Amino acid dipepetide frequency for Methanolobus sp. SY-01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.505AlaAla: 5.505 ± 0.107	0.888AlaCys: 0.888 ± 0.037	4.412AlaAsp: 4.412 ± 0.088	4.81AlaGlu: 4.81 ± 0.093	2.748AlaPhe: 2.748 ± 0.07	5.963AlaGly: 5.963 ± 0.097	1.318AlaHis: 1.318 ± 0.044	5.577AlaIle: 5.577 ± 0.094	3.823AlaLys: 3.823 ± 0.071	6.399AlaLeu: 6.399 ± 0.096	1.971AlaMet: 1.971 ± 0.05	2.474AlaAsn: 2.474 ± 0.057	2.025AlaPro: 2.025 ± 0.061	1.711AlaGln: 1.711 ± 0.05	3.452AlaArg: 3.452 ± 0.078	4.68AlaSer: 4.68 ± 0.089	3.495AlaThr: 3.495 ± 0.073	5.373AlaVal: 5.373 ± 0.092	0.511AlaTrp: 0.511 ± 0.03	2.085AlaTyr: 2.085 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.758CysAla: 0.758 ± 0.034	0.201CysCys: 0.201 ± 0.019	0.72CysAsp: 0.72 ± 0.034	0.783CysGlu: 0.783 ± 0.031	0.438CysPhe: 0.438 ± 0.028	1.249CysGly: 1.249 ± 0.039	0.283CysHis: 0.283 ± 0.023	0.902CysIle: 0.902 ± 0.041	0.686CysLys: 0.686 ± 0.03	0.881CysLeu: 0.881 ± 0.038	0.326CysMet: 0.326 ± 0.021	0.558CysAsn: 0.558 ± 0.032	0.801CysPro: 0.801 ± 0.036	0.307CysGln: 0.307 ± 0.021	0.642CysArg: 0.642 ± 0.031	0.826CysSer: 0.826 ± 0.041	0.668CysThr: 0.668 ± 0.032	0.756CysVal: 0.756 ± 0.036	0.069CysTrp: 0.069 ± 0.01	0.365CysTyr: 0.365 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.176AspAla: 4.176 ± 0.085	0.661AspCys: 0.661 ± 0.03	3.317AspAsp: 3.317 ± 0.104	4.548AspGlu: 4.548 ± 0.099	2.742AspPhe: 2.742 ± 0.066	3.946AspGly: 3.946 ± 0.109	1.167AspHis: 1.167 ± 0.043	6.409AspIle: 6.409 ± 0.104	3.182AspLys: 3.182 ± 0.074	5.277AspLeu: 5.277 ± 0.092	2.031AspMet: 2.031 ± 0.05	2.636AspAsn: 2.636 ± 0.079	2.592AspPro: 2.592 ± 0.067	1.221AspGln: 1.221 ± 0.043	2.831AspArg: 2.831 ± 0.065	3.967AspSer: 3.967 ± 0.087	3.205AspThr: 3.205 ± 0.072	4.894AspVal: 4.894 ± 0.092	0.486AspTrp: 0.486 ± 0.028	2.217AspTyr: 2.217 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.681GluAla: 4.681 ± 0.096	0.839GluCys: 0.839 ± 0.034	4.509GluAsp: 4.509 ± 0.08	6.459GluGlu: 6.459 ± 0.111	2.706GluPhe: 2.706 ± 0.065	4.681GluGly: 4.681 ± 0.087	1.552GluHis: 1.552 ± 0.048	6.022GluIle: 6.022 ± 0.09	5.641GluLys: 5.641 ± 0.112	7.382GluLeu: 7.382 ± 0.138	2.711GluMet: 2.711 ± 0.066	3.746GluAsn: 3.746 ± 0.085	2.17GluPro: 2.17 ± 0.065	2.21GluGln: 2.21 ± 0.06	3.545GluArg: 3.545 ± 0.077	4.173GluSer: 4.173 ± 0.077	3.449GluThr: 3.449 ± 0.085	4.984GluVal: 4.984 ± 0.084	0.7GluTrp: 0.7 ± 0.028	2.709GluTyr: 2.709 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	2.948PheAla: 2.948 ± 0.069	0.47PheCys: 0.47 ± 0.029	2.585PheAsp: 2.585 ± 0.061	2.839PheGlu: 2.839 ± 0.066	1.797PhePhe: 1.797 ± 0.057	3.088PheGly: 3.088 ± 0.076	0.696PheHis: 0.696 ± 0.029	3.098PheIle: 3.098 ± 0.083	2.025PheLys: 2.025 ± 0.053	3.56PheLeu: 3.56 ± 0.085	1.063PheMet: 1.063 ± 0.042	1.634PheAsn: 1.634 ± 0.054	1.357PhePro: 1.357 ± 0.041	0.85PheGln: 0.85 ± 0.039	1.9PheArg: 1.9 ± 0.057	2.981PheSer: 2.981 ± 0.067	2.35PheThr: 2.35 ± 0.059	2.85PheVal: 2.85 ± 0.063	0.356PheTrp: 0.356 ± 0.023	1.311PheTyr: 1.311 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.826GlyAla: 4.826 ± 0.102	1.036GlyCys: 1.036 ± 0.038	3.991GlyAsp: 3.991 ± 0.087	4.635GlyGlu: 4.635 ± 0.111	3.153GlyPhe: 3.153 ± 0.076	4.773GlyGly: 4.773 ± 0.118	1.45GlyHis: 1.45 ± 0.047	6.663GlyIle: 6.663 ± 0.107	5.155GlyLys: 5.155 ± 0.091	5.962GlyLeu: 5.962 ± 0.098	2.424GlyMet: 2.424 ± 0.066	3.243GlyAsn: 3.243 ± 0.086	2.131GlyPro: 2.131 ± 0.057	1.625GlyGln: 1.625 ± 0.051	3.196GlyArg: 3.196 ± 0.071	5.126GlySer: 5.126 ± 0.093	4.398GlyThr: 4.398 ± 0.091	4.995GlyVal: 4.995 ± 0.088	0.667GlyTrp: 0.667 ± 0.028	2.716GlyTyr: 2.716 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.334HisAla: 1.334 ± 0.046	0.308HisCys: 0.308 ± 0.021	1.132HisAsp: 1.132 ± 0.036	1.311HisGlu: 1.311 ± 0.044	0.79HisPhe: 0.79 ± 0.037	1.431HisGly: 1.431 ± 0.045	0.442HisHis: 0.442 ± 0.023	1.615HisIle: 1.615 ± 0.044	0.956HisLys: 0.956 ± 0.035	1.782HisLeu: 1.782 ± 0.047	0.6HisMet: 0.6 ± 0.024	0.792HisAsn: 0.792 ± 0.041	1.067HisPro: 1.067 ± 0.04	0.483HisGln: 0.483 ± 0.028	0.975HisArg: 0.975 ± 0.04	1.186HisSer: 1.186 ± 0.044	0.968HisThr: 0.968 ± 0.036	1.452HisVal: 1.452 ± 0.044	0.147HisTrp: 0.147 ± 0.014	0.686HisTyr: 0.686 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.89IleAla: 5.89 ± 0.093	1.032IleCys: 1.032 ± 0.039	5.301IleAsp: 5.301 ± 0.092	6.074IleGlu: 6.074 ± 0.105	3.148IlePhe: 3.148 ± 0.084	5.954IleGly: 5.954 ± 0.093	1.596IleHis: 1.596 ± 0.045	6.083IleIle: 6.083 ± 0.113	4.414IleLys: 4.414 ± 0.084	7.28IleLeu: 7.28 ± 0.114	2.109IleMet: 2.109 ± 0.055	3.191IleAsn: 3.191 ± 0.072	3.574IlePro: 3.574 ± 0.065	1.796IleGln: 1.796 ± 0.055	4.088IleArg: 4.088 ± 0.083	6.159IleSer: 6.159 ± 0.1	4.577IleThr: 4.577 ± 0.095	5.945IleVal: 5.945 ± 0.096	0.6IleTrp: 0.6 ± 0.035	2.464IleTyr: 2.464 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	4.042LysAla: 4.042 ± 0.079	0.768LysCys: 0.768 ± 0.035	3.902LysAsp: 3.902 ± 0.082	5.215LysGlu: 5.215 ± 0.107	1.835LysPhe: 1.835 ± 0.052	4.177LysGly: 4.177 ± 0.079	1.202LysHis: 1.202 ± 0.045	4.642LysIle: 4.642 ± 0.09	4.758LysLys: 4.758 ± 0.116	4.859LysLeu: 4.859 ± 0.094	1.971LysMet: 1.971 ± 0.054	2.916LysAsn: 2.916 ± 0.065	1.928LysPro: 1.928 ± 0.052	1.963LysGln: 1.963 ± 0.062	2.981LysArg: 2.981 ± 0.074	3.324LysSer: 3.324 ± 0.068	3.042LysThr: 3.042 ± 0.059	4.264LysVal: 4.264 ± 0.088	0.558LysTrp: 0.558 ± 0.03	2.146LysTyr: 2.146 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.687LeuAla: 6.687 ± 0.109	0.988LeuCys: 0.988 ± 0.042	5.376LeuAsp: 5.376 ± 0.093	6.951LeuGlu: 6.951 ± 0.106	3.675LeuPhe: 3.675 ± 0.094	6.012LeuGly: 6.012 ± 0.112	1.6LeuHis: 1.6 ± 0.05	6.827LeuIle: 6.827 ± 0.124	5.855LeuLys: 5.855 ± 0.099	8.716LeuLeu: 8.716 ± 0.179	2.6LeuMet: 2.6 ± 0.056	3.828LeuAsn: 3.828 ± 0.084	3.528LeuPro: 3.528 ± 0.075	2.379LeuGln: 2.379 ± 0.062	4.11LeuArg: 4.11 ± 0.082	6.576LeuSer: 6.576 ± 0.103	4.634LeuThr: 4.634 ± 0.087	5.997LeuVal: 5.997 ± 0.095	0.618LeuTrp: 0.618 ± 0.027	2.696LeuTyr: 2.696 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.152MetAla: 2.152 ± 0.053	0.346MetCys: 0.346 ± 0.021	1.947MetAsp: 1.947 ± 0.048	2.295MetGlu: 2.295 ± 0.054	1.011MetPhe: 1.011 ± 0.038	2.218MetGly: 2.218 ± 0.053	0.615MetHis: 0.615 ± 0.028	2.163MetIle: 2.163 ± 0.059	1.993MetLys: 1.993 ± 0.055	2.691MetLeu: 2.691 ± 0.071	0.875MetMet: 0.875 ± 0.04	1.379MetAsn: 1.379 ± 0.047	1.175MetPro: 1.175 ± 0.045	0.988MetGln: 0.988 ± 0.036	1.374MetArg: 1.374 ± 0.043	1.995MetSer: 1.995 ± 0.051	1.509MetThr: 1.509 ± 0.04	2.107MetVal: 2.107 ± 0.05	0.243MetTrp: 0.243 ± 0.019	0.882MetTyr: 0.882 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.988AsnAla: 2.988 ± 0.078	0.499AsnCys: 0.499 ± 0.026	2.407AsnAsp: 2.407 ± 0.059	2.791AsnGlu: 2.791 ± 0.078	1.506AsnPhe: 1.506 ± 0.053	2.85AsnGly: 2.85 ± 0.076	0.707AsnHis: 0.707 ± 0.029	4.176AsnIle: 4.176 ± 0.09	2.361AsnLys: 2.361 ± 0.056	3.584AsnLeu: 3.584 ± 0.07	1.2AsnMet: 1.2 ± 0.033	2.1AsnAsn: 2.1 ± 0.083	2.089AsnPro: 2.089 ± 0.048	0.977AsnGln: 0.977 ± 0.039	2.052AsnArg: 2.052 ± 0.053	2.756AsnSer: 2.756 ± 0.075	2.395AsnThr: 2.395 ± 0.089	3.355AsnVal: 3.355 ± 0.101	0.461AsnTrp: 0.461 ± 0.027	1.525AsnTyr: 1.525 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.752ProAla: 2.752 ± 0.055	0.453ProCys: 0.453 ± 0.026	2.859ProAsp: 2.859 ± 0.076	3.791ProGlu: 3.791 ± 0.074	1.697ProPhe: 1.697 ± 0.06	3.042ProGly: 3.042 ± 0.081	0.783ProHis: 0.783 ± 0.032	2.359ProIle: 2.359 ± 0.064	1.703ProLys: 1.703 ± 0.051	3.316ProLeu: 3.316 ± 0.069	0.91ProMet: 0.91 ± 0.039	1.195ProAsn: 1.195 ± 0.043	1.331ProPro: 1.331 ± 0.049	1.077ProGln: 1.077 ± 0.04	1.429ProArg: 1.429 ± 0.046	2.311ProSer: 2.311 ± 0.063	1.661ProThr: 1.661 ± 0.049	3.605ProVal: 3.605 ± 0.073	0.3ProTrp: 0.3 ± 0.02	1.295ProTyr: 1.295 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.772GlnAla: 1.772 ± 0.047	0.294GlnCys: 0.294 ± 0.021	1.445GlnAsp: 1.445 ± 0.046	2.031GlnGlu: 2.031 ± 0.053	0.902GlnPhe: 0.902 ± 0.035	1.565GlnGly: 1.565 ± 0.039	0.515GlnHis: 0.515 ± 0.024	2.039GlnIle: 2.039 ± 0.063	1.893GlnLys: 1.893 ± 0.055	2.438GlnLeu: 2.438 ± 0.065	0.956GlnMet: 0.956 ± 0.04	1.189GlnAsn: 1.189 ± 0.043	0.764GlnPro: 0.764 ± 0.034	0.854GlnGln: 0.854 ± 0.042	1.274GlnArg: 1.274 ± 0.05	1.581GlnSer: 1.581 ± 0.044	1.313GlnThr: 1.313 ± 0.045	1.667GlnVal: 1.667 ± 0.057	0.261GlnTrp: 0.261 ± 0.017	0.964GlnTyr: 0.964 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.882ArgAla: 2.882 ± 0.077	0.526ArgCys: 0.526 ± 0.029	2.928ArgAsp: 2.928 ± 0.075	3.742ArgGlu: 3.742 ± 0.091	1.868ArgPhe: 1.868 ± 0.058	2.825ArgGly: 2.825 ± 0.074	0.932ArgHis: 0.932 ± 0.035	4.082ArgIle: 4.082 ± 0.077	3.582ArgLys: 3.582 ± 0.072	3.902ArgLeu: 3.902 ± 0.086	1.527ArgMet: 1.527 ± 0.051	2.281ArgAsn: 2.281 ± 0.056	1.638ArgPro: 1.638 ± 0.053	1.379ArgGln: 1.379 ± 0.042	2.179ArgArg: 2.179 ± 0.065	3.241ArgSer: 3.241 ± 0.07	2.606ArgThr: 2.606 ± 0.059	2.974ArgVal: 2.974 ± 0.071	0.401ArgTrp: 0.401 ± 0.025	1.789ArgTyr: 1.789 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.273SerAla: 4.273 ± 0.091	0.838SerCys: 0.838 ± 0.04	4.003SerAsp: 4.003 ± 0.099	4.777SerGlu: 4.777 ± 0.081	2.868SerPhe: 2.868 ± 0.071	5.684SerGly: 5.684 ± 0.096	1.297SerHis: 1.297 ± 0.043	5.476SerIle: 5.476 ± 0.097	3.788SerLys: 3.788 ± 0.085	6.072SerLeu: 6.072 ± 0.098	2.031SerMet: 2.031 ± 0.051	2.717SerAsn: 2.717 ± 0.104	2.482SerPro: 2.482 ± 0.061	1.729SerGln: 1.729 ± 0.053	3.402SerArg: 3.402 ± 0.076	4.978SerSer: 4.978 ± 0.115	3.698SerThr: 3.698 ± 0.069	4.741SerVal: 4.741 ± 0.086	0.579SerTrp: 0.579 ± 0.03	2.266SerTyr: 2.266 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	3.63ThrAla: 3.63 ± 0.076	0.563ThrCys: 0.563 ± 0.032	3.455ThrAsp: 3.455 ± 0.086	3.694ThrGlu: 3.694 ± 0.072	2.134ThrPhe: 2.134 ± 0.054	4.883ThrGly: 4.883 ± 0.084	1.015ThrHis: 1.015 ± 0.038	4.352ThrIle: 4.352 ± 0.097	2.463ThrLys: 2.463 ± 0.053	4.715ThrLeu: 4.715 ± 0.089	1.427ThrMet: 1.427 ± 0.045	1.935ThrAsn: 1.935 ± 0.064	2.382ThrPro: 2.382 ± 0.054	1.25ThrGln: 1.25 ± 0.04	2.434ThrArg: 2.434 ± 0.059	3.625ThrSer: 3.625 ± 0.082	3.07ThrThr: 3.07 ± 0.065	4.17ThrVal: 4.17 ± 0.096	0.421ThrTrp: 0.421 ± 0.031	1.843ThrTyr: 1.843 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.203ValAla: 5.203 ± 0.1	0.968ValCys: 0.968 ± 0.035	4.484ValAsp: 4.484 ± 0.082	5.088ValGlu: 5.088 ± 0.091	2.952ValPhe: 2.952 ± 0.068	4.683ValGly: 4.683 ± 0.101	1.432ValHis: 1.432 ± 0.041	5.822ValIle: 5.822 ± 0.092	4.024ValLys: 4.024 ± 0.087	6.845ValLeu: 6.845 ± 0.115	2.016ValMet: 2.016 ± 0.056	2.996ValAsn: 2.996 ± 0.069	3.055ValPro: 3.055 ± 0.068	1.791ValGln: 1.791 ± 0.05	3.416ValArg: 3.416 ± 0.077	5.29ValSer: 5.29 ± 0.108	4.109ValThr: 4.109 ± 0.092	5.428ValVal: 5.428 ± 0.097	0.563ValTrp: 0.563 ± 0.032	2.196ValTyr: 2.196 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.508TrpAla: 0.508 ± 0.025	0.117TrpCys: 0.117 ± 0.014	0.558TrpAsp: 0.558 ± 0.03	0.608TrpGlu: 0.608 ± 0.029	0.349TrpPhe: 0.349 ± 0.023	0.66TrpGly: 0.66 ± 0.034	0.156TrpHis: 0.156 ± 0.014	0.658TrpIle: 0.658 ± 0.03	0.629TrpLys: 0.629 ± 0.035	0.75TrpLeu: 0.75 ± 0.033	0.276TrpMet: 0.276 ± 0.02	0.396TrpAsn: 0.396 ± 0.026	0.217TrpPro: 0.217 ± 0.015	0.256TrpGln: 0.256 ± 0.018	0.332TrpArg: 0.332 ± 0.023	0.488TrpSer: 0.488 ± 0.028	0.475TrpThr: 0.475 ± 0.034	0.581TrpVal: 0.581 ± 0.033	0.115TrpTrp: 0.115 ± 0.013	0.304TrpTyr: 0.304 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.214TyrAla: 2.214 ± 0.058	0.426TyrCys: 0.426 ± 0.024	2.175TyrAsp: 2.175 ± 0.07	2.425TyrGlu: 2.425 ± 0.062	1.439TyrPhe: 1.439 ± 0.052	2.481TyrGly: 2.481 ± 0.056	0.699TyrHis: 0.699 ± 0.033	2.31TyrIle: 2.31 ± 0.055	1.561TyrLys: 1.561 ± 0.05	3.245TyrLeu: 3.245 ± 0.071	0.933TyrMet: 0.933 ± 0.037	1.571TyrAsn: 1.571 ± 0.062	1.561TyrPro: 1.561 ± 0.043	0.871TyrGln: 0.871 ± 0.035	1.675TyrArg: 1.675 ± 0.046	2.436TyrSer: 2.436 ± 0.064	1.838TyrThr: 1.838 ± 0.058	2.223TyrVal: 2.223 ± 0.054	0.375TyrTrp: 0.375 ± 0.025	1.365TyrTyr: 1.365 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2452 proteins (719907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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