Amino acid dipepetide frequency for Roseovarius atlanticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.752AlaAla: 15.752 ± 0.158	1.18AlaCys: 1.18 ± 0.037	6.912AlaAsp: 6.912 ± 0.085	8.3AlaGlu: 8.3 ± 0.118	4.314AlaPhe: 4.314 ± 0.07	10.415AlaGly: 10.415 ± 0.101	2.397AlaHis: 2.397 ± 0.043	5.545AlaIle: 5.545 ± 0.073	3.759AlaLys: 3.759 ± 0.06	13.292AlaLeu: 13.292 ± 0.12	3.659AlaMet: 3.659 ± 0.061	2.658AlaAsn: 2.658 ± 0.045	5.597AlaPro: 5.597 ± 0.072	4.48AlaGln: 4.48 ± 0.064	8.72AlaArg: 8.72 ± 0.104	5.374AlaSer: 5.374 ± 0.07	5.817AlaThr: 5.817 ± 0.083	8.422AlaVal: 8.422 ± 0.09	1.527AlaTrp: 1.527 ± 0.033	2.553AlaTyr: 2.553 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.03	0.137CysCys: 0.137 ± 0.011	0.676CysAsp: 0.676 ± 0.025	0.5CysGlu: 0.5 ± 0.019	0.347CysPhe: 0.347 ± 0.019	0.993CysGly: 0.993 ± 0.03	0.294CysHis: 0.294 ± 0.015	0.492CysIle: 0.492 ± 0.019	0.213CysLys: 0.213 ± 0.015	0.892CysLeu: 0.892 ± 0.029	0.181CysMet: 0.181 ± 0.011	0.243CysAsn: 0.243 ± 0.013	0.515CysPro: 0.515 ± 0.022	0.243CysGln: 0.243 ± 0.015	0.592CysArg: 0.592 ± 0.021	0.439CysSer: 0.439 ± 0.021	0.491CysThr: 0.491 ± 0.021	0.68CysVal: 0.68 ± 0.024	0.131CysTrp: 0.131 ± 0.01	0.239CysTyr: 0.239 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.629AspAla: 7.629 ± 0.097	0.535AspCys: 0.535 ± 0.022	3.825AspAsp: 3.825 ± 0.062	3.801AspGlu: 3.801 ± 0.065	2.246AspPhe: 2.246 ± 0.045	5.703AspGly: 5.703 ± 0.082	1.43AspHis: 1.43 ± 0.039	3.288AspIle: 3.288 ± 0.052	1.8AspLys: 1.8 ± 0.044	6.324AspLeu: 6.324 ± 0.078	1.853AspMet: 1.853 ± 0.039	1.32AspAsn: 1.32 ± 0.034	3.72AspPro: 3.72 ± 0.048	1.883AspGln: 1.883 ± 0.035	4.484AspArg: 4.484 ± 0.063	2.335AspSer: 2.335 ± 0.051	3.495AspThr: 3.495 ± 0.063	4.482AspVal: 4.482 ± 0.065	1.219AspTrp: 1.219 ± 0.033	1.575AspTyr: 1.575 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.344GluAla: 8.344 ± 0.103	0.406GluCys: 0.406 ± 0.019	3.945GluAsp: 3.945 ± 0.064	3.948GluGlu: 3.948 ± 0.089	1.947GluPhe: 1.947 ± 0.042	5.029GluGly: 5.029 ± 0.079	1.183GluHis: 1.183 ± 0.029	3.639GluIle: 3.639 ± 0.056	2.292GluLys: 2.292 ± 0.047	5.136GluLeu: 5.136 ± 0.072	2.035GluMet: 2.035 ± 0.044	1.793GluAsn: 1.793 ± 0.041	2.628GluPro: 2.628 ± 0.057	1.996GluGln: 1.996 ± 0.042	4.41GluArg: 4.41 ± 0.069	2.285GluSer: 2.285 ± 0.041	4.203GluThr: 4.203 ± 0.062	4.523GluVal: 4.523 ± 0.056	0.722GluTrp: 0.722 ± 0.025	1.165GluTyr: 1.165 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.386PheAla: 4.386 ± 0.056	0.446PheCys: 0.446 ± 0.018	2.898PheAsp: 2.898 ± 0.048	2.341PheGlu: 2.341 ± 0.047	1.476PhePhe: 1.476 ± 0.041	3.703PheGly: 3.703 ± 0.061	0.755PheHis: 0.755 ± 0.026	1.713PheIle: 1.713 ± 0.038	0.938PheLys: 0.938 ± 0.026	3.39PheLeu: 3.39 ± 0.064	0.889PheMet: 0.889 ± 0.028	1.041PheAsn: 1.041 ± 0.032	1.522PhePro: 1.522 ± 0.031	1.056PheGln: 1.056 ± 0.023	2.219PheArg: 2.219 ± 0.044	2.039PheSer: 2.039 ± 0.039	2.127PheThr: 2.127 ± 0.044	2.654PheVal: 2.654 ± 0.047	0.607PheTrp: 0.607 ± 0.026	0.952PheTyr: 0.952 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.809GlyAla: 9.809 ± 0.114	0.919GlyCys: 0.919 ± 0.028	4.89GlyAsp: 4.89 ± 0.071	4.896GlyGlu: 4.896 ± 0.055	3.724GlyPhe: 3.724 ± 0.051	7.473GlyGly: 7.473 ± 0.114	2.056GlyHis: 2.056 ± 0.037	4.411GlyIle: 4.411 ± 0.06	3.026GlyLys: 3.026 ± 0.06	9.22GlyLeu: 9.22 ± 0.104	2.724GlyMet: 2.724 ± 0.046	2.15GlyAsn: 2.15 ± 0.046	3.843GlyPro: 3.843 ± 0.055	3.159GlyGln: 3.159 ± 0.048	5.752GlyArg: 5.752 ± 0.076	4.2GlySer: 4.2 ± 0.073	4.92GlyThr: 4.92 ± 0.078	6.504GlyVal: 6.504 ± 0.081	1.473GlyTrp: 1.473 ± 0.033	2.373GlyTyr: 2.373 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.42HisAla: 2.42 ± 0.047	0.234HisCys: 0.234 ± 0.012	1.367HisAsp: 1.367 ± 0.042	1.152HisGlu: 1.152 ± 0.028	0.823HisPhe: 0.823 ± 0.027	2.039HisGly: 2.039 ± 0.036	0.57HisHis: 0.57 ± 0.023	0.984HisIle: 0.984 ± 0.029	0.535HisLys: 0.535 ± 0.02	2.099HisLeu: 2.099 ± 0.043	0.565HisMet: 0.565 ± 0.019	0.46HisAsn: 0.46 ± 0.02	1.373HisPro: 1.373 ± 0.032	0.592HisGln: 0.592 ± 0.024	1.322HisArg: 1.322 ± 0.033	0.92HisSer: 0.92 ± 0.027	0.9HisThr: 0.9 ± 0.03	1.603HisVal: 1.603 ± 0.034	0.341HisTrp: 0.341 ± 0.017	0.546HisTyr: 0.546 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.628IleAla: 6.628 ± 0.086	0.664IleCys: 0.664 ± 0.026	3.552IleAsp: 3.552 ± 0.06	3.643IleGlu: 3.643 ± 0.053	1.795IlePhe: 1.795 ± 0.051	4.772IleGly: 4.772 ± 0.069	0.909IleHis: 0.909 ± 0.025	2.206IleIle: 2.206 ± 0.047	1.386IleLys: 1.386 ± 0.033	4.805IleLeu: 4.805 ± 0.069	1.072IleMet: 1.072 ± 0.028	1.311IleAsn: 1.311 ± 0.035	2.331IlePro: 2.331 ± 0.047	1.187IleGln: 1.187 ± 0.033	3.084IleArg: 3.084 ± 0.046	2.826IleSer: 2.826 ± 0.051	2.87IleThr: 2.87 ± 0.048	3.737IleVal: 3.737 ± 0.055	0.686IleTrp: 0.686 ± 0.025	1.165IleTyr: 1.165 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.774LysAla: 3.774 ± 0.061	0.192LysCys: 0.192 ± 0.012	1.796LysAsp: 1.796 ± 0.045	1.634LysGlu: 1.634 ± 0.044	0.934LysPhe: 0.934 ± 0.031	2.683LysGly: 2.683 ± 0.057	0.603LysHis: 0.603 ± 0.023	1.619LysIle: 1.619 ± 0.04	1.298LysLys: 1.298 ± 0.038	3.063LysLeu: 3.063 ± 0.052	0.843LysMet: 0.843 ± 0.024	0.779LysAsn: 0.779 ± 0.026	1.86LysPro: 1.86 ± 0.038	0.902LysGln: 0.902 ± 0.028	2.319LysArg: 2.319 ± 0.046	1.824LysSer: 1.824 ± 0.044	1.953LysThr: 1.953 ± 0.04	2.307LysVal: 2.307 ± 0.05	0.393LysTrp: 0.393 ± 0.019	0.66LysTyr: 0.66 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.331LeuAla: 12.331 ± 0.133	0.992LeuCys: 0.992 ± 0.029	6.235LeuAsp: 6.235 ± 0.071	5.582LeuGlu: 5.582 ± 0.072	3.457LeuPhe: 3.457 ± 0.054	8.417LeuGly: 8.417 ± 0.102	1.89LeuHis: 1.89 ± 0.038	5.021LeuIle: 5.021 ± 0.071	3.221LeuLys: 3.221 ± 0.055	8.629LeuLeu: 8.629 ± 0.128	2.682LeuMet: 2.682 ± 0.048	2.656LeuAsn: 2.656 ± 0.048	5.413LeuPro: 5.413 ± 0.067	2.662LeuGln: 2.662 ± 0.051	6.928LeuArg: 6.928 ± 0.071	6.447LeuSer: 6.447 ± 0.074	5.918LeuThr: 5.918 ± 0.078	7.045LeuVal: 7.045 ± 0.089	1.289LeuTrp: 1.289 ± 0.034	2.019LeuTyr: 2.019 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.548MetAla: 3.548 ± 0.055	0.215MetCys: 0.215 ± 0.013	1.49MetAsp: 1.49 ± 0.038	1.419MetGlu: 1.419 ± 0.033	0.859MetPhe: 0.859 ± 0.028	2.349MetGly: 2.349 ± 0.047	0.517MetHis: 0.517 ± 0.02	1.546MetIle: 1.546 ± 0.041	1.089MetLys: 1.089 ± 0.03	2.598MetLeu: 2.598 ± 0.053	0.804MetMet: 0.804 ± 0.026	0.811MetAsn: 0.811 ± 0.027	1.545MetPro: 1.545 ± 0.03	1.064MetGln: 1.064 ± 0.028	1.997MetArg: 1.997 ± 0.039	1.799MetSer: 1.799 ± 0.037	2.168MetThr: 2.168 ± 0.04	1.87MetVal: 1.87 ± 0.036	0.254MetTrp: 0.254 ± 0.015	0.376MetTyr: 0.376 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.18AsnAla: 3.18 ± 0.054	0.258AsnCys: 0.258 ± 0.015	1.452AsnAsp: 1.452 ± 0.038	1.309AsnGlu: 1.309 ± 0.032	0.938AsnPhe: 0.938 ± 0.028	2.297AsnGly: 2.297 ± 0.049	0.509AsnHis: 0.509 ± 0.021	1.37AsnIle: 1.37 ± 0.032	0.639AsnLys: 0.639 ± 0.024	2.44AsnLeu: 2.44 ± 0.047	0.693AsnMet: 0.693 ± 0.023	0.642AsnAsn: 0.642 ± 0.028	1.791AsnPro: 1.791 ± 0.038	0.698AsnGln: 0.698 ± 0.022	1.769AsnArg: 1.769 ± 0.041	1.077AsnSer: 1.077 ± 0.028	1.361AsnThr: 1.361 ± 0.037	1.842AsnVal: 1.842 ± 0.038	0.42AsnTrp: 0.42 ± 0.018	0.628AsnTyr: 0.628 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.314ProAla: 5.314 ± 0.075	0.375ProCys: 