3.314 ± 0.029	4.748ValSer: 4.748 ± 0.027	3.641ValThr: 3.641 ± 0.027	4.22ValVal: 4.22 ± 0.034	0.813ValTrp: 0.813 ± 0.014	1.761ValTyr: 1.761 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.017	0.185TrpCys: 0.185 ± 0.006	0.882TrpAsp: 0.882 ± 0.016	0.821TrpGlu: 0.821 ± 0.014	0.534TrpPhe: 0.534 ± 0.01	0.834TrpGly: 0.834 ± 0.015	0.352TrpHis: 0.352 ± 0.007	0.83TrpIle: 0.83 ± 0.014	0.799TrpLys: 0.799 ± 0.012	1.341TrpLeu: 1.341 ± 0.017	0.372TrpMet: 0.372 ± 0.009	0.657TrpAsn: 0.657 ± 0.013	0.57TrpPro: 0.57 ± 0.01	0.579TrpGln: 0.579 ± 0.011	0.927TrpArg: 0.927 ± 0.013	1.044TrpSer: 1.044 ± 0.015	0.893TrpThr: 0.893 ± 0.015	0.871TrpVal: 0.871 ± 0.014	0.27TrpTrp: 0.27 ± 0.007	0.423TrpTyr: 0.423 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.202TyrAla: 2.202 ± 0.02	0.42TyrCys: 0.42 ± 0.009	1.754TyrAsp: 1.754 ± 0.017	1.667TyrGlu: 1.667 ± 0.018	1.233TyrPhe: 1.233 ± 0.017	2.15TyrGly: 2.15 ± 0.022	0.788TyrHis: 0.788 ± 0.013	1.651TyrIle: 1.651 ± 0.019	1.229TyrLys: 1.229 ± 0.017	2.803TyrLeu: 2.803 ± 0.022	0.67TyrMet: 0.67 ± 0.012	1.292TyrAsn: 1.292 ± 0.018	1.54TyrPro: 1.54 ± 0.018	1.221TyrGln: 1.221 ± 0.013	1.643TyrArg: 1.643 ± 0.018	2.162TyrSer: 2.162 ± 0.023	1.705TyrThr: 1.705 ± 0.019	1.674TyrVal: 1.674 ± 0.02	0.452TyrTrp: 0.452 ± 0.011	1.035TyrTyr: 1.035 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 10448 proteins (5285136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---