Amino acid dipepetide frequency for Rhodobium orientis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.436AlaAla: 17.436 ± 0.188	1.086AlaCys: 1.086 ± 0.03	7.747AlaAsp: 7.747 ± 0.085	8.62AlaGlu: 8.62 ± 0.083	4.745AlaPhe: 4.745 ± 0.066	11.196AlaGly: 11.196 ± 0.127	2.159AlaHis: 2.159 ± 0.036	6.524AlaIle: 6.524 ± 0.078	4.018AlaLys: 4.018 ± 0.064	12.669AlaLeu: 12.669 ± 0.129	3.357AlaMet: 3.357 ± 0.049	2.815AlaAsn: 2.815 ± 0.045	5.604AlaPro: 5.604 ± 0.092	2.68AlaGln: 2.68 ± 0.043	8.835AlaArg: 8.835 ± 0.086	5.944AlaSer: 5.944 ± 0.075	6.158AlaThr: 6.158 ± 0.076	9.392AlaVal: 9.392 ± 0.098	1.369AlaTrp: 1.369 ± 0.036	2.591AlaTyr: 2.591 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.949CysAla: 0.949 ± 0.029	0.118CysCys: 0.118 ± 0.009	0.589CysAsp: 0.589 ± 0.021	0.433CysGlu: 0.433 ± 0.018	0.303CysPhe: 0.303 ± 0.014	1.016CysGly: 1.016 ± 0.026	0.291CysHis: 0.291 ± 0.018	0.412CysIle: 0.412 ± 0.018	0.216CysLys: 0.216 ± 0.012	0.836CysLeu: 0.836 ± 0.026	0.17CysMet: 0.17 ± 0.011	0.227CysAsn: 0.227 ± 0.014	0.484CysPro: 0.484 ± 0.02	0.237CysGln: 0.237 ± 0.012	0.754CysArg: 0.754 ± 0.022	0.439CysSer: 0.439 ± 0.019	0.39CysThr: 0.39 ± 0.017	0.584CysVal: 0.584 ± 0.024	0.105CysTrp: 0.105 ± 0.008	0.231CysTyr: 0.231 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.645AspAla: 7.645 ± 0.086	0.514AspCys: 0.514 ± 0.019	3.975AspAsp: 3.975 ± 0.073	3.826AspGlu: 3.826 ± 0.061	2.398AspPhe: 2.398 ± 0.041	5.766AspGly: 5.766 ± 0.079	1.281AspHis: 1.281 ± 0.029	3.466AspIle: 3.466 ± 0.045	1.879AspLys: 1.879 ± 0.037	6.316AspLeu: 6.316 ± 0.065	1.383AspMet: 1.383 ± 0.03	1.351AspAsn: 1.351 ± 0.03	3.708AspPro: 3.708 ± 0.055	1.481AspGln: 1.481 ± 0.035	4.662AspArg: 4.662 ± 0.066	1.999AspSer: 1.999 ± 0.04	2.919AspThr: 2.919 ± 0.045	4.446AspVal: 4.446 ± 0.065	1.02AspTrp: 1.02 ± 0.028	1.607AspTyr: 1.607 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.401GluAla: 8.401 ± 0.1	0.406GluCys: 0.406 ± 0.019	3.342GluAsp: 3.342 ± 0.049	4.113GluGlu: 4.113 ± 0.062	1.846GluPhe: 1.846 ± 0.038	4.325GluGly: 4.325 ± 0.06	1.215GluHis: 1.215 ± 0.035	3.867GluIle: 3.867 ± 0.062	2.728GluLys: 2.728 ± 0.053	5.25GluLeu: 5.25 ± 0.06	1.769GluMet: 1.769 ± 0.034	1.697GluAsn: 1.697 ± 0.031	2.969GluPro: 2.969 ± 0.056	1.686GluGln: 1.686 ± 0.033	5.277GluArg: 5.277 ± 0.071	2.357GluSer: 2.357 ± 0.035	4.191GluThr: 4.191 ± 0.052	4.233GluVal: 4.233 ± 0.062	0.636GluTrp: 0.636 ± 0.021	0.957GluTyr: 0.957 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.749PheAla: 4.749 ± 0.071	0.444PheCys: 0.444 ± 0.02	2.849PheAsp: 2.849 ± 0.046	2.318PheGlu: 2.318 ± 0.046	1.573PhePhe: 1.573 ± 0.038	3.759PheGly: 3.759 ± 0.05	0.798PheHis: 0.798 ± 0.024	1.65PheIle: 1.65 ± 0.035	1.068PheLys: 1.068 ± 0.028	3.849PheLeu: 3.849 ± 0.058	0.745PheMet: 0.745 ± 0.021	1.048PheAsn: 1.048 ± 0.029	1.535PhePro: 1.535 ± 0.033	1.005PheGln: 1.005 ± 0.024	2.37PheArg: 2.37 ± 0.041	2.487PheSer: 2.487 ± 0.039	1.867PheThr: 1.867 ± 0.036	3.012PheVal: 3.012 ± 0.054	0.587PheTrp: 0.587 ± 0.022	0.901PheTyr: 0.901 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.562GlyAla: 9.562 ± 0.103	0.881GlyCys: 0.881 ± 0.024	4.886GlyAsp: 4.886 ± 0.067	5.039GlyGlu: 5.039 ± 0.063	3.72GlyPhe: 3.72 ± 0.051	7.412GlyGly: 7.412 ± 0.11	1.899GlyHis: 1.899 ± 0.036	4.968GlyIle: 4.968 ± 0.065	3.212GlyLys: 3.212 ± 0.046	8.722GlyLeu: 8.722 ± 0.099	2.268GlyMet: 2.268 ± 0.041	2.227GlyAsn: 2.227 ± 0.05	3.694GlyPro: 3.694 ± 0.049	2.259GlyGln: 2.259 ± 0.044	6.331GlyArg: 6.331 ± 0.067	4.429GlySer: 4.429 ± 0.062	4.993GlyThr: 4.993 ± 0.057	6.175GlyVal: 6.175 ± 0.072	1.29GlyTrp: 1.29 ± 0.032	2.334GlyTyr: 2.334 ± 0.041	0.001GlyXaa: 0.001 ± 0.001
His	2.124HisAla: 2.124 ± 0.044	0.249HisCys: 0.249 ± 0.012	1.243HisAsp: 1.243 ± 0.032	1.084HisGlu: 1.084 ± 0.031	0.838HisPhe: 0.838 ± 0.024	1.911HisGly: 1.911 ± 0.04	0.575HisHis: 0.575 ± 0.02	1.007HisIle: 1.007 ± 0.029	0.526HisLys: 0.526 ± 0.02	2.078HisLeu: 2.078 ± 0.041	0.511HisMet: 0.511 ± 0.018	0.445HisAsn: 0.445 ± 0.018	1.315HisPro: 1.315 ± 0.031	0.514HisGln: 0.514 ± 0.019	1.522HisArg: 1.522 ± 0.031	0.892HisSer: 0.892 ± 0.028	0.82HisThr: 0.82 ± 0.024	1.503HisVal: 1.503 ± 0.035	0.325HisTrp: 0.325 ± 0.014	0.567HisTyr: 0.567 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.917IleAla: 7.917 ± 0.079	0.53IleCys: 0.53 ± 0.02	3.887IleAsp: 3.887 ± 0.048	3.553IleGlu: 3.553 ± 0.051	1.815IlePhe: 1.815 ± 0.037	5.259IleGly: 5.259 ± 0.066	0.973IleHis: 0.973 ± 0.027	2.179IleIle: 2.179 ± 0.049	1.401IleLys: 1.401 ± 0.03	4.594IleLeu: 4.594 ± 0.067	0.894IleMet: 0.894 ± 0.027	1.325IleAsn: 1.325 ± 0.033	2.3IlePro: 2.3 ± 0.036	1.058IleGln: 1.058 ± 0.03	3.316IleArg: 3.316 ± 0.044	2.937IleSer: 2.937 ± 0.052	2.565IleThr: 2.565 ± 0.046	4.719IleVal: 4.719 ± 0.068	0.609IleTrp: 0.609 ± 0.021	1.169IleTyr: 1.169 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.424LysAla: 4.424 ± 0.062	0.189LysCys: 0.189 ± 0.01	1.901LysAsp: 1.901 ± 0.037	1.896LysGlu: 1.896 ± 0.041	0.896LysPhe: 0.896 ± 0.025	2.717LysGly: 2.717 ± 0.048	0.591LysHis: 0.591 ± 0.023	1.718LysIle: 1.718 ± 0.038	1.564LysLys: 1.564 ± 0.034	3.21LysLeu: 3.21 ± 0.056	0.826LysMet: 0.826 ± 0.022	0.918LysAsn: 0.918 ± 0.026	1.985LysPro: 1.985 ± 0.034	0.822LysGln: 0.822 ± 0.023	2.544LysArg: 2.544 ± 0.044	1.766LysSer: 1.766 ± 0.039	2.196LysThr: 2.196 ± 0.044	2.65LysVal: 2.65 ± 0.044	0.372LysTrp: 0.372 ± 0.016	0.634LysTyr: 0.634 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.146LeuAla: 13.146 ± 0.14	0.879LeuCys: 0.879 ± 0.028	6.186LeuAsp: 6.186 ± 0.07	5.422LeuGlu: 5.422 ± 0.054	3.922LeuPhe: 3.922 ± 0.052	8.182LeuGly: 8.182 ± 0.085	1.727LeuHis: 1.727 ± 0.04	5.179LeuIle: 5.179 ± 0.068	3.917LeuLys: 3.917 ± 0.047	8.503LeuLeu: 8.503 ± 0.102	2.326LeuMet: 2.326 ± 0.043	2.452LeuAsn: 2.452 ± 0.04	5.09LeuPro: 5.09 ± 0.058	2.36LeuGln: 2.36 ± 0.038	5.99LeuArg: 5.99 ± 0.079	6.319LeuSer: 6.319 ± 0.063	5.604LeuThr: 5.604 ± 0.063	7.501LeuVal: 7.501 ± 0.086	1.066LeuTrp: 1.066 ± 0.031	2.03LeuTyr: 2.03 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.127MetAla: 3.127 ± 0.047	0.169MetCys: 0.169 ± 0.011	1.16MetAsp: 1.16 ± 0.03	1.297MetGlu: 1.297 ± 0.032	0.723MetPhe: 0.723 ± 0.021	1.709MetGly: 1.709 ± 0.037	0.442MetHis: 0.442 ± 0.018	1.343MetIle: 1.343 ± 0.029	0.941MetLys: 0.941 ± 0.027	2.402MetLeu: 2.402 ± 0.044	0.685MetMet: 0.685 ± 0.021	0.666MetAsn: 0.666 ± 0.02	1.525MetPro: 1.525 ± 0.037	0.701MetGln: 0.701 ± 0.021	1.808MetArg: 1.808 ± 0.036	1.568MetSer: 1.568 ± 0.032	1.982MetThr: 1.982 ± 0.038	1.821MetVal: 1.821 ± 0.037	0.232MetTrp: 0.232 ± 0.014	0.293MetTyr: 0.293 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.035AsnAla: 3.035 ± 0.052	0.26AsnCys: 0.26 ± 0.013	1.507AsnAsp: 1.507 ± 0.035	1.327AsnGlu: 1.327 ± 0.032	0.889AsnPhe: 0.889 ± 0.028	2.395AsnGly: 2.395 ± 0.047	0.477AsnHis: 0.477 ± 0.016	1.323AsnIle: 1.323 ± 0.032	0.687AsnLys: 0.687 ± 0.027	2.39AsnLeu: 2.39 ± 0.039	0.597AsnMet: 0.597 ± 0.02	0.651AsnAsn: 0.651 ± 0.022	1.682AsnPro: 1.682 ± 0.033	0.639AsnGln: 0.639 ± 0.025	1.888AsnArg: 1.888 ± 0.039	1.095AsnSer: 1.095 ± 0.029	1.201AsnThr: 1.201 ± 0.03	2.02AsnVal: 2.02 ± 0.037	0.387AsnTrp: 0.387 ± 0.016	0.628AsnTyr: 0.628 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.131ProAla: 6.131 ± 0.095	0.335ProCys: 0.335 ± 0.015	3.875ProAsp: 3.875 ± 0.045	4.098ProGlu: 4.098 ± 0.063	2.1ProPhe: 2.1 ± 0.038	4.48ProGly: 4.48 ± 0.062	1.054ProHis: 1.054 ± 0.024	2.307ProIle: 2.307 ± 0.045	1.769ProLys: 1.769 ± 0.039	4.56ProLeu: 4.56 ± 0.061	1.197ProMet: 1.197 ± 0.03	1.237ProAsn: 1.237 ± 0.031	2.581ProPro: 2.581 ± 0.048	1.459ProGln: 1.459 ± 0.035	2.738ProArg: 2.738 ± 0.049	2.519ProSer: 2.519 ± 0.044	2.458ProThr: 2.458 ± 0.043	4.289ProVal: 4.289 ± 0.061	0.591ProTrp: 0.591 ± 0.021	1.211ProTyr: 1.211 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.022GlnAla: 3.022 ± 0.05	0.19GlnCys: 0.19 ± 0.012	1.236GlnAsp: 1.236 ± 0.028	1.385GlnGlu: 1.385 ± 0.032	0.927GlnPhe: 0.927 ± 0.028	1.719GlnGly: 1.719 ± 0.037	0.544GlnHis: 0.544 ± 0.019	1.594GlnIle: 1.594 ± 0.033	1.058GlnLys: 1.058 ± 0.027	2.325GlnLeu: 2.325 ± 0.045	0.848GlnMet: 0.848 ± 0.024	0.779GlnAsn: 0.779 ± 0.023	1.385GlnPro: 1.385 ± 0.033	0.905GlnGln: 0.905 ± 0.039	2.025GlnArg: 2.025 ± 0.049	1.436GlnSer: 1.436 ± 0.033	1.513GlnThr: 1.513 ± 0.032	1.848GlnVal: 1.848 ± 0.035	0.301GlnTrp: 0.301 ± 0.016	0.502GlnTyr: 0.502 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.59ArgAla: 7.59 ± 0.082	0.575ArgCys: 0.575 ± 0.021	4.31ArgAsp: 4.31 ± 0.057	4.256ArgGlu: 4.256 ± 0.056	3.04ArgPhe: 3.04 ± 0.05	4.801ArgGly: 4.801 ± 0.063	1.746ArgHis: 1.746 ± 0.038	4.278ArgIle: 4.278 ± 0.05	2.414ArgLys: 2.414 ± 0.046	7.937ArgLeu: 7.937 ± 0.098	1.818ArgMet: 1.818 ± 0.034	1.849ArgAsn: 1.849 ± 0.039	3.62ArgPro: 3.62 ± 0.053	2.428ArgGln: 2.428 ± 0.048	6.069ArgArg: 6.069 ± 0.088	3.527ArgSer: 3.527 ± 0.053	3.507ArgThr: 3.507 ± 0.047	4.548ArgVal: 4.548 ± 0.059	0.914ArgTrp: 0.914 ± 0.025	1.71ArgTyr: 1.71 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.806SerAla: 5.806 ± 0.075	0.452SerCys: 0.452 ± 0.018	3.143SerAsp: 3.143 ± 0.054	2.994SerGlu: 2.994 ± 0.048	2.192SerPhe: 2.192 ± 0.036	5.485SerGly: 5.485 ± 0.062	1.042SerHis: 1.042 ± 0.029	2.633SerIle: 2.633 ± 0.044	1.504SerLys: 1.504 ± 0.034	5.102SerLeu: 5.102 ± 0.064	1.277SerMet: 1.277 ± 0.033	1.319SerAsn: 1.319 ± 0.035	2.585SerPro: 2.585 ± 0.041	1.312SerGln: 1.312 ± 0.034	3.549SerArg: 3.549 ± 0.045	2.722SerSer: 2.722 ± 0.047	2.391SerThr: 2.391 ± 0.04	3.851SerVal: 3.851 ± 0.052	0.683SerTrp: 0.683 ± 0.021	1.235SerTyr: 1.235 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.481ThrAla: 6.481 ± 0.074	0.462ThrCys: 0.462 ± 0.019	3.132ThrAsp: 3.132 ± 0.049	3.071ThrGlu: 3.071 ± 0.048	2.08ThrPhe: 2.08 ± 0.032	5.307ThrGly: 5.307 ± 0.066	0.988ThrHis: 0.988 ± 0.027	2.886ThrIle: 2.886 ± 0.044	1.505ThrLys: 1.505 ± 0.038	5.585ThrLeu: 5.585 ± 0.068	1.213ThrMet: 1.213 ± 0.03	1.235ThrAsn: 1.235 ± 0.03	3.219ThrPro: 3.219 ± 0.052	1.13ThrGln: 1.13 ± 0.026	3.354ThrArg: 3.354 ± 0.049	2.67ThrSer: 2.67 ± 0.049	2.811ThrThr: 2.811 ± 0.047	4.902ThrVal: 4.902 ± 0.069	0.654ThrTrp: 0.654 ± 0.022	1.231ThrTyr: 1.231 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.802ValAla: 9.802 ± 0.091	0.661ValCys: 0.661 ± 0.022	4.576ValAsp: 4.576 ± 0.06	4.692ValGlu: 4.692 ± 0.058	3.164ValPhe: 3.164 ± 0.052	5.816ValGly: 5.816 ± 0.059	1.435ValHis: 1.435 ± 0.029	4.099ValIle: 4.099 ± 0.058	2.301ValLys: 2.301 ± 0.047	7.677ValLeu: 7.677 ± 0.08	1.909ValMet: 1.909 ± 0.034	1.841ValAsn: 1.841 ± 0.039	3.971ValPro: 3.971 ± 0.054	1.647ValGln: 1.647 ± 0.038	4.943ValArg: 4.943 ± 0.057	4.307ValSer: 4.307 ± 0.055	4.598ValThr: 4.598 ± 0.065	6.566ValVal: 6.566 ± 0.081	0.888ValTrp: 0.888 ± 0.026	1.598ValTyr: 1.598 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.174TrpAla: 1.174 ± 0.027	0.138TrpCys: 0.138 ± 0.01	0.643TrpAsp: 0.643 ± 0.023	0.564TrpGlu: 0.564 ± 0.019	0.512TrpPhe: 0.512 ± 0.02	0.871TrpGly: 0.871 ± 0.025	0.313TrpHis: 0.313 ± 0.014	0.661TrpIle: 0.661 ± 0.02	0.454TrpLys: 0.454 ± 0.016	1.474TrpLeu: 1.474 ± 0.029	0.346TrpMet: 0.346 ± 0.018	0.394TrpAsn: 0.394 ± 0.017	0.665TrpPro: 0.665 ± 0.023	0.563TrpGln: 0.563 ± 0.022	1.119TrpArg: 1.119 ± 0.025	0.754TrpSer: 0.754 ± 0.027	0.7TrpThr: 0.7 ± 0.022	0.784TrpVal: 0.784 ± 0.026	0.219TrpTrp: 0.219 ± 0.01	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.039	0.249TyrCys: 0.249 ± 0.013	1.452TyrAsp: 1.452 ± 0.032	1.277TyrGlu: 1.277 ± 0.029	0.932TyrPhe: 0.932 ± 0.023	2.175TyrGly: 2.175 ± 0.037	0.498TyrHis: 0.498 ± 0.02	0.907TyrIle: 0.907 ± 0.027	0.657TyrLys: 0.657 ± 0.024	2.321TyrLeu: 2.321 ± 0.043	0.456TyrMet: 0.456 ± 0.017	0.601TyrAsn: 0.601 ± 0.024	1.071TyrPro: 1.071 ± 0.026	0.656TyrGln: 0.656 ± 0.021	1.84TyrArg: 1.84 ± 0.037	1.112TyrSer: 1.112 ± 0.03	1.053TyrThr: 1.053 ± 0.027	1.648TyrVal: 1.648 ± 0.033	0.381TyrTrp: 0.381 ± 0.016	0.625TyrTyr: 0.625 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4696 proteins (1496865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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