0.375 ± 0.017	4.221ProAsp: 4.221 ± 0.07	4.393ProGlu: 4.393 ± 0.073	1.98ProPhe: 1.98 ± 0.042	4.78ProGly: 4.78 ± 0.06	1.054ProHis: 1.054 ± 0.029	2.179ProIle: 2.179 ± 0.041	1.706ProLys: 1.706 ± 0.039	4.445ProLeu: 4.445 ± 0.055	1.363ProMet: 1.363 ± 0.036	1.242ProAsn: 1.242 ± 0.031	2.232ProPro: 2.232 ± 0.045	1.588ProGln: 1.588 ± 0.038	2.816ProArg: 2.816 ± 0.053	2.355ProSer: 2.355 ± 0.039	2.401ProThr: 2.401 ± 0.044	4.273ProVal: 4.273 ± 0.058	0.703ProTrp: 0.703 ± 0.024	1.149ProTyr: 1.149 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.075GlnAla: 4.075 ± 0.069	0.248GlnCys: 0.248 ± 0.013	1.838GlnAsp: 1.838 ± 0.037	1.653GlnGlu: 1.653 ± 0.037	1.082GlnPhe: 1.082 ± 0.029	2.565GlnGly: 2.565 ± 0.043	0.552GlnHis: 0.552 ± 0.02	1.849GlnIle: 1.849 ± 0.037	1.06GlnLys: 1.06 ± 0.03	2.721GlnLeu: 2.721 ± 0.048	1.135GlnMet: 1.135 ± 0.026	0.896GlnAsn: 0.896 ± 0.028	1.567GlnPro: 1.567 ± 0.034	1.025GlnGln: 1.025 ± 0.031	2.091GlnArg: 2.091 ± 0.043	1.812GlnSer: 1.812 ± 0.035	1.828GlnThr: 1.828 ± 0.035	2.422GlnVal: 2.422 ± 0.046	0.409GlnTrp: 0.409 ± 0.019	0.565GlnTyr: 0.565 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.993ArgAla: 7.993 ± 0.098	0.502ArgCys: 0.502 ± 0.02	4.559ArgAsp: 4.559 ± 0.069	4.111ArgGlu: 4.111 ± 0.073	2.681ArgPhe: 2.681 ± 0.042	4.637ArgGly: 4.637 ± 0.054	1.583ArgHis: 1.583 ± 0.034	3.777ArgIle: 3.777 ± 0.054	2.294ArgLys: 2.294 ± 0.048	7.362ArgLeu: 7.362 ± 0.091	1.982ArgMet: 1.982 ± 0.042	1.761ArgAsn: 1.761 ± 0.039	3.298ArgPro: 3.298 ± 0.052	2.296ArgGln: 2.296 ± 0.045	4.973ArgArg: 4.973 ± 0.073	3.133ArgSer: 3.133 ± 0.044	3.124ArgThr: 3.124 ± 0.054	4.787ArgVal: 4.787 ± 0.063	0.888ArgTrp: 0.888 ± 0.031	1.594ArgTyr: 1.594 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.564SerAla: 5.564 ± 0.077	0.418SerCys: 0.418 ± 0.018	3.467SerAsp: 3.467 ± 0.055	3.007SerGlu: 3.007 ± 0.076	2.192SerPhe: 2.192 ± 0.044	5.222SerGly: 5.222 ± 0.074	1.059SerHis: 1.059 ± 0.029	2.403SerIle: 2.403 ± 0.053	1.497SerLys: 1.497 ± 0.044	4.925SerLeu: 4.925 ± 0.06	1.349SerMet: 1.349 ± 0.03	1.255SerAsn: 1.255 ± 0.033	2.384SerPro: 2.384 ± 0.047	1.589SerGln: 1.589 ± 0.039	3.184SerArg: 3.184 ± 0.056	2.496SerSer: 2.496 ± 0.053	2.419SerThr: 2.419 ± 0.043	3.868SerVal: 3.868 ± 0.055	0.653SerTrp: 0.653 ± 0.024	1.27SerTyr: 1.27 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.149ThrAla: 6.149 ± 0.078	0.558ThrCys: 0.558 ± 0.021	3.293ThrAsp: 3.293 ± 0.058	3.221ThrGlu: 3.221 ± 0.052	1.995ThrPhe: 1.995 ± 0.044	5.658ThrGly: 5.658 ± 0.07	1.178ThrHis: 1.178 ± 0.029	2.781ThrIle: 2.781 ± 0.049	1.447ThrLys: 1.447 ± 0.032	6.093ThrLeu: 6.093 ± 0.07	1.311ThrMet: 1.311 ± 0.035	1.309ThrAsn: 1.309 ± 0.035	3.474ThrPro: 3.474 ± 0.058	1.603ThrGln: 1.603 ± 0.036	3.681ThrArg: 3.681 ± 0.054	2.683ThrSer: 2.683 ± 0.051	2.927ThrThr: 2.927 ± 0.062	4.329ThrVal: 4.329 ± 0.062	0.757ThrTrp: 0.757 ± 0.026	1.36ThrTyr: 1.36 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.738ValAla: 8.738 ± 0.085	0.693ValCys: 0.693 ± 0.023	4.059ValAsp: 4.059 ± 0.059	4.73ValGlu: 4.73 ± 0.062	2.875ValPhe: 2.875 ± 0.051	5.556ValGly: 5.556 ± 0.073	1.394ValHis: 1.394 ± 0.035	4.159ValIle: 4.159 ± 0.061	2.16ValLys: 2.16 ± 0.05	7.492ValLeu: 7.492 ± 0.095	2.241ValMet: 2.241 ± 0.045	1.96ValAsn: 1.96 ± 0.042	3.698ValPro: 3.698 ± 0.062	2.109ValGln: 2.109 ± 0.038	4.357ValArg: 4.357 ± 0.072	4.235ValSer: 4.235 ± 0.058	4.9ValThr: 4.9 ± 0.068	5.589ValVal: 5.589 ± 0.082	0.982ValTrp: 0.982 ± 0.026	1.483ValTyr: 1.483 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.372TrpAla: 1.372 ± 0.034	0.162TrpCys: 0.162 ± 0.012	0.773TrpAsp: 0.773 ± 0.022	0.66TrpGlu: 0.66 ± 0.021	0.572TrpPhe: 0.572 ± 0.022	1.069TrpGly: 1.069 ± 0.036	0.361TrpHis: 0.361 ± 0.019	0.698TrpIle: 0.698 ± 0.028	0.47TrpLys: 0.47 ± 0.019	1.628TrpLeu: 1.628 ± 0.036	0.427TrpMet: 0.427 ± 0.019	0.424TrpAsn: 0.424 ± 0.018	0.717TrpPro: 0.717 ± 0.026	0.62TrpGln: 0.62 ± 0.023	1.065TrpArg: 1.065 ± 0.026	0.811TrpSer: 0.811 ± 0.03	0.797TrpThr: 0.797 ± 0.024	0.929TrpVal: 0.929 ± 0.026	0.232TrpTrp: 0.232 ± 0.014	0.262TrpTyr: 0.262 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.046	0.259TyrCys: 0.259 ± 0.015	1.697TyrAsp: 1.697 ± 0.038	1.33TyrGlu: 1.33 ± 0.034	0.915TyrPhe: 0.915 ± 0.028	2.164TyrGly: 2.164 ± 0.043	0.551TyrHis: 0.551 ± 0.019	0.948TyrIle: 0.948 ± 0.025	0.606TyrLys: 0.606 ± 0.023	2.277TyrLeu: 2.277 ± 0.04	0.51TyrMet: 0.51 ± 0.02	0.603TyrAsn: 0.603 ± 0.023	1.061TyrPro: 1.061 ± 0.026	0.642TyrGln: 0.642 ± 0.023	1.569TyrArg: 1.569 ± 0.039	1.133TyrSer: 1.133 ± 0.027	1.19TyrThr: 1.19 ± 0.035	1.545TyrVal: 1.545 ± 0.034	0.366TyrTrp: 0.366 ± 0.017	0.6TyrTyr: 0.6 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4236 proteins (1284231 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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