Amino acid dipepetide frequency for Hubei picorna-like virus 25

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.286AlaAla: 2.286 ± 0.638
0.381AlaCys: 0.381 ± 0.436
2.286AlaAsp: 2.286 ± 0.681
4.19AlaGlu: 4.19 ± 0.18
2.286AlaPhe: 2.286 ± 0.022
4.571AlaGly: 4.571 ± 0.044
1.524AlaHis: 1.524 ± 0.234
3.048AlaIle: 3.048 ± 1.128
4.952AlaLys: 4.952 ± 2.246
4.952AlaLeu: 4.952 ± 0.392
1.524AlaMet: 1.524 ± 0.244
3.81AlaAsn: 3.81 ± 0.403
2.286AlaPro: 2.286 ± 0.638
1.524AlaGln: 1.524 ± 0.894
0.381AlaArg: 0.381 ± 0.224
3.429AlaSer: 3.429 ± 0.033
3.429AlaThr: 3.429 ± 0.033
3.429AlaVal: 3.429 ± 0.033
0.0AlaTrp: 0.0 ± 0.0
1.524AlaTyr: 1.524 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.143CysAsp: 1.143 ± 0.671
0.381CysGlu: 0.381 ± 0.224
0.0CysPhe: 0.0 ± 0.0
1.143CysGly: 1.143 ± 0.671
0.381CysHis: 0.381 ± 0.224
0.381CysIle: 0.381 ± 0.224
0.762CysLys: 0.762 ± 0.447
0.381CysLeu: 0.381 ± 0.224
0.381CysMet: 0.381 ± 0.224
0.762CysAsn: 0.762 ± 0.447
1.143CysPro: 1.143 ± 0.649
0.0CysGln: 0.0 ± 0.0
0.762CysArg: 0.762 ± 0.213
1.143CysSer: 1.143 ± 0.011
0.381CysThr: 0.381 ± 0.224
0.381CysVal: 0.381 ± 0.224
0.762CysTrp: 0.762 ± 0.213
1.143CysTyr: 1.143 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.429AspAla: 3.429 ± 0.692
0.762AspCys: 0.762 ± 0.447
3.81AspAsp: 3.81 ± 0.256
5.714AspGlu: 5.714 ± 0.714
5.714AspPhe: 5.714 ± 2.033
5.333AspGly: 5.333 ± 1.81
0.381AspHis: 0.381 ± 0.224
6.476AspIle: 6.476 ± 0.502
2.286AspLys: 2.286 ± 1.341
4.952AspLeu: 4.952 ± 0.267
0.381AspMet: 0.381 ± 0.224
4.952AspAsn: 4.952 ± 0.267
1.143AspPro: 1.143 ± 0.011
1.524AspGln: 1.524 ± 1.085
1.143AspArg: 1.143 ± 0.671
6.476AspSer: 6.476 ± 1.477
2.667AspThr: 2.667 ± 1.074
3.429AspVal: 3.429 ± 0.692
0.381AspTrp: 0.381 ± 0.224
1.524AspTyr: 1.524 ± 0.234
0.0AspXaa: 0.0 ± 0.0
Glu
3.81GluAla: 3.81 ± 0.256
1.143GluCys: 1.143 ± 0.671
4.19GluAsp: 4.19 ± 0.48
4.952GluGlu: 4.952 ± 0.392
2.286GluPhe: 2.286 ± 0.022
2.667GluGly: 2.667 ± 1.733
1.143GluHis: 1.143 ± 0.671
2.667GluIle: 2.667 ± 0.245
5.714GluLys: 5.714 ± 2.693
6.095GluLeu: 6.095 ± 0.938
1.905GluMet: 1.905 ± 0.202
1.905GluAsn: 1.905 ± 0.861
1.524GluPro: 1.524 ± 0.425
1.905GluGln: 1.905 ± 0.202
3.048GluArg: 3.048 ± 1.128
4.571GluSer: 4.571 ± 0.044
4.952GluThr: 4.952 ± 1.712
3.429GluVal: 3.429 ± 0.627
1.143GluTrp: 1.143 ± 0.011
2.286GluTyr: 2.286 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
2.667PheAla: 2.667 ± 0.905
0.0PheCys: 0.0 ± 0.0
6.095PheAsp: 6.095 ± 0.278
2.667PheGlu: 2.667 ± 0.414
1.143PhePhe: 1.143 ± 0.671
1.905PheGly: 1.905 ± 0.202
1.524PheHis: 1.524 ± 0.234
1.905PheIle: 1.905 ± 0.458
3.048PheLys: 3.048 ± 0.85
3.81PheLeu: 3.81 ± 0.916
1.143PheMet: 1.143 ± 0.649
1.524PheAsn: 1.524 ± 0.234
1.905PhePro: 1.905 ± 0.202
0.0PheGln: 0.0 ± 0.0
2.667PheArg: 2.667 ± 0.414
6.857PheSer: 6.857 ± 0.725
4.571PheThr: 4.571 ± 0.044
3.81PheVal: 3.81 ± 0.916
0.762PheTrp: 0.762 ± 0.213
2.286PheTyr: 2.286 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
2.286GlyAla: 2.286 ± 0.638
0.381GlyCys: 0.381 ± 0.224
3.429GlyAsp: 3.429 ± 0.692
3.048GlyGlu: 3.048 ± 0.191
3.048GlyPhe: 3.048 ± 0.469
3.048GlyGly: 3.048 ± 2.17
1.143GlyHis: 1.143 ± 0.671
4.19GlyIle: 4.19 ± 0.48
4.952GlyLys: 4.952 ± 0.927
4.571GlyLeu: 4.571 ± 0.616
1.143GlyMet: 1.143 ± 0.649
3.429GlyAsn: 3.429 ± 0.627
0.381GlyPro: 0.381 ± 0.436
2.667GlyGln: 2.667 ± 0.905
1.143GlyArg: 1.143 ± 0.649
2.667GlySer: 2.667 ± 0.414
2.667GlyThr: 2.667 ± 0.414
6.095GlyVal: 6.095 ± 1.041
0.0GlyTrp: 0.0 ± 0.0
3.048GlyTyr: 3.048 ± 0.85
0.0GlyXaa: 0.0 ± 0.0
His
1.143HisAla: 1.143 ± 0.649
0.381HisCys: 0.381 ± 0.224
1.143HisAsp: 1.143 ± 0.671
1.524HisGlu: 1.524 ± 0.234
0.381HisPhe: 0.381 ± 0.224
1.143HisGly: 1.143 ± 0.671
0.381HisHis: 0.381 ± 0.436
1.524HisIle: 1.524 ± 0.234
0.381HisLys: 0.381 ± 0.224
1.905HisLeu: 1.905 ± 1.118
0.381HisMet: 0.381 ± 0.224
0.381HisAsn: 0.381 ± 0.224
0.762HisPro: 0.762 ± 0.447
0.0HisGln: 0.0 ± 0.0
0.381HisArg: 0.381 ± 0.436
1.143HisSer: 1.143 ± 0.011
1.905HisThr: 1.905 ± 1.118
1.143HisVal: 1.143 ± 0.011
0.381HisTrp: 0.381 ± 0.224
1.524HisTyr: 1.524 ± 0.234
0.0HisXaa: 0.0 ± 0.0
Ile
4.19IleAla: 4.19 ± 0.48
0.762IleCys: 0.762 ± 0.213
5.333IleAsp: 5.333 ± 1.81
8.0IleGlu: 8.0 ± 1.396
5.714IlePhe: 5.714 ± 2.033
3.048IleGly: 3.048 ± 1.788
1.524IleHis: 1.524 ± 0.894
3.429IleIle: 3.429 ± 1.286
5.714IleLys: 5.714 ± 1.374
6.476IleLeu: 6.476 ± 0.158
1.143IleMet: 1.143 ± 0.671
3.81IleAsn: 3.81 ± 0.916
3.048IlePro: 3.048 ± 0.191
0.381IleGln: 0.381 ± 0.224
2.286IleArg: 2.286 ± 0.638
6.095IleSer: 6.095 ± 3.02
6.095IleThr: 6.095 ± 0.278
3.429IleVal: 3.429 ± 0.627
1.143IleTrp: 1.143 ± 1.308
2.667IleTyr: 2.667 ± 0.414
0.0IleXaa: 0.0 ± 0.0
Lys
3.048LysAla: 3.048 ± 0.469
1.143LysCys: 1.143 ± 0.671
3.81LysAsp: 3.81 ± 1.576
2.286LysGlu: 2.286 ± 0.681
3.048LysPhe: 3.048 ± 0.85
1.905LysGly: 1.905 ± 0.458
2.286LysHis: 2.286 ± 0.681
8.0LysIle: 8.0 ± 2.055
4.19LysLys: 4.19 ± 1.139
4.952LysLeu: 4.952 ± 0.267
0.381LysMet: 0.381 ± 0.436
2.667LysAsn: 2.667 ± 0.245
3.429LysPro: 3.429 ± 0.033
2.667LysGln: 2.667 ± 0.245
2.667LysArg: 2.667 ± 0.905
2.667LysSer: 2.667 ± 1.565
8.381LysThr: 8.381 ± 1.619
4.571LysVal: 4.571 ± 0.703
1.524LysTrp: 1.524 ± 0.234
4.571LysTyr: 4.571 ± 1.363
0.0LysXaa: 0.0 ± 0.0
Leu
6.857LeuAla: 6.857 ± 0.066
1.524LeuCys: 1.524 ± 0.234
4.571LeuAsp: 4.571 ± 2.023
5.714LeuGlu: 5.714 ± 0.055
4.952LeuPhe: 4.952 ± 0.392
4.952LeuGly: 4.952 ± 0.927
0.381LeuHis: 0.381 ± 0.224
6.476LeuIle: 6.476 ± 0.818
6.095LeuLys: 6.095 ± 1.597
5.333LeuLeu: 5.333 ± 1.15
2.286LeuMet: 2.286 ± 0.681
7.238LeuAsn: 7.238 ± 0.289
2.667LeuPro: 2.667 ± 1.074
1.524LeuGln: 1.524 ± 0.894
3.81LeuArg: 3.81 ± 0.256
3.048LeuSer: 3.048 ± 0.469
5.333LeuThr: 5.333 ± 2.807
6.476LeuVal: 6.476 ± 0.158
0.762LeuTrp: 0.762 ± 0.447
2.667LeuTyr: 2.667 ± 0.905
0.0LeuXaa: 0.0 ± 0.0
Met
1.524MetAla: 1.524 ± 0.894
0.762MetCys: 0.762 ± 0.213
0.762MetAsp: 0.762 ± 0.872
0.381MetGlu: 0.381 ± 0.224
0.381MetPhe: 0.381 ± 0.436
0.0MetGly: 0.0 ± 0.0
0.381MetHis: 0.381 ± 0.224
1.524MetIle: 1.524 ± 0.234
1.524MetLys: 1.524 ± 0.894
1.905MetLeu: 1.905 ± 0.458
1.143MetMet: 1.143 ± 0.55
0.381MetAsn: 0.381 ± 0.224
0.762MetPro: 0.762 ± 0.872
0.762MetGln: 0.762 ± 0.213
2.286MetArg: 2.286 ± 0.681
1.143MetSer: 1.143 ± 0.011
2.286MetThr: 2.286 ± 0.022
1.143MetVal: 1.143 ± 0.011
0.0MetTrp: 0.0 ± 0.0
0.762MetTyr: 0.762 ± 0.872
0.0MetXaa: 0.0 ± 0.0
Asn
3.81AsnAla: 3.81 ± 0.916
0.0AsnCys: 0.0 ± 0.0
3.81AsnAsp: 3.81 ± 0.403
3.048AsnGlu: 3.048 ± 0.85
3.048AsnPhe: 3.048 ± 0.191
2.286AsnGly: 2.286 ± 0.022
0.381AsnHis: 0.381 ± 0.436
8.0AsnIle: 8.0 ± 0.077
3.429AsnLys: 3.429 ± 0.692
7.238AsnLeu: 7.238 ± 0.289
1.905AsnMet: 1.905 ± 1.118
1.143AsnAsn: 1.143 ± 0.671
3.81AsnPro: 3.81 ± 0.916
2.667AsnGln: 2.667 ± 0.414
2.667AsnArg: 2.667 ± 0.414
3.429AsnSer: 3.429 ± 1.286
5.333AsnThr: 5.333 ± 0.169
5.333AsnVal: 5.333 ± 0.828
1.524AsnTrp: 1.524 ± 0.234
1.524AsnTyr: 1.524 ± 0.234
0.0AsnXaa: 0.0 ± 0.0
Pro
1.905ProAla: 1.905 ± 1.521
0.381ProCys: 0.381 ± 0.224
2.286ProAsp: 2.286 ± 1.341
2.667ProGlu: 2.667 ± 0.905
2.667ProPhe: 2.667 ± 0.414
3.429ProGly: 3.429 ± 1.286
0.381ProHis: 0.381 ± 0.224
1.524ProIle: 1.524 ± 0.425
3.048ProLys: 3.048 ± 0.85
1.524ProLeu: 1.524 ± 1.085
0.381ProMet: 0.381 ± 0.224
3.429ProAsn: 3.429 ± 0.033
1.905ProPro: 1.905 ± 0.202
1.143ProGln: 1.143 ± 0.011
2.667ProArg: 2.667 ± 0.414
3.048ProSer: 3.048 ± 0.85
3.81ProThr: 3.81 ± 1.063
2.286ProVal: 2.286 ± 1.957
0.0ProTrp: 0.0 ± 0.0
2.286ProTyr: 2.286 ± 0.638
0.0ProXaa: 0.0 ± 0.0
Gln
1.524GlnAla: 1.524 ± 0.234
0.381GlnCys: 0.381 ± 0.224
1.143GlnAsp: 1.143 ± 0.671
1.905GlnGlu: 1.905 ± 0.458
2.667GlnPhe: 2.667 ± 0.414
2.286GlnGly: 2.286 ± 0.638
0.762GlnHis: 0.762 ± 0.447
3.048GlnIle: 3.048 ± 0.191
1.524GlnLys: 1.524 ± 0.425
1.905GlnLeu: 1.905 ± 0.202
0.381GlnMet: 0.381 ± 0.224
3.048GlnAsn: 3.048 ± 2.17
1.524GlnPro: 1.524 ± 0.234
1.905GlnGln: 1.905 ± 0.861
0.762GlnArg: 0.762 ± 0.447
0.762GlnSer: 0.762 ± 0.447
2.667GlnThr: 2.667 ± 0.414
1.524GlnVal: 1.524 ± 0.425
0.0GlnTrp: 0.0 ± 0.0
0.762GlnTyr: 0.762 ± 0.872
0.0GlnXaa: 0.0 ± 0.0
Arg
1.143ArgAla: 1.143 ± 0.011
0.381ArgCys: 0.381 ± 0.224
3.048ArgAsp: 3.048 ± 0.469
1.143ArgGlu: 1.143 ± 0.011
0.762ArgPhe: 0.762 ± 0.872
2.286ArgGly: 2.286 ± 1.297
0.762ArgHis: 0.762 ± 0.447
3.429ArgIle: 3.429 ± 0.692
3.048ArgLys: 3.048 ± 1.788
3.048ArgLeu: 3.048 ± 1.128
1.143ArgMet: 1.143 ± 0.011
3.048ArgAsn: 3.048 ± 0.469
1.524ArgPro: 1.524 ± 1.085
1.524ArgGln: 1.524 ± 0.234
4.19ArgArg: 4.19 ± 0.48
2.286ArgSer: 2.286 ± 0.638
4.952ArgThr: 4.952 ± 0.927
3.048ArgVal: 3.048 ± 0.469
0.0ArgTrp: 0.0 ± 0.0
3.048ArgTyr: 3.048 ± 1.51
0.0ArgXaa: 0.0 ± 0.0
Ser
3.048SerAla: 3.048 ± 0.191
0.762SerCys: 0.762 ± 0.447
3.429SerAsp: 3.429 ± 1.286
4.952SerGlu: 4.952 ± 1.052
1.524SerPhe: 1.524 ± 0.234
3.429SerGly: 3.429 ± 0.627
0.762SerHis: 0.762 ± 0.213
5.333SerIle: 5.333 ± 0.491
4.19SerLys: 4.19 ± 0.839
5.333SerLeu: 5.333 ± 0.828
0.762SerMet: 0.762 ± 0.447
5.333SerAsn: 5.333 ± 1.488
3.429SerPro: 3.429 ± 1.286
4.571SerGln: 4.571 ± 1.275
3.81SerArg: 3.81 ± 0.256
3.81SerSer: 3.81 ± 1.063
4.571SerThr: 4.571 ± 2.595
4.571SerVal: 4.571 ± 1.275
0.762SerTrp: 0.762 ± 0.213
2.286SerTyr: 2.286 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
3.81ThrAla: 3.81 ± 0.256
0.762ThrCys: 0.762 ± 0.213
3.429ThrAsp: 3.429 ± 0.033
3.81ThrGlu: 3.81 ± 0.256
5.714ThrPhe: 5.714 ± 0.714
2.667ThrGly: 2.667 ± 0.414
1.524ThrHis: 1.524 ± 0.894
3.81ThrIle: 3.81 ± 0.256
4.952ThrLys: 4.952 ± 2.246
9.143ThrLeu: 9.143 ± 1.891
1.905ThrMet: 1.905 ± 0.861
3.81ThrAsn: 3.81 ± 0.403
4.571ThrPro: 4.571 ± 1.275
3.048ThrGln: 3.048 ± 0.85
2.286ThrArg: 2.286 ± 0.022
6.857ThrSer: 6.857 ± 3.892
7.238ThrThr: 7.238 ± 1.03
3.429ThrVal: 3.429 ± 0.033
1.524ThrTrp: 1.524 ± 0.234
5.333ThrTyr: 5.333 ± 2.148
0.0ThrXaa: 0.0 ± 0.0
Val
3.429ValAla: 3.429 ± 0.692
0.381ValCys: 0.381 ± 0.224
5.333ValAsp: 5.333 ± 1.488
2.667ValGlu: 2.667 ± 0.414
3.048ValPhe: 3.048 ± 1.128
4.571ValGly: 4.571 ± 1.935
1.524ValHis: 1.524 ± 0.425
6.857ValIle: 6.857 ± 0.066
3.81ValLys: 3.81 ± 0.403
2.667ValLeu: 2.667 ± 0.905
1.143ValMet: 1.143 ± 0.011
4.952ValAsn: 4.952 ± 1.586
3.048ValPro: 3.048 ± 1.51
1.524ValGln: 1.524 ± 1.744
3.429ValArg: 3.429 ± 1.352
3.429ValSer: 3.429 ± 1.286
4.571ValThr: 4.571 ± 0.616
2.667ValVal: 2.667 ± 0.245
0.381ValTrp: 0.381 ± 0.436
4.19ValTyr: 4.19 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
0.381TrpAla: 0.381 ± 0.224
0.0TrpCys: 0.0 ± 0.0
1.143TrpAsp: 1.143 ± 0.011
0.762TrpGlu: 0.762 ± 0.213
0.381TrpPhe: 0.381 ± 0.436
0.762TrpGly: 0.762 ± 0.447
0.381TrpHis: 0.381 ± 0.436
0.762TrpIle: 0.762 ± 0.872
2.286TrpLys: 2.286 ± 0.022
0.381TrpLeu: 0.381 ± 0.224
0.0TrpMet: 0.0 ± 0.0
1.143TrpAsn: 1.143 ± 0.671
0.0TrpPro: 0.0 ± 0.0
0.381TrpGln: 0.381 ± 0.436
0.381TrpArg: 0.381 ± 0.436
0.762TrpSer: 0.762 ± 0.447
1.143TrpThr: 1.143 ± 0.671
0.381TrpVal: 0.381 ± 0.436
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.524TyrAla: 1.524 ± 0.425
1.143TyrCys: 1.143 ± 0.011
2.286TyrAsp: 2.286 ± 0.638
1.524TyrGlu: 1.524 ± 0.425
1.524TyrPhe: 1.524 ± 1.085
1.905TyrGly: 1.905 ± 0.861
0.381TyrHis: 0.381 ± 0.224
1.905TyrIle: 1.905 ± 0.458
2.286TyrLys: 2.286 ± 0.638
6.095TyrLeu: 6.095 ± 2.257
0.381TyrMet: 0.381 ± 0.436
7.619TyrAsn: 7.619 ± 0.147
1.905TyrPro: 1.905 ± 0.458
0.762TyrGln: 0.762 ± 0.447
3.048TyrArg: 3.048 ± 0.85
3.048TyrSer: 3.048 ± 2.17
2.667TyrThr: 2.667 ± 1.074
3.048TyrVal: 3.048 ± 0.469
0.381TyrTrp: 0.381 ± 0.224
2.286TyrTyr: 2.286 ± 0.638
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski