Amino acid dipepetide frequency for Morelia viridis nidovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.304AlaAla: 5.304 ± 1.061
1.05AlaCys: 1.05 ± 0.459
1.547AlaAsp: 1.547 ± 0.184
2.707AlaGlu: 2.707 ± 0.213
2.431AlaPhe: 2.431 ± 0.323
2.32AlaGly: 2.32 ± 0.643
1.547AlaHis: 1.547 ± 0.286
4.254AlaIle: 4.254 ± 0.54
2.873AlaLys: 2.873 ± 0.381
4.917AlaLeu: 4.917 ± 0.34
1.215AlaMet: 1.215 ± 0.171
3.812AlaAsn: 3.812 ± 0.162
1.492AlaPro: 1.492 ± 0.227
3.37AlaGln: 3.37 ± 0.555
2.155AlaArg: 2.155 ± 0.312
4.641AlaSer: 4.641 ± 0.493
6.243AlaThr: 6.243 ± 0.246
4.586AlaVal: 4.586 ± 0.41
0.442AlaTrp: 0.442 ± 0.109
2.155AlaTyr: 2.155 ± 0.33
0.0AlaXaa: 0.0 ± 0.0
Cys
1.105CysAla: 1.105 ± 0.262
0.939CysCys: 0.939 ± 0.133
1.492CysAsp: 1.492 ± 0.243
0.387CysGlu: 0.387 ± 0.13
1.271CysPhe: 1.271 ± 0.235
1.436CysGly: 1.436 ± 0.222
0.939CysHis: 0.939 ± 0.133
1.16CysIle: 1.16 ± 0.113
1.657CysLys: 1.657 ± 0.342
1.492CysLeu: 1.492 ± 0.348
0.276CysMet: 0.276 ± 0.12
1.934CysAsn: 1.934 ± 0.216
0.608CysPro: 0.608 ± 0.439
1.878CysGln: 1.878 ± 0.231
1.657CysArg: 1.657 ± 0.292
2.21CysSer: 2.21 ± 0.257
1.657CysThr: 1.657 ± 0.409
1.326CysVal: 1.326 ± 0.38
0.0CysTrp: 0.0 ± 0.0
1.105CysTyr: 1.105 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
2.431AspAla: 2.431 ± 0.369
1.05AspCys: 1.05 ± 0.217
2.265AspAsp: 2.265 ± 0.437
2.431AspGlu: 2.431 ± 0.397
2.265AspPhe: 2.265 ± 0.31
1.657AspGly: 1.657 ± 0.347
1.713AspHis: 1.713 ± 0.325
3.978AspIle: 3.978 ± 0.55
3.702AspLys: 3.702 ± 0.366
3.812AspLeu: 3.812 ± 0.639
0.829AspMet: 0.829 ± 0.284
3.923AspAsn: 3.923 ± 0.785
1.768AspPro: 1.768 ± 0.706
3.646AspGln: 3.646 ± 0.964
1.271AspArg: 1.271 ± 0.379
3.315AspSer: 3.315 ± 0.346
2.265AspThr: 2.265 ± 0.21
3.315AspVal: 3.315 ± 0.499
0.663AspTrp: 0.663 ± 0.101
3.26AspTyr: 3.26 ± 0.64
0.0AspXaa: 0.0 ± 0.0
Glu
3.646GluAla: 3.646 ± 0.36
0.994GluCys: 0.994 ± 0.131
2.597GluAsp: 2.597 ± 0.249
5.912GluGlu: 5.912 ± 1.443
2.597GluPhe: 2.597 ± 0.246
1.657GluGly: 1.657 ± 0.385
1.215GluHis: 1.215 ± 0.262
2.099GluIle: 2.099 ± 0.14
3.425GluLys: 3.425 ± 0.724
4.365GluLeu: 4.365 ± 0.488
1.436GluMet: 1.436 ± 0.345
2.099GluAsn: 2.099 ± 0.504
2.099GluPro: 2.099 ± 0.614
3.702GluGln: 3.702 ± 0.886
0.939GluArg: 0.939 ± 0.215
2.762GluSer: 2.762 ± 0.356
3.315GluThr: 3.315 ± 0.447
3.425GluVal: 3.425 ± 0.633
