Amino acid dipepetide frequency for Gleimia coleocanis DSM 15436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.575AlaAla: 11.575 ± 0.207
0.949AlaCys: 0.949 ± 0.049
6.464AlaAsp: 6.464 ± 0.106
8.004AlaGlu: 8.004 ± 0.161
3.62AlaPhe: 3.62 ± 0.096
9.115AlaGly: 9.115 ± 0.157
2.094AlaHis: 2.094 ± 0.065
5.039AlaIle: 5.039 ± 0.129
4.846AlaLys: 4.846 ± 0.108
11.459AlaLeu: 11.459 ± 0.185
2.419AlaMet: 2.419 ± 0.076
3.285AlaAsn: 3.285 ± 0.08
4.26AlaPro: 4.26 ± 0.118
4.523AlaGln: 4.523 ± 0.097
5.312AlaArg: 5.312 ± 0.115
5.772AlaSer: 5.772 ± 0.111
6.733AlaThr: 6.733 ± 0.122
8.709AlaVal: 8.709 ± 0.141
1.477AlaTrp: 1.477 ± 0.056
2.4AlaTyr: 2.4 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.802CysAla: 0.802 ± 0.039
0.083CysCys: 0.083 ± 0.014
0.449CysAsp: 0.449 ± 0.032
0.501CysGlu: 0.501 ± 0.036
0.323CysPhe: 0.323 ± 0.027
0.847CysGly: 0.847 ± 0.042
0.159CysHis: 0.159 ± 0.017
0.275CysIle: 0.275 ± 0.025
0.226CysLys: 0.226 ± 0.02
0.661CysLeu: 0.661 ± 0.037
0.12CysMet: 0.12 ± 0.015
0.236CysAsn: 0.236 ± 0.023
0.437CysPro: 0.437 ± 0.03
0.232CysGln: 0.232 ± 0.018
0.348CysArg: 0.348 ± 0.026
0.452CysSer: 0.452 ± 0.032
0.394CysThr: 0.394 ± 0.025
0.574CysVal: 0.574 ± 0.039
0.081CysTrp: 0.081 ± 0.015
0.188CysTyr: 0.188 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.474AspAla: 5.474 ± 0.097
0.41AspCys: 0.41 ± 0.029
2.438AspAsp: 2.438 ± 0.082
3.641AspGlu: 3.641 ± 0.089
2.282AspPhe: 2.282 ± 0.068
4.055AspGly: 4.055 ± 0.087
0.977AspHis: 0.977 ± 0.048
2.68AspIle: 2.68 ± 0.075
1.862AspLys: 1.862 ± 0.064
5.807AspLeu: 5.807 ± 0.117
0.988AspMet: 0.988 ± 0.051
1.404AspAsn: 1.404 ± 0.065
2.989AspPro: 2.989 ± 0.086
1.576AspGln: 1.576 ± 0.062
2.595AspArg: 2.595 ± 0.088
2.829AspSer: 2.829 ± 0.07
2.848AspThr: 2.848 ± 0.076
4.01AspVal: 4.01 ± 0.101
0.816AspTrp: 0.816 ± 0.045
1.589AspTyr: 1.589 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
7.516GluAla: 7.516 ± 0.155
0.423GluCys: 0.423 ± 0.032
3.022GluAsp: 3.022 ± 0.079
4.155GluGlu: 4.155 ± 0.126
2.216GluPhe: 2.216 ± 0.055
4.301GluGly: 4.301 ± 0.104
1.236GluHis: 1.236 ± 0.056
4.368GluIle: 4.368 ± 0.089
3.374GluLys: 3.374 ± 0.082
7.081GluLeu: 7.081 ± 0.148
1.466GluMet: 1.466 ± 0.055
2.93GluAsn: 2.93 ± 0.076
2.487GluPro: 2.487 ± 0.088
2.086GluGln: 2.086 ± 0.069
3.461GluArg: 3.461 ± 0.101
3.227GluSer: 3.227 ± 0.075
4.422GluThr: 4.422 ± 0.097
5.604GluVal: 5.604 ± 0.123
0.799GluTrp: 0.799 ± 0.044
1.688GluTyr: 1.688 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.985PheAla: 3.985 ± 0.097
0.271PheCys: 0.271 ± 0.026
2.117PheAsp: 2.117 ± 0.066
2.199PheGlu: 2.199 ± 0.062
1.477PhePhe: 1.477 ± 0.06
3.171PheGly: 3.171 ± 0.094
0.648PheHis: 0.648 ± 0.032
1.961PheIle: 1.961 ± 0.061
1.535PheLys: 1.535 ± 0.056
3.514PheLeu: 3.514 ± 0.11
0.756PheMet: 0.756 ± 0.038
1.464PheAsn: 1.464 ± 0.052
1.777PhePro: 1.777 ± 0.055
1.098PheGln: 1.098 ± 0.046
1.624PheArg: 1.624 ± 0.044
2.578PheSer: 2.578 ± 0.077
2.686PheThr: 2.686 ± 0.08
2.814PheVal: 2.814 ± 0.078
0.497PheTrp: 0.497 ± 0.034
0.955PheTyr: 0.955 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
7.493GlyAla: 7.493 ± 0.131
0.636GlyCys: 0.636 ± 0.035
3.637GlyAsp: 3.637 ± 0.107
4.883GlyGlu: 4.883 ± 0.117
3.386GlyPhe: 3.386 ± 0.084
5.584GlyGly: 5.584 ± 0.143
1.522GlyHis: 1.522 ± 0.067
4.927GlyIle: 4.927 ± 0.111
4.239GlyLys: 4.239 ± 0.103
7.69GlyLeu: 7.69 ± 0.129
2.075GlyMet: 2.075 ± 0.067
2.552GlyAsn: 2.552 ± 0.077
2.585GlyPro: 2.585 ± 0.072
2.626GlyGln: 2.626 ± 0.072
4.022GlyArg: 4.022 ± 0.099
4.347GlySer: 4.347 ± 0.091
4.826GlyThr: 4.826 ± 0.11
6.72GlyVal: 6.72 ± 0.134
1.276GlyTrp: 1.276 ± 0.053
2.226GlyTyr: 2.226 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
2.081HisAla: 2.081 ± 0.065
0.155HisCys: 0.155 ± 0.018
1.05HisAsp: 1.05 ± 0.053
1.087HisGlu: 1.087 ± 0.047
0.741HisPhe: 0.741 ± 0.034
1.595HisGly: 1.595 ± 0.054
0.536HisHis: 0.536 ± 0.034
0.911HisIle: 0.911 ± 0.04
0.607HisLys: 0.607 ± 0.033
2.11HisLeu: 2.11 ± 0.068
0.427HisMet: 0.427 ± 0.029
0.619HisAsn: 0.619 ± 0.039
1.265HisPro: 1.265 ± 0.055
0.708HisGln: 0.708 ± 0.035
1.154HisArg: 1.154 ± 0.051
1.129HisSer: 1.129 ± 0.046
1.168HisThr: 1.168 ± 0.043
1.441HisVal: 1.441 ± 0.061
0.292HisTrp: 0.292 ± 0.023
0.576HisTyr: 0.576 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.82IleAla: 5.82 ± 0.108
0.443IleCys: 0.443 ± 0.029
3.026IleAsp: 3.026 ± 0.077
3.374IleGlu: 3.374 ± 0.084
2.013IlePhe: 2.013 ± 0.076
4.252IleGly: 4.252 ± 0.096
0.942IleHis: 0.942 ± 0.041
2.955IleIle: 2.955 ± 0.102
1.92IleLys: 1.92 ± 0.062
5.113IleLeu: 5.113 ± 0.125
1.06IleMet: 1.06 ± 0.053
1.814IleAsn: 1.814 ± 0.06
3.133IlePro: 3.133 ± 0.089
1.487IleGln: 1.487 ± 0.054
2.775IleArg: 2.775 ± 0.088
3.67IleSer: 3.67 ± 0.092
3.492IleThr: 3.492 ± 0.083
4.219IleVal: 4.219 ± 0.097
0.644IleTrp: 0.644 ± 0.034
1.363IleTyr: 1.363 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.399LysAla: 4.399 ± 0.104
0.251LysCys: 0.251 ± 0.018
2.121LysAsp: 2.121 ± 0.072
2.794LysGlu: 2.794 ± 0.078
1.323LysPhe: 1.323 ± 0.048
2.578LysGly: 2.578 ± 0.078
0.903LysHis: 0.903 ± 0.042
2.102LysIle: 2.102 ± 0.068
1.841LysLys: 1.841 ± 0.088
4.374LysLeu: 4.374 ± 0.079
0.955LysMet: 0.955 ± 0.044
1.539LysAsn: 1.539 ± 0.054
2.33LysPro: 2.33 ± 0.078
1.646LysGln: 1.646 ± 0.068
2.522LysArg: 2.522 ± 0.077
2.11LysSer: 2.11 ± 0.059
2.889LysThr: 2.889 ± 0.079
3.514LysVal: 3.514 ± 0.105
0.569LysTrp: 0.569 ± 0.027
1.123LysTyr: 1.123 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
11.627LeuAla: 11.627 ± 0.176
0.659LeuCys: 0.659 ± 0.039
5.48LeuAsp: 5.48 ± 0.122
6.76LeuGlu: 6.76 ± 0.14
3.322LeuPhe: 3.322 ± 0.103
8.311LeuGly: 8.311 ± 0.141
1.936LeuHis: 1.936 ± 0.063
5.236LeuIle: 5.236 ± 0.124
4.005LeuLys: 4.005 ± 0.094
10.069LeuLeu: 10.069 ± 0.193
1.984LeuMet: 1.984 ± 0.064
3.469LeuAsn: 3.469 ± 0.084
5.503LeuPro: 5.503 ± 0.115
3.539LeuGln: 3.539 ± 0.091
5.757LeuArg: 5.757 ± 0.112
6.217LeuSer: 6.217 ± 0.134
6.71LeuThr: 6.71 ± 0.12
8.93LeuVal: 8.93 ± 0.172
1.197LeuTrp: 1.197 ± 0.05
2.059LeuTyr: 2.059 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.148MetAla: 2.148 ± 0.073
0.147MetCys: 0.147 ± 0.016
0.938MetAsp: 0.938 ± 0.04
1.129MetGlu: 1.129 ± 0.048
0.721MetPhe: 0.721 ± 0.04
1.588MetGly: 1.588 ± 0.062
0.451MetHis: 0.451 ± 0.026
1.156MetIle: 1.156 ± 0.055
0.942MetLys: 0.942 ± 0.039
2.179MetLeu: 2.179 ± 0.071
0.47MetMet: 0.47 ± 0.032
0.754MetAsn: 0.754 ± 0.039
1.116MetPro: 1.116 ± 0.045
0.841MetGln: 0.841 ± 0.036
1.464MetArg: 1.464 ± 0.052
1.535MetSer: 1.535 ± 0.06
1.33MetThr: 1.33 ± 0.05
1.738MetVal: 1.738 ± 0.062
0.251MetTrp: 0.251 ± 0.024
0.385MetTyr: 0.385 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.256AsnAla: 3.256 ± 0.098
0.271AsnCys: 0.271 ± 0.023
1.479AsnAsp: 1.479 ± 0.059
1.961AsnGlu: 1.961 ± 0.064
1.197AsnPhe: 1.197 ± 0.054
2.67AsnGly: 2.67 ± 0.089
0.762AsnHis: 0.762 ± 0.037
1.586AsnIle: 1.586 ± 0.057
1.093AsnLys: 1.093 ± 0.049
3.738AsnLeu: 3.738 ± 0.089
0.714AsnMet: 0.714 ± 0.043
1.067AsnAsn: 1.067 ± 0.048
2.527AsnPro: 2.527 ± 0.076
1.404AsnGln: 1.404 ± 0.057
1.818AsnArg: 1.818 ± 0.062
1.783AsnSer: 1.783 ± 0.062
1.947AsnThr: 1.947 ± 0.075
2.347AsnVal: 2.347 ± 0.085
0.592AsnTrp: 0.592 ± 0.034
1.019AsnTyr: 1.019 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
5.857ProAla: 5.857 ± 0.127
0.278ProCys: 0.278 ± 0.027
2.4ProAsp: 2.4 ± 0.066
3.767ProGlu: 3.767 ± 0.081
1.688ProPhe: 1.688 ± 0.066
3.989ProGly: 3.989 ± 0.112
1.0ProHis: 1.0 ± 0.045
2.073ProIle: 2.073 ± 0.063
1.82ProLys: 1.82 ± 0.067
4.631ProLeu: 4.631 ± 0.108
0.845ProMet: 0.845 ± 0.041
1.533ProAsn: 1.533 ± 0.055
1.506ProPro: 1.506 ± 0.076
2.201ProGln: 2.201 ± 0.068
2.26ProArg: 2.26 ± 0.081
2.38ProSer: 2.38 ± 0.066
3.191ProThr: 3.191 ± 0.101
4.693ProVal: 4.693 ± 0.101
0.623ProTrp: 0.623 ± 0.039
1.11ProTyr: 1.11 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.084GlnAla: 4.084 ± 0.094
0.213GlnCys: 0.213 ± 0.02
1.369GlnAsp: 1.369 ± 0.05
1.953GlnGlu: 1.953 ± 0.065
1.137GlnPhe: 1.137 ± 0.051
2.326GlnGly: 2.326 ± 0.071
0.715GlnHis: 0.715 ± 0.039
2.419GlnIle: 2.419 ± 0.062
1.553GlnLys: 1.553 ± 0.053
4.15GlnLeu: 4.15 ± 0.109
0.951GlnMet: 0.951 ± 0.044
1.12GlnAsn: 1.12 ± 0.048
1.789GlnPro: 1.789 ± 0.078
1.731GlnGln: 1.731 ± 0.063
2.39GlnArg: 2.39 ± 0.072
1.626GlnSer: 1.626 ± 0.057
1.99GlnThr: 1.99 ± 0.073
3.45GlnVal: 3.45 ± 0.087
0.625GlnTrp: 0.625 ± 0.04
0.721GlnTyr: 0.721 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
5.262ArgAla: 5.262 ± 0.109
0.414ArgCys: 0.414 ± 0.027
2.638ArgAsp: 2.638 ± 0.08
3.616ArgGlu: 3.616 ± 0.104
2.131ArgPhe: 2.131 ± 0.056
3.653ArgGly: 3.653 ± 0.101
1.079ArgHis: 1.079 ± 0.046
3.156ArgIle: 3.156 ± 0.09
2.369ArgLys: 2.369 ± 0.076
5.395ArgLeu: 5.395 ± 0.103
1.185ArgMet: 1.185 ± 0.058
1.76ArgAsn: 1.76 ± 0.057
2.342ArgPro: 2.342 ± 0.073
1.982ArgGln: 1.982 ± 0.067
3.738ArgArg: 3.738 ± 0.123
2.999ArgSer: 2.999 ± 0.072
2.947ArgThr: 2.947 ± 0.075
4.55ArgVal: 4.55 ± 0.101
0.772ArgTrp: 0.772 ± 0.039
1.46ArgTyr: 1.46 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
6.46SerAla: 6.46 ± 0.112
0.373SerCys: 0.373 ± 0.028
2.651SerAsp: 2.651 ± 0.077
4.07SerGlu: 4.07 ± 0.086
2.444SerPhe: 2.444 ± 0.073
4.956SerGly: 4.956 ± 0.1
1.11SerHis: 1.11 ± 0.049
2.843SerIle: 2.843 ± 0.094
2.226SerLys: 2.226 ± 0.057
6.163SerLeu: 6.163 ± 0.126
1.239SerMet: 1.239 ± 0.051
1.599SerAsn: 1.599 ± 0.059
2.272SerPro: 2.272 ± 0.065
2.193SerGln: 2.193 ± 0.071
2.779SerArg: 2.779 ± 0.071
3.165SerSer: 3.165 ± 0.086
3.454SerThr: 3.454 ± 0.084
4.803SerVal: 4.803 ± 0.1
0.868SerTrp: 0.868 ± 0.043
1.543SerTyr: 1.543 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
6.596ThrAla: 6.596 ± 0.118
0.443ThrCys: 0.443 ± 0.027
3.374ThrAsp: 3.374 ± 0.091
3.864ThrGlu: 3.864 ± 0.092
2.243ThrPhe: 2.243 ± 0.087
5.248ThrGly: 5.248 ± 0.108
1.303ThrHis: 1.303 ± 0.049
3.274ThrIle: 3.274 ± 0.092
2.288ThrLys: 2.288 ± 0.068
6.381ThrLeu: 6.381 ± 0.118
1.118ThrMet: 1.118 ± 0.046
1.938ThrAsn: 1.938 ± 0.061
3.682ThrPro: 3.682 ± 0.093
2.433ThrGln: 2.433 ± 0.066
2.937ThrArg: 2.937 ± 0.084
3.465ThrSer: 3.465 ± 0.093
3.747ThrThr: 3.747 ± 0.101
5.679ThrVal: 5.679 ± 0.128
0.98ThrTrp: 0.98 ± 0.042
1.617ThrTyr: 1.617 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
9.647ValAla: 9.647 ± 0.157
0.632ValCys: 0.632 ± 0.035
4.585ValAsp: 4.585 ± 0.103
5.784ValGlu: 5.784 ± 0.132
3.212ValPhe: 3.212 ± 0.079
6.008ValGly: 6.008 ± 0.118
1.533ValHis: 1.533 ± 0.055
4.712ValIle: 4.712 ± 0.096
3.74ValLys: 3.74 ± 0.098
7.975ValLeu: 7.975 ± 0.133
1.762ValMet: 1.762 ± 0.069
2.771ValAsn: 2.771 ± 0.074
4.051ValPro: 4.051 ± 0.098
2.231ValGln: 2.231 ± 0.067
4.202ValArg: 4.202 ± 0.109
5.658ValSer: 5.658 ± 0.126
5.631ValThr: 5.631 ± 0.146
7.655ValVal: 7.655 ± 0.14
0.955ValTrp: 0.955 ± 0.048
1.735ValTyr: 1.735 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.315TrpAla: 1.315 ± 0.049
0.11TrpCys: 0.11 ± 0.015
0.781TrpAsp: 0.781 ± 0.036
0.938TrpGlu: 0.938 ± 0.05
0.557TrpPhe: 0.557 ± 0.039
0.936TrpGly: 0.936 ± 0.04
0.304TrpHis: 0.304 ± 0.027
0.781TrpIle: 0.781 ± 0.04
0.667TrpLys: 0.667 ± 0.04
1.483TrpLeu: 1.483 ± 0.056
0.36TrpMet: 0.36 ± 0.03
0.599TrpAsn: 0.599 ± 0.042
0.46TrpPro: 0.46 ± 0.029
0.663TrpGln: 0.663 ± 0.032
0.768TrpArg: 0.768 ± 0.037
0.766TrpSer: 0.766 ± 0.04
0.748TrpThr: 0.748 ± 0.04
1.166TrpVal: 1.166 ± 0.056
0.3TrpTrp: 0.3 ± 0.027
0.34TrpTyr: 0.34 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.071
0.226TyrCys: 0.226 ± 0.02
1.251TyrAsp: 1.251 ± 0.058
1.385TyrGlu: 1.385 ± 0.051
1.094TyrPhe: 1.094 ± 0.048
2.069TyrGly: 2.069 ± 0.068
0.443TyrHis: 0.443 ± 0.03
1.062TyrIle: 1.062 ± 0.05
0.731TyrLys: 0.731 ± 0.041
2.798TyrLeu: 2.798 ± 0.078
0.391TyrMet: 0.391 ± 0.029
0.777TyrAsn: 0.777 ± 0.043
1.332TyrPro: 1.332 ± 0.052
1.112TyrGln: 1.112 ± 0.052
1.52TyrArg: 1.52 ± 0.063
1.502TyrSer: 1.502 ± 0.062
1.456TyrThr: 1.456 ± 0.058
1.862TyrVal: 1.862 ± 0.059
0.429TyrTrp: 0.429 ± 0.03
0.667TyrTyr: 0.667 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1546 proteins (517147 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski