Amino acid dipepetide frequency for Moraxella phage Mcat1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.623AlaAla: 3.623 ± 0.851
0.576AlaCys: 0.576 ± 0.303
6.011AlaAsp: 6.011 ± 0.554
3.211AlaGlu: 3.211 ± 0.459
3.705AlaPhe: 3.705 ± 0.654
4.446AlaGly: 4.446 ± 0.67
1.729AlaHis: 1.729 ± 0.473
6.834AlaIle: 6.834 ± 0.643
7.822AlaLys: 7.822 ± 0.903
7.493AlaLeu: 7.493 ± 0.642
2.552AlaMet: 2.552 ± 0.533
4.611AlaAsn: 4.611 ± 0.824
2.552AlaPro: 2.552 ± 0.526
4.529AlaGln: 4.529 ± 0.592
3.376AlaArg: 3.376 ± 0.713
6.175AlaSer: 6.175 ± 0.8
6.422AlaThr: 6.422 ± 1.189
6.422AlaVal: 6.422 ± 0.63
1.729AlaTrp: 1.729 ± 0.353
3.047AlaTyr: 3.047 ± 0.458
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.21
0.165CysCys: 0.165 ± 0.123
0.659CysAsp: 0.659 ± 0.215
0.906CysGlu: 0.906 ± 0.305
0.412CysPhe: 0.412 ± 0.212
1.153CysGly: 1.153 ± 0.402
0.329CysHis: 0.329 ± 0.176
0.494CysIle: 0.494 ± 0.204
0.494CysLys: 0.494 ± 0.194
0.741CysLeu: 0.741 ± 0.286
0.082CysMet: 0.082 ± 0.084
0.247CysAsn: 0.247 ± 0.159
0.659CysPro: 0.659 ± 0.272
0.412CysGln: 0.412 ± 0.183
0.329CysArg: 0.329 ± 0.157
0.659CysSer: 0.659 ± 0.237
0.412CysThr: 0.412 ± 0.211
0.741CysVal: 0.741 ± 0.273
0.0CysTrp: 0.0 ± 0.0
0.741CysTyr: 0.741 ± 0.303
0.0CysXaa: 0.0 ± 0.0
Asp
3.623AspAla: 3.623 ± 0.493
0.823AspCys: 0.823 ± 0.421
5.846AspAsp: 5.846 ± 0.946
5.434AspGlu: 5.434 ± 0.935
3.047AspPhe: 3.047 ± 0.579
5.764AspGly: 5.764 ± 0.582
0.823AspHis: 0.823 ± 0.294
3.952AspIle: 3.952 ± 0.587
5.681AspLys: 5.681 ± 0.699
4.776AspLeu: 4.776 ± 0.566
1.4AspMet: 1.4 ± 0.442
4.611AspAsn: 4.611 ± 0.565
1.4AspPro: 1.4 ± 0.373
1.4AspGln: 1.4 ± 0.355
1.729AspArg: 1.729 ± 0.375
2.717AspSer: 2.717 ± 0.465
3.623AspThr: 3.623 ± 0.586
2.223AspVal: 2.223 ± 0.447
0.823AspTrp: 0.823 ± 0.245
2.47AspTyr: 2.47 ± 0.528
0.0AspXaa: 0.0 ± 0.0
Glu
3.294GluAla: 3.294 ± 0.597
0.906GluCys: 0.906 ± 0.335
1.07GluAsp: 1.07 ± 0.302
1.482GluGlu: 1.482 ± 0.535
2.552GluPhe: 2.552 ± 0.461
2.141GluGly: 2.141 ± 0.485
1.647GluHis: 1.647 ± 0.432
4.446GluIle: 4.446 ± 0.656
3.458GluLys: 3.458 ± 0.821
6.422GluLeu: 6.422 ± 0.625
1.729GluMet: 1.729 ± 0.461
2.305GluAsn: 2.305 ± 0.426
2.058GluPro: 2.058 ± 0.523
4.035GluGln: 4.035 ± 0.447
3.294GluArg: 3.294 ± 0.68
2.964GluSer: 2.964 ± 0.498
2.223GluThr: 2.223 ± 0.283
2.717GluVal: 2.717 ± 0.51
0.659GluTrp: 0.659 ± 0.247
2.141GluTyr: 2.141 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
4.199PheAla: 4.199 ± 0.493
0.741PheCys: 0.741 ± 0.253
3.047PheAsp: 3.047 ± 0.601
2.47PheGlu: 2.47 ± 0.384
0.988PhePhe: 0.988 ± 0.216
3.047PheGly: 3.047 ± 0.374
0.741PheHis: 0.741 ± 0.257
2.964PheIle: 2.964 ± 0.594
1.976PheLys: 1.976 ± 0.341
2.552PheLeu: 2.552 ± 0.573
1.153PheMet: 1.153 ± 0.329
1.482PheAsn: 1.482 ± 0.366
0.741PhePro: 0.741 ± 0.219
0.329PheGln: 0.329 ± 0.159
1.317PheArg: 1.317 ± 0.314
2.141PheSer: 2.141 ± 0.334
1.482PheThr: 1.482 ± 0.327
1.894PheVal: 1.894 ± 0.416
0.576PheTrp: 0.576 ± 0.221
1.564PheTyr: 1.564 ± 0.34
0.0PheXaa: 0.0 ± 0.0
Gly
4.611GlyAla: 4.611 ± 0.725
0.576GlyCys: 0.576 ± 0.221
4.611GlyAsp: 4.611 ± 0.575
4.529GlyGlu: 4.529 ± 0.658
2.552GlyPhe: 2.552 ± 0.491
5.434GlyGly: 5.434 ± 0.616
1.07GlyHis: 1.07 ± 0.31
4.529GlyIle: 4.529 ± 0.695
4.776GlyLys: 4.776 ± 0.466
5.517GlyLeu: 5.517 ± 0.646
2.058GlyMet: 2.058 ± 0.415
3.788GlyAsn: 3.788 ± 0.696
0.0GlyPro: 0.0 ± 0.0
2.552GlyGln: 2.552 ± 0.59
3.376GlyArg: 3.376 ± 0.611
3.541GlySer: 3.541 ± 0.423
3.623GlyThr: 3.623 ± 0.795
5.517GlyVal: 5.517 ± 0.652
1.564GlyTrp: 1.564 ± 0.341
2.8GlyTyr: 2.8 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
2.717HisAla: 2.717 ± 0.504
0.165HisCys: 0.165 ± 0.094
1.235HisAsp: 1.235 ± 0.365
1.811HisGlu: 1.811 ± 0.324
0.823HisPhe: 0.823 ± 0.259
2.47HisGly: 2.47 ± 0.515
0.906HisHis: 0.906 ± 0.294
1.482HisIle: 1.482 ± 0.372
1.235HisLys: 1.235 ± 0.314
1.894HisLeu: 1.894 ± 0.403
0.412HisMet: 0.412 ± 0.148
1.4HisAsn: 1.4 ± 0.355
0.906HisPro: 0.906 ± 0.322
0.823HisGln: 0.823 ± 0.242
1.317HisArg: 1.317 ± 0.335
1.153HisSer: 1.153 ± 0.256
2.552HisThr: 2.552 ± 0.586
0.659HisVal: 0.659 ± 0.223
0.329HisTrp: 0.329 ± 0.18
0.906HisTyr: 0.906 ± 0.263
0.0HisXaa: 0.0 ± 0.0
Ile
6.505IleAla: 6.505 ± 0.969
0.576IleCys: 0.576 ± 0.243
5.928IleAsp: 5.928 ± 0.511
2.8IleGlu: 2.8 ± 0.484
2.305IlePhe: 2.305 ± 0.483
5.27IleGly: 5.27 ± 0.689
0.988IleHis: 0.988 ± 0.291
4.117IleIle: 4.117 ± 0.559
5.105IleLys: 5.105 ± 0.8
4.035IleLeu: 4.035 ± 0.72
1.07IleMet: 1.07 ± 0.262
5.187IleAsn: 5.187 ± 1.09
2.964IlePro: 2.964 ± 0.599
2.141IleGln: 2.141 ± 0.364
3.129IleArg: 3.129 ± 0.514
5.434IleSer: 5.434 ± 0.963
5.681IleThr: 5.681 ± 0.747
2.8IleVal: 2.8 ± 0.594
0.494IleTrp: 0.494 ± 0.215
