Amino acid dipepetide frequency for Arachidicoccus sp. BS20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.844AlaAla: 5.844 ± 0.096
0.595AlaCys: 0.595 ± 0.022
3.965AlaAsp: 3.965 ± 0.069
3.961AlaGlu: 3.961 ± 0.064
3.575AlaPhe: 3.575 ± 0.069
5.0AlaGly: 5.0 ± 0.073
1.255AlaHis: 1.255 ± 0.038
5.176AlaIle: 5.176 ± 0.087
5.013AlaLys: 5.013 ± 0.075
6.589AlaLeu: 6.589 ± 0.102
1.578AlaMet: 1.578 ± 0.046
3.998AlaAsn: 3.998 ± 0.073
2.255AlaPro: 2.255 ± 0.054
3.097AlaGln: 3.097 ± 0.059
2.249AlaArg: 2.249 ± 0.053
4.516AlaSer: 4.516 ± 0.074
4.114AlaThr: 4.114 ± 0.072
4.706AlaVal: 4.706 ± 0.084
0.775AlaTrp: 0.775 ± 0.03
2.971AlaTyr: 2.971 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.549CysAla: 0.549 ± 0.022
0.128CysCys: 0.128 ± 0.012
0.378CysAsp: 0.378 ± 0.02
0.393CysGlu: 0.393 ± 0.02
0.481CysPhe: 0.481 ± 0.025
0.665CysGly: 0.665 ± 0.027
0.157CysHis: 0.157 ± 0.014
0.658CysIle: 0.658 ± 0.024
0.526CysLys: 0.526 ± 0.024
0.779CysLeu: 0.779 ± 0.028
0.176CysMet: 0.176 ± 0.013
0.453CysAsn: 0.453 ± 0.023
0.293CysPro: 0.293 ± 0.017
0.172CysGln: 0.172 ± 0.012
0.286CysArg: 0.286 ± 0.017
0.552CysSer: 0.552 ± 0.022
0.451CysThr: 0.451 ± 0.021
0.489CysVal: 0.489 ± 0.021
0.085CysTrp: 0.085 ± 0.009
0.308CysTyr: 0.308 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.341AspAla: 4.341 ± 0.074
0.369AspCys: 0.369 ± 0.021
2.8AspAsp: 2.8 ± 0.067
3.759AspGlu: 3.759 ± 0.07
3.241AspPhe: 3.241 ± 0.065
3.536AspGly: 3.536 ± 0.073
0.606AspHis: 0.606 ± 0.022
4.235AspIle: 4.235 ± 0.064
4.331AspLys: 4.331 ± 0.069
4.326AspLeu: 4.326 ± 0.065
1.123AspMet: 1.123 ± 0.034
3.328AspAsn: 3.328 ± 0.061
1.477AspPro: 1.477 ± 0.043
0.949AspGln: 0.949 ± 0.03
1.616AspArg: 1.616 ± 0.044
3.756AspSer: 3.756 ± 0.079
2.898AspThr: 2.898 ± 0.064
3.591AspVal: 3.591 ± 0.065
0.866AspTrp: 0.866 ± 0.031
2.765AspTyr: 2.765 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.032GluAla: 4.032 ± 0.061
0.303GluCys: 0.303 ± 0.017
2.778GluAsp: 2.778 ± 0.062
3.73GluGlu: 3.73 ± 0.09
2.27GluPhe: 2.27 ± 0.045
2.839GluGly: 2.839 ± 0.059
1.134GluHis: 1.134 ± 0.034
4.53GluIle: 4.53 ± 0.075
5.318GluLys: 5.318 ± 0.099
5.253GluLeu: 5.253 ± 0.088
1.504GluMet: 1.504 ± 0.04
4.192GluAsn: 4.192 ± 0.072
1.48GluPro: 1.48 ± 0.037
2.534GluGln: 2.534 ± 0.059
2.265GluArg: 2.265 ± 0.056
2.688GluSer: 2.688 ± 0.049
3.067GluThr: 3.067 ± 0.062
3.258GluVal: 3.258 ± 0.064
0.674GluTrp: 0.674 ± 0.027
2.136GluTyr: 2.136 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.462PheAla: 3.462 ± 0.053
0.501PheCys: 0.501 ± 0.024
3.004PheAsp: 3.004 ± 0.054
2.549PheGlu: 2.549 ± 0.054
2.608PhePhe: 2.608 ± 0.074
3.639PheGly: 3.639 ± 0.063
0.928PheHis: 0.928 ± 0.03
3.997PheIle: 3.997 ± 0.075
3.148PheLys: 3.148 ± 0.062
4.608PheLeu: 4.608 ± 0.093
1.019PheMet: 1.019 ± 0.033
3.069PheAsn: 3.069 ± 0.059
1.915PhePro: 1.915 ± 0.047
1.562PheGln: 1.562 ± 0.041
1.807PheArg: 1.807 ± 0.048
4.131PheSer: 4.131 ± 0.071
3.026PheThr: 3.026 ± 0.058
3.184PheVal: 3.184 ± 0.057
0.667PheTrp: 0.667 ± 0.029
2.291PheTyr: 2.291 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.389GlyAla: 4.389 ± 0.077
0.567GlyCys: 0.567 ± 0.025
3.168GlyAsp: 3.168 ± 0.058
3.056GlyGlu: 3.056 ± 0.059
3.525GlyPhe: 3.525 ± 0.061
4.527GlyGly: 4.527 ± 0.101
1.1GlyHis: 1.1 ± 0.033
5.355GlyIle: 5.355 ± 0.072
5.468GlyLys: 5.468 ± 0.074
5.474GlyLeu: 5.474 ± 0.08
1.552GlyMet: 1.552 ± 0.042
4.227GlyAsn: 4.227 ± 0.073
1.083GlyPro: 1.083 ± 0.03
1.939GlyGln: 1.939 ± 0.046
2.253GlyArg: 2.253 ± 0.051
4.107GlySer: 4.107 ± 0.08
3.993GlyThr: 3.993 ± 0.067
4.038GlyVal: 4.038 ± 0.073
1.04GlyTrp: 1.04 ± 0.034
3.075GlyTyr: 3.075 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.153HisAla: 1.153 ± 0.032
0.171HisCys: 0.171 ± 0.012
0.924HisAsp: 0.924 ± 0.029
0.999HisGlu: 0.999 ± 0.031
1.251HisPhe: 1.251 ± 0.037
1.13HisGly: 1.13 ± 0.035
0.581HisHis: 0.581 ± 0.024
1.539HisIle: 1.539 ± 0.04
1.174HisLys: 1.174 ± 0.032
1.924HisLeu: 1.924 ± 0.047
0.295HisMet: 0.295 ± 0.015
1.089HisAsn: 1.089 ± 0.034
0.978HisPro: 0.978 ± 0.03
0.728HisGln: 0.728 ± 0.027
0.751HisArg: 0.751 ± 0.027
1.233HisSer: 1.233 ± 0.038
1.128HisThr: 1.128 ± 0.028
0.889HisVal: 0.889 ± 0.031
0.288HisTrp: 0.288 ± 0.015
0.969HisTyr: 0.969 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.912IleAla: 5.912 ± 0.088
0.672IleCys: 0.672 ± 0.025
4.611IleAsp: 4.611 ± 0.069
4.302IleGlu: 4.302 ± 0.07
3.663IlePhe: 3.663 ± 0.078
4.913IleGly: 4.913 ± 0.068
1.576IleHis: 1.576 ± 0.041
5.828IleIle: 5.828 ± 0.098
5.025IleLys: 5.025 ± 0.074
6.345IleLeu: 6.345 ± 0.091
1.292IleMet: 1.292 ± 0.042
4.582IleAsn: 4.582 ± 0.065
3.145IlePro: 3.145 ± 0.054
2.566IleGln: 2.566 ± 0.053
2.756IleArg: 2.756 ± 0.061
5.411IleSer: 5.411 ± 0.074
4.378IleThr: 4.378 ± 0.067
4.884IleVal: 4.884 ± 0.086
0.718IleTrp: 0.718 ± 0.027
2.829IleTyr: 2.829 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.734LysAla: 4.734 ± 0.077
0.351LysCys: 0.351 ± 0.018
4.498LysAsp: 4.498 ± 0.065
5.241LysGlu: 5.241 ± 0.087
2.784LysPhe: 2.784 ± 0.059
4.312LysGly: 4.312 ± 0.061
1.367LysHis: 1.367 ± 0.034
6.189LysIle: 6.189 ± 0.088
6.153LysLys: 6.153 ± 0.093
5.896LysLeu: 5.896 ± 0.075
1.97LysMet: 1.97 ± 0.049
5.531LysAsn: 5.531 ± 0.074
2.509LysPro: 2.509 ± 0.054
3.113LysGln: 3.113 ± 0.059
2.677LysArg: 2.677 ± 0.059
4.11LysSer: 4.11 ± 0.068
4.408LysThr: 4.408 ± 0.075
4.048LysVal: 4.048 ± 0.054
0.834LysTrp: 0.834 ± 0.031
3.358LysTyr: 3.358 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
5.945LeuAla: 5.945 ± 0.082
0.878LeuCys: 0.878 ± 0.03
4.56LeuAsp: 4.56 ± 0.073
4.548LeuGlu: 4.548 ± 0.085
4.898LeuPhe: 4.898 ± 0.091
5.382LeuGly: 5.382 ± 0.093
2.012LeuHis: 2.012 ± 0.048
6.24LeuIle: 6.24 ± 0.101
7.056LeuLys: 7.056 ± 0.106
9.115LeuLeu: 9.115 ± 0.129
2.034LeuMet: 2.034 ± 0.049
5.791LeuAsn: 5.791 ± 0.075
4.105LeuPro: 4.105 ± 0.059
4.354LeuGln: 4.354 ± 0.081
3.598LeuArg: 3.598 ± 0.067
7.084LeuSer: 7.084 ± 0.084
4.782LeuThr: 4.782 ± 0.075
4.796LeuVal: 4.796 ± 0.092
1.002LeuTrp: 1.002 ± 0.039
3.604LeuTyr: 3.604 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
1.463MetAla: 1.463 ± 0.038
0.163MetCys: 0.163 ± 0.013
1.061MetAsp: 1.061 ± 0.033
1.305MetGlu: 1.305 ± 0.038
0.923MetPhe: 0.923 ± 0.031
1.189MetGly: 1.189 ± 0.036
0.43MetHis: 0.43 ± 0.021
1.438MetIle: 1.438 ± 0.043
1.966MetLys: 1.966 ± 0.046
2.152MetLeu: 2.152 ± 0.053
0.604MetMet: 0.604 ± 0.026
1.452MetAsn: 1.452 ± 0.04
0.992MetPro: 0.992 ± 0.031
1.18MetGln: 1.18 ± 0.042
0.995MetArg: 0.995 ± 0.031
1.437MetSer: 1.437 ± 0.043
1.015MetThr: 1.015 ± 0.031
1.103MetVal: 1.103 ± 0.034
0.207MetTrp: 0.207 ± 0.015
0.734MetTyr: 0.734 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.642AsnAla: 4.642 ± 0.075
0.44AsnCys: 0.44 ± 0.02
3.509AsnAsp: 3.509 ± 0.061
3.576AsnGlu: 3.576 ± 0.061
3.066AsnPhe: 3.066 ± 0.064
4.322AsnGly: 4.322 ± 0.093
1.206AsnHis: 1.206 ± 0.033
5.416AsnIle: 5.416 ± 0.073
4.455AsnLys: 4.455 ± 0.072
5.201AsnLeu: 5.201 ± 0.08
1.22AsnMet: 1.22 ± 0.034
4.137AsnAsn: 4.137 ± 0.09
2.895AsnPro: 2.895 ± 0.055
2.037AsnGln: 2.037 ± 0.049
2.138AsnArg: 2.138 ± 0.052
3.628AsnSer: 3.628 ± 0.064
3.427AsnThr: 3.427 ± 0.064
3.827AsnVal: 3.827 ± 0.06
0.817AsnTrp: 0.817 ± 0.027
3.136AsnTyr: 3.136 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.743ProAla: 2.743 ± 0.059
0.254ProCys: 0.254 ± 0.016
2.418ProAsp: 2.418 ± 0.052
2.471ProGlu: 2.471 ± 0.055
1.978ProPhe: 1.978 ± 0.041
2.21ProGly: 2.21 ± 0.047
0.693ProHis: 0.693 ± 0.024
2.033ProIle: 2.033 ± 0.04
2.327ProLys: 2.327 ± 0.045
3.361ProLeu: 3.361 ± 0.059
0.727ProMet: 0.727 ± 0.027
2.105ProAsn: 2.105 ± 0.054
1.027ProPro: 1.027 ± 0.035
1.554ProGln: 1.554 ± 0.04
0.98ProArg: 0.98 ± 0.031
2.255ProSer: 2.255 ± 0.046
1.945ProThr: 1.945 ± 0.05
2.845ProVal: 2.845 ± 0.056
0.391ProTrp: 0.391 ± 0.022
1.683ProTyr: 1.683 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
2.436GlnAla: 2.436 ± 0.053
0.192GlnCys: 0.192 ± 0.014
1.607GlnAsp: 1.607 ± 0.041
1.788GlnGlu: 1.788 ± 0.051
1.812GlnPhe: 1.812 ± 0.043
1.928GlnGly: 1.928 ± 0.044
0.846GlnHis: 0.846 ± 0.027
2.799GlnIle: 2.799 ± 0.054
2.968GlnLys: 2.968 ± 0.061
3.96GlnLeu: 3.96 ± 0.065
0.956GlnMet: 0.956 ± 0.029
2.559GlnAsn: 2.559 ± 0.051
1.535GlnPro: 1.535 ± 0.041
2.428GlnGln: 2.428 ± 0.059
1.553GlnArg: 1.553 ± 0.044
2.63GlnSer: 2.63 ± 0.057
2.362GlnThr: 2.362 ± 0.05
1.913GlnVal: 1.913 ± 0.048
0.44GlnTrp: 0.44 ± 0.021
1.752GlnTyr: 1.752 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.267ArgAla: 2.267 ± 0.052
0.229ArgCys: 0.229 ± 0.014
1.708ArgAsp: 1.708 ± 0.038
2.074ArgGlu: 2.074 ± 0.057
1.936ArgPhe: 1.936 ± 0.042
1.978ArgGly: 1.978 ± 0.041
0.671ArgHis: 0.671 ± 0.028
2.776ArgIle: 2.776 ± 0.054
3.075ArgLys: 3.075 ± 0.06
3.577ArgLeu: 3.577 ± 0.064
0.956ArgMet: 0.956 ± 0.028
2.289ArgAsn: 2.289 ± 0.053
1.099ArgPro: 1.099 ± 0.032
1.414ArgGln: 1.414 ± 0.038
1.456ArgArg: 1.456 ± 0.041
1.954ArgSer: 1.954 ± 0.045
1.938ArgThr: 1.938 ± 0.043
2.029ArgVal: 2.029 ± 0.054
0.499ArgTrp: 0.499 ± 0.02
1.765ArgTyr: 1.765 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.794SerAla: 4.794 ± 0.078
0.626SerCys: 0.626 ± 0.025
3.526SerAsp: 3.526 ± 0.06
3.277SerGlu: 3.277 ± 0.06
3.924SerPhe: 3.924 ± 0.063
4.763SerGly: 4.763 ± 0.083
1.146SerHis: 1.146 ± 0.035
4.964SerIle: 4.964 ± 0.074
4.132SerLys: 4.132 ± 0.07
6.564SerLeu: 6.564 ± 0.08
1.272SerMet: 1.272 ± 0.036
3.742SerAsn: 3.742 ± 0.066
2.294SerPro: 2.294 ± 0.049
2.148SerGln: 2.148 ± 0.047
2.12SerArg: 2.12 ± 0.05
4.719SerSer: 4.719 ± 0.101
3.599SerThr: 3.599 ± 0.065
4.662SerVal: 4.662 ± 0.067
0.834SerTrp: 0.834 ± 0.028
2.942SerTyr: 2.942 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.259ThrAla: 4.259 ± 0.074
0.334ThrCys: 0.334 ± 0.019
3.234ThrAsp: 3.234 ± 0.064
2.892ThrGlu: 2.892 ± 0.051
2.792ThrPhe: 2.792 ± 0.053
4.329ThrGly: 4.329 ± 0.07
1.088ThrHis: 1.088 ± 0.035
4.397ThrIle: 4.397 ± 0.071
3.659ThrLys: 3.659 ± 0.057
5.346ThrLeu: 5.346 ± 0.066
0.998ThrMet: 0.998 ± 0.031
3.131ThrAsn: 3.131 ± 0.07
2.476ThrPro: 2.476 ± 0.056
2.101ThrGln: 2.101 ± 0.045
1.715ThrArg: 1.715 ± 0.041
3.651ThrSer: 3.651 ± 0.074
3.536ThrThr: 3.536 ± 0.088
3.85ThrVal: 3.85 ± 0.074
0.636ThrTrp: 0.636 ± 0.028
2.437ThrTyr: 2.437 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.56ValAla: 4.56 ± 0.072
0.659ValCys: 0.659 ± 0.025
3.129ValAsp: 3.129 ± 0.062
3.338ValGlu: 3.338 ± 0.067
3.192ValPhe: 3.192 ± 0.068
3.549ValGly: 3.549 ± 0.066
1.204ValHis: 1.204 ± 0.044
4.276ValIle: 4.276 ± 0.077
4.228ValLys: 4.228 ± 0.063
5.948ValLeu: 5.948 ± 0.097
1.334ValMet: 1.334 ± 0.043
3.582ValAsn: 3.582 ± 0.07
2.438ValPro: 2.438 ± 0.056
2.194ValGln: 2.194 ± 0.045
2.22ValArg: 2.22 ± 0.043
4.432ValSer: 4.432 ± 0.077
3.473ValThr: 3.473 ± 0.069
4.044ValVal: 4.044 ± 0.079
0.76ValTrp: 0.76 ± 0.03
2.538ValTyr: 2.538 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.761TrpAla: 0.761 ± 0.026
0.151TrpCys: 0.151 ± 0.014
0.638TrpAsp: 0.638 ± 0.026
0.612TrpGlu: 0.612 ± 0.026
0.615TrpPhe: 0.615 ± 0.028
0.81TrpGly: 0.81 ± 0.034
0.303TrpHis: 0.303 ± 0.019
0.841TrpIle: 0.841 ± 0.031
0.976TrpLys: 0.976 ± 0.033
1.341TrpLeu: 1.341 ± 0.039
0.362TrpMet: 0.362 ± 0.019
0.911TrpAsn: 0.911 ± 0.035
0.193TrpPro: 0.193 ± 0.017
0.647TrpGln: 0.647 ± 0.031
0.507TrpArg: 0.507 ± 0.024
0.686TrpSer: 0.686 ± 0.026
0.67TrpThr: 0.67 ± 0.027
0.593TrpVal: 0.593 ± 0.024
0.208TrpTrp: 0.208 ± 0.015
0.514TrpTyr: 0.514 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.946TyrAla: 2.946 ± 0.054
0.393TyrCys: 0.393 ± 0.018
2.395TyrAsp: 2.395 ± 0.059
2.114TyrGlu: 2.114 ± 0.047
2.582TyrPhe: 2.582 ± 0.052
2.914TyrGly: 2.914 ± 0.061
0.893TyrHis: 0.893 ± 0.032
2.725TyrIle: 2.725 ± 0.049
3.088TyrLys: 3.088 ± 0.059
4.026TyrLeu: 4.026 ± 0.059
0.833TyrMet: 0.833 ± 0.032
2.927TyrAsn: 2.927 ± 0.07
1.809TyrPro: 1.809 ± 0.043
1.749TyrGln: 1.749 ± 0.042
1.747TyrArg: 1.747 ± 0.041
3.069TyrSer: 3.069 ± 0.06
2.654TyrThr: 2.654 ± 0.064
2.347TyrVal: 2.347 ± 0.04
0.596TyrTrp: 0.596 ± 0.026
2.157TyrTyr: 2.157 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2946 proteins (1021605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski