Amino acid dipepetide frequency for Leuconostoc carnosum (strain JB16)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.772AlaAla: 6.772 ± 0.15
0.15AlaCys: 0.15 ± 0.017
4.843AlaAsp: 4.843 ± 0.098
4.194AlaGlu: 4.194 ± 0.1
3.376AlaPhe: 3.376 ± 0.085
5.859AlaGly: 5.859 ± 0.123
1.659AlaHis: 1.659 ± 0.059
6.554AlaIle: 6.554 ± 0.125
5.226AlaLys: 5.226 ± 0.096
8.182AlaLeu: 8.182 ± 0.163
2.208AlaMet: 2.208 ± 0.065
3.887AlaAsn: 3.887 ± 0.1
2.313AlaPro: 2.313 ± 0.071
3.869AlaGln: 3.869 ± 0.099
3.117AlaArg: 3.117 ± 0.086
4.338AlaSer: 4.338 ± 0.107
5.254AlaThr: 5.254 ± 0.121
6.153AlaVal: 6.153 ± 0.129
0.678AlaTrp: 0.678 ± 0.043
2.566AlaTyr: 2.566 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.13CysAla: 0.13 ± 0.019
0.014CysCys: 0.014 ± 0.005
0.107CysAsp: 0.107 ± 0.014
0.074CysGlu: 0.074 ± 0.012
0.101CysPhe: 0.101 ± 0.015
0.195CysGly: 0.195 ± 0.021
0.058CysHis: 0.058 ± 0.012
0.099CysIle: 0.099 ± 0.013
0.056CysLys: 0.056 ± 0.01
0.197CysLeu: 0.197 ± 0.021
0.047CysMet: 0.047 ± 0.01
0.06CysAsn: 0.06 ± 0.01
0.095CysPro: 0.095 ± 0.015
0.105CysGln: 0.105 ± 0.018
0.09CysArg: 0.09 ± 0.012
0.134CysSer: 0.134 ± 0.019
0.107CysThr: 0.107 ± 0.016
0.103CysVal: 0.103 ± 0.013
0.016CysTrp: 0.016 ± 0.005
0.068CysTyr: 0.068 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.344AspAla: 4.344 ± 0.105
0.072AspCys: 0.072 ± 0.013
3.789AspAsp: 3.789 ± 0.106
4.091AspGlu: 4.091 ± 0.096
2.872AspPhe: 2.872 ± 0.082
3.729AspGly: 3.729 ± 0.114
1.178AspHis: 1.178 ± 0.051
4.541AspIle: 4.541 ± 0.088
3.813AspLys: 3.813 ± 0.104
5.452AspLeu: 5.452 ± 0.105
1.632AspMet: 1.632 ± 0.059
3.17AspAsn: 3.17 ± 0.081
1.774AspPro: 1.774 ± 0.062
2.428AspGln: 2.428 ± 0.077
2.15AspArg: 2.15 ± 0.061
3.02AspSer: 3.02 ± 0.079
3.38AspThr: 3.38 ± 0.094
4.336AspVal: 4.336 ± 0.09
0.781AspTrp: 0.781 ± 0.04
2.37AspTyr: 2.37 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.625GluAla: 4.625 ± 0.113
0.066GluCys: 0.066 ± 0.013
2.574GluAsp: 2.574 ± 0.079
3.006GluGlu: 3.006 ± 0.096
2.136GluPhe: 2.136 ± 0.072
2.572GluGly: 2.572 ± 0.074
1.129GluHis: 1.129 ± 0.047
4.095GluIle: 4.095 ± 0.1
4.225GluLys: 4.225 ± 0.105
5.606GluLeu: 5.606 ± 0.115
1.62GluMet: 1.62 ± 0.054
3.334GluAsn: 3.334 ± 0.09
1.686GluPro: 1.686 ± 0.057
2.839GluGln: 2.839 ± 0.083
2.416GluArg: 2.416 ± 0.084
2.975GluSer: 2.975 ± 0.067
3.371GluThr: 3.371 ± 0.09
3.717GluVal: 3.717 ± 0.085
0.498GluTrp: 0.498 ± 0.03
1.616GluTyr: 1.616 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.279PheAla: 3.279 ± 0.095
0.113PheCys: 0.113 ± 0.016
2.96PheAsp: 2.96 ± 0.081
2.633PheGlu: 2.633 ± 0.08
1.943PhePhe: 1.943 ± 0.076
3.626PheGly: 3.626 ± 0.083
0.73PheHis: 0.73 ± 0.039
3.199PheIle: 3.199 ± 0.077
2.57PheLys: 2.57 ± 0.069
3.809PheLeu: 3.809 ± 0.11
1.104PheMet: 1.104 ± 0.049
2.49PheAsn: 2.49 ± 0.074
1.361PhePro: 1.361 ± 0.056
1.511PheGln: 1.511 ± 0.058
1.244PheArg: 1.244 ± 0.054
3.125PheSer: 3.125 ± 0.084
2.502PheThr: 2.502 ± 0.078
3.211PheVal: 3.211 ± 0.079
0.578PheTrp: 0.578 ± 0.038
1.507PheTyr: 1.507 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.059GlyAla: 5.059 ± 0.124
0.136GlyCys: 0.136 ± 0.018
3.633GlyAsp: 3.633 ± 0.096
3.435GlyGlu: 3.435 ± 0.085
3.154GlyPhe: 3.154 ± 0.1
4.342GlyGly: 4.342 ± 0.113
1.569GlyHis: 1.569 ± 0.067
5.446GlyIle: 5.446 ± 0.103
3.871GlyLys: 3.871 ± 0.102
6.453GlyLeu: 6.453 ± 0.14
1.895GlyMet: 1.895 ± 0.06
2.753GlyAsn: 2.753 ± 0.081
1.505GlyPro: 1.505 ± 0.06
3.238GlyGln: 3.238 ± 0.088
2.749GlyArg: 2.749 ± 0.077
3.768GlySer: 3.768 ± 0.1
4.011GlyThr: 4.011 ± 0.089
5.006GlyVal: 5.006 ± 0.108
0.734GlyTrp: 0.734 ± 0.044
2.492GlyTyr: 2.492 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.618HisAla: 1.618 ± 0.056
0.041HisCys: 0.041 ± 0.012
1.4HisAsp: 1.4 ± 0.058
1.246HisGlu: 1.246 ± 0.048
1.065HisPhe: 1.065 ± 0.043
1.453HisGly: 1.453 ± 0.05
0.596HisHis: 0.596 ± 0.036
1.649HisIle: 1.649 ± 0.052
0.935HisLys: 0.935 ± 0.045
2.111HisLeu: 2.111 ± 0.061
0.5HisMet: 0.5 ± 0.029
0.933HisAsn: 0.933 ± 0.045
0.874HisPro: 0.874 ± 0.046
1.118HisGln: 1.118 ± 0.054
0.781HisArg: 0.781 ± 0.04
1.038HisSer: 1.038 ± 0.045
1.139HisThr: 1.139 ± 0.05
1.655HisVal: 1.655 ± 0.049
0.243HisTrp: 0.243 ± 0.022
0.939HisTyr: 0.939 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
6.951IleAla: 6.951 ± 0.118
0.22IleCys: 0.22 ± 0.024
4.648IleAsp: 4.648 ± 0.092
4.064IleGlu: 4.064 ± 0.103
3.361IlePhe: 3.361 ± 0.094
5.622IleGly: 5.622 ± 0.12
1.375IleHis: 1.375 ± 0.053
6.153IleIle: 6.153 ± 0.129
4.523IleLys: 4.523 ± 0.109
7.304IleLeu: 7.304 ± 0.141
1.856IleMet: 1.856 ± 0.071
3.978IleAsn: 3.978 ± 0.08
2.648IlePro: 2.648 ± 0.063
2.886IleGln: 2.886 ± 0.069
2.541IleArg: 2.541 ± 0.073
4.922IleSer: 4.922 ± 0.104
4.743IleThr: 4.743 ± 0.107
5.958IleVal: 5.958 ± 0.132
0.719IleTrp: 0.719 ± 0.041
2.191IleTyr: 2.191 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.506LysAla: 4.506 ± 0.09
0.078LysCys: 0.078 ± 0.012
3.084LysAsp: 3.084 ± 0.085
3.123LysGlu: 3.123 ± 0.097
2.119LysPhe: 2.119 ± 0.073
2.88LysGly: 2.88 ± 0.087
1.326LysHis: 1.326 ± 0.047
4.839LysIle: 4.839 ± 0.1
4.697LysLys: 4.697 ± 0.13
5.59LysLeu: 5.59 ± 0.114
2.011LysMet: 2.011 ± 0.059
3.778LysAsn: 3.778 ± 0.106
1.978LysPro: 1.978 ± 0.062
3.489LysGln: 3.489 ± 0.09
2.835LysArg: 2.835 ± 0.088
3.91LysSer: 3.91 ± 0.101
3.994LysThr: 3.994 ± 0.104
3.781LysVal: 3.781 ± 0.109
0.588LysTrp: 0.588 ± 0.032
2.294LysTyr: 2.294 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
8.749LeuAla: 8.749 ± 0.143
0.16LeuCys: 0.16 ± 0.022
5.559LeuAsp: 5.559 ± 0.108
4.584LeuGlu: 4.584 ± 0.111
4.06LeuPhe: 4.06 ± 0.113
6.134LeuGly: 6.134 ± 0.133
1.809LeuHis: 1.809 ± 0.059
7.16LeuIle: 7.16 ± 0.158
5.847LeuLys: 5.847 ± 0.114
9.345LeuLeu: 9.345 ± 0.183
2.598LeuMet: 2.598 ± 0.083
4.996LeuAsn: 4.996 ± 0.104
4.208LeuPro: 4.208 ± 0.093
4.003LeuGln: 4.003 ± 0.109
3.742LeuArg: 3.742 ± 0.094
6.988LeuSer: 6.988 ± 0.099
6.879LeuThr: 6.879 ± 0.129
6.827LeuVal: 6.827 ± 0.119
0.791LeuTrp: 0.791 ± 0.038
2.71LeuTyr: 2.71 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.512MetAla: 2.512 ± 0.069
0.047MetCys: 0.047 ± 0.01
1.26MetAsp: 1.26 ± 0.059
0.777MetGlu: 0.777 ± 0.039
0.94MetPhe: 0.94 ± 0.048
1.727MetGly: 1.727 ± 0.056
0.419MetHis: 0.419 ± 0.028
2.29MetIle: 2.29 ± 0.069
1.567MetLys: 1.567 ± 0.053
2.36MetLeu: 2.36 ± 0.072
0.839MetMet: 0.839 ± 0.042
1.377MetAsn: 1.377 ± 0.057
1.201MetPro: 1.201 ± 0.046
1.215MetGln: 1.215 ± 0.047
1.067MetArg: 1.067 ± 0.05
1.998MetSer: 1.998 ± 0.058
2.469MetThr: 2.469 ± 0.069
1.825MetVal: 1.825 ± 0.057
0.204MetTrp: 0.204 ± 0.02
0.627MetTyr: 0.627 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.776AsnAla: 3.776 ± 0.091
0.084AsnCys: 0.084 ± 0.013
3.269AsnAsp: 3.269 ± 0.074
2.736AsnGlu: 2.736 ± 0.078
2.177AsnPhe: 2.177 ± 0.063
3.462AsnGly: 3.462 ± 0.112
1.359AsnHis: 1.359 ± 0.056
4.029AsnIle: 4.029 ± 0.09
2.857AsnLys: 2.857 ± 0.084
4.299AsnLeu: 4.299 ± 0.1
1.33AsnMet: 1.33 ± 0.06
2.744AsnAsn: 2.744 ± 0.078
2.041AsnPro: 2.041 ± 0.057
2.783AsnGln: 2.783 ± 0.086
1.815AsnArg: 1.815 ± 0.064
2.732AsnSer: 2.732 ± 0.088
2.915AsnThr: 2.915 ± 0.079
3.443AsnVal: 3.443 ± 0.094
0.715AsnTrp: 0.715 ± 0.036
1.932AsnTyr: 1.932 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.527ProAla: 2.527 ± 0.086
0.053ProCys: 0.053 ± 0.011
2.284ProAsp: 2.284 ± 0.069
2.64ProGlu: 2.64 ± 0.08
1.548ProPhe: 1.548 ± 0.061
1.928ProGly: 1.928 ± 0.066
0.678ProHis: 0.678 ± 0.035
2.71ProIle: 2.71 ± 0.08
2.309ProLys: 2.309 ± 0.076
2.985ProLeu: 2.985 ± 0.086
0.853ProMet: 0.853 ± 0.041
1.821ProAsn: 1.821 ± 0.05
0.483ProPro: 0.483 ± 0.035
1.363ProGln: 1.363 ± 0.051
1.141ProArg: 1.141 ± 0.05
1.963ProSer: 1.963 ± 0.066
2.411ProThr: 2.411 ± 0.055
2.73ProVal: 2.73 ± 0.083
0.325ProTrp: 0.325 ± 0.026
1.211ProTyr: 1.211 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.99GlnAla: 3.99 ± 0.078
0.084GlnCys: 0.084 ± 0.014
2.193GlnAsp: 2.193 ± 0.069
2.473GlnGlu: 2.473 ± 0.073
1.937GlnPhe: 1.937 ± 0.064
2.378GlnGly: 2.378 ± 0.069
1.137GlnHis: 1.137 ± 0.04
3.176GlnIle: 3.176 ± 0.077
3.162GlnLys: 3.162 ± 0.081
5.248GlnLeu: 5.248 ± 0.124
1.196GlnMet: 1.196 ± 0.05
2.448GlnAsn: 2.448 ± 0.071
1.577GlnPro: 1.577 ± 0.049
2.946GlnGln: 2.946 ± 0.106
2.138GlnArg: 2.138 ± 0.067
2.783GlnSer: 2.783 ± 0.088
3.117GlnThr: 3.117 ± 0.083
3.306GlnVal: 3.306 ± 0.09
0.52GlnTrp: 0.52 ± 0.033
1.749GlnTyr: 1.749 ± 0.067
0.0GlnXaa: 0.0 ± 0.0
Arg
2.847ArgAla: 2.847 ± 0.076
0.068ArgCys: 0.068 ± 0.012
2.442ArgAsp: 2.442 ± 0.076
2.522ArgGlu: 2.522 ± 0.081
1.809ArgPhe: 1.809 ± 0.06
2.45ArgGly: 2.45 ± 0.064
1.028ArgHis: 1.028 ± 0.055
2.757ArgIle: 2.757 ± 0.081
2.054ArgLys: 2.054 ± 0.071
3.89ArgLeu: 3.89 ± 0.087
1.075ArgMet: 1.075 ± 0.048
1.616ArgAsn: 1.616 ± 0.068
1.34ArgPro: 1.34 ± 0.057
2.368ArgGln: 2.368 ± 0.072
1.969ArgArg: 1.969 ± 0.072
2.015ArgSer: 2.015 ± 0.063
2.12ArgThr: 2.12 ± 0.074
2.946ArgVal: 2.946 ± 0.08
0.393ArgTrp: 0.393 ± 0.027
1.603ArgTyr: 1.603 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.829SerAla: 4.829 ± 0.098
0.111SerCys: 0.111 ± 0.015
4.114SerAsp: 4.114 ± 0.101
3.848SerGlu: 3.848 ± 0.1
2.897SerPhe: 2.897 ± 0.085
4.724SerGly: 4.724 ± 0.12
1.32SerHis: 1.32 ± 0.054
4.138SerIle: 4.138 ± 0.088
3.484SerLys: 3.484 ± 0.09
5.906SerLeu: 5.906 ± 0.109
1.441SerMet: 1.441 ± 0.051
2.744SerAsn: 2.744 ± 0.089
1.852SerPro: 1.852 ± 0.065
2.968SerGln: 2.968 ± 0.094
2.407SerArg: 2.407 ± 0.07
3.756SerSer: 3.756 ± 0.141
3.487SerThr: 3.487 ± 0.101
4.13SerVal: 4.13 ± 0.092
0.724SerTrp: 0.724 ± 0.043
1.937SerTyr: 1.937 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.965ThrAla: 4.965 ± 0.097
0.121ThrCys: 0.121 ± 0.018
3.663ThrAsp: 3.663 ± 0.096
3.04ThrGlu: 3.04 ± 0.075
2.716ThrPhe: 2.716 ± 0.075
4.459ThrGly: 4.459 ± 0.098
1.379ThrHis: 1.379 ± 0.048
5.141ThrIle: 5.141 ± 0.112
3.676ThrLys: 3.676 ± 0.09
6.371ThrLeu: 6.371 ± 0.1
1.507ThrMet: 1.507 ± 0.048
3.045ThrAsn: 3.045 ± 0.094
2.744ThrPro: 2.744 ± 0.072
2.825ThrGln: 2.825 ± 0.078
2.344ThrArg: 2.344 ± 0.077
3.85ThrSer: 3.85 ± 0.105
4.331ThrThr: 4.331 ± 0.108
4.835ThrVal: 4.835 ± 0.114
0.615ThrTrp: 0.615 ± 0.034
2.146ThrTyr: 2.146 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
6.455ValAla: 6.455 ± 0.128
0.119ValCys: 0.119 ± 0.016
4.434ValAsp: 4.434 ± 0.099
3.509ValGlu: 3.509 ± 0.104
2.812ValPhe: 2.812 ± 0.076
4.811ValGly: 4.811 ± 0.108
1.291ValHis: 1.291 ± 0.051
5.912ValIle: 5.912 ± 0.115
4.095ValLys: 4.095 ± 0.107
6.998ValLeu: 6.998 ± 0.121
1.934ValMet: 1.934 ± 0.06
3.472ValAsn: 3.472 ± 0.083
2.804ValPro: 2.804 ± 0.079
2.633ValGln: 2.633 ± 0.067
2.615ValArg: 2.615 ± 0.079
4.983ValSer: 4.983 ± 0.106
5.193ValThr: 5.193 ± 0.106
5.571ValVal: 5.571 ± 0.11
0.631ValTrp: 0.631 ± 0.037
2.074ValTyr: 2.074 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.701TrpAla: 0.701 ± 0.034
0.029TrpCys: 0.029 ± 0.007
0.458TrpAsp: 0.458 ± 0.028
0.417TrpGlu: 0.417 ± 0.028
0.606TrpPhe: 0.606 ± 0.037
0.549TrpGly: 0.549 ± 0.033
0.428TrpHis: 0.428 ± 0.029
0.625TrpIle: 0.625 ± 0.034
0.331TrpLys: 0.331 ± 0.029
1.373TrpLeu: 1.373 ± 0.054
0.232TrpMet: 0.232 ± 0.02
0.376TrpAsn: 0.376 ± 0.027
0.277TrpPro: 0.277 ± 0.023
0.94TrpGln: 0.94 ± 0.046
0.594TrpArg: 0.594 ± 0.032
0.592TrpSer: 0.592 ± 0.033
0.557TrpThr: 0.557 ± 0.034
0.685TrpVal: 0.685 ± 0.035
0.173TrpTrp: 0.173 ± 0.021
0.391TrpTyr: 0.391 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.564TyrAla: 2.564 ± 0.074
0.093TyrCys: 0.093 ± 0.014
2.208TyrAsp: 2.208 ± 0.07
1.698TyrGlu: 1.698 ± 0.058
1.867TyrPhe: 1.867 ± 0.082
2.354TyrGly: 2.354 ± 0.069
0.865TyrHis: 0.865 ± 0.041
2.15TyrIle: 2.15 ± 0.07
1.601TyrLys: 1.601 ± 0.063
3.67TyrLeu: 3.67 ± 0.095
0.843TyrMet: 0.843 ± 0.041
1.474TyrAsn: 1.474 ± 0.048
1.201TyrPro: 1.201 ± 0.054
2.029TyrGln: 2.029 ± 0.074
1.556TyrArg: 1.556 ± 0.047
1.926TyrSer: 1.926 ± 0.068
1.791TyrThr: 1.791 ± 0.056
2.124TyrVal: 2.124 ± 0.068
0.407TyrTrp: 0.407 ± 0.028
1.384TyrTyr: 1.384 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1690 proteins (513563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski