Amino acid dipepetide frequency for Comamonas kerstersii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.257AlaAla: 16.257 ± 0.211
1.322AlaCys: 1.322 ± 0.05
5.687AlaAsp: 5.687 ± 0.089
6.521AlaGlu: 6.521 ± 0.109
3.761AlaPhe: 3.761 ± 0.071
8.948AlaGly: 8.948 ± 0.112
2.759AlaHis: 2.759 ± 0.064
5.407AlaIle: 5.407 ± 0.083
4.545AlaLys: 4.545 ± 0.098
14.174AlaLeu: 14.174 ± 0.178
3.875AlaMet: 3.875 ± 0.067
2.901AlaAsn: 2.901 ± 0.069
5.318AlaPro: 5.318 ± 0.105
7.636AlaGln: 7.636 ± 0.137
6.898AlaArg: 6.898 ± 0.097
6.428AlaSer: 6.428 ± 0.09
5.515AlaThr: 5.515 ± 0.086
8.57AlaVal: 8.57 ± 0.119
1.954AlaTrp: 1.954 ± 0.048
2.557AlaTyr: 2.557 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.158CysAla: 1.158 ± 0.038
0.127CysCys: 0.127 ± 0.013
0.524CysAsp: 0.524 ± 0.025
0.518CysGlu: 0.518 ± 0.026
0.32CysPhe: 0.32 ± 0.017
0.95CysGly: 0.95 ± 0.037
0.313CysHis: 0.313 ± 0.023
0.541CysIle: 0.541 ± 0.029
0.298CysLys: 0.298 ± 0.019
0.886CysLeu: 0.886 ± 0.034
0.339CysMet: 0.339 ± 0.018
0.292CysAsn: 0.292 ± 0.018
0.51CysPro: 0.51 ± 0.026
0.376CysGln: 0.376 ± 0.023
0.458CysArg: 0.458 ± 0.027
0.566CysSer: 0.566 ± 0.03
0.558CysThr: 0.558 ± 0.029
0.757CysVal: 0.757 ± 0.033
0.139CysTrp: 0.139 ± 0.015
0.219CysTyr: 0.219 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
6.451AspAla: 6.451 ± 0.096
0.445AspCys: 0.445 ± 0.027
2.24AspAsp: 2.24 ± 0.059
2.86AspGlu: 2.86 ± 0.061
1.999AspPhe: 1.999 ± 0.048
4.089AspGly: 4.089 ± 0.075
1.037AspHis: 1.037 ± 0.038
2.754AspIle: 2.754 ± 0.055
2.026AspLys: 2.026 ± 0.055
4.907AspLeu: 4.907 ± 0.081
1.517AspMet: 1.517 ± 0.035
1.267AspAsn: 1.267 ± 0.034
2.397AspPro: 2.397 ± 0.056
1.694AspGln: 1.694 ± 0.053
2.567AspArg: 2.567 ± 0.063
2.321AspSer: 2.321 ± 0.053
2.504AspThr: 2.504 ± 0.057
4.075AspVal: 4.075 ± 0.081
0.959AspTrp: 0.959 ± 0.032
1.353AspTyr: 1.353 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.96GluAla: 6.96 ± 0.119
0.406GluCys: 0.406 ± 0.022
2.538GluAsp: 2.538 ± 0.058
2.895GluGlu: 2.895 ± 0.07
1.745GluPhe: 1.745 ± 0.051
3.797GluGly: 3.797 ± 0.075
1.536GluHis: 1.536 ± 0.046
2.815GluIle: 2.815 ± 0.07
2.312GluLys: 2.312 ± 0.061
5.808GluLeu: 5.808 ± 0.086
1.394GluMet: 1.394 ± 0.04
1.491GluAsn: 1.491 ± 0.046
2.252GluPro: 2.252 ± 0.055
3.631GluGln: 3.631 ± 0.079
4.25GluArg: 4.25 ± 0.079
2.403GluSer: 2.403 ± 0.056
2.426GluThr: 2.426 ± 0.054
4.323GluVal: 4.323 ± 0.08
0.747GluTrp: 0.747 ± 0.026
1.111GluTyr: 1.111 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.117PheAla: 4.117 ± 0.077
0.377PheCys: 0.377 ± 0.021
2.21PheAsp: 2.21 ± 0.056
2.013PheGlu: 2.013 ± 0.047
1.333PhePhe: 1.333 ± 0.05
3.271PheGly: 3.271 ± 0.072
0.716PheHis: 0.716 ± 0.029
1.618PheIle: 1.618 ± 0.051
1.305PheLys: 1.305 ± 0.039
2.911PheLeu: 2.911 ± 0.063
0.915PheMet: 0.915 ± 0.036
1.158PheAsn: 1.158 ± 0.034
1.393PhePro: 1.393 ± 0.045
1.221PheGln: 1.221 ± 0.035
1.597PheArg: 1.597 ± 0.047
2.076PheSer: 2.076 ± 0.045
1.815PheThr: 1.815 ± 0.053
2.769PheVal: 2.769 ± 0.057
0.51PheTrp: 0.51 ± 0.024
0.838PheTyr: 0.838 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
7.668GlyAla: 7.668 ± 0.103
0.959GlyCys: 0.959 ± 0.034
3.519GlyAsp: 3.519 ± 0.086
4.059GlyGlu: 4.059 ± 0.08
3.078GlyPhe: 3.078 ± 0.067
5.984GlyGly: 5.984 ± 0.125
1.924GlyHis: 1.924 ± 0.054
4.042GlyIle: 4.042 ± 0.074
3.888GlyLys: 3.888 ± 0.079
8.228GlyLeu: 8.228 ± 0.106
2.654GlyMet: 2.654 ± 0.059
2.318GlyAsn: 2.318 ± 0.063
2.525GlyPro: 2.525 ± 0.062
3.743GlyGln: 3.743 ± 0.071
4.221GlyArg: 4.221 ± 0.062
4.389GlySer: 4.389 ± 0.075
4.105GlyThr: 4.105 ± 0.082
6.474GlyVal: 6.474 ± 0.103
1.428GlyTrp: 1.428 ± 0.041
2.191GlyTyr: 2.191 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.984HisAla: 2.984 ± 0.064
0.321HisCys: 0.321 ± 0.021
1.19HisAsp: 1.19 ± 0.033
1.224HisGlu: 1.224 ± 0.04
0.902HisPhe: 0.902 ± 0.029
2.029HisGly: 2.029 ± 0.052
0.639HisHis: 0.639 ± 0.027
1.277HisIle: 1.277 ± 0.037
0.737HisLys: 0.737 ± 0.027
2.286HisLeu: 2.286 ± 0.049
0.695HisMet: 0.695 ± 0.028
0.649HisAsn: 0.649 ± 0.027
1.472HisPro: 1.472 ± 0.049
1.003HisGln: 1.003 ± 0.035
1.291HisArg: 1.291 ± 0.04
1.344HisSer: 1.344 ± 0.043
1.315HisThr: 1.315 ± 0.04
1.714HisVal: 1.714 ± 0.046
0.452HisTrp: 0.452 ± 0.022
0.684HisTyr: 0.684 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.385IleAla: 6.385 ± 0.09
0.469IleCys: 0.469 ± 0.026
2.831IleAsp: 2.831 ± 0.063
3.065IleGlu: 3.065 ± 0.068
1.557IlePhe: 1.557 ± 0.048
3.995IleGly: 3.995 ± 0.074
1.031IleHis: 1.031 ± 0.035
1.921IleIle: 1.921 ± 0.057
1.82IleLys: 1.82 ± 0.047
3.637IleLeu: 3.637 ± 0.075
1.027IleMet: 1.027 ± 0.039
1.642IleAsn: 1.642 ± 0.045
2.286IlePro: 2.286 ± 0.058
1.702IleGln: 1.702 ± 0.043
2.576IleArg: 2.576 ± 0.059
2.665IleSer: 2.665 ± 0.065
2.813IleThr: 2.813 ± 0.057
3.47IleVal: 3.47 ± 0.08
0.614IleTrp: 0.614 ± 0.028
1.192IleTyr: 1.192 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.851LysAla: 4.851 ± 0.086
0.203LysCys: 0.203 ± 0.015
2.089LysAsp: 2.089 ± 0.062
2.104LysGlu: 2.104 ± 0.051
1.087LysPhe: 1.087 ± 0.044
2.786LysGly: 2.786 ± 0.073
0.894LysHis: 0.894 ± 0.031
1.749LysIle: 1.749 ± 0.048
1.812LysLys: 1.812 ± 0.062
4.191LysLeu: 4.191 ± 0.073
0.984LysMet: 0.984 ± 0.032
1.225LysAsn: 1.225 ± 0.042
2.287LysPro: 2.287 ± 0.06
1.821LysGln: 1.821 ± 0.048
2.253LysArg: 2.253 ± 0.056
2.034LysSer: 2.034 ± 0.05
2.175LysThr: 2.175 ± 0.051
2.969LysVal: 2.969 ± 0.069
0.384LysTrp: 0.384 ± 0.019
0.785LysTyr: 0.785 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
12.759LeuAla: 12.759 ± 0.141
1.207LeuCys: 1.207 ± 0.039
5.401LeuAsp: 5.401 ± 0.084
5.479LeuGlu: 5.479 ± 0.091
3.267LeuPhe: 3.267 ± 0.081
8.155LeuGly: 8.155 ± 0.113
2.718LeuHis: 2.718 ± 0.055
4.583LeuIle: 4.583 ± 0.079
3.923LeuLys: 3.923 ± 0.083
11.479LeuLeu: 11.479 ± 0.171
2.846LeuMet: 2.846 ± 0.065
3.04LeuAsn: 3.04 ± 0.058
6.072LeuPro: 6.072 ± 0.102
6.345LeuGln: 6.345 ± 0.133
6.933LeuArg: 6.933 ± 0.097
6.204LeuSer: 6.204 ± 0.084
5.243LeuThr: 5.243 ± 0.084
7.285LeuVal: 7.285 ± 0.11
1.369LeuTrp: 1.369 ± 0.045
2.093LeuTyr: 2.093 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
3.462MetAla: 3.462 ± 0.061
0.228MetCys: 0.228 ± 0.016
1.382MetAsp: 1.382 ± 0.035
1.459MetGlu: 1.459 ± 0.04
0.799MetPhe: 0.799 ± 0.037
2.312MetGly: 2.312 ± 0.061
0.717MetHis: 0.717 ± 0.03
1.017MetIle: 1.017 ± 0.034
1.059MetLys: 1.059 ± 0.037
3.197MetLeu: 3.197 ± 0.072
0.654MetMet: 0.654 ± 0.03
0.89MetAsn: 0.89 ± 0.033
1.659MetPro: 1.659 ± 0.048
1.744MetGln: 1.744 ± 0.043
1.754MetArg: 1.754 ± 0.05
1.776MetSer: 1.776 ± 0.05
1.61MetThr: 1.61 ± 0.05
2.026MetVal: 2.026 ± 0.051
0.258MetTrp: 0.258 ± 0.018
0.485MetTyr: 0.485 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.48AsnAla: 3.48 ± 0.071
0.269AsnCys: 0.269 ± 0.019
1.451AsnAsp: 1.451 ± 0.05
1.348AsnGlu: 1.348 ± 0.047
1.029AsnPhe: 1.029 ± 0.034
2.35AsnGly: 2.35 ± 0.062
0.572AsnHis: 0.572 ± 0.027
1.463AsnIle: 1.463 ± 0.044
1.12AsnLys: 1.12 ± 0.04
2.74AsnLeu: 2.74 ± 0.057
0.765AsnMet: 0.765 ± 0.029
0.894AsnAsn: 0.894 ± 0.043
1.977AsnPro: 1.977 ± 0.051
1.157AsnGln: 1.157 ± 0.039
1.515AsnArg: 1.515 ± 0.046
1.365AsnSer: 1.365 ± 0.045
1.712AsnThr: 1.712 ± 0.047
2.065AsnVal: 2.065 ± 0.055
0.482AsnTrp: 0.482 ± 0.025
0.781AsnTyr: 0.781 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
6.338ProAla: 6.338 ± 0.12
0.364ProCys: 0.364 ± 0.02
2.731ProAsp: 2.731 ± 0.059
3.656ProGlu: 3.656 ± 0.067
1.657ProPhe: 1.657 ± 0.045
3.741ProGly: 3.741 ± 0.08
1.197ProHis: 1.197 ± 0.038
1.922ProIle: 1.922 ± 0.048
1.726ProLys: 1.726 ± 0.049
4.921ProLeu: 4.921 ± 0.073
1.371ProMet: 1.371 ± 0.043
1.271ProAsn: 1.271 ± 0.044
1.869ProPro: 1.869 ± 0.058
2.629ProGln: 2.629 ± 0.059
2.286ProArg: 2.286 ± 0.063
2.769ProSer: 2.769 ± 0.058
2.306ProThr: 2.306 ± 0.052
4.09ProVal: 4.09 ± 0.07
0.783ProTrp: 0.783 ± 0.03
1.151ProTyr: 1.151 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
7.386GlnAla: 7.386 ± 0.143
0.41GlnCys: 0.41 ± 0.024
2.146GlnAsp: 2.146 ± 0.059
2.573GlnGlu: 2.573 ± 0.063
1.445GlnPhe: 1.445 ± 0.046
3.843GlnGly: 3.843 ± 0.069
1.471GlnHis: 1.471 ± 0.043
2.141GlnIle: 2.141 ± 0.054
1.595GlnLys: 1.595 ± 0.044
5.87GlnLeu: 5.87 ± 0.111
1.331GlnMet: 1.331 ± 0.039
1.185GlnAsn: 1.185 ± 0.035
2.86GlnPro: 2.86 ± 0.065
3.631GlnGln: 3.631 ± 0.111
3.93GlnArg: 3.93 ± 0.071
2.662GlnSer: 2.662 ± 0.055
2.377GlnThr: 2.377 ± 0.059
3.668GlnVal: 3.668 ± 0.077
1.029GlnTrp: 1.029 ± 0.032
0.966GlnTyr: 0.966 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.059ArgAla: 6.059 ± 0.09
0.563ArgCys: 0.563 ± 0.029
2.949ArgAsp: 2.949 ± 0.062
3.629ArgGlu: 3.629 ± 0.072
2.353ArgPhe: 2.353 ± 0.057
3.665ArgGly: 3.665 ± 0.058
1.557ArgHis: 1.557 ± 0.045
3.27ArgIle: 3.27 ± 0.062
2.416ArgLys: 2.416 ± 0.061
6.338ArgLeu: 6.338 ± 0.106
2.067ArgMet: 2.067 ± 0.048
2.012ArgAsn: 2.012 ± 0.052
2.412ArgPro: 2.412 ± 0.054
2.975ArgGln: 2.975 ± 0.067
3.632ArgArg: 3.632 ± 0.075
3.347ArgSer: 3.347 ± 0.06
2.895ArgThr: 2.895 ± 0.052
4.099ArgVal: 4.099 ± 0.082
1.107ArgTrp: 1.107 ± 0.04
1.731ArgTyr: 1.731 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
6.196SerAla: 6.196 ± 0.095
0.502SerCys: 0.502 ± 0.027
2.523SerAsp: 2.523 ± 0.058
2.591SerGlu: 2.591 ± 0.06
2.189SerPhe: 2.189 ± 0.047
4.496SerGly: 4.496 ± 0.077
1.31SerHis: 1.31 ± 0.035
2.675SerIle: 2.675 ± 0.058
2.236SerLys: 2.236 ± 0.047
5.62SerLeu: 5.62 ± 0.089
1.686SerMet: 1.686 ± 0.044
1.652SerAsn: 1.652 ± 0.042
2.563SerPro: 2.563 ± 0.052
2.404SerGln: 2.404 ± 0.058
3.022SerArg: 3.022 ± 0.06
3.459SerSer: 3.459 ± 0.084
3.271SerThr: 3.271 ± 0.069
4.014SerVal: 4.014 ± 0.075
0.835SerTrp: 0.835 ± 0.029
1.378SerTyr: 1.378 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
6.001ThrAla: 6.001 ± 0.093