2.552IleTyr: 2.552 ± 0.603
0.0IleXaa: 0.0 ± 0.0
Lys
6.834LysAla: 6.834 ± 0.826
0.412LysCys: 0.412 ± 0.208
3.623LysAsp: 3.623 ± 0.633
4.035LysGlu: 4.035 ± 0.619
2.305LysPhe: 2.305 ± 0.418
3.541LysGly: 3.541 ± 0.579
1.894LysHis: 1.894 ± 0.332
4.94LysIle: 4.94 ± 0.603
4.364LysLys: 4.364 ± 0.701
5.352LysLeu: 5.352 ± 0.684
1.729LysMet: 1.729 ± 0.463
2.8LysAsn: 2.8 ± 0.583
2.8LysPro: 2.8 ± 0.548
3.952LysGln: 3.952 ± 0.525
3.458LysArg: 3.458 ± 0.549
4.776LysSer: 4.776 ± 0.569
5.105LysThr: 5.105 ± 0.722
4.117LysVal: 4.117 ± 0.575
0.823LysTrp: 0.823 ± 0.339
1.894LysTyr: 1.894 ± 0.384
0.0LysXaa: 0.0 ± 0.0
Leu
7.74LeuAla: 7.74 ± 1.232
1.07LeuCys: 1.07 ± 0.369
6.175LeuAsp: 6.175 ± 0.644
2.882LeuGlu: 2.882 ± 0.479
2.635LeuPhe: 2.635 ± 0.523
6.175LeuGly: 6.175 ± 0.66
1.976LeuHis: 1.976 ± 0.505
5.928LeuIle: 5.928 ± 0.867
5.023LeuLys: 5.023 ± 0.657
5.928LeuLeu: 5.928 ± 0.78
1.647LeuMet: 1.647 ± 0.411
4.858LeuAsn: 4.858 ± 0.752
3.376LeuPro: 3.376 ± 0.629
3.623LeuGln: 3.623 ± 0.542
3.458LeuArg: 3.458 ± 0.452
6.916LeuSer: 6.916 ± 0.671
6.752LeuThr: 6.752 ± 0.756
4.776LeuVal: 4.776 ± 0.585
0.659LeuTrp: 0.659 ± 0.214
2.552LeuTyr: 2.552 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
2.388MetAla: 2.388 ± 0.481
0.165MetCys: 0.165 ± 0.127
1.235MetAsp: 1.235 ± 0.305
0.165MetGlu: 0.165 ± 0.102
0.823MetPhe: 0.823 ± 0.248
1.482MetGly: 1.482 ± 0.276
0.576MetHis: 0.576 ± 0.272
1.4MetIle: 1.4 ± 0.389
1.07MetLys: 1.07 ± 0.264
1.976MetLeu: 1.976 ± 0.572
0.659MetMet: 0.659 ± 0.287
1.153MetAsn: 1.153 ± 0.256
0.988MetPro: 0.988 ± 0.294
1.482MetGln: 1.482 ± 0.43
0.741MetArg: 0.741 ± 0.27
2.717MetSer: 2.717 ± 0.567
1.894MetThr: 1.894 ± 0.439
0.906MetVal: 0.906 ± 0.225
0.329MetTrp: 0.329 ± 0.16
0.576MetTyr: 0.576 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
5.352AsnAla: 5.352 ± 0.837
0.247AsnCys: 0.247 ± 0.159
2.388AsnAsp: 2.388 ± 0.488
2.717AsnGlu: 2.717 ± 0.415
1.647AsnPhe: 1.647 ± 0.36
3.623AsnGly: 3.623 ± 0.849
1.482AsnHis: 1.482 ± 0.32
2.552AsnIle: 2.552 ± 0.378
4.199AsnLys: 4.199 ± 0.721
3.788AsnLeu: 3.788 ± 0.63
0.823AsnMet: 0.823 ± 0.27
3.623AsnAsn: 3.623 ± 0.7
3.129AsnPro: 3.129 ± 0.659
3.541AsnGln: 3.541 ± 0.665
1.894AsnArg: 1.894 ± 0.36
3.952AsnSer: 3.952 ± 0.836
3.623AsnThr: 3.623 ± 0.841
2.717AsnVal: 2.717 ± 0.513
0.576AsnTrp: 0.576 ± 0.199
2.223AsnTyr: 2.223 ± 0.386
0.0AsnXaa: 0.0 ± 0.0
Pro
3.376ProAla: 3.376 ± 0.586
0.329ProCys: 0.329 ± 0.201
1.976ProAsp: 1.976 ± 0.361
1.235ProGlu: 1.235 ± 0.354
1.4ProPhe: 1.4 ± 0.347
0.165ProGly: 0.165 ± 0.122
0.494ProHis: 0.494 ± 0.182
2.141ProIle: 2.141 ± 0.463
3.129ProLys: 3.129 ± 0.616
3.047ProLeu: 3.047 ± 0.599
0.988ProMet: 0.988 ± 0.214
2.223ProAsn: 2.223 ± 0.413
1.4ProPro: 1.4 ± 0.41
1.811ProGln: 1.811 ± 0.424
1.482ProArg: 1.482 ± 0.266
2.47ProSer: 2.47 ± 0.629
3.211ProThr: 3.211 ± 0.522
2.305ProVal: 2.305 ± 0.386
0.247ProTrp: 0.247 ± 0.138
0.988ProTyr: 0.988 ± 0.33
0.0ProXaa: 0.0 ± 0.0
Gln
5.517GlnAla: 5.517 ± 0.719
0.412GlnCys: 0.412 ± 0.196
2.223GlnAsp: 2.223 ± 0.44
1.894GlnGlu: 1.894 ± 0.362
1.564GlnPhe: 1.564 ± 0.333
3.129GlnGly: 3.129 ± 0.618
0.823GlnHis: 0.823 ± 0.224
4.035GlnIle: 4.035 ± 0.542
3.952GlnLys: 3.952 ± 0.57
3.87GlnLeu: 3.87 ± 0.576
1.07GlnMet: 1.07 ± 0.323
3.211GlnAsn: 3.211 ± 0.559
1.235GlnPro: 1.235 ± 0.336
1.647GlnGln: 1.647 ± 0.442
1.729GlnArg: 1.729 ± 0.468
3.788GlnSer: 3.788 ± 0.854
2.964GlnThr: 2.964 ± 0.337
1.976GlnVal: 1.976 ± 0.431
0.329GlnTrp: 0.329 ± 0.126
1.317GlnTyr: 1.317 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
4.529ArgAla: 4.529 ± 1.067
0.329ArgCys: 0.329 ± 0.143
2.058ArgAsp: 2.058 ± 0.39
2.141ArgGlu: 2.141 ± 0.406
2.141ArgPhe: 2.141 ± 0.538
1.811ArgGly: 1.811 ± 0.419
1.976ArgHis: 1.976 ± 0.351
3.129ArgIle: 3.129 ± 0.787
2.305ArgLys: 2.305 ± 0.482
4.364ArgLeu: 4.364 ± 0.606
0.988ArgMet: 0.988 ± 0.281
0.988ArgAsn: 0.988 ± 0.233
1.729ArgPro: 1.729 ± 0.402
3.129ArgGln: 3.129 ± 0.352
2.141ArgArg: 2.141 ± 0.412
2.635ArgSer: 2.635 ± 0.444
2.882ArgThr: 2.882 ± 0.477
2.388ArgVal: 2.388 ± 0.444
0.165ArgTrp: 0.165 ± 0.11
1.729ArgTyr: 1.729 ± 0.298
0.0ArgXaa: 0.0 ± 0.0
Ser
5.681SerAla: 5.681 ± 0.727
0.659SerCys: 0.659 ± 0.294
4.199SerAsp: 4.199 ± 0.576
4.282SerGlu: 4.282 ± 0.507
1.729SerPhe: 1.729 ± 0.363
4.529SerGly: 4.529 ± 0.835
3.047SerHis: 3.047 ± 0.9
4.94SerIle: 4.94 ± 0.773
3.788SerLys: 3.788 ± 0.568
6.34SerLeu: 6.34 ± 0.958
1.317SerMet: 1.317 ± 0.229
3.211SerAsn: 3.211 ± 0.641
1.317SerPro: 1.317 ± 0.478
3.541SerGln: 3.541 ± 0.484
2.882SerArg: 2.882 ± 0.439
3.788SerSer: 3.788 ± 0.963
3.376SerThr: 3.376 ± 0.394
5.764SerVal: 5.764 ± 0.889
0.906SerTrp: 0.906 ± 0.321
1.729SerTyr: 1.729 ± 0.439
0.0SerXaa: 0.0 ± 0.0
Thr
6.505ThrAla: 6.505 ± 0.759
0.329ThrCys: 0.329 ± 0.159
4.282ThrAsp: 4.282 ± 0.594
3.705ThrGlu: 3.705 ± 0.571
1.647ThrPhe: 1.647 ± 0.321
5.352ThrGly: 5.352 ± 0.825
2.141ThrHis: 2.141 ± 0.437
3.705ThrIle: 3.705 ± 0.466
5.434ThrLys: 5.434 ± 0.927
6.752ThrLeu: 6.752 ± 0.801
1.153ThrMet: 1.153 ± 0.296
3.376ThrAsn: 3.376 ± 0.634
3.541ThrPro: 3.541 ± 0.654
2.635ThrGln: 2.635 ± 0.594
2.305ThrArg: 2.305 ± 0.48
4.364ThrSer: 4.364 ± 1.003
4.446ThrThr: 4.446 ± 0.842
3.87ThrVal: 3.87 ± 0.916
0.659ThrTrp: 0.659 ± 0.186
0.741ThrTyr: 0.741 ± 0.248
0.0ThrXaa: 0.0 ± 0.0
Val
5.105ValAla: 5.105 ± 0.649
0.659ValCys: 0.659 ± 0.231
2.8ValAsp: 2.8 ± 0.536
2.717ValGlu: 2.717 ± 0.46
2.141ValPhe: 2.141 ± 0.398
5.023ValGly: 5.023 ± 0.665
1.07ValHis: 1.07 ± 0.272
4.693ValIle: 4.693 ± 0.73
2.964ValLys: 2.964 ± 0.624
4.693ValLeu: 4.693 ± 0.592
0.988ValMet: 0.988 ± 0.33
2.8ValAsn: 2.8 ± 0.522
2.141ValPro: 2.141 ± 0.431
2.388ValGln: 2.388 ± 0.366
3.376ValArg: 3.376 ± 0.66
4.446ValSer: 4.446 ± 0.626
3.788ValThr: 3.788 ± 0.796
3.047ValVal: 3.047 ± 0.628
0.906ValTrp: 0.906 ± 0.235
2.223ValTyr: 2.223 ± 0.301
0.0ValXaa: 0.0 ± 0.0
Trp
1.482TrpAla: 1.482 ± 0.287
0.412TrpCys: 0.412 ± 0.2
0.659TrpAsp: 0.659 ± 0.242
0.988TrpGlu: 0.988 ± 0.315
0.329TrpPhe: 0.329 ± 0.15
0.659TrpGly: 0.659 ± 0.253
0.329TrpHis: 0.329 ± 0.176
0.247TrpIle: 0.247 ± 0.156
0.494TrpLys: 0.494 ± 0.213
1.317TrpLeu: 1.317 ± 0.35
0.0TrpMet: 0.0 ± 0.0
0.494TrpAsn: 0.494 ± 0.178
0.0TrpPro: 0.0 ± 0.0
1.235TrpGln: 1.235 ± 0.489
0.494TrpArg: 0.494 ± 0.212
0.741TrpSer: 0.741 ± 0.294
0.741TrpThr: 0.741 ± 0.192
1.4TrpVal: 1.4 ± 0.394
0.247TrpTrp: 0.247 ± 0.144
0.329TrpTyr: 0.329 ± 0.134
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.376TyrAla: 3.376 ± 0.527
0.494TyrCys: 0.494 ± 0.226
2.141TyrAsp: 2.141 ± 0.497
2.223TyrGlu: 2.223 ± 0.393
0.659TyrPhe: 0.659 ± 0.21
1.811TyrGly: 1.811 ± 0.36
1.153TyrHis: 1.153 ± 0.336
2.552TyrIle: 2.552 ± 0.551
1.482TyrLys: 1.482 ± 0.352
3.294TyrLeu: 3.294 ± 0.677
0.823TyrMet: 0.823 ± 0.235
1.729TyrAsn: 1.729 ± 0.415
1.482TyrPro: 1.482 ± 0.339
1.482TyrGln: 1.482 ± 0.363
1.729TyrArg: 1.729 ± 0.342
1.647TyrSer: 1.647 ± 0.385
2.141TyrThr: 2.141 ± 0.415
1.729TyrVal: 1.729 ± 0.307
0.576TyrTrp: 0.576 ± 0.2
1.235TyrTyr: 1.235 ± 0.387
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski