Amino acid dipepetide frequency for Calypte anna (Anna s hummingbird) (Archilochus anna)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.801AlaAla: 5.801 ± 0.045	1.301AlaCys: 1.301 ± 0.018	2.959AlaAsp: 2.959 ± 0.025	4.666AlaGlu: 4.666 ± 0.039	2.597AlaPhe: 2.597 ± 0.022	3.93AlaGly: 3.93 ± 0.03	1.37AlaHis: 1.37 ± 0.016	3.056AlaIle: 3.056 ± 0.027	3.696AlaLys: 3.696 ± 0.031	6.511AlaLeu: 6.511 ± 0.045	1.507AlaMet: 1.507 ± 0.017	2.199AlaAsn: 2.199 ± 0.019	3.004AlaPro: 3.004 ± 0.034	2.814AlaGln: 2.814 ± 0.028	3.008AlaArg: 3.008 ± 0.025	5.053AlaSer: 5.053 ± 0.034	3.308AlaThr: 3.308 ± 0.026	4.846AlaVal: 4.846 ± 0.037	0.721AlaTrp: 0.721 ± 0.01	1.614AlaTyr: 1.614 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.185CysAla: 1.185 ± 0.015	0.671CysCys: 0.671 ± 0.012	1.053CysAsp: 1.053 ± 0.018	1.303CysGlu: 1.303 ± 0.021	0.917CysPhe: 0.917 ± 0.015	1.474CysGly: 1.474 ± 0.023	0.662CysHis: 0.662 ± 0.013	1.155CysIle: 1.155 ± 0.016	1.306CysLys: 1.306 ± 0.015	2.237CysLeu: 2.237 ± 0.025	0.453CysMet: 0.453 ± 0.01	0.914CysAsn: 0.914 ± 0.014	1.322CysPro: 1.322 ± 0.024	1.122CysGln: 1.122 ± 0.019	1.231CysArg: 1.231 ± 0.016	2.057CysSer: 2.057 ± 0.022	1.182CysThr: 1.182 ± 0.018	1.393CysVal: 1.393 ± 0.023	0.304CysTrp: 0.304 ± 0.007	0.679CysTyr: 0.679 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	2.813AspAla: 2.813 ± 0.025	1.096AspCys: 1.096 ± 0.017	2.759AspAsp: 2.759 ± 0.033	3.577AspGlu: 3.577 ± 0.029	2.286AspPhe: 2.286 ± 0.022	3.254AspGly: 3.254 ± 0.033	1.163AspHis: 1.163 ± 0.015	2.956AspIle: 2.956 ± 0.023	2.761AspLys: 2.761 ± 0.025	5.047AspLeu: 5.047 ± 0.032	1.123AspMet: 1.123 ± 0.013	1.904AspAsn: 1.904 ± 0.026	2.689AspPro: 2.689 ± 0.022	1.809AspGln: 1.809 ± 0.02	2.341AspArg: 2.341 ± 0.026	4.097AspSer: 4.097 ± 0.032	2.539AspThr: 2.539 ± 0.021	3.186AspVal: 3.186 ± 0.028	0.656AspTrp: 0.656 ± 0.013	1.633AspTyr: 1.633 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.666GluAla: 4.666 ± 0.039	1.308GluCys: 1.308 ± 0.022	4.456GluAsp: 4.456 ± 0.038	8.017GluGlu: 8.017 ± 0.071	2.228GluPhe: 2.228 ± 0.019	4.088GluGly: 4.088 ± 0.04	1.58GluHis: 1.58 ± 0.019	3.501GluIle: 3.501 ± 0.032	5.777GluLys: 5.777 ± 0.052	6.432GluLeu: 6.432 ± 0.05	1.8GluMet: 1.8 ± 0.022	3.4GluAsn: 3.4 ± 0.028	2.606GluPro: 2.606 ± 0.027	3.292GluGln: 3.292 ± 0.035	3.976GluArg: 3.976 ± 0.034	4.458GluSer: 4.458 ± 0.035	3.474GluThr: 3.474 ± 0.029	4.419GluVal: 4.419 ± 0.029	0.754GluTrp: 0.754 ± 0.011	1.83GluTyr: 1.83 ± 0.021	0.001GluXaa: 0.001 ± 0.0
Phe	2.149PheAla: 2.149 ± 0.025	1.015PheCys: 1.015 ± 0.015	1.815PheAsp: 1.815 ± 0.019	2.121PheGlu: 2.121 ± 0.023	1.873PhePhe: 1.873 ± 0.024	2.356PheGly: 2.356 ± 0.025	1.107PheHis: 1.107 ± 0.015	2.109PheIle: 2.109 ± 0.022	2.052PheLys: 2.052 ± 0.023	4.27PheLeu: 4.27 ± 0.033	0.792PheMet: 0.792 ± 0.012	1.516PheAsn: 1.516 ± 0.018	2.022PhePro: 2.022 ± 0.02	1.863PheGln: 1.863 ± 0.021	1.924PheArg: 1.924 ± 0.021	3.522PheSer: 3.522 ± 0.024	2.249PheThr: 2.249 ± 0.025	2.368PheVal: 2.368 ± 0.023	0.534PheTrp: 0.534 ± 0.01	1.341PheTyr: 1.341 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.574GlyAla: 3.574 ± 0.034	1.293GlyCys: 1.293 ± 0.017	3.037GlyAsp: 3.037 ± 0.027	3.86GlyGlu: 3.86 ± 0.038	2.499GlyPhe: 2.499 ± 0.026	4.131GlyGly: 4.131 ± 0.045	1.597GlyHis: 1.597 ± 0.018	3.099GlyIle: 3.099 ± 0.023	4.127GlyLys: 4.127 ± 0.037	5.309GlyLeu: 5.309 ± 0.032	1.423GlyMet: 1.423 ± 0.019	2.555GlyAsn: 2.555 ± 0.025	2.777GlyPro: 2.777 ± 0.059	2.542GlyGln: 2.542 ± 0.026	3.269GlyArg: 3.269 ± 0.038	5.149GlySer: 5.149 ± 0.039	3.522GlyThr: 3.522 ± 0.031	3.558GlyVal: 3.558 ± 0.028	0.794GlyTrp: 0.794 ± 0.014	1.869GlyTyr: 1.869 ± 0.025	0.001GlyXaa: 0.001 ± 0.0
His	1.282HisAla: 1.282 ± 0.014	0.74HisCys: 0.74 ± 0.015	0.919HisAsp: 0.919 ± 0.011	1.351HisGlu: 1.351 ± 0.017	1.137HisPhe: 1.137 ± 0.015	1.526HisGly: 1.526 ± 0.017	0.911HisHis: 0.911 ± 0.017	1.345HisIle: 1.345 ± 0.017	1.377HisLys: 1.377 ± 0.019	2.921HisLeu: 2.921 ± 0.025	0.569HisMet: 0.569 ± 0.011	0.986HisAsn: 0.986 ± 0.013	1.607HisPro: 1.607 ± 0.021	1.233HisGln: 1.233 ± 0.016	1.49HisArg: 1.49 ± 0.016	2.221HisSer: 2.221 ± 0.022	1.358HisThr: 1.358 ± 0.02	1.515HisVal: 1.515 ± 0.017	0.36HisTrp: 0.36 ± 0.008	0.892HisTyr: 0.892 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	2.978IleAla: 2.978 ± 0.024	1.218IleCys: 1.218 ± 0.017	2.301IleAsp: 2.301 ± 0.021	2.849IleGlu: 2.849 ± 0.027	2.188IlePhe: 2.188 ± 0.026	2.438IleGly: 2.438 ± 0.025	1.405IleHis: 1.405 ± 0.013	2.742IleIle: 2.742 ± 0.027	3.01IleLys: 3.01 ± 0.027	5.008IleLeu: 5.008 ± 0.041	1.054IleMet: 1.054 ± 0.013	2.128IleAsn: 2.128 ± 0.022	2.89IlePro: 2.89 ± 0.027	2.461IleGln: 2.461 ± 0.023	2.569IleArg: 2.569 ± 0.021	4.09IleSer: 4.09 ± 0.031	2.878IleThr: 2.878 ± 0.025	2.83IleVal: 2.83 ± 0.024	0.592IleTrp: 0.592 ± 0.012	1.613IleTyr: 1.613 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.119LysAla: 4.119 ± 0.034	1.243LysCys: 1.243 ± 0.018	3.445LysAsp: 3.445 ± 0.03	5.829LysGlu: 5.829 ± 0.055	1.941LysPhe: 1.941 ± 0.019	3.546LysGly: 3.546 ± 0.042	1.576LysHis: 1.576 ± 0.017	3.15LysIle: 3.15 ± 0.026	5.444LysLys: 5.444 ± 0.055	5.732LysLeu: 5.732 ± 0.045	1.559LysMet: 1.559 ± 0.02	2.746LysAsn: 2.746 ± 0.022	3.069LysPro: 3.069 ± 0.03	2.969LysGln: 2.969 ± 0.033	3.57LysArg: 3.57 ± 0.035	4.211LysSer: 4.211 ± 0.034	3.337LysThr: 3.337 ± 0.027	3.75LysVal: 3.75 ± 0.027	0.679LysTrp: 0.679 ± 0.01	1.876LysTyr: 1.876 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.27LeuAla: 6.27 ± 0.041	2.281LeuCys: 2.281 ± 0.026	4.823LeuAsp: 4.823 ± 0.036	7.153LeuGlu: 7.153 ± 0.055	3.653LeuPhe: 3.653 ± 0.034	5.41LeuGly: 5.41 ± 0.029	2.752LeuHis: 2.752 ± 0.027	4.276LeuIle: 4.276 ± 0.035	6.408LeuLys: 6.408 ± 0.047	10.295LeuLeu: 10.295 ± 0.063	2.035LeuMet: 2.035 ± 0.019	3.804LeuAsn: 3.804 ± 0.029	5.531LeuPro: 5.531 ± 0.042	5.735LeuGln: 5.735 ± 0.053	5.241LeuArg: 5.241 ± 0.036	7.947LeuSer: 7.947 ± 0.049	4.957LeuThr: 4.957 ± 0.032	5.52LeuVal: 5.52 ± 0.039	1.122LeuTrp: 1.122 ± 0.016	2.834LeuTyr: 2.834 ± 0.024	0.001LeuXaa: 0.001 ± 0.0
Met	1.675MetAla: 1.675 ± 0.016	0.44MetCys: 0.44 ± 0.008	1.286MetAsp: 1.286 ± 0.014	1.894MetGlu: 1.894 ± 0.022	0.824MetPhe: 0.824 ± 0.012	1.307MetGly: 1.307 ± 0.018	0.497MetHis: 0.497 ± 0.009	0.957MetIle: 0.957 ± 0.014	1.613MetLys: 1.613 ± 0.018	2.031MetLeu: 2.031 ± 0.02	0.598MetMet: 0.598 ± 0.012	0.983MetAsn: 0.983 ± 0.014	1.003MetPro: 1.003 ± 0.014	0.996MetGln: 0.996 ± 0.014	1.068MetArg: 1.068 ± 0.02	1.545MetSer: 1.545 ± 0.016	1.126MetThr: 1.126 ± 0.014	1.467MetVal: 1.467 ± 0.017	0.25MetTrp: 0.25 ± 0.007	0.65MetTyr: 0.65 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.261AsnAla: 2.261 ± 0.021	0.962AsnCys: 0.962 ± 0.015	1.665AsnAsp: 1.665 ± 0.021	2.52AsnGlu: 2.52 ± 0.022	1.662AsnPhe: 1.662 ± 0.017	2.733AsnGly: 2.733 ± 0.028	0.998AsnHis: 0.998 ± 0.014	2.454AsnIle: 2.454 ± 0.024	2.565AsnLys: 2.565 ± 0.027	4.034AsnLeu: 4.034 ± 0.033	0.99AsnMet: 0.99 ± 0.012	1.791AsnAsn: 1.791 ± 0.02	2.314AsnPro: 2.314 ± 0.028	1.74AsnGln: 1.74 ± 0.018	1.952AsnArg: 1.952 ± 0.016	3.402AsnSer: 3.402 ± 0.028	2.214AsnThr: 2.214 ± 0.021	2.432AsnVal: 2.432 ± 0.019	0.494AsnTrp: 0.494 ± 0.009	1.27AsnTyr: 1.27 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	3.759ProAla: 3.759 ± 0.034	1.089ProCys: 1.089 ± 0.021	2.593ProAsp: 2.593 ± 0.023	3.925ProGlu: 3.925 ± 0.03	1.926ProPhe: 1.926 ± 0.022	3.855ProGly: 3.855 ± 0.07	1.33ProHis: 1.33 ± 0.018	1.971ProIle: 1.971 ± 0.022	2.768ProLys: 2.768 ± 0.032	4.766ProLeu: 4.766 ± 0.032	0.939ProMet: 0.939 ± 0.014	1.906ProAsn: 1.906 ± 0.021	4.413ProPro: 4.413 ± 0.064	2.424ProGln: 2.424 ± 0.029	2.551ProArg: 2.551 ± 0.021	5.022ProSer: 5.022 ± 0.043	2.656ProThr: 2.656 ± 0.029	3.737ProVal: 3.737 ± 0.032	0.594ProTrp: 0.594 ± 0.01	1.49ProTyr: 1.49 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.073GlnAla: 3.073 ± 0.033	1.001GlnCys: 1.001 ± 0.016	2.256GlnAsp: 2.256 ± 0.018	3.785GlnGlu: 3.785 ± 0.038	1.508GlnPhe: 1.508 ± 0.018	2.581GlnGly: 2.581 ± 0.028	1.357GlnHis: 1.357 ± 0.014	2.21GlnIle: 2.21 ± 0.02	3.185GlnLys: 3.185 ± 0.033	4.657GlnLeu: 4.657 ± 0.04	1.122GlnMet: 1.122 ± 0.014	2.025GlnAsn: 2.025 ± 0.02	2.388GlnPro: 2.388 ± 0.029	3.075GlnGln: 3.075 ± 0.05	2.708GlnArg: 2.708 ± 0.024	3.181GlnSer: 3.181 ± 0.027	2.394GlnThr: 2.394 ± 0.025	2.849GlnVal: 2.849 ± 0.023	0.538GlnTrp: 0.538 ± 0.009	1.314GlnTyr: 1.314 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	3.173ArgAla: 3.173 ± 0.029	1.125ArgCys: 1.125 ± 0.019	2.627ArgAsp: 2.627 ± 0.025	3.789ArgGlu: 3.789 ± 0.035	1.896ArgPhe: 1.896 ± 0.021	3.045ArgGly: 3.045 ± 0.036	1.435ArgHis: 1.435 ± 0.017	2.553ArgIle: 2.553 ± 0.022	4.012ArgLys: 4.012 ± 0.046	4.921ArgLeu: 4.921 ± 0.037	1.182ArgMet: 1.182 ± 0.016	2.217ArgAsn: 2.217 ± 0.02	2.414ArgPro: 2.414 ± 0.024	2.481ArgGln: 2.481 ± 0.025	3.784ArgArg: 3.784 ± 0.038	3.947ArgSer: 3.947 ± 0.039	2.646ArgThr: 2.646 ± 0.019	2.993ArgVal: 2.993 ± 0.027	0.637ArgTrp: 0.637 ± 0.011	1.597ArgTyr: 1.597 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	5.066SerAla: 5.066 ± 0.035	1.909SerCys: 1.909 ± 0.023	3.929SerAsp: 3.929 ± 0.034	5.066SerGlu: 5.066 ± 0.039	3.143SerPhe: 3.143 ± 0.025	4.983SerGly: 4.983 ± 0.034	2.068SerHis: 2.068 ± 0.019	3.625SerIle: 3.625 ± 0.028	4.437SerLys: 4.437 ± 0.034	8.032SerLeu: 8.032 ± 0.05	1.603SerMet: 1.603 ± 0.017	3.012SerAsn: 3.012 ± 0.028	5.241SerPro: 5.241 ± 0.048	3.727SerGln: 3.727 ± 0.034	4.11SerArg: 4.11 ± 0.035	9.229SerSer: 9.229 ± 0.076	4.523SerThr: 4.523 ± 0.044	4.995SerVal: 4.995 ± 0.032	1.029SerTrp: 1.029 ± 0.017	2.252SerTyr: 2.252 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	3.777ThrAla: 3.777 ± 0.031	1.304ThrCys: 1.304 ± 0.022	2.661ThrAsp: 2.661 ± 0.023	3.743ThrGlu: 3.743 ± 0.027	2.203ThrPhe: 2.203 ± 0.022	3.458ThrGly: 3.458 ± 0.03	1.231ThrHis: 1.231 ± 0.02	2.574ThrIle: 2.574 ± 0.023	2.869ThrLys: 2.869 ± 0.022	5.191ThrLeu: 5.191 ± 0.034	1.104ThrMet: 1.104 ± 0.015	1.936ThrAsn: 1.936 ± 0.019	3.114ThrPro: 3.114 ± 0.032	2.174ThrGln: 2.174 ± 0.021	2.358ThrArg: 2.358 ± 0.021	4.612ThrSer: 4.612 ± 0.032	2.99ThrThr: 2.99 ± 0.033	3.975ThrVal: 3.975 ± 0.035	0.692ThrTrp: 0.692 ± 0.012	1.547ThrTyr: 1.547 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	4.097ValAla: 4.097 ± 0.027	1.58ValCys: 1.58 ± 0.022	2.991ValAsp: 2.991 ± 0.027	3.986ValGlu: 3.986 ± 0.031	2.64ValPhe: 2.64 ± 0.027	3.391ValGly: 3.391 ± 0.033	1.572ValHis: 1.572 ± 0.018	3.244ValIle: 3.244 ± 0.029	3.784ValLys: 3.784 ± 0.028	6.446ValLeu: 6.446 ± 0.045	1.368ValMet: 1.368 ± 0.015	2.487ValAsn: 2.487 ± 0.025	3.48ValPro: 3.48 ± 0.028	2.859ValGln: 2.859 ± 0.025	2.958ValArg: 2.958 ± 0.023	4.931ValSer: 4.931 ± 0.031	3.87ValThr: 3.87 ± 0.031	4.284ValVal: 4.284 ± 0.033	0.739ValTrp: 0.739 ± 0.013	1.849ValTyr: 1.849 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.714TrpAla: 0.714 ± 0.012	0.263TrpCys: 0.263 ± 0.007	0.679TrpAsp: 0.679 ± 0.012	0.797TrpGlu: 0.797 ± 0.011	0.476TrpPhe: 0.476 ± 0.01	0.68TrpGly: 0.68 ± 0.016	0.319TrpHis: 0.319 ± 0.008	0.632TrpIle: 0.632 ± 0.011	0.899TrpLys: 0.899 ± 0.013	1.223TrpLeu: 1.223 ± 0.016	0.315TrpMet: 0.315 ± 0.007	0.636TrpAsn: 0.636 ± 0.012	0.443TrpPro: 0.443 ± 0.008	0.548TrpGln: 0.548 ± 0.011	0.666TrpArg: 0.666 ± 0.013	0.881TrpSer: 0.881 ± 0.014	0.646TrpThr: 0.646 ± 0.011	0.704TrpVal: 0.704 ± 0.013	0.203TrpTrp: 0.203 ± 0.006	0.374TrpTyr: 0.374 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.527TyrAla: 1.527 ± 0.016	0.78TyrCys: 0.78 ± 0.01	1.436TyrAsp: 1.436 ± 0.018	1.832TyrGlu: 1.832 ± 0.018	1.401TyrPhe: 1.401 ± 0.016	1.801TyrGly: 1.801 ± 0.022	0.809TyrHis: 0.809 ± 0.012	1.634TyrIle: 1.634 ± 0.017	1.703TyrLys: 1.703 ± 0.019	2.982TyrLeu: 2.982 ± 0.029	0.675TyrMet: 0.675 ± 0.011	1.307TyrAsn: 1.307 ± 0.018	1.387TyrPro: 1.387 ± 0.016	1.34TyrGln: 1.34 ± 0.017	1.7TyrArg: 1.7 ± 0.018	2.422TyrSer: 2.422 ± 0.021	1.643TyrThr: 1.643 ± 0.02	1.739TyrVal: 1.739 ± 0.018	0.407TyrTrp: 0.407 ± 0.011	1.114TyrTyr: 1.114 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.02XaaXaa: 0.02 ± 0.004

Statistics based on 13267 proteins (5940916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---