0.939GluTrp: 0.939 ± 0.151
1.326GluTyr: 1.326 ± 0.145
0.0GluXaa: 0.0 ± 0.0
Phe
2.155PheAla: 2.155 ± 0.315
1.547PheCys: 1.547 ± 0.466
2.818PheAsp: 2.818 ± 0.236
2.044PheGlu: 2.044 ± 0.268
2.044PhePhe: 2.044 ± 0.187
2.652PheGly: 2.652 ± 0.224
1.05PheHis: 1.05 ± 0.169
3.757PheIle: 3.757 ± 0.627
2.928PheLys: 2.928 ± 0.34
3.591PheLeu: 3.591 ± 0.778
0.663PheMet: 0.663 ± 0.225
2.652PheAsn: 2.652 ± 1.0
1.326PhePro: 1.326 ± 0.345
1.547PheGln: 1.547 ± 0.561
1.547PheArg: 1.547 ± 0.361
3.481PheSer: 3.481 ± 0.327
2.707PheThr: 2.707 ± 0.351
3.481PheVal: 3.481 ± 0.921
0.276PheTrp: 0.276 ± 0.103
1.602PheTyr: 1.602 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
1.16GlyAla: 1.16 ± 0.404
0.663GlyCys: 0.663 ± 0.213
3.204GlyAsp: 3.204 ± 0.617
1.381GlyGlu: 1.381 ± 0.217
1.05GlyPhe: 1.05 ± 0.268
1.436GlyGly: 1.436 ± 0.618
0.829GlyHis: 0.829 ± 0.133
3.37GlyIle: 3.37 ± 0.464
3.757GlyLys: 3.757 ± 0.735
3.536GlyLeu: 3.536 ± 0.837
0.552GlyMet: 0.552 ± 0.225
3.149GlyAsn: 3.149 ± 0.359
1.436GlyPro: 1.436 ± 0.54
1.381GlyGln: 1.381 ± 0.243
1.768GlyArg: 1.768 ± 0.677
2.541GlySer: 2.541 ± 0.292
3.039GlyThr: 3.039 ± 0.79
2.32GlyVal: 2.32 ± 0.543
0.663GlyTrp: 0.663 ± 0.277
0.663GlyTyr: 0.663 ± 0.18
0.0GlyXaa: 0.0 ± 0.0
His
2.265HisAla: 2.265 ± 0.314
0.829HisCys: 0.829 ± 0.202
2.762HisAsp: 2.762 ± 0.551
1.768HisGlu: 1.768 ± 0.14
1.878HisPhe: 1.878 ± 0.289
1.492HisGly: 1.492 ± 0.159
2.099HisHis: 2.099 ± 0.457
1.436HisIle: 1.436 ± 0.256
1.547HisLys: 1.547 ± 0.243
2.707HisLeu: 2.707 ± 0.63
0.442HisMet: 0.442 ± 0.172
2.486HisAsn: 2.486 ± 0.301
0.884HisPro: 0.884 ± 0.217
2.928HisGln: 2.928 ± 0.914
0.884HisArg: 0.884 ± 0.216
1.602HisSer: 1.602 ± 0.294
2.265HisThr: 2.265 ± 0.307
1.436HisVal: 1.436 ± 0.442
0.552HisTrp: 0.552 ± 0.159
1.381HisTyr: 1.381 ± 0.282
0.0HisXaa: 0.0 ± 0.0
Ile
3.867IleAla: 3.867 ± 0.662
2.099IleCys: 2.099 ± 0.263
3.536IleAsp: 3.536 ± 0.735
3.039IleGlu: 3.039 ± 0.407
3.646IlePhe: 3.646 ± 0.3
2.044IleGly: 2.044 ± 0.174
1.492IleHis: 1.492 ± 0.243
3.37IleIle: 3.37 ± 0.604
5.138IleLys: 5.138 ± 0.496
4.53IleLeu: 4.53 ± 0.683
0.608IleMet: 0.608 ± 0.299
4.807IleAsn: 4.807 ± 0.816
2.541IlePro: 2.541 ± 0.308
3.149IleGln: 3.149 ± 0.309
2.265IleArg: 2.265 ± 0.421
3.425IleSer: 3.425 ± 0.303
4.199IleThr: 4.199 ± 0.712
3.481IleVal: 3.481 ± 0.846
1.105IleTrp: 1.105 ± 0.153
2.652IleTyr: 2.652 ± 0.168
