Amino acid dipepetide frequency for Celeribacter halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.648AlaAla: 13.648 ± 0.163	1.08AlaCys: 1.08 ± 0.032	6.156AlaAsp: 6.156 ± 0.077	7.893AlaGlu: 7.893 ± 0.11	4.315AlaPhe: 4.315 ± 0.065	9.236AlaGly: 9.236 ± 0.101	2.175AlaHis: 2.175 ± 0.052	5.784AlaIle: 5.784 ± 0.078	4.496AlaLys: 4.496 ± 0.073	13.141AlaLeu: 13.141 ± 0.146	3.63AlaMet: 3.63 ± 0.06	2.609AlaAsn: 2.609 ± 0.051	5.269AlaPro: 5.269 ± 0.086	4.597AlaGln: 4.597 ± 0.075	7.422AlaArg: 7.422 ± 0.105	5.688AlaSer: 5.688 ± 0.083	5.806AlaThr: 5.806 ± 0.068	7.631AlaVal: 7.631 ± 0.09	1.262AlaTrp: 1.262 ± 0.037	2.498AlaTyr: 2.498 ± 0.044	0.001AlaXaa: 0.001 ± 0.001
Cys	1.107CysAla: 1.107 ± 0.034	0.102CysCys: 0.102 ± 0.011	0.649CysAsp: 0.649 ± 0.023	0.531CysGlu: 0.531 ± 0.021	0.359CysPhe: 0.359 ± 0.02	0.908CysGly: 0.908 ± 0.029	0.247CysHis: 0.247 ± 0.016	0.443CysIle: 0.443 ± 0.019	0.236CysLys: 0.236 ± 0.014	0.894CysLeu: 0.894 ± 0.028	0.173CysMet: 0.173 ± 0.011	0.222CysAsn: 0.222 ± 0.015	0.477CysPro: 0.477 ± 0.02	0.261CysGln: 0.261 ± 0.015	0.488CysArg: 0.488 ± 0.02	0.487CysSer: 0.487 ± 0.024	0.451CysThr: 0.451 ± 0.02	0.681CysVal: 0.681 ± 0.028	0.088CysTrp: 0.088 ± 0.009	0.196CysTyr: 0.196 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.639AspAla: 6.639 ± 0.089	0.516AspCys: 0.516 ± 0.021	3.332AspAsp: 3.332 ± 0.093	3.81AspGlu: 3.81 ± 0.072	2.314AspPhe: 2.314 ± 0.051	5.261AspGly: 5.261 ± 0.086	1.416AspHis: 1.416 ± 0.038	3.299AspIle: 3.299 ± 0.059	1.973AspLys: 1.973 ± 0.051	6.533AspLeu: 6.533 ± 0.08	1.852AspMet: 1.852 ± 0.036	1.349AspAsn: 1.349 ± 0.041	3.335AspPro: 3.335 ± 0.056	1.861AspGln: 1.861 ± 0.044	3.611AspArg: 3.611 ± 0.06	2.218AspSer: 2.218 ± 0.046	3.133AspThr: 3.133 ± 0.067	4.302AspVal: 4.302 ± 0.072	1.062AspTrp: 1.062 ± 0.031	1.676AspTyr: 1.676 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.317GluAla: 8.317 ± 0.116	0.364GluCys: 0.364 ± 0.018	3.873GluAsp: 3.873 ± 0.073	4.278GluGlu: 4.278 ± 0.085	2.062GluPhe: 2.062 ± 0.039	5.111GluGly: 5.111 ± 0.067	1.265GluHis: 1.265 ± 0.032	4.16GluIle: 4.16 ± 0.067	2.785GluLys: 2.785 ± 0.056	5.518GluLeu: 5.518 ± 0.071	2.019GluMet: 2.019 ± 0.043	2.032GluAsn: 2.032 ± 0.044	2.389GluPro: 2.389 ± 0.056	2.139GluGln: 2.139 ± 0.049	4.193GluArg: 4.193 ± 0.063	2.511GluSer: 2.511 ± 0.047	4.217GluThr: 4.217 ± 0.069	4.632GluVal: 4.632 ± 0.074	0.722GluTrp: 0.722 ± 0.03	1.143GluTyr: 1.143 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.331PheAla: 4.331 ± 0.074	0.443PheCys: 0.443 ± 0.02	2.899PheAsp: 2.899 ± 0.046	2.497PheGlu: 2.497 ± 0.047	1.589PhePhe: 1.589 ± 0.046	3.844PheGly: 3.844 ± 0.057	0.739PheHis: 0.739 ± 0.025	1.775PheIle: 1.775 ± 0.042	1.21PheLys: 1.21 ± 0.039	3.623PheLeu: 3.623 ± 0.069	0.984PheMet: 0.984 ± 0.034	1.141PheAsn: 1.141 ± 0.029	1.604PhePro: 1.604 ± 0.04	1.02PheGln: 1.02 ± 0.03	1.972PheArg: 1.972 ± 0.045	2.523PheSer: 2.523 ± 0.049	2.212PheThr: 2.212 ± 0.048	2.733PheVal: 2.733 ± 0.054	0.596PheTrp: 0.596 ± 0.025	1.041PheTyr: 1.041 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.957GlyAla: 8.957 ± 0.102	0.822GlyCys: 0.822 ± 0.029	4.437GlyAsp: 4.437 ± 0.093	4.939GlyGlu: 4.939 ± 0.064	3.753GlyPhe: 3.753 ± 0.054	6.78GlyGly: 6.78 ± 0.11	1.86GlyHis: 1.86 ± 0.044	4.586GlyIle: 4.586 ± 0.072	3.531GlyLys: 3.531 ± 0.053	9.026GlyLeu: 9.026 ± 0.113	2.57GlyMet: 2.57 ± 0.054	2.057GlyAsn: 2.057 ± 0.048	3.286GlyPro: 3.286 ± 0.054	2.925GlyGln: 2.925 ± 0.057	4.956GlyArg: 4.956 ± 0.066	4.104GlySer: 4.104 ± 0.069	4.506GlyThr: 4.506 ± 0.074	6.402GlyVal: 6.402 ± 0.079	1.291GlyTrp: 1.291 ± 0.031	2.304GlyTyr: 2.304 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.198HisAla: 2.198 ± 0.047	0.226HisCys: 0.226 ± 0.012	1.293HisAsp: 1.293 ± 0.032	1.169HisGlu: 1.169 ± 0.035	0.85HisPhe: 0.85 ± 0.028	1.817HisGly: 1.817 ± 0.042	0.559HisHis: 0.559 ± 0.025	1.098HisIle: 1.098 ± 0.034	0.675HisLys: 0.675 ± 0.023	2.118HisLeu: 2.118 ± 0.047	0.628HisMet: 0.628 ± 0.021	0.501HisAsn: 0.501 ± 0.019	1.357HisPro: 1.357 ± 0.032	0.574HisGln: 0.574 ± 0.021	1.277HisArg: 1.277 ± 0.036	1.02HisSer: 1.02 ± 0.031	0.873HisThr: 0.873 ± 0.025	1.507HisVal: 1.507 ± 0.037	0.336HisTrp: 0.336 ± 0.018	0.575HisTyr: 0.575 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.972IleAla: 6.972 ± 0.086	0.644IleCys: 0.644 ± 0.024	3.471IleAsp: 3.471 ± 0.058	3.761IleGlu: 3.761 ± 0.067	1.933IlePhe: 1.933 ± 0.05	4.914IleGly: 4.914 ± 0.071	1.0IleHis: 1.0 ± 0.034	2.469IleIle: 2.469 ± 0.06	1.843IleLys: 1.843 ± 0.043	5.024IleLeu: 5.024 ± 0.078	1.245IleMet: 1.245 ± 0.033	1.466IleAsn: 1.466 ± 0.04	2.494IlePro: 2.494 ± 0.045	1.238IleGln: 1.238 ± 0.031	3.019IleArg: 3.019 ± 0.055	3.49IleSer: 3.49 ± 0.063	3.186IleThr: 3.186 ± 0.06	3.977IleVal: 3.977 ± 0.061	0.721IleTrp: 0.721 ± 0.026	1.331IleTyr: 1.331 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.58LysAla: 4.58 ± 0.08	0.218LysCys: 0.218 ± 0.016	2.195LysAsp: 2.195 ± 0.049	2.164LysGlu: 2.164 ± 0.051	1.165LysPhe: 1.165 ± 0.036	3.188LysGly: 3.188 ± 0.057	0.776LysHis: 0.776 ± 0.027	2.135LysIle: 2.135 ± 0.05	1.656LysLys: 1.656 ± 0.047	3.502LysLeu: 3.502 ± 0.057	1.09LysMet: 1.09 ± 0.034	1.034LysAsn: 1.034 ± 0.033	2.123LysPro: 2.123 ± 0.05	1.05LysGln: 1.05 ± 0.034	2.608LysArg: 2.608 ± 0.057	2.251LysSer: 2.251 ± 0.049	2.493LysThr: 2.493 ± 0.047	2.606LysVal: 2.606 ± 0.05	0.476LysTrp: 0.476 ± 0.02	0.76LysTyr: 0.76 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.649LeuAla: 11.649 ± 0.125	0.989LeuCys: 0.989 ± 0.03	6.005LeuAsp: 6.005 ± 0.076	5.739LeuGlu: 5.739 ± 0.069	3.668LeuPhe: 3.668 ± 0.072	8.425LeuGly: 8.425 ± 0.101	1.927LeuHis: 1.927 ± 0.046	5.384LeuIle: 5.384 ± 0.086	4.044LeuLys: 4.044 ± 0.069	8.901LeuLeu: 8.901 ± 0.118	2.804LeuMet: 2.804 ± 0.06	2.742LeuAsn: 2.742 ± 0.053	5.535LeuPro: 5.535 ± 0.087	2.567LeuGln: 2.567 ± 0.051	6.327LeuArg: 6.327 ± 0.083	7.225LeuSer: 7.225 ± 0.095	6.085LeuThr: 6.085 ± 0.082	6.958LeuVal: 6.958 ± 0.093	1.265LeuTrp: 1.265 ± 0.04	2.125LeuTyr: 2.125 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	3.325MetAla: 3.325 ± 0.064	0.217MetCys: 0.217 ± 0.014	1.458MetAsp: 1.458 ± 0.039	1.521MetGlu: 1.521 ± 0.037	0.95MetPhe: 0.95 ± 0.035	2.231MetGly: 2.231 ± 0.043	0.482MetHis: 0.482 ± 0.022	1.731MetIle: 1.731 ± 0.04	1.296MetLys: 1.296 ± 0.037	2.653MetLeu: 2.653 ± 0.048	0.811MetMet: 0.811 ± 0.03	0.955MetAsn: 0.955 ± 0.028	1.526MetPro: 1.526 ± 0.039	0.927MetGln: 0.927 ± 0.029	1.846MetArg: 1.846 ± 0.046	2.066MetSer: 2.066 ± 0.04	2.214MetThr: 2.214 ± 0.047	2.012MetVal: 2.012 ± 0.041	0.257MetTrp: 0.257 ± 0.015	0.383MetTyr: 0.383 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.184AsnAla: 3.184 ± 0.05	0.263AsnCys: 0.263 ± 0.014	1.478AsnAsp: 1.478 ± 0.044	1.324AsnGlu: 1.324 ± 0.033	1.042AsnPhe: 1.042 ± 0.026	2.433AsnGly: 2.433 ± 0.052	0.541AsnHis: 0.541 ± 0.023	1.609AsnIle: 1.609 ± 0.037	0.855AsnLys: 0.855 ± 0.03	2.691AsnLeu: 2.691 ± 0.049	0.771AsnMet: 0.771 ± 0.029	0.679AsnAsn: 0.679 ± 0.025	1.785AsnPro: 1.785 ± 0.047	0.691AsnGln: 0.691 ± 0.025	1.639AsnArg: 1.639 ± 0.036	1.354AsnSer: 1.354 ± 0.035	1.5AsnThr: 1.5 ± 0.04	1.928AsnVal: 1.928 ± 0.039	0.48AsnTrp: 0.48 ± 0.02	0.685AsnTyr: 0.685 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.076ProAla: 5.076 ± 0.076	0.356ProCys: 0.356 ± 0.018	3.703ProAsp: 3.703 ± 0.063	4.528ProGlu: 4.528 ± 0.067	1.974ProPhe: 1.974 ± 0.045	3.3ProGly: 3.3 ± 0.06	1.067ProHis: 1.067 ± 0.032	2.168ProIle: 2.168 ± 0.048	2.008ProLys: 2.008 ± 0.042	4.55ProLeu: 4.55 ± 0.062	1.281ProMet: 1.281 ± 0.038	1.277ProAsn: 1.277 ± 0.031	2.006ProPro: 2.006 ± 0.047	1.63ProGln: 1.63 ± 0.041	2.554ProArg: 2.554 ± 0.046	2.706ProSer: 2.706 ± 0.051	2.501ProThr: 2.501 ± 0.048	4.29ProVal: 4.29 ± 0.064	0.636ProTrp: 0.636 ± 0.027	1.224ProTyr: 1.224 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.671GlnAla: 3.671 ± 0.063	0.238GlnCys: 0.238 ± 0.014	1.748GlnAsp: 1.748 ± 0.039	1.701GlnGlu: 1.701 ± 0.042	1.129GlnPhe: 1.129 ± 0.03	2.536GlnGly: 2.536 ± 0.051	0.622GlnHis: 0.622 ± 0.029	2.099GlnIle: 2.099 ± 0.039	1.281GlnLys: 1.281 ± 0.034	2.728GlnLeu: 2.728 ± 0.048	1.057GlnMet: 1.057 ± 0.032	1.034GlnAsn: 1.034 ± 0.031	1.485GlnPro: 1.485 ± 0.037	0.993GlnGln: 0.993 ± 0.035	2.063GlnArg: 2.063 ± 0.047	1.938GlnSer: 1.938 ± 0.042	1.853GlnThr: 1.853 ± 0.047	2.251GlnVal: 2.251 ± 0.047	0.367GlnTrp: 0.367 ± 0.017	0.585GlnTyr: 0.585 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.815ArgAla: 6.815 ± 0.086	0.474ArgCys: 0.474 ± 0.02	3.775ArgAsp: 3.775 ± 0.066	3.893ArgGlu: 3.893 ± 0.071	2.566ArgPhe: 2.566 ± 0.05	3.985ArgGly: 3.985 ± 0.07	1.485ArgHis: 1.485 ± 0.039	3.628ArgIle: 3.628 ± 0.063	2.553ArgLys: 2.553 ± 0.053	6.548ArgLeu: 6.548 ± 0.088	1.817ArgMet: 1.817 ± 0.039	1.816ArgAsn: 1.816 ± 0.042	2.862ArgPro: 2.862 ± 0.046	2.148ArgGln: 2.148 ± 0.049	4.146ArgArg: 4.146 ± 0.071	3.006ArgSer: 3.006 ± 0.049	2.799ArgThr: 2.799 ± 0.056	4.418ArgVal: 4.418 ± 0.068	0.792ArgTrp: 0.792 ± 0.028	1.561ArgTyr: 1.561 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.821SerAla: 5.821 ± 0.071	0.496SerCys: 0.496 ± 0.021	3.45SerAsp: 3.45 ± 0.071	3.603SerGlu: 3.603 ± 0.058	2.475SerPhe: 2.475 ± 0.048	5.493SerGly: 5.493 ± 0.083	1.191SerHis: 1.191 ± 0.035	2.651SerIle: 2.651 ± 0.051	1.963SerLys: 1.963 ± 0.046	5.426SerLeu: 5.426 ± 0.075	1.53SerMet: 1.53 ± 0.037	1.47SerAsn: 1.47 ± 0.04	2.56SerPro: 2.56 ± 0.048	1.688SerGln: 1.688 ± 0.04	3.223SerArg: 3.223 ± 0.064	2.985SerSer: 2.985 ± 0.066	2.844SerThr: 2.844 ± 0.057	4.083SerVal: 4.083 ± 0.061	0.705SerTrp: 0.705 ± 0.026	1.598SerTyr: 1.598 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.946ThrAla: 5.946 ± 0.077	0.514ThrCys: 0.514 ± 0.024	3.158ThrAsp: 3.158 ± 0.049	3.347ThrGlu: 3.347 ± 0.055	2.071ThrPhe: 2.071 ± 0.052	5.265ThrGly: 5.265 ± 0.077	1.189ThrHis: 1.189 ± 0.031	2.862ThrIle: 2.862 ± 0.056	1.769ThrLys: 1.769 ± 0.04	6.284ThrLeu: 6.284 ± 0.075	1.441ThrMet: 1.441 ± 0.037	1.374ThrAsn: 1.374 ± 0.039	3.56ThrPro: 3.56 ± 0.059	1.765ThrGln: 1.765 ± 0.036	3.384ThrArg: 3.384 ± 0.062	3.052ThrSer: 3.052 ± 0.059	2.938ThrThr: 2.938 ± 0.062	4.4ThrVal: 4.4 ± 0.072	0.655ThrTrp: 0.655 ± 0.023	1.372ThrTyr: 1.372 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.31ValAla: 8.31 ± 0.098	0.638ValCys: 0.638 ± 0.024	4.04ValAsp: 4.04 ± 0.06	4.831ValGlu: 4.831 ± 0.073	2.953ValPhe: 2.953 ± 0.057	5.21ValGly: 5.21 ± 0.073	1.252ValHis: 1.252 ± 0.035	4.534ValIle: 4.534 ± 0.068	2.633ValLys: 2.633 ± 0.056	7.449ValLeu: 7.449 ± 0.09	2.228ValMet: 2.228 ± 0.047	2.078ValAsn: 2.078 ± 0.047	3.482ValPro: 3.482 ± 0.053	2.056ValGln: 2.056 ± 0.046	3.873ValArg: 3.873 ± 0.067	4.65ValSer: 4.65 ± 0.073	4.768ValThr: 4.768 ± 0.066	5.548ValVal: 5.548 ± 0.085	0.88ValTrp: 0.88 ± 0.028	1.54ValTyr: 1.54 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.225TrpAla: 1.225 ± 0.034	0.14TrpCys: 0.14 ± 0.011	0.73TrpAsp: 0.73 ± 0.026	0.716TrpGlu: 0.716 ± 0.027	0.61TrpPhe: 0.61 ± 0.024	0.975TrpGly: 0.975 ± 0.034	0.33TrpHis: 0.33 ± 0.016	0.717TrpIle: 0.717 ± 0.024	0.49TrpLys: 0.49 ± 0.024	1.48TrpLeu: 1.48 ± 0.042	0.367TrpMet: 0.367 ± 0.018	0.412TrpAsn: 0.412 ± 0.018	0.601TrpPro: 0.601 ± 0.024	0.53TrpGln: 0.53 ± 0.021	1.006TrpArg: 1.006 ± 0.032	0.743TrpSer: 0.743 ± 0.026	0.697TrpThr: 0.697 ± 0.027	0.901TrpVal: 0.901 ± 0.03	0.191TrpTrp: 0.191 ± 0.014	0.281TrpTyr: 0.281 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.566TyrAla: 2.566 ± 0.049	0.264TyrCys: 0.264 ± 0.017	1.642TyrAsp: 1.642 ± 0.038	1.481TyrGlu: 1.481 ± 0.042	0.999TyrPhe: 0.999 ± 0.031	2.179TyrGly: 2.179 ± 0.047	0.527TyrHis: 0.527 ± 0.025	1.063TyrIle: 1.063 ± 0.032	0.773TyrLys: 0.773 ± 0.027	2.274TyrLeu: 2.274 ± 0.049	0.561TyrMet: 0.561 ± 0.022	0.684TyrAsn: 0.684 ± 0.025	1.099TyrPro: 1.099 ± 0.032	0.722TyrGln: 0.722 ± 0.023	1.481TyrArg: 1.481 ± 0.033	1.237TyrSer: 1.237 ± 0.034	1.27TyrThr: 1.27 ± 0.033	1.692TyrVal: 1.692 ± 0.039	0.363TyrTrp: 0.363 ± 0.017	0.596TyrTyr: 0.596 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.013XaaXaa: 0.013 ± 0.011

Statistics based on 3717 proteins (1141706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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