Amino acid dipepetide frequency for Ajellomyces capsulatus (strain NAm1 / WU24) (Darling s disease fungus) (Histoplasma capsulatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.098AlaAla: 8.098 ± 0.072	0.98AlaCys: 0.98 ± 0.017	3.965AlaAsp: 3.965 ± 0.034	4.921AlaGlu: 4.921 ± 0.042	2.805AlaPhe: 2.805 ± 0.028	5.375AlaGly: 5.375 ± 0.038	1.675AlaHis: 1.675 ± 0.022	4.172AlaIle: 4.172 ± 0.031	4.154AlaLys: 4.154 ± 0.037	6.999AlaLeu: 6.999 ± 0.045	1.701AlaMet: 1.701 ± 0.02	2.876AlaAsn: 2.876 ± 0.028	4.175AlaPro: 4.175 ± 0.034	3.111AlaGln: 3.111 ± 0.032	5.002AlaArg: 5.002 ± 0.043	6.666AlaSer: 6.666 ± 0.052	4.991AlaThr: 4.991 ± 0.039	4.984AlaVal: 4.984 ± 0.04	0.96AlaTrp: 0.96 ± 0.017	1.976AlaTyr: 1.976 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.885CysAla: 0.885 ± 0.015	0.256CysCys: 0.256 ± 0.008	0.651CysAsp: 0.651 ± 0.014	0.672CysGlu: 0.672 ± 0.013	0.537CysPhe: 0.537 ± 0.012	1.051CysGly: 1.051 ± 0.02	0.382CysHis: 0.382 ± 0.01	0.689CysIle: 0.689 ± 0.013	0.575CysLys: 0.575 ± 0.013	1.258CysLeu: 1.258 ± 0.019	0.252CysMet: 0.252 ± 0.008	0.437CysAsn: 0.437 ± 0.011	0.717CysPro: 0.717 ± 0.016	0.503CysGln: 0.503 ± 0.011	0.86CysArg: 0.86 ± 0.016	0.988CysSer: 0.988 ± 0.017	0.672CysThr: 0.672 ± 0.015	0.81CysVal: 0.81 ± 0.015	0.24CysTrp: 0.24 ± 0.008	0.352CysTyr: 0.352 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.248AspAla: 4.248 ± 0.03	0.638AspCys: 0.638 ± 0.013	4.343AspAsp: 4.343 ± 0.046	4.41AspGlu: 4.41 ± 0.04	2.094AspPhe: 2.094 ± 0.021	4.118AspGly: 4.118 ± 0.035	1.238AspHis: 1.238 ± 0.018	3.393AspIle: 3.393 ± 0.033	2.444AspLys: 2.444 ± 0.029	4.894AspLeu: 4.894 ± 0.038	1.227AspMet: 1.227 ± 0.017	2.107AspAsn: 2.107 ± 0.023	3.285AspPro: 3.285 ± 0.032	1.833AspGln: 1.833 ± 0.025	3.174AspArg: 3.174 ± 0.038	4.124AspSer: 4.124 ± 0.031	2.898AspThr: 2.898 ± 0.031	3.519AspVal: 3.519 ± 0.032	0.828AspTrp: 0.828 ± 0.015	1.515AspTyr: 1.515 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.165GluAla: 5.165 ± 0.041	0.715GluCys: 0.715 ± 0.013	4.089GluAsp: 4.089 ± 0.039	5.655GluGlu: 5.655 ± 0.06	2.069GluPhe: 2.069 ± 0.023	3.742GluGly: 3.742 ± 0.033	1.477GluHis: 1.477 ± 0.021	3.355GluIle: 3.355 ± 0.033	3.882GluLys: 3.882 ± 0.038	5.454GluLeu: 5.454 ± 0.044	1.509GluMet: 1.509 ± 0.019	2.67GluAsn: 2.67 ± 0.03	2.821GluPro: 2.821 ± 0.037	2.504GluGln: 2.504 ± 0.028	4.345GluArg: 4.345 ± 0.039	4.412GluSer: 4.412 ± 0.035	3.36GluThr: 3.36 ± 0.033	3.389GluVal: 3.389 ± 0.035	0.887GluTrp: 0.887 ± 0.016	1.758GluTyr: 1.758 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.701PheAla: 2.701 ± 0.026	0.598PheCys: 0.598 ± 0.013	2.264PheAsp: 2.264 ± 0.026	2.155PheGlu: 2.155 ± 0.021	1.436PhePhe: 1.436 ± 0.02	2.457PheGly: 2.457 ± 0.026	0.947PheHis: 0.947 ± 0.015	1.789PheIle: 1.789 ± 0.023	1.585PheLys: 1.585 ± 0.021	3.374PheLeu: 3.374 ± 0.034	0.746PheMet: 0.746 ± 0.014	1.427PheAsn: 1.427 ± 0.02	1.946PhePro: 1.946 ± 0.022	1.357PheGln: 1.357 ± 0.02	2.07PheArg: 2.07 ± 0.024	3.059PheSer: 3.059 ± 0.028	2.037PheThr: 2.037 ± 0.023	2.235PheVal: 2.235 ± 0.025	0.53PheTrp: 0.53 ± 0.012	1.042PheTyr: 1.042 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.735GlyAla: 4.735 ± 0.039	0.902GlyCys: 0.902 ± 0.016	3.652GlyAsp: 3.652 ± 0.036	3.85GlyGlu: 3.85 ± 0.037	2.625GlyPhe: 2.625 ± 0.027	5.701GlyGly: 5.701 ± 0.066	1.651GlyHis: 1.651 ± 0.022	3.473GlyIle: 3.473 ± 0.029	3.654GlyLys: 3.654 ± 0.033	5.485GlyLeu: 5.485 ± 0.046	1.586GlyMet: 1.586 ± 0.02	2.678GlyAsn: 2.678 ± 0.026	3.072GlyPro: 3.072 ± 0.032	2.396GlyGln: 2.396 ± 0.031	4.311GlyArg: 4.311 ± 0.036	5.583GlySer: 5.583 ± 0.039	3.754GlyThr: 3.754 ± 0.031	4.141GlyVal: 4.141 ± 0.037	1.129GlyTrp: 1.129 ± 0.018	1.96GlyTyr: 1.96 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.843HisAla: 1.843 ± 0.025	0.365HisCys: 0.365 ± 0.009	1.299HisAsp: 1.299 ± 0.018	1.301HisGlu: 1.301 ± 0.017	0.966HisPhe: 0.966 ± 0.015	1.738HisGly: 1.738 ± 0.022	0.915HisHis: 0.915 ± 0.017	1.385HisIle: 1.385 ± 0.02	0.977HisLys: 0.977 ± 0.015	2.35HisLeu: 2.35 ± 0.024	0.497HisMet: 0.497 ± 0.012	0.97HisAsn: 0.97 ± 0.016	1.836HisPro: 1.836 ± 0.025	1.17HisGln: 1.17 ± 0.018	1.733HisArg: 1.733 ± 0.025	2.038HisSer: 2.038 ± 0.024	1.352HisThr: 1.352 ± 0.02	1.467HisVal: 1.467 ± 0.02	0.346HisTrp: 0.346 ± 0.01	0.714HisTyr: 0.714 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.908IleAla: 3.908 ± 0.032	0.815IleCys: 0.815 ± 0.015	3.042IleAsp: 3.042 ± 0.026	3.146IleGlu: 3.146 ± 0.027	2.006IlePhe: 2.006 ± 0.024	3.007IleGly: 3.007 ± 0.032	1.396IleHis: 1.396 ± 0.019	2.671IleIle: 2.671 ± 0.027	2.365IleLys: 2.365 ± 0.029	4.851IleLeu: 4.851 ± 0.037	0.973IleMet: 0.973 ± 0.017	1.93IleAsn: 1.93 ± 0.022	3.345IlePro: 3.345 ± 0.027	2.088IleGln: 2.088 ± 0.025	3.113IleArg: 3.113 ± 0.026	4.433IleSer: 4.433 ± 0.041	2.877IleThr: 2.877 ± 0.025	3.044IleVal: 3.044 ± 0.027	0.724IleTrp: 0.724 ± 0.017	1.503IleTyr: 1.503 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.073LysAla: 4.073 ± 0.033	0.565LysCys: 0.565 ± 0.012	2.775LysAsp: 2.775 ± 0.031	3.629LysGlu: 3.629 ± 0.037	1.587LysPhe: 1.587 ± 0.021	3.172LysGly: 3.172 ± 0.038	1.262LysHis: 1.262 ± 0.019	2.631LysIle: 2.631 ± 0.024	3.429LysLys: 3.429 ± 0.049	4.423LysLeu: 4.423 ± 0.035	1.093LysMet: 1.093 ± 0.015	1.965LysAsn: 1.965 ± 0.027	2.835LysPro: 2.835 ± 0.034	2.13LysGln: 2.13 ± 0.023	3.938LysArg: 3.938 ± 0.037	3.845LysSer: 3.845 ± 0.033	2.81LysThr: 2.81 ± 0.028	2.86LysVal: 2.86 ± 0.03	0.697LysTrp: 0.697 ± 0.014	1.466LysTyr: 1.466 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.162LeuAla: 7.162 ± 0.048	1.238LeuCys: 1.238 ± 0.021	5.16LeuAsp: 5.16 ± 0.035	5.553LeuGlu: 5.553 ± 0.046	3.192LeuPhe: 3.192 ± 0.032	5.498LeuGly: 5.498 ± 0.043	2.272LeuHis: 2.272 ± 0.023	3.968LeuIle: 3.968 ± 0.031	4.501LeuLys: 4.501 ± 0.034	8.268LeuLeu: 8.268 ± 0.058	1.681LeuMet: 1.681 ± 0.021	3.32LeuAsn: 3.32 ± 0.029	5.332LeuPro: 5.332 ± 0.038	4.005LeuGln: 4.005 ± 0.038	6.27LeuArg: 6.27 ± 0.045	7.486LeuSer: 7.486 ± 0.051	4.704LeuThr: 4.704 ± 0.042	5.046LeuVal: 5.046 ± 0.037	1.089LeuTrp: 1.089 ± 0.02	2.295LeuTyr: 2.295 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.137MetAla: 2.137 ± 0.022	0.22MetCys: 0.22 ± 0.006	1.315MetAsp: 1.315 ± 0.02	1.427MetGlu: 1.427 ± 0.018	0.674MetPhe: 0.674 ± 0.013	1.416MetGly: 1.416 ± 0.021	0.457MetHis: 0.457 ± 0.012	1.01MetIle: 1.01 ± 0.016	1.094MetLys: 1.094 ± 0.017	1.722MetLeu: 1.722 ± 0.021	0.521MetMet: 0.521 ± 0.013	0.789MetAsn: 0.789 ± 0.014	1.203MetPro: 1.203 ± 0.019	0.843MetGln: 0.843 ± 0.015	1.268MetArg: 1.268 ± 0.016	1.749MetSer: 1.749 ± 0.019	1.254MetThr: 1.254 ± 0.015	1.252MetVal: 1.252 ± 0.019	0.257MetTrp: 0.257 ± 0.01	0.471MetTyr: 0.471 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.097AsnAla: 3.097 ± 0.031	0.495AsnCys: 0.495 ± 0.011	2.122AsnAsp: 2.122 ± 0.025	2.32AsnGlu: 2.32 ± 0.024	1.398AsnPhe: 1.398 ± 0.022	2.95AsnGly: 2.95 ± 0.03	0.994AsnHis: 0.994 ± 0.015	2.349AsnIle: 2.349 ± 0.023	1.8AsnLys: 1.8 ± 0.02	3.39AsnLeu: 3.39 ± 0.031	0.874AsnMet: 0.874 ± 0.016	1.85AsnAsn: 1.85 ± 0.03	2.714AsnPro: 2.714 ± 0.027	1.455AsnGln: 1.455 ± 0.02	2.345AsnArg: 2.345 ± 0.024	3.061AsnSer: 3.061 ± 0.032	2.255AsnThr: 2.255 ± 0.023	2.307AsnVal: 2.307 ± 0.027	0.525AsnTrp: 0.525 ± 0.011	1.059AsnTyr: 1.059 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.823ProAla: 4.823 ± 0.043	0.585ProCys: 0.585 ± 0.013	3.134ProAsp: 3.134 ± 0.029	3.669ProGlu: 3.669 ± 0.034	1.982ProPhe: 1.982 ± 0.024	3.698ProGly: 3.698 ± 0.034	1.496ProHis: 1.496 ± 0.024	2.742ProIle: 2.742 ± 0.026	2.754ProLys: 2.754 ± 0.031	4.879ProLeu: 4.879 ± 0.039	1.039ProMet: 1.039 ± 0.018	2.427ProAsn: 2.427 ± 0.029	5.544ProPro: 5.544 ± 0.064	2.667ProGln: 2.667 ± 0.034	3.491ProArg: 3.491 ± 0.033	6.208ProSer: 6.208 ± 0.048	4.252ProThr: 4.252 ± 0.044	3.299ProVal: 3.299 ± 0.034	0.711ProTrp: 0.711 ± 0.015	1.465ProTyr: 1.465 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.154GlnAla: 3.154 ± 0.034	0.476GlnCys: 0.476 ± 0.013	1.931GlnAsp: 1.931 ± 0.021	2.487GlnGlu: 2.487 ± 0.028	1.291GlnPhe: 1.291 ± 0.018	2.361GlnGly: 2.361 ± 0.029	1.238GlnHis: 1.238 ± 0.023	2.029GlnIle: 2.029 ± 0.022	2.213GlnLys: 2.213 ± 0.025	3.695GlnLeu: 3.695 ± 0.033	0.911GlnMet: 0.911 ± 0.018	1.772GlnAsn: 1.772 ± 0.022	2.706GlnPro: 2.706 ± 0.031	2.885GlnGln: 2.885 ± 0.057	3.082GlnArg: 3.082 ± 0.029	3.239GlnSer: 3.239 ± 0.035	2.346GlnThr: 2.346 ± 0.02	2.169GlnVal: 2.169 ± 0.028	0.506GlnTrp: 0.506 ± 0.01	1.099GlnTyr: 1.099 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.793ArgAla: 4.793 ± 0.034	0.837ArgCys: 0.837 ± 0.016	3.501ArgAsp: 3.501 ± 0.034	4.181ArgGlu: 4.181 ± 0.038	2.242ArgPhe: 2.242 ± 0.025	4.122ArgGly: 4.122 ± 0.037	1.812ArgHis: 1.812 ± 0.023	3.227ArgIle: 3.227 ± 0.036	3.993ArgLys: 3.993 ± 0.035	5.745ArgLeu: 5.745 ± 0.04	1.429ArgMet: 1.429 ± 0.02	2.578ArgAsn: 2.578 ± 0.03	3.653ArgPro: 3.653 ± 0.03	2.954ArgGln: 2.954 ± 0.031	5.681ArgArg: 5.681 ± 0.052	5.12ArgSer: 5.12 ± 0.045	3.516ArgThr: 3.516 ± 0.029	3.461ArgVal: 3.461 ± 0.03	1.054ArgTrp: 1.054 ± 0.021	1.785ArgTyr: 1.785 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.29SerAla: 6.29 ± 0.048	0.929SerCys: 0.929 ± 0.015	4.297SerAsp: 4.297 ± 0.036	4.347SerGlu: 4.347 ± 0.035	2.983SerPhe: 2.983 ± 0.029	5.414SerGly: 5.414 ± 0.041	2.208SerHis: 2.208 ± 0.025	4.168SerIle: 4.168 ± 0.032	4.018SerLys: 4.018 ± 0.037	7.214SerLeu: 7.214 ± 0.045	1.683SerMet: 1.683 ± 0.019	3.37SerAsn: 3.37 ± 0.03	5.875SerPro: 5.875 ± 0.059	3.586SerGln: 3.586 ± 0.033	5.495SerArg: 5.495 ± 0.042	9.296SerSer: 9.296 ± 0.082	5.724SerThr: 5.724 ± 0.048	4.332SerVal: 4.332 ± 0.032	1.079SerTrp: 1.079 ± 0.018	1.974SerTyr: 1.974 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	4.85ThrAla: 4.85 ± 0.04	0.778ThrCys: 0.778 ± 0.015	2.828ThrAsp: 2.828 ± 0.035	3.176ThrGlu: 3.176 ± 0.03	2.093ThrPhe: 2.093 ± 0.025	3.938ThrGly: 3.938 ± 0.035	1.378ThrHis: 1.378 ± 0.021	3.048ThrIle: 3.048 ± 0.028	2.724ThrLys: 2.724 ± 0.026	4.998ThrLeu: 4.998 ± 0.033	1.158ThrMet: 1.158 ± 0.016	2.185ThrAsn: 2.185 ± 0.024	4.394ThrPro: 4.394 ± 0.039	2.166ThrGln: 2.166 ± 0.027	3.333ThrArg: 3.333 ± 0.029	5.501ThrSer: 5.501 ± 0.045	4.361ThrThr: 4.361 ± 0.042	3.489ThrVal: 3.489 ± 0.034	0.767ThrTrp: 0.767 ± 0.014	1.467ThrTyr: 1.467 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.725ValAla: 4.725 ± 0.037	0.788ValCys: 0.788 ± 0.015	3.63ValAsp: 3.63 ± 0.034	3.996ValGlu: 3.996 ± 0.032	2.217ValPhe: 2.217 ± 0.026	3.813ValGly: 3.813 ± 0.033	1.349ValHis: 1.349 ± 0.019	2.995ValIle: 2.995 ± 0.029	2.986ValLys: 2.986 ± 0.033	5.188ValLeu: 5.188 ± 0.044	1.234ValMet: 1.234 ± 0.017	2.245ValAsn: 2.245 ± 0.02	3.325ValPro: 3.325 ± 0.031	2.254ValGln: 2.254 ± 0.023	3.41ValArg: 3.41 ± 0.026	4.501ValSer: 4.501 ± 0.034	3.218ValThr: 3.218 ± 0.026	3.931ValVal: 3.931 ± 0.034	0.752ValTrp: 0.752 ± 0.012	1.549ValTyr: 1.549 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.058TrpAla: 1.058 ± 0.015	0.16TrpCys: 0.16 ± 0.006	0.784TrpAsp: 0.784 ± 0.016	0.879TrpGlu: 0.879 ± 0.016	0.458TrpPhe: 0.458 ± 0.011	0.821TrpGly: 0.821 ± 0.016	0.354TrpHis: 0.354 ± 0.01	0.688TrpIle: 0.688 ± 0.013	0.882TrpLys: 0.882 ± 0.014	1.263TrpLeu: 1.263 ± 0.021	0.339TrpMet: 0.339 ± 0.008	0.591TrpAsn: 0.591 ± 0.014	0.574TrpPro: 0.574 ± 0.012	0.565TrpGln: 0.565 ± 0.012	1.027TrpArg: 1.027 ± 0.016	0.967TrpSer: 0.967 ± 0.014	0.781TrpThr: 0.781 ± 0.014	0.87TrpVal: 0.87 ± 0.013	0.283TrpTrp: 0.283 ± 0.01	0.408TrpTyr: 0.408 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.839TyrAla: 1.839 ± 0.023	0.449TyrCys: 0.449 ± 0.01	1.546TyrAsp: 1.546 ± 0.023	1.484TyrGlu: 1.484 ± 0.018	1.102TyrPhe: 1.102 ± 0.017	1.947TyrGly: 1.947 ± 0.022	0.759TyrHis: 0.759 ± 0.015	1.454TyrIle: 1.454 ± 0.02	1.156TyrLys: 1.156 ± 0.019	2.589TyrLeu: 2.589 ± 0.027	0.626TyrMet: 0.626 ± 0.012	1.175TyrAsn: 1.175 ± 0.018	1.517TyrPro: 1.517 ± 0.032	1.116TyrGln: 1.116 ± 0.019	1.736TyrArg: 1.736 ± 0.023	2.005TyrSer: 2.005 ± 0.024	1.47TyrThr: 1.47 ± 0.019	1.502TyrVal: 1.502 ± 0.02	0.387TyrTrp: 0.387 ± 0.011	0.886TyrTyr: 0.886 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.131XaaXaa: 0.131 ± 0.117

Statistics based on 9252 proteins (4057025 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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