0.0IleXaa: 0.0 ± 0.0
Lys
3.923LysAla: 3.923 ± 0.32
1.934LysCys: 1.934 ± 0.241
3.702LysAsp: 3.702 ± 0.318
3.646LysGlu: 3.646 ± 1.046
2.762LysPhe: 2.762 ± 0.354
1.713LysGly: 1.713 ± 0.184
2.099LysHis: 2.099 ± 0.307
3.26LysIle: 3.26 ± 0.712
2.928LysLys: 2.928 ± 0.423
5.414LysLeu: 5.414 ± 0.314
0.608LysMet: 0.608 ± 0.098
2.873LysAsn: 2.873 ± 0.254
4.807LysPro: 4.807 ± 0.521
7.182LysGln: 7.182 ± 1.088
1.934LysArg: 1.934 ± 0.294
3.702LysSer: 3.702 ± 0.545
4.033LysThr: 4.033 ± 0.412
5.691LysVal: 5.691 ± 0.425
0.994LysTrp: 0.994 ± 0.156
3.039LysTyr: 3.039 ± 0.373
0.0LysXaa: 0.0 ± 0.0
Leu
5.028LeuAla: 5.028 ± 0.482
2.265LeuCys: 2.265 ± 0.322
4.144LeuAsp: 4.144 ± 0.656
3.039LeuGlu: 3.039 ± 0.25
3.481LeuPhe: 3.481 ± 0.922
2.873LeuGly: 2.873 ± 0.776
2.652LeuHis: 2.652 ± 0.43
4.586LeuIle: 4.586 ± 1.362
3.812LeuLys: 3.812 ± 0.578
6.243LeuLeu: 6.243 ± 0.73
1.271LeuMet: 1.271 ± 0.262
5.635LeuAsn: 5.635 ± 0.411
3.094LeuPro: 3.094 ± 0.251
6.022LeuGln: 6.022 ± 0.602
3.646LeuArg: 3.646 ± 0.499
5.193LeuSer: 5.193 ± 0.656
5.635LeuThr: 5.635 ± 0.399
5.083LeuVal: 5.083 ± 0.772
0.552LeuTrp: 0.552 ± 0.386
3.149LeuTyr: 3.149 ± 0.327
0.0LeuXaa: 0.0 ± 0.0
Met
0.884MetAla: 0.884 ± 0.226
0.387MetCys: 0.387 ± 0.142
0.442MetAsp: 0.442 ± 0.176
0.387MetGlu: 0.387 ± 0.112
0.884MetPhe: 0.884 ± 0.247
0.276MetGly: 0.276 ± 0.366
0.221MetHis: 0.221 ± 0.053
0.552MetIle: 0.552 ± 0.235
0.552MetLys: 0.552 ± 0.266
1.989MetLeu: 1.989 ± 0.258
0.221MetMet: 0.221 ± 0.189
0.497MetAsn: 0.497 ± 0.11
0.884MetPro: 0.884 ± 0.239
1.768MetGln: 1.768 ± 0.539
0.773MetArg: 0.773 ± 0.169
1.215MetSer: 1.215 ± 0.272
1.713MetThr: 1.713 ± 0.115
0.663MetVal: 0.663 ± 0.12
0.0MetTrp: 0.0 ± 0.0
0.608MetTyr: 0.608 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
3.425AsnAla: 3.425 ± 0.445
1.547AsnCys: 1.547 ± 0.243
2.928AsnAsp: 2.928 ± 0.431
3.26AsnGlu: 3.26 ± 0.167
4.088AsnPhe: 4.088 ± 0.314
2.873AsnGly: 2.873 ± 0.708
1.878AsnHis: 1.878 ± 0.267
6.575AsnIle: 6.575 ± 0.593
4.53AsnLys: 4.53 ± 0.497
3.315AsnLeu: 3.315 ± 0.55
0.829AsnMet: 0.829 ± 0.133
4.751AsnAsn: 4.751 ± 0.334
1.713AsnPro: 1.713 ± 0.196
4.42AsnGln: 4.42 ± 0.268
2.265AsnArg: 2.265 ± 0.353
4.033AsnSer: 4.033 ± 0.331
5.856AsnThr: 5.856 ± 0.246
2.376AsnVal: 2.376 ± 0.519
0.718AsnTrp: 0.718 ± 0.135
3.425AsnTyr: 3.425 ± 0.402
0.0AsnXaa: 0.0 ± 0.0
Pro
2.928ProAla: 2.928 ± 0.112
0.552ProCys: 0.552 ± 0.082
1.823ProAsp: 1.823 ± 0.357
2.099ProGlu: 2.099 ± 0.224
1.215ProPhe: 1.215 ± 0.561
1.105ProGly: 1.105 ± 0.273
1.16ProHis: 1.16 ± 0.151
3.039ProIle: 3.039 ± 0.441
2.762ProLys: 2.762 ± 0.313
2.983ProLeu: 2.983 ± 0.323
0.497ProMet: 0.497 ± 0.427
1.657ProAsn: 1.657 ± 0.18
1.768ProPro: 1.768 ± 0.398
4.53ProGln: 4.53 ± 0.988
1.492ProArg: 1.492 ± 0.532
3.094ProSer: 3.094 ± 0.238
2.873ProThr: 2.873 ± 0.668
2.762ProVal: 2.762 ± 0.626
0.166ProTrp: 0.166 ± 0.084
1.16ProTyr: 1.16 ± 0.143
0.0ProXaa: 0.0 ± 0.0
Gln
5.691GlnAla: 5.691 ± 1.057
0.718GlnCys: 0.718 ± 0.143
2.597GlnAsp: 2.597 ± 0.298
6.022GlnGlu: 6.022 ± 1.887
1.657GlnPhe: 1.657 ± 0.629
2.155GlnGly: 2.155 ± 0.244
3.149GlnHis: 3.149 ± 0.756
2.32GlnIle: 2.32 ± 0.388
5.746GlnLys: 5.746 ± 1.457
6.133GlnLeu: 6.133 ± 0.663
1.768GlnMet: 1.768 ± 0.459
2.21GlnAsn: 2.21 ± 0.176
3.812GlnPro: 3.812 ± 0.554
26.851GlnGln: 26.851 ± 9.187
2.486GlnArg: 2.486 ± 0.454
4.365GlnSer: 4.365 ± 1.073
2.541GlnThr: 2.541 ± 0.205
4.309GlnVal: 4.309 ± 0.412
0.331GlnTrp: 0.331 ± 0.073
2.652GlnTyr: 2.652 ± 0.466
0.0GlnXaa: 0.0 ± 0.0
Arg
1.381ArgAla: 1.381 ± 0.346
0.718ArgCys: 0.718 ± 0.245
1.16ArgAsp: 1.16 ± 0.228
1.878ArgGlu: 1.878 ± 0.101
1.934ArgPhe: 1.934 ± 0.553
1.492ArgGly: 1.492 ± 0.194
1.878ArgHis: 1.878 ± 0.289
1.768ArgIle: 1.768 ± 0.449
2.818ArgLys: 2.818 ± 0.265
3.867ArgLeu: 3.867 ± 0.693
0.276ArgMet: 0.276 ± 0.102
2.265ArgAsn: 2.265 ± 0.283
1.602ArgPro: 1.602 ± 0.394
2.044ArgGln: 2.044 ± 0.334
1.05ArgArg: 1.05 ± 0.726
2.597ArgSer: 2.597 ± 0.295
2.707ArgThr: 2.707 ± 0.403
2.376ArgVal: 2.376 ± 0.548
0.0ArgTrp: 0.0 ± 0.0
1.547ArgTyr: 1.547 ± 0.379
0.0ArgXaa: 0.0 ± 0.0
Ser
2.707SerAla: 2.707 ± 0.573
1.271SerCys: 1.271 ± 0.419
3.37SerAsp: 3.37 ± 0.365
2.818SerGlu: 2.818 ± 0.437
2.32SerPhe: 2.32 ± 0.423
2.486SerGly: 2.486 ± 0.322
2.597SerHis: 2.597 ± 0.521
3.702SerIle: 3.702 ± 0.426
4.033SerLys: 4.033 ± 0.358
4.696SerLeu: 4.696 ± 0.234
0.994SerMet: 0.994 ± 0.352
5.691SerAsn: 5.691 ± 0.543
2.707SerPro: 2.707 ± 0.609
4.751SerGln: 4.751 ± 0.709
2.983SerArg: 2.983 ± 0.133
6.188SerSer: 6.188 ± 0.796
6.74SerThr: 6.74 ± 0.43
3.757SerVal: 3.757 ± 0.843
0.939SerTrp: 0.939 ± 0.114
2.486SerTyr: 2.486 ± 0.264
0.0SerXaa: 0.0 ± 0.0
Thr
5.746ThrAla: 5.746 ± 0.62
2.265ThrCys: 2.265 ± 0.511
3.204ThrAsp: 3.204 ± 0.626
3.149ThrGlu: 3.149 ± 0.185
1.381ThrPhe: 1.381 ± 0.183
3.425ThrGly: 3.425 ± 0.358
1.878ThrHis: 1.878 ± 0.193
4.53ThrIle: 4.53 ± 0.461
6.74ThrLys: 6.74 ± 0.315
4.641ThrLeu: 4.641 ± 0.412
0.442ThrMet: 0.442 ± 0.163
6.243ThrAsn: 6.243 ± 0.508
3.757ThrPro: 3.757 ± 0.186
3.26ThrGln: 3.26 ± 0.195
2.818ThrArg: 2.818 ± 0.581
6.077ThrSer: 6.077 ± 0.423
8.011ThrThr: 8.011 ± 0.672
4.862ThrVal: 4.862 ± 0.395
0.331ThrTrp: 0.331 ± 0.133
1.602ThrTyr: 1.602 ± 0.253
0.0ThrXaa: 0.0 ± 0.0
Val
2.983ValAla: 2.983 ± 0.485
1.934ValCys: 1.934 ± 0.598
3.039ValAsp: 3.039 ± 0.317
2.099ValGlu: 2.099 ± 0.162
3.26ValPhe: 3.26 ± 0.408
2.044ValGly: 2.044 ± 0.72
1.823ValHis: 1.823 ± 0.286
4.862ValIle: 4.862 ± 0.408
4.696ValLys: 4.696 ± 0.399
5.138ValLeu: 5.138 ± 0.808
1.05ValMet: 1.05 ± 0.377
4.641ValAsn: 4.641 ± 1.003
2.265ValPro: 2.265 ± 0.329
2.541ValGln: 2.541 ± 0.313
1.768ValArg: 1.768 ± 0.481
4.199ValSer: 4.199 ± 0.522
5.746ValThr: 5.746 ± 0.604
4.972ValVal: 4.972 ± 0.426
0.331ValTrp: 0.331 ± 0.109
3.591ValTyr: 3.591 ± 0.609
0.0ValXaa: 0.0 ± 0.0
Trp
0.387TrpAla: 0.387 ± 0.13
0.442TrpCys: 0.442 ± 0.105
0.829TrpAsp: 0.829 ± 0.193
0.387TrpGlu: 0.387 ± 0.13
1.105TrpPhe: 1.105 ± 0.122
0.331TrpGly: 0.331 ± 0.073
0.608TrpHis: 0.608 ± 0.107
0.221TrpIle: 0.221 ± 0.053
0.552TrpLys: 0.552 ± 0.159
0.608TrpLeu: 0.608 ± 0.223
0.11TrpMet: 0.11 ± 0.183
0.276TrpAsn: 0.276 ± 0.12
0.221TrpPro: 0.221 ± 0.088
0.718TrpGln: 0.718 ± 0.153
0.552TrpArg: 0.552 ± 0.247
0.718TrpSer: 0.718 ± 0.2
0.552TrpThr: 0.552 ± 0.221
0.442TrpVal: 0.442 ± 0.233
0.331TrpTrp: 0.331 ± 0.133
0.387TrpTyr: 0.387 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.044TyrAla: 2.044 ± 0.284
1.326TyrCys: 1.326 ± 0.152
2.099TyrAsp: 2.099 ± 0.459
2.099TyrGlu: 2.099 ± 0.428
2.597TyrPhe: 2.597 ± 0.422
2.431TyrGly: 2.431 ± 0.219
2.818TyrHis: 2.818 ± 0.183
2.155TyrIle: 2.155 ± 0.254
1.989TyrLys: 1.989 ± 0.207
3.425TyrLeu: 3.425 ± 0.299
0.829TyrMet: 0.829 ± 0.184
3.204TyrAsn: 3.204 ± 0.526
0.884TyrPro: 0.884 ± 0.481
1.823TyrGln: 1.823 ± 0.276
1.105TyrArg: 1.105 ± 0.261
1.934TyrSer: 1.934 ± 0.36
2.265TyrThr: 2.265 ± 0.324
2.32TyrVal: 2.32 ± 0.253
0.442TyrTrp: 0.442 ± 0.177
1.823TyrTyr: 1.823 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (18101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski