Amino acid dipepetide frequency for Micromonospora sp. (strain ATCC 39149 / NRRL 15099 / SCC 1413)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.696AlaAla: 22.696 ± 0.166	1.05AlaCys: 1.05 ± 0.024	8.849AlaAsp: 8.849 ± 0.084	8.313AlaGlu: 8.313 ± 0.091	3.183AlaPhe: 3.183 ± 0.043	15.244AlaGly: 15.244 ± 0.102	2.621AlaHis: 2.621 ± 0.039	3.751AlaIle: 3.751 ± 0.054	2.297AlaLys: 2.297 ± 0.046	14.056AlaLeu: 14.056 ± 0.121	2.417AlaMet: 2.417 ± 0.041	2.264AlaAsn: 2.264 ± 0.044	7.212AlaPro: 7.212 ± 0.075	3.552AlaGln: 3.552 ± 0.05	11.152AlaArg: 11.152 ± 0.097	5.638AlaSer: 5.638 ± 0.056	8.069AlaThr: 8.069 ± 0.085	12.553AlaVal: 12.553 ± 0.107	1.94AlaTrp: 1.94 ± 0.036	2.86AlaTyr: 2.86 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.026	0.154CysCys: 0.154 ± 0.01	0.519CysAsp: 0.519 ± 0.016	0.339CysGlu: 0.339 ± 0.014	0.212CysPhe: 0.212 ± 0.011	1.028CysGly: 1.028 ± 0.026	0.221CysHis: 0.221 ± 0.011	0.144CysIle: 0.144 ± 0.009	0.097CysLys: 0.097 ± 0.008	0.757CysLeu: 0.757 ± 0.02	0.117CysMet: 0.117 ± 0.008	0.153CysAsn: 0.153 ± 0.01	0.583CysPro: 0.583 ± 0.02	0.195CysGln: 0.195 ± 0.012	0.819CysArg: 0.819 ± 0.025	0.462CysSer: 0.462 ± 0.02	0.477CysThr: 0.477 ± 0.016	0.688CysVal: 0.688 ± 0.019	0.191CysTrp: 0.191 ± 0.011	0.187CysTyr: 0.187 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.813AspAla: 7.813 ± 0.068	0.439AspCys: 0.439 ± 0.016	3.611AspAsp: 3.611 ± 0.06	3.577AspGlu: 3.577 ± 0.052	1.43AspPhe: 1.43 ± 0.026	6.295AspGly: 6.295 ± 0.075	1.327AspHis: 1.327 ± 0.027	1.568AspIle: 1.568 ± 0.03	0.867AspLys: 0.867 ± 0.027	6.48AspLeu: 6.48 ± 0.069	0.739AspMet: 0.739 ± 0.021	0.991AspAsn: 0.991 ± 0.026	4.928AspPro: 4.928 ± 0.054	1.626AspGln: 1.626 ± 0.032	5.748AspArg: 5.748 ± 0.068	2.264AspSer: 2.264 ± 0.036	2.785AspThr: 2.785 ± 0.035	5.005AspVal: 5.005 ± 0.058	1.02AspTrp: 1.02 ± 0.027	1.114AspTyr: 1.114 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.302GluAla: 6.302 ± 0.072	0.356GluCys: 0.356 ± 0.015	2.03GluAsp: 2.03 ± 0.034	2.398GluGlu: 2.398 ± 0.046	1.439GluPhe: 1.439 ± 0.029	3.17GluGly: 3.17 ± 0.046	1.391GluHis: 1.391 ± 0.027	2.1GluIle: 2.1 ± 0.039	0.994GluLys: 0.994 ± 0.029	6.348GluLeu: 6.348 ± 0.07	0.803GluMet: 0.803 ± 0.022	0.817GluAsn: 0.817 ± 0.021	3.332GluPro: 3.332 ± 0.051	2.094GluGln: 2.094 ± 0.038	4.98GluArg: 4.98 ± 0.06	2.104GluSer: 2.104 ± 0.033	2.313GluThr: 2.313 ± 0.037	4.551GluVal: 4.551 ± 0.055	0.687GluTrp: 0.687 ± 0.021	1.056GluTyr: 1.056 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.751PheAla: 3.751 ± 0.044	0.254PheCys: 0.254 ± 0.012	1.966PheAsp: 1.966 ± 0.034	1.117PheGlu: 1.117 ± 0.025	0.832PhePhe: 0.832 ± 0.024	2.924PheGly: 2.924 ± 0.044	0.569PheHis: 0.569 ± 0.017	0.649PheIle: 0.649 ± 0.018	0.388PheLys: 0.388 ± 0.015	2.415PheLeu: 2.415 ± 0.045	0.314PheMet: 0.314 ± 0.014	0.564PheAsn: 0.564 ± 0.02	1.334PhePro: 1.334 ± 0.03	0.596PheGln: 0.596 ± 0.016	1.826PheArg: 1.826 ± 0.029	1.333PheSer: 1.333 ± 0.031	1.904PheThr: 1.904 ± 0.038	2.406PheVal: 2.406 ± 0.041	0.406PheTrp: 0.406 ± 0.015	0.588PheTyr: 0.588 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.064GlyAla: 11.064 ± 0.094	0.978GlyCys: 0.978 ± 0.026	5.408GlyAsp: 5.408 ± 0.059	4.687GlyGlu: 4.687 ± 0.05	2.771GlyPhe: 2.771 ± 0.045	9.496GlyGly: 9.496 ± 0.1	2.248GlyHis: 2.248 ± 0.038	3.099GlyIle: 3.099 ± 0.048	1.89GlyLys: 1.89 ± 0.038	9.296GlyLeu: 9.296 ± 0.084	1.952GlyMet: 1.952 ± 0.032	1.845GlyAsn: 1.845 ± 0.041	5.79GlyPro: 5.79 ± 0.065	2.881GlyGln: 2.881 ± 0.042	9.048GlyArg: 9.048 ± 0.094	4.956GlySer: 4.956 ± 0.058	6.056GlyThr: 6.056 ± 0.077	8.193GlyVal: 8.193 ± 0.081	2.013GlyTrp: 2.013 ± 0.035	2.415GlyTyr: 2.415 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.539HisAla: 2.539 ± 0.042	0.202HisCys: 0.202 ± 0.011	1.362HisAsp: 1.362 ± 0.027	0.98HisGlu: 0.98 ± 0.025	0.585HisPhe: 0.585 ± 0.018	2.198HisGly: 2.198 ± 0.038	0.711HisHis: 0.711 ± 0.022	0.533HisIle: 0.533 ± 0.018	0.268HisLys: 0.268 ± 0.012	2.48HisLeu: 2.48 ± 0.039	0.248HisMet: 0.248 ± 0.011	0.371HisAsn: 0.371 ± 0.015	1.899HisPro: 1.899 ± 0.037	0.63HisGln: 0.63 ± 0.019	2.448HisArg: 2.448 ± 0.043	0.901HisSer: 0.901 ± 0.021	1.093HisThr: 1.093 ± 0.026	1.731HisVal: 1.731 ± 0.036	0.339HisTrp: 0.339 ± 0.015	0.424HisTyr: 0.424 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.536IleAla: 4.536 ± 0.053	0.318IleCys: 0.318 ± 0.014	2.298IleAsp: 2.298 ± 0.04	1.821IleGlu: 1.821 ± 0.032	0.82IlePhe: 0.82 ± 0.021	3.366IleGly: 3.366 ± 0.045	0.529IleHis: 0.529 ± 0.018	0.876IleIle: 0.876 ± 0.025	0.603IleLys: 0.603 ± 0.023	2.336IleLeu: 2.336 ± 0.039	0.431IleMet: 0.431 ± 0.017	0.719IleAsn: 0.719 ± 0.022	1.562IlePro: 1.562 ± 0.032	0.683IleGln: 0.683 ± 0.019	2.417IleArg: 2.417 ± 0.035	1.624IleSer: 1.624 ± 0.027	2.05IleThr: 2.05 ± 0.033	2.762IleVal: 2.762 ± 0.048	0.409IleTrp: 0.409 ± 0.014	0.556IleTyr: 0.556 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.105LysAla: 2.105 ± 0.042	0.112LysCys: 0.112 ± 0.008	0.795LysAsp: 0.795 ± 0.026	0.751LysGlu: 0.751 ± 0.025	0.379LysPhe: 0.379 ± 0.016	1.247LysGly: 1.247 ± 0.036	0.334LysHis: 0.334 ± 0.015	0.765LysIle: 0.765 ± 0.024	0.476LysLys: 0.476 ± 0.022	1.738LysLeu: 1.738 ± 0.032	0.285LysMet: 0.285 ± 0.012	0.351LysAsn: 0.351 ± 0.015	1.118LysPro: 1.118 ± 0.027	0.555LysGln: 0.555 ± 0.02	1.238LysArg: 1.238 ± 0.028	0.862LysSer: 0.862 ± 0.023	0.994LysThr: 0.994 ± 0.027	1.534LysVal: 1.534 ± 0.031	0.221LysTrp: 0.221 ± 0.014	0.351LysTyr: 0.351 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.328LeuAla: 16.328 ± 0.126	0.783LeuCys: 0.783 ± 0.021	6.807LeuAsp: 6.807 ± 0.071	3.724LeuGlu: 3.724 ± 0.05	2.481LeuPhe: 2.481 ± 0.042	9.156LeuGly: 9.156 ± 0.08	2.284LeuHis: 2.284 ± 0.041	3.08LeuIle: 3.08 ± 0.047	1.342LeuLys: 1.342 ± 0.032	11.128LeuLeu: 11.128 ± 0.108	1.36LeuMet: 1.36 ± 0.03	1.649LeuAsn: 1.649 ± 0.035	6.725LeuPro: 6.725 ± 0.064	1.831LeuGln: 1.831 ± 0.033	9.384LeuArg: 9.384 ± 0.086	4.692LeuSer: 4.692 ± 0.057	6.759LeuThr: 6.759 ± 0.066	9.525LeuVal: 9.525 ± 0.096	1.234LeuTrp: 1.234 ± 0.028	1.729LeuTyr: 1.729 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.038	0.121MetCys: 0.121 ± 0.009	0.716MetAsp: 0.716 ± 0.018	0.576MetGlu: 0.576 ± 0.019	0.453MetPhe: 0.453 ± 0.014	1.167MetGly: 1.167 ± 0.026	0.328MetHis: 0.328 ± 0.014	0.682MetIle: 0.682 ± 0.021	0.315MetLys: 0.315 ± 0.014	1.697MetLeu: 1.697 ± 0.036	0.277MetMet: 0.277 ± 0.013	0.345MetAsn: 0.345 ± 0.013	1.104MetPro: 1.104 ± 0.024	0.43MetGln: 0.43 ± 0.014	1.421MetArg: 1.421 ± 0.03	1.165MetSer: 1.165 ± 0.026	1.472MetThr: 1.472 ± 0.033	1.342MetVal: 1.342 ± 0.028	0.187MetTrp: 0.187 ± 0.011	0.266MetTyr: 0.266 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.196AsnAla: 2.196 ± 0.042	0.162AsnCys: 0.162 ± 0.01	0.974AsnAsp: 0.974 ± 0.023	0.73AsnGlu: 0.73 ± 0.02	0.503AsnPhe: 0.503 ± 0.019	1.922AsnGly: 1.922 ± 0.047	0.397AsnHis: 0.397 ± 0.012	0.605AsnIle: 0.605 ± 0.018	0.33AsnLys: 0.33 ± 0.014	1.852AsnLeu: 1.852 ± 0.035	0.292AsnMet: 0.292 ± 0.013	0.506AsnAsn: 0.506 ± 0.024	1.462AsnPro: 1.462 ± 0.032	0.578AsnGln: 0.578 ± 0.021	1.448AsnArg: 1.448 ± 0.028	0.944AsnSer: 0.944 ± 0.025	1.084AsnThr: 1.084 ± 0.034	1.483AsnVal: 1.483 ± 0.033	0.337AsnTrp: 0.337 ± 0.014	0.449AsnTyr: 0.449 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	10.533ProAla: 10.533 ± 0.093	0.4ProCys: 0.4 ± 0.016	4.574ProAsp: 4.574 ± 0.053	3.725ProGlu: 3.725 ± 0.047	1.42ProPhe: 1.42 ± 0.029	7.297ProGly: 7.297 ± 0.072	1.281ProHis: 1.281 ± 0.028	1.587ProIle: 1.587 ± 0.031	0.952ProLys: 0.952 ± 0.027	5.219ProLeu: 5.219 ± 0.054	1.064ProMet: 1.064 ± 0.023	1.057ProAsn: 1.057 ± 0.027	4.643ProPro: 4.643 ± 0.082	1.674ProGln: 1.674 ± 0.031	4.467ProArg: 4.467 ± 0.057	3.136ProSer: 3.136 ± 0.046	4.177ProThr: 4.177 ± 0.064	5.967ProVal: 5.967 ± 0.057	0.952ProTrp: 0.952 ± 0.021	1.316ProTyr: 1.316 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.578GlnAla: 3.578 ± 0.046	0.168GlnCys: 0.168 ± 0.01	1.046GlnAsp: 1.046 ± 0.021	1.137GlnGlu: 1.137 ± 0.027	0.74GlnPhe: 0.74 ± 0.02	1.895GlnGly: 1.895 ± 0.03	0.632GlnHis: 0.632 ± 0.019	1.042GlnIle: 1.042 ± 0.025	0.427GlnLys: 0.427 ± 0.016	3.114GlnLeu: 3.114 ± 0.041	0.432GlnMet: 0.432 ± 0.017	0.469GlnAsn: 0.469 ± 0.018	1.961GlnPro: 1.961 ± 0.034	1.211GlnGln: 1.211 ± 0.035	2.822GlnArg: 2.822 ± 0.039	1.127GlnSer: 1.127 ± 0.025	1.334GlnThr: 1.334 ± 0.028	2.726GlnVal: 2.726 ± 0.04	0.529GlnTrp: 0.529 ± 0.017	0.527GlnTyr: 0.527 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.05ArgAla: 11.05 ± 0.101	0.837ArgCys: 0.837 ± 0.024	4.664ArgAsp: 4.664 ± 0.054	4.295ArgGlu: 4.295 ± 0.057	2.441ArgPhe: 2.441 ± 0.037	6.501ArgGly: 6.501 ± 0.077	2.417ArgHis: 2.417 ± 0.04	3.112ArgIle: 3.112 ± 0.043	1.296ArgLys: 1.296 ± 0.032	9.635ArgLeu: 9.635 ± 0.082	1.86ArgMet: 1.86 ± 0.034	1.492ArgAsn: 1.492 ± 0.033	6.366ArgPro: 6.366 ± 0.08	2.738ArgGln: 2.738 ± 0.04	10.213ArgArg: 10.213 ± 0.124	4.343ArgSer: 4.343 ± 0.053	4.932ArgThr: 4.932 ± 0.054	6.77ArgVal: 6.77 ± 0.062	1.787ArgTrp: 1.787 ± 0.034	2.066ArgTyr: 2.066 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.365SerAla: 6.365 ± 0.055	0.466SerCys: 0.466 ± 0.019	2.296SerAsp: 2.296 ± 0.036	1.874SerGlu: 1.874 ± 0.034	1.416SerPhe: 1.416 ± 0.027	5.537SerGly: 5.537 ± 0.063	0.908SerHis: 0.908 ± 0.022	1.489SerIle: 1.489 ± 0.033	0.742SerLys: 0.742 ± 0.022	4.148SerLeu: 4.148 ± 0.054	0.984SerMet: 0.984 ± 0.021	0.933SerAsn: 0.933 ± 0.025	3.327SerPro: 3.327 ± 0.046	1.12SerGln: 1.12 ± 0.027	3.929SerArg: 3.929 ± 0.045	2.662SerSer: 2.662 ± 0.047	3.195SerThr: 3.195 ± 0.048	3.967SerVal: 3.967 ± 0.045	0.959SerTrp: 0.959 ± 0.024	1.184SerTyr: 1.184 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	8.404ThrAla: 8.404 ± 0.074	0.509ThrCys: 0.509 ± 0.017	3.572ThrAsp: 3.572 ± 0.046	2.871ThrGlu: 2.871 ± 0.037	1.61ThrPhe: 1.61 ± 0.034	6.877ThrGly: 6.877 ± 0.065	1.074ThrHis: 1.074 ± 0.027	1.98ThrIle: 1.98 ± 0.033	0.952ThrLys: 0.952 ± 0.025	5.636ThrLeu: 5.636 ± 0.066	0.998ThrMet: 0.998 ± 0.021	1.151ThrAsn: 1.151 ± 0.033	4.264ThrPro: 4.264 ± 0.063	1.251ThrGln: 1.251 ± 0.029	4.246ThrArg: 4.246 ± 0.048	2.989ThrSer: 2.989 ± 0.053	3.957ThrThr: 3.957 ± 0.089	6.193ThrVal: 6.193 ± 0.063	0.986ThrTrp: 0.986 ± 0.026	1.34ThrTyr: 1.34 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	12.611ValAla: 12.611 ± 0.101	0.77ValCys: 0.77 ± 0.018	5.886ValAsp: 5.886 ± 0.062	4.72ValGlu: 4.72 ± 0.055	2.308ValPhe: 2.308 ± 0.037	7.59ValGly: 7.59 ± 0.077	1.791ValHis: 1.791 ± 0.032	2.709ValIle: 2.709 ± 0.041	1.399ValLys: 1.399 ± 0.03	9.475ValLeu: 9.475 ± 0.086	1.169ValMet: 1.169 ± 0.028	1.744ValAsn: 1.744 ± 0.035	5.556ValPro: 5.556 ± 0.063	1.947ValGln: 1.947 ± 0.031	7.543ValArg: 7.543 ± 0.071	4.28ValSer: 4.28 ± 0.043	6.033ValThr: 6.033 ± 0.069	8.748ValVal: 8.748 ± 0.097	1.137ValTrp: 1.137 ± 0.022	1.531ValTyr: 1.531 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.726TrpAla: 1.726 ± 0.028	0.197TrpCys: 0.197 ± 0.012	0.796TrpAsp: 0.796 ± 0.025	0.616TrpGlu: 0.616 ± 0.02	0.512TrpPhe: 0.512 ± 0.018	1.04TrpGly: 1.04 ± 0.027	0.441TrpHis: 0.441 ± 0.016	0.546TrpIle: 0.546 ± 0.016	0.289TrpLys: 0.289 ± 0.013	1.892TrpLeu: 1.892 ± 0.035	0.264TrpMet: 0.264 ± 0.013	0.404TrpAsn: 0.404 ± 0.018	1.034TrpPro: 1.034 ± 0.027	0.648TrpGln: 0.648 ± 0.02	1.658TrpArg: 1.658 ± 0.033	1.12TrpSer: 1.12 ± 0.026	1.079TrpThr: 1.079 ± 0.031	1.078TrpVal: 1.078 ± 0.025	0.408TrpTrp: 0.408 ± 0.015	0.366TrpTyr: 0.366 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.863TyrAla: 2.863 ± 0.04	0.179TyrCys: 0.179 ± 0.009	1.46TyrAsp: 1.46 ± 0.036	1.016TyrGlu: 1.016 ± 0.023	0.601TyrPhe: 0.601 ± 0.017	2.137TyrGly: 2.137 ± 0.039	0.437TyrHis: 0.437 ± 0.017	0.396TyrIle: 0.396 ± 0.014	0.289TyrLys: 0.289 ± 0.013	2.298TyrLeu: 2.298 ± 0.039	0.202TyrMet: 0.202 ± 0.012	0.432TyrAsn: 0.432 ± 0.019	1.239TyrPro: 1.239 ± 0.03	0.675TyrGln: 0.675 ± 0.02	2.006TyrArg: 2.006 ± 0.036	0.899TyrSer: 0.899 ± 0.025	1.097TyrThr: 1.097 ± 0.027	1.726TyrVal: 1.726 ± 0.033	0.373TyrTrp: 0.373 ± 0.014	0.46TyrTyr: 0.46 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5614 proteins (1848376 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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