Amino acid dipepetide frequency for Curtobacterium sp. MCBD17_040

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.896AlaAla: 21.896 ± 0.219	0.618AlaCys: 0.618 ± 0.023	8.75AlaAsp: 8.75 ± 0.095	7.233AlaGlu: 7.233 ± 0.094	3.942AlaPhe: 3.942 ± 0.056	12.236AlaGly: 12.236 ± 0.109	2.574AlaHis: 2.574 ± 0.049	5.185AlaIle: 5.185 ± 0.075	2.323AlaLys: 2.323 ± 0.056	13.52AlaLeu: 13.52 ± 0.135	2.723AlaMet: 2.723 ± 0.048	2.299AlaAsn: 2.299 ± 0.047	6.741AlaPro: 6.741 ± 0.092	3.56AlaGln: 3.56 ± 0.069	9.553AlaArg: 9.553 ± 0.105	7.473AlaSer: 7.473 ± 0.103	8.689AlaThr: 8.689 ± 0.098	13.432AlaVal: 13.432 ± 0.131	1.926AlaTrp: 1.926 ± 0.042	2.347AlaTyr: 2.347 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.587CysAla: 0.587 ± 0.021	0.045CysCys: 0.045 ± 0.006	0.312CysAsp: 0.312 ± 0.019	0.188CysGlu: 0.188 ± 0.012	0.165CysPhe: 0.165 ± 0.012	0.529CysGly: 0.529 ± 0.022	0.122CysHis: 0.122 ± 0.011	0.182CysIle: 0.182 ± 0.013	0.072CysLys: 0.072 ± 0.008	0.385CysLeu: 0.385 ± 0.018	0.084CysMet: 0.084 ± 0.008	0.099CysAsn: 0.099 ± 0.009	0.289CysPro: 0.289 ± 0.017	0.107CysGln: 0.107 ± 0.009	0.335CysArg: 0.335 ± 0.017	0.408CysSer: 0.408 ± 0.02	0.356CysThr: 0.356 ± 0.022	0.441CysVal: 0.441 ± 0.02	0.087CysTrp: 0.087 ± 0.01	0.097CysTyr: 0.097 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	9.358AspAla: 9.358 ± 0.1	0.255AspCys: 0.255 ± 0.014	4.968AspAsp: 4.968 ± 0.082	4.088AspGlu: 4.088 ± 0.077	1.466AspPhe: 1.466 ± 0.043	6.507AspGly: 6.507 ± 0.086	1.561AspHis: 1.561 ± 0.043	2.011AspIle: 2.011 ± 0.046	0.891AspLys: 0.891 ± 0.03	6.518AspLeu: 6.518 ± 0.08	0.834AspMet: 0.834 ± 0.028	0.851AspAsn: 0.851 ± 0.031	4.424AspPro: 4.424 ± 0.064	1.827AspGln: 1.827 ± 0.042	5.565AspArg: 5.565 ± 0.098	2.317AspSer: 2.317 ± 0.044	3.521AspThr: 3.521 ± 0.062	6.298AspVal: 6.298 ± 0.089	0.983AspTrp: 0.983 ± 0.031	1.1AspTyr: 1.1 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.222GluAla: 6.222 ± 0.09	0.21GluCys: 0.21 ± 0.013	3.087GluAsp: 3.087 ± 0.059	2.335GluGlu: 2.335 ± 0.055	1.477GluPhe: 1.477 ± 0.032	3.319GluGly: 3.319 ± 0.064	1.767GluHis: 1.767 ± 0.038	1.875GluIle: 1.875 ± 0.041	0.868GluLys: 0.868 ± 0.032	5.201GluLeu: 5.201 ± 0.083	0.772GluMet: 0.772 ± 0.025	0.906GluAsn: 0.906 ± 0.029	2.911GluPro: 2.911 ± 0.065	2.349GluGln: 2.349 ± 0.046	5.322GluArg: 5.322 ± 0.079	2.306GluSer: 2.306 ± 0.042	2.667GluThr: 2.667 ± 0.047	4.27GluVal: 4.27 ± 0.07	0.712GluTrp: 0.712 ± 0.028	1.081GluTyr: 1.081 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.959PheAla: 3.959 ± 0.061	0.185PheCys: 0.185 ± 0.013	2.288PheAsp: 2.288 ± 0.046	1.394PheGlu: 1.394 ± 0.031	0.892PhePhe: 0.892 ± 0.031	3.188PheGly: 3.188 ± 0.063	0.616PheHis: 0.616 ± 0.022	0.978PheIle: 0.978 ± 0.027	0.394PheLys: 0.394 ± 0.02	2.679PheLeu: 2.679 ± 0.064	0.405PheMet: 0.405 ± 0.017	0.582PheAsn: 0.582 ± 0.023	1.384PhePro: 1.384 ± 0.04	0.752PheGln: 0.752 ± 0.026	2.049PheArg: 2.049 ± 0.042	1.549PheSer: 1.549 ± 0.037	2.122PheThr: 2.122 ± 0.04	2.954PheVal: 2.954 ± 0.056	0.446PheTrp: 0.446 ± 0.023	0.516PheTyr: 0.516 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.05GlyAla: 11.05 ± 0.115	0.529GlyCys: 0.529 ± 0.024	5.128GlyAsp: 5.128 ± 0.072	3.866GlyGlu: 3.866 ± 0.068	3.021GlyPhe: 3.021 ± 0.055	7.785GlyGly: 7.785 ± 0.105	2.099GlyHis: 2.099 ± 0.045	4.059GlyIle: 4.059 ± 0.074	1.956GlyLys: 1.956 ± 0.044	8.349GlyLeu: 8.349 ± 0.104	1.741GlyMet: 1.741 ± 0.036	1.828GlyAsn: 1.828 ± 0.047	4.264GlyPro: 4.264 ± 0.066	2.588GlyGln: 2.588 ± 0.05	7.172GlyArg: 7.172 ± 0.082	5.924GlySer: 5.924 ± 0.088	6.566GlyThr: 6.566 ± 0.1	8.309GlyVal: 8.309 ± 0.091	1.685GlyTrp: 1.685 ± 0.039	2.161GlyTyr: 2.161 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.744HisAla: 2.744 ± 0.051	0.122HisCys: 0.122 ± 0.009	1.655HisAsp: 1.655 ± 0.037	1.224HisGlu: 1.224 ± 0.032	0.558HisPhe: 0.558 ± 0.022	2.271HisGly: 2.271 ± 0.047	0.68HisHis: 0.68 ± 0.028	0.695HisIle: 0.695 ± 0.028	0.256HisLys: 0.256 ± 0.016	2.178HisLeu: 2.178 ± 0.044	0.349HisMet: 0.349 ± 0.019	0.338HisAsn: 0.338 ± 0.018	1.621HisPro: 1.621 ± 0.034	0.593HisGln: 0.593 ± 0.023	1.95HisArg: 1.95 ± 0.045	0.865HisSer: 0.865 ± 0.029	1.161HisThr: 1.161 ± 0.036	2.075HisVal: 2.075 ± 0.038	0.324HisTrp: 0.324 ± 0.016	0.403HisTyr: 0.403 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.235IleAla: 6.235 ± 0.082	0.22IleCys: 0.22 ± 0.012	3.017IleAsp: 3.017 ± 0.054	2.127IleGlu: 2.127 ± 0.049	0.673IlePhe: 0.673 ± 0.027	4.239IleGly: 4.239 ± 0.073	0.625IleHis: 0.625 ± 0.021	1.26IleIle: 1.26 ± 0.036	0.632IleLys: 0.632 ± 0.026	2.555IleLeu: 2.555 ± 0.059	0.472IleMet: 0.472 ± 0.022	0.706IleAsn: 0.706 ± 0.028	2.002IlePro: 2.002 ± 0.044	0.847IleGln: 0.847 ± 0.032	2.664IleArg: 2.664 ± 0.05	1.842IleSer: 1.842 ± 0.044	2.704IleThr: 2.704 ± 0.055	4.034IleVal: 4.034 ± 0.067	0.441IleTrp: 0.441 ± 0.02	0.554IleTyr: 0.554 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.134LysAla: 2.134 ± 0.058	0.056LysCys: 0.056 ± 0.007	1.034LysAsp: 1.034 ± 0.036	0.746LysGlu: 0.746 ± 0.029	0.419LysPhe: 0.419 ± 0.02	1.486LysGly: 1.486 ± 0.04	0.441LysHis: 0.441 ± 0.019	0.676LysIle: 0.676 ± 0.028	0.651LysLys: 0.651 ± 0.033	1.5LysLeu: 1.5 ± 0.04	0.298LysMet: 0.298 ± 0.017	0.454LysAsn: 0.454 ± 0.022	1.045LysPro: 1.045 ± 0.038	0.801LysGln: 0.801 ± 0.03	1.406LysArg: 1.406 ± 0.039	1.001LysSer: 1.001 ± 0.035	1.198LysThr: 1.198 ± 0.034	1.477LysVal: 1.477 ± 0.04	0.228LysTrp: 0.228 ± 0.016	0.4LysTyr: 0.4 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.411LeuAla: 13.411 ± 0.115	0.434LeuCys: 0.434 ± 0.019	6.57LeuAsp: 6.57 ± 0.088	4.595LeuGlu: 4.595 ± 0.073	2.617LeuPhe: 2.617 ± 0.06	8.69LeuGly: 8.69 ± 0.097	2.044LeuHis: 2.044 ± 0.045	3.013LeuIle: 3.013 ± 0.062	1.254LeuLys: 1.254 ± 0.038	8.941LeuLeu: 8.941 ± 0.119	1.348LeuMet: 1.348 ± 0.035	1.61LeuAsn: 1.61 ± 0.041	5.554LeuPro: 5.554 ± 0.072	2.512LeuGln: 2.512 ± 0.045	7.438LeuArg: 7.438 ± 0.091	4.685LeuSer: 4.685 ± 0.071	6.198LeuThr: 6.198 ± 0.066	10.144LeuVal: 10.144 ± 0.125	1.139LeuTrp: 1.139 ± 0.032	1.542LeuTyr: 1.542 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.037	0.076MetCys: 0.076 ± 0.008	0.854MetAsp: 0.854 ± 0.027	0.602MetGlu: 0.602 ± 0.021	0.481MetPhe: 0.481 ± 0.021	1.15MetGly: 1.15 ± 0.035	0.376MetHis: 0.376 ± 0.018	0.638MetIle: 0.638 ± 0.021	0.325MetLys: 0.325 ± 0.017	1.668MetLeu: 1.668 ± 0.038	0.271MetMet: 0.271 ± 0.017	0.406MetAsn: 0.406 ± 0.018	1.159MetPro: 1.159 ± 0.032	0.529MetGln: 0.529 ± 0.021	1.381MetArg: 1.381 ± 0.036	1.357MetSer: 1.357 ± 0.032	1.837MetThr: 1.837 ± 0.035	1.372MetVal: 1.372 ± 0.036	0.201MetTrp: 0.201 ± 0.013	0.274MetTyr: 0.274 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.484AsnAla: 2.484 ± 0.05	0.103AsnCys: 0.103 ± 0.009	1.167AsnAsp: 1.167 ± 0.038	0.893AsnGlu: 0.893 ± 0.029	0.461AsnPhe: 0.461 ± 0.021	2.094AsnGly: 2.094 ± 0.054	0.392AsnHis: 0.392 ± 0.02	0.682AsnIle: 0.682 ± 0.024	0.385AsnLys: 0.385 ± 0.02	1.694AsnLeu: 1.694 ± 0.037	0.292AsnMet: 0.292 ± 0.02	0.4AsnAsn: 0.4 ± 0.019	1.302AsnPro: 1.302 ± 0.038	0.602AsnGln: 0.602 ± 0.022	1.324AsnArg: 1.324 ± 0.033	0.889AsnSer: 0.889 ± 0.031	1.251AsnThr: 1.251 ± 0.039	1.598AsnVal: 1.598 ± 0.044	0.303AsnTrp: 0.303 ± 0.019	0.442AsnTyr: 0.442 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.555ProAla: 7.555 ± 0.095	0.2ProCys: 0.2 ± 0.014	4.369ProAsp: 4.369 ± 0.064	3.419ProGlu: 3.419 ± 0.065	1.699ProPhe: 1.699 ± 0.038	5.209ProGly: 5.209 ± 0.073	1.154ProHis: 1.154 ± 0.033	1.864ProIle: 1.864 ± 0.042	1.023ProLys: 1.023 ± 0.031	4.479ProLeu: 4.479 ± 0.069	0.919ProMet: 0.919 ± 0.033	1.032ProAsn: 1.032 ± 0.031	2.282ProPro: 2.282 ± 0.061	1.504ProGln: 1.504 ± 0.046	3.662ProArg: 3.662 ± 0.053	3.552ProSer: 3.552 ± 0.058	4.263ProThr: 4.263 ± 0.074	5.502ProVal: 5.502 ± 0.079	0.885ProTrp: 0.885 ± 0.027	1.104ProTyr: 1.104 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.597GlnAla: 3.597 ± 0.054	0.116GlnCys: 0.116 ± 0.009	1.534GlnAsp: 1.534 ± 0.035	1.338GlnGlu: 1.338 ± 0.033	0.909GlnPhe: 0.909 ± 0.032	2.194GlnGly: 2.194 ± 0.049	0.778GlnHis: 0.778 ± 0.022	1.198GlnIle: 1.198 ± 0.03	0.635GlnLys: 0.635 ± 0.028	2.862GlnLeu: 2.862 ± 0.053	0.532GlnMet: 0.532 ± 0.02	0.624GlnAsn: 0.624 ± 0.027	1.583GlnPro: 1.583 ± 0.042	1.467GlnGln: 1.467 ± 0.053	2.572GlnArg: 2.572 ± 0.051	1.454GlnSer: 1.454 ± 0.041	1.642GlnThr: 1.642 ± 0.043	2.61GlnVal: 2.61 ± 0.055	0.443GlnTrp: 0.443 ± 0.018	0.72GlnTyr: 0.72 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.931ArgAla: 9.931 ± 0.12	0.363ArgCys: 0.363 ± 0.02	4.469ArgAsp: 4.469 ± 0.063	3.829ArgGlu: 3.829 ± 0.065	2.587ArgPhe: 2.587 ± 0.049	5.716ArgGly: 5.716 ± 0.066	1.829ArgHis: 1.829 ± 0.044	3.529ArgIle: 3.529 ± 0.058	1.29ArgLys: 1.29 ± 0.036	7.017ArgLeu: 7.017 ± 0.084	1.721ArgMet: 1.721 ± 0.035	1.484ArgAsn: 1.484 ± 0.038	4.461ArgPro: 4.461 ± 0.072	2.279ArgGln: 2.279 ± 0.047	7.601ArgArg: 7.601 ± 0.12	4.793ArgSer: 4.793 ± 0.076	5.164ArgThr: 5.164 ± 0.073	6.706ArgVal: 6.706 ± 0.083	1.376ArgTrp: 1.376 ± 0.032	1.608ArgTyr: 1.608 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.362SerAla: 7.362 ± 0.093	0.296SerCys: 0.296 ± 0.016	3.38SerAsp: 3.38 ± 0.057	2.312SerGlu: 2.312 ± 0.044	1.786SerPhe: 1.786 ± 0.039	6.066SerGly: 6.066 ± 0.086	0.935SerHis: 0.935 ± 0.026	2.284SerIle: 2.284 ± 0.042	1.122SerLys: 1.122 ± 0.038	4.527SerLeu: 4.527 ± 0.081	1.126SerMet: 1.126 ± 0.031	1.15SerAsn: 1.15 ± 0.037	2.841SerPro: 2.841 ± 0.048	1.364SerGln: 1.364 ± 0.039	3.644SerArg: 3.644 ± 0.058	3.901SerSer: 3.901 ± 0.083	4.172SerThr: 4.172 ± 0.081	5.065SerVal: 5.065 ± 0.065	0.954SerTrp: 0.954 ± 0.027	1.13SerTyr: 1.13 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	9.49ThrAla: 9.49 ± 0.114	0.336ThrCys: 0.336 ± 0.02	4.155ThrAsp: 4.155 ± 0.059	2.944ThrGlu: 2.944 ± 0.054	1.962ThrPhe: 1.962 ± 0.045	6.489ThrGly: 6.489 ± 0.101	1.236ThrHis: 1.236 ± 0.026	2.881ThrIle: 2.881 ± 0.058	1.279ThrLys: 1.279 ± 0.042	5.95ThrLeu: 5.95 ± 0.067	1.088ThrMet: 1.088 ± 0.03	1.41ThrAsn: 1.41 ± 0.037	4.382ThrPro: 4.382 ± 0.078	1.502ThrGln: 1.502 ± 0.039	4.05ThrArg: 4.05 ± 0.054	4.056ThrSer: 4.056 ± 0.072	5.395ThrThr: 5.395 ± 0.102	6.74ThrVal: 6.74 ± 0.095	1.056ThrTrp: 1.056 ± 0.032	1.389ThrTyr: 1.389 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	13.037ValAla: 13.037 ± 0.131	0.476ValCys: 0.476 ± 0.022	6.341ValAsp: 6.341 ± 0.073	4.893ValGlu: 4.893 ± 0.068	3.005ValPhe: 3.005 ± 0.054	7.932ValGly: 7.932 ± 0.097	2.119ValHis: 2.119 ± 0.04	3.696ValIle: 3.696 ± 0.072	1.461ValLys: 1.461 ± 0.039	10.201ValLeu: 10.201 ± 0.105	1.403ValMet: 1.403 ± 0.036	1.717ValAsn: 1.717 ± 0.046	5.688ValPro: 5.688 ± 0.078	2.413ValGln: 2.413 ± 0.049	7.251ValArg: 7.251 ± 0.089	4.915ValSer: 4.915 ± 0.072	6.658ValThr: 6.658 ± 0.092	11.226ValVal: 11.226 ± 0.125	1.175ValTrp: 1.175 ± 0.035	1.568ValTyr: 1.568 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.672TrpAla: 1.672 ± 0.037	0.114TrpCys: 0.114 ± 0.011	0.86TrpAsp: 0.86 ± 0.028	0.604TrpGlu: 0.604 ± 0.022	0.587TrpPhe: 0.587 ± 0.025	1.058TrpGly: 1.058 ± 0.032	0.362TrpHis: 0.362 ± 0.018	0.583TrpIle: 0.583 ± 0.024	0.29TrpLys: 0.29 ± 0.016	1.588TrpLeu: 1.588 ± 0.043	0.303TrpMet: 0.303 ± 0.018	0.404TrpAsn: 0.404 ± 0.02	0.741TrpPro: 0.741 ± 0.024	0.562TrpGln: 0.562 ± 0.023	1.236TrpArg: 1.236 ± 0.031	1.093TrpSer: 1.093 ± 0.032	1.048TrpThr: 1.048 ± 0.038	1.261TrpVal: 1.261 ± 0.035	0.363TrpTrp: 0.363 ± 0.019	0.326TrpTyr: 0.326 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.048	0.136TyrCys: 0.136 ± 0.011	1.407TyrAsp: 1.407 ± 0.044	1.025TyrGlu: 1.025 ± 0.027	0.627TyrPhe: 0.627 ± 0.027	1.921TyrGly: 1.921 ± 0.042	0.35TyrHis: 0.35 ± 0.017	0.56TyrIle: 0.56 ± 0.023	0.343TyrLys: 0.343 ± 0.02	1.927TyrLeu: 1.927 ± 0.046	0.255TyrMet: 0.255 ± 0.016	0.46TyrAsn: 0.46 ± 0.02	1.002TyrPro: 1.002 ± 0.027	0.651TyrGln: 0.651 ± 0.023	1.574TyrArg: 1.574 ± 0.037	1.039TyrSer: 1.039 ± 0.034	1.178TyrThr: 1.178 ± 0.036	1.662TyrVal: 1.662 ± 0.04	0.329TyrTrp: 0.329 ± 0.017	0.45TyrTyr: 0.45 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3754 proteins (1159833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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