0.452ThrCys: 0.452 ± 0.022
2.428ThrAsp: 2.428 ± 0.055
2.628ThrGlu: 2.628 ± 0.053
1.589ThrPhe: 1.589 ± 0.046
4.496ThrGly: 4.496 ± 0.077
1.185ThrHis: 1.185 ± 0.036
2.297ThrIle: 2.297 ± 0.05
1.591ThrLys: 1.591 ± 0.049
5.821ThrLeu: 5.821 ± 0.105
1.221ThrMet: 1.221 ± 0.036
1.324ThrAsn: 1.324 ± 0.041
3.38ThrPro: 3.38 ± 0.068
2.528ThrGln: 2.528 ± 0.056
2.719ThrArg: 2.719 ± 0.061
2.794ThrSer: 2.794 ± 0.053
2.712ThrThr: 2.712 ± 0.061
4.134ThrVal: 4.134 ± 0.071
0.656ThrTrp: 0.656 ± 0.029
1.115ThrTyr: 1.115 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
8.523ValAla: 8.523 ± 0.105
0.78ValCys: 0.78 ± 0.031
3.758ValAsp: 3.758 ± 0.064
4.222ValGlu: 4.222 ± 0.083
2.581ValPhe: 2.581 ± 0.051
5.368ValGly: 5.368 ± 0.105
1.785ValHis: 1.785 ± 0.05
3.596ValIle: 3.596 ± 0.081
2.807ValLys: 2.807 ± 0.065
8.704ValLeu: 8.704 ± 0.126
2.127ValMet: 2.127 ± 0.059
2.154ValAsn: 2.154 ± 0.046
3.749ValPro: 3.749 ± 0.076
4.148ValGln: 4.148 ± 0.086
4.621ValArg: 4.621 ± 0.076
3.933ValSer: 3.933 ± 0.077
3.77ValThr: 3.77 ± 0.066
6.265ValVal: 6.265 ± 0.111
1.081ValTrp: 1.081 ± 0.039
1.585ValTyr: 1.585 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.381TrpAla: 1.381 ± 0.043
0.195TrpCys: 0.195 ± 0.016
0.625TrpAsp: 0.625 ± 0.027
0.643TrpGlu: 0.643 ± 0.029
0.559TrpPhe: 0.559 ± 0.023
1.087TrpGly: 1.087 ± 0.035
0.384TrpHis: 0.384 ± 0.022
0.648TrpIle: 0.648 ± 0.028
0.612TrpLys: 0.612 ± 0.028
2.322TrpLeu: 2.322 ± 0.063
0.482TrpMet: 0.482 ± 0.025
0.482TrpAsn: 0.482 ± 0.025
0.687TrpPro: 0.687 ± 0.033
1.111TrpGln: 1.111 ± 0.046
1.113TrpArg: 1.113 ± 0.038
0.8TrpSer: 0.8 ± 0.031
0.67TrpThr: 0.67 ± 0.03
1.12TrpVal: 1.12 ± 0.035
0.32TrpTrp: 0.32 ± 0.023
0.277TrpTyr: 0.277 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.615TyrAla: 2.615 ± 0.065
0.251TyrCys: 0.251 ± 0.017
1.238TyrAsp: 1.238 ± 0.038
1.354TyrGlu: 1.354 ± 0.042
0.915TyrPhe: 0.915 ± 0.038
2.033TyrGly: 2.033 ± 0.058
0.462TyrHis: 0.462 ± 0.024
0.964TyrIle: 0.964 ± 0.033
0.858TyrLys: 0.858 ± 0.033
2.362TyrLeu: 2.362 ± 0.056
0.535TyrMet: 0.535 ± 0.026
0.689TyrAsn: 0.689 ± 0.029
1.109TyrPro: 1.109 ± 0.035
1.019TyrGln: 1.019 ± 0.037
1.443TyrArg: 1.443 ± 0.041
1.285TyrSer: 1.285 ± 0.047
1.278TyrThr: 1.278 ± 0.037
1.672TyrVal: 1.672 ± 0.041
0.41TyrTrp: 0.41 ± 0.021
0.608TyrTyr: 0.608 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2662 proteins (856518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski