Amino acid dipepetide frequency for Paenibacillus pectinilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.768AlaAla: 7.768 ± 0.083	0.695AlaCys: 0.695 ± 0.015	4.118AlaAsp: 4.118 ± 0.05	4.677AlaGlu: 4.677 ± 0.057	3.317AlaPhe: 3.317 ± 0.041	6.068AlaGly: 6.068 ± 0.073	1.487AlaHis: 1.487 ± 0.027	5.685AlaIle: 5.685 ± 0.059	4.402AlaLys: 4.402 ± 0.055	7.684AlaLeu: 7.684 ± 0.07	2.259AlaMet: 2.259 ± 0.035	3.28AlaAsn: 3.28 ± 0.054	2.687AlaPro: 2.687 ± 0.04	2.881AlaGln: 2.881 ± 0.041	2.926AlaArg: 2.926 ± 0.04	5.634AlaSer: 5.634 ± 0.065	4.6AlaThr: 4.6 ± 0.089	5.797AlaVal: 5.797 ± 0.059	1.015AlaTrp: 1.015 ± 0.023	2.793AlaTyr: 2.793 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.503CysAla: 0.503 ± 0.016	0.098CysCys: 0.098 ± 0.007	0.364CysAsp: 0.364 ± 0.011	0.448CysGlu: 0.448 ± 0.015	0.307CysPhe: 0.307 ± 0.012	0.645CysGly: 0.645 ± 0.019	0.185CysHis: 0.185 ± 0.01	0.461CysIle: 0.461 ± 0.013	0.31CysLys: 0.31 ± 0.013	0.744CysLeu: 0.744 ± 0.018	0.211CysMet: 0.211 ± 0.01	0.248CysAsn: 0.248 ± 0.012	0.297CysPro: 0.297 ± 0.014	0.25CysGln: 0.25 ± 0.01	0.346CysArg: 0.346 ± 0.014	0.537CysSer: 0.537 ± 0.016	0.41CysThr: 0.41 ± 0.015	0.474CysVal: 0.474 ± 0.014	0.092CysTrp: 0.092 ± 0.007	0.26CysTyr: 0.26 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.066AspAla: 4.066 ± 0.051	0.343AspCys: 0.343 ± 0.014	2.402AspAsp: 2.402 ± 0.043	3.461AspGlu: 3.461 ± 0.052	2.281AspPhe: 2.281 ± 0.031	3.996AspGly: 3.996 ± 0.06	1.183AspHis: 1.183 ± 0.027	3.599AspIle: 3.599 ± 0.039	2.744AspLys: 2.744 ± 0.041	4.935AspLeu: 4.935 ± 0.054	1.415AspMet: 1.415 ± 0.027	2.008AspAsn: 2.008 ± 0.038	2.306AspPro: 2.306 ± 0.032	2.144AspGln: 2.144 ± 0.033	2.378AspArg: 2.378 ± 0.037	2.891AspSer: 2.891 ± 0.04	2.756AspThr: 2.756 ± 0.038	3.804AspVal: 3.804 ± 0.047	0.924AspTrp: 0.924 ± 0.021	2.124AspTyr: 2.124 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.34GluAla: 5.34 ± 0.063	0.333GluCys: 0.333 ± 0.013	2.907GluAsp: 2.907 ± 0.043	4.354GluGlu: 4.354 ± 0.071	2.069GluPhe: 2.069 ± 0.031	3.913GluGly: 3.913 ± 0.047	1.465GluHis: 1.465 ± 0.03	4.149GluIle: 4.149 ± 0.052	3.685GluLys: 3.685 ± 0.046	6.47GluLeu: 6.47 ± 0.07	1.89GluMet: 1.89 ± 0.033	2.339GluAsn: 2.339 ± 0.034	1.906GluPro: 1.906 ± 0.03	3.198GluGln: 3.198 ± 0.056	3.204GluArg: 3.204 ± 0.048	3.36GluSer: 3.36 ± 0.04	3.13GluThr: 3.13 ± 0.039	4.175GluVal: 4.175 ± 0.055	0.808GluTrp: 0.808 ± 0.018	1.659GluTyr: 1.659 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.215PheAla: 3.215 ± 0.037	0.322PheCys: 0.322 ± 0.011	2.341PheAsp: 2.341 ± 0.033	2.384PheGlu: 2.384 ± 0.034	1.811PhePhe: 1.811 ± 0.033	3.091PheGly: 3.091 ± 0.04	1.026PheHis: 1.026 ± 0.021	3.176PheIle: 3.176 ± 0.053	2.193PheLys: 2.193 ± 0.037	3.919PheLeu: 3.919 ± 0.049	1.183PheMet: 1.183 ± 0.025	1.803PheAsn: 1.803 ± 0.035	1.649PhePro: 1.649 ± 0.03	1.697PheGln: 1.697 ± 0.033	1.851PheArg: 1.851 ± 0.027	2.861PheSer: 2.861 ± 0.038	2.815PheThr: 2.815 ± 0.04	3.005PheVal: 3.005 ± 0.037	0.536PheTrp: 0.536 ± 0.015	1.621PheTyr: 1.621 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.466GlyAla: 5.466 ± 0.098	0.664GlyCys: 0.664 ± 0.019	3.456GlyAsp: 3.456 ± 0.046	3.927GlyGlu: 3.927 ± 0.044	3.313GlyPhe: 3.313 ± 0.037	5.144GlyGly: 5.144 ± 0.077	1.508GlyHis: 1.508 ± 0.031	5.576GlyIle: 5.576 ± 0.061	4.381GlyLys: 4.381 ± 0.054	6.936GlyLeu: 6.936 ± 0.06	2.164GlyMet: 2.164 ± 0.032	2.964GlyAsn: 2.964 ± 0.045	1.902GlyPro: 1.902 ± 0.038	2.665GlyGln: 2.665 ± 0.04	2.884GlyArg: 2.884 ± 0.038	4.857GlySer: 4.857 ± 0.052	4.883GlyThr: 4.883 ± 0.084	5.223GlyVal: 5.223 ± 0.057	1.079GlyTrp: 1.079 ± 0.026	2.891GlyTyr: 2.891 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.648HisAla: 1.648 ± 0.031	0.201HisCys: 0.201 ± 0.01	1.015HisAsp: 1.015 ± 0.024	1.231HisGlu: 1.231 ± 0.024	1.188HisPhe: 1.188 ± 0.022	1.484HisGly: 1.484 ± 0.029	0.623HisHis: 0.623 ± 0.017	1.573HisIle: 1.573 ± 0.029	0.895HisLys: 0.895 ± 0.021	2.157HisLeu: 2.157 ± 0.036	0.59HisMet: 0.59 ± 0.019	0.762HisAsn: 0.762 ± 0.019	1.12HisPro: 1.12 ± 0.024	0.877HisGln: 0.877 ± 0.021	1.021HisArg: 1.021 ± 0.022	1.192HisSer: 1.192 ± 0.027	1.198HisThr: 1.198 ± 0.024	1.605HisVal: 1.605 ± 0.025	0.333HisTrp: 0.333 ± 0.013	0.955HisTyr: 0.955 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.803IleAla: 5.803 ± 0.059	0.617IleCys: 0.617 ± 0.016	3.8IleAsp: 3.8 ± 0.039	4.183IleGlu: 4.183 ± 0.049	2.544IlePhe: 2.544 ± 0.038	5.309IleGly: 5.309 ± 0.058	1.655IleHis: 1.655 ± 0.029	4.464IleIle: 4.464 ± 0.052	3.139IleLys: 3.139 ± 0.039	6.184IleLeu: 6.184 ± 0.071	1.71IleMet: 1.71 ± 0.028	2.761IleAsn: 2.761 ± 0.044	3.233IlePro: 3.233 ± 0.041	2.969IleGln: 2.969 ± 0.043	3.537IleArg: 3.537 ± 0.049	4.952IleSer: 4.952 ± 0.054	4.272IleThr: 4.272 ± 0.051	5.208IleVal: 5.208 ± 0.058	0.807IleTrp: 0.807 ± 0.018	2.22IleTyr: 2.22 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.34LysAla: 4.34 ± 0.047	0.223LysCys: 0.223 ± 0.01	3.168LysAsp: 3.168 ± 0.044	3.971LysGlu: 3.971 ± 0.053	1.763LysPhe: 1.763 ± 0.032	3.715LysGly: 3.715 ± 0.039	1.142LysHis: 1.142 ± 0.023	3.269LysIle: 3.269 ± 0.043	3.447LysLys: 3.447 ± 0.054	5.62LysLeu: 5.62 ± 0.052	1.762LysMet: 1.762 ± 0.031	2.213LysAsn: 2.213 ± 0.033	2.26LysPro: 2.26 ± 0.032	2.632LysGln: 2.632 ± 0.036	2.516LysArg: 2.516 ± 0.033	3.245LysSer: 3.245 ± 0.04	2.856LysThr: 2.856 ± 0.044	3.779LysVal: 3.779 ± 0.052	0.765LysTrp: 0.765 ± 0.02	1.825LysTyr: 1.825 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	7.879LeuAla: 7.879 ± 0.069	0.771LeuCys: 0.771 ± 0.017	5.018LeuAsp: 5.018 ± 0.053	5.518LeuGlu: 5.518 ± 0.06	4.498LeuPhe: 4.498 ± 0.06	6.542LeuGly: 6.542 ± 0.065	2.214LeuHis: 2.214 ± 0.035	6.684LeuIle: 6.684 ± 0.075	5.221LeuLys: 5.221 ± 0.05	10.347LeuLeu: 10.347 ± 0.1	2.585LeuMet: 2.585 ± 0.041	4.028LeuAsn: 4.028 ± 0.048	4.434LeuPro: 4.434 ± 0.048	4.435LeuGln: 4.435 ± 0.064	4.461LeuArg: 4.461 ± 0.061	7.076LeuSer: 7.076 ± 0.057	6.171LeuThr: 6.171 ± 0.059	6.413LeuVal: 6.413 ± 0.061	1.024LeuTrp: 1.024 ± 0.024	3.179LeuTyr: 3.179 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.148MetAla: 2.148 ± 0.031	0.157MetCys: 0.157 ± 0.008	1.581MetAsp: 1.581 ± 0.027	1.668MetGlu: 1.668 ± 0.027	1.105MetPhe: 1.105 ± 0.02	1.815MetGly: 1.815 ± 0.029	0.5MetHis: 0.5 ± 0.015	2.014MetIle: 2.014 ± 0.034	2.087MetLys: 2.087 ± 0.033	2.839MetLeu: 2.839 ± 0.038	0.919MetMet: 0.919 ± 0.02	1.514MetAsn: 1.514 ± 0.027	1.171MetPro: 1.171 ± 0.022	1.064MetGln: 1.064 ± 0.022	1.249MetArg: 1.249 ± 0.027	1.878MetSer: 1.878 ± 0.029	1.795MetThr: 1.795 ± 0.031	1.77MetVal: 1.77 ± 0.027	0.26MetTrp: 0.26 ± 0.011	0.881MetTyr: 0.881 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.114AsnAla: 3.114 ± 0.052	0.262AsnCys: 0.262 ± 0.012	2.119AsnAsp: 2.119 ± 0.038	2.587AsnGlu: 2.587 ± 0.035	1.651AsnPhe: 1.651 ± 0.03	3.593AsnGly: 3.593 ± 0.07	0.912AsnHis: 0.912 ± 0.017	2.532AsnIle: 2.532 ± 0.036	2.284AsnLys: 2.284 ± 0.033	3.664AsnLeu: 3.664 ± 0.042	1.138AsnMet: 1.138 ± 0.019	1.927AsnAsn: 1.927 ± 0.045	2.17AsnPro: 2.17 ± 0.035	1.783AsnGln: 1.783 ± 0.03	1.969AsnArg: 1.969 ± 0.029	2.485AsnSer: 2.485 ± 0.047	2.531AsnThr: 2.531 ± 0.052	3.05AsnVal: 3.05 ± 0.046	0.706AsnTrp: 0.706 ± 0.022	1.668AsnTyr: 1.668 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.165ProAla: 3.165 ± 0.048	0.214ProCys: 0.214 ± 0.01	2.367ProAsp: 2.367 ± 0.034	2.725ProGlu: 2.725 ± 0.04	1.916ProPhe: 1.916 ± 0.029	2.601ProGly: 2.601 ± 0.04	0.909ProHis: 0.909 ± 0.021	2.863ProIle: 2.863 ± 0.036	1.854ProLys: 1.854 ± 0.029	3.837ProLeu: 3.837 ± 0.045	1.016ProMet: 1.016 ± 0.022	1.766ProAsn: 1.766 ± 0.035	1.161ProPro: 1.161 ± 0.025	1.436ProGln: 1.436 ± 0.025	1.28ProArg: 1.28 ± 0.029	2.811ProSer: 2.811 ± 0.037	2.526ProThr: 2.526 ± 0.05	2.982ProVal: 2.982 ± 0.045	0.545ProTrp: 0.545 ± 0.016	1.564ProTyr: 1.564 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.503GlnAla: 3.503 ± 0.047	0.2GlnCys: 0.2 ± 0.01	1.942GlnAsp: 1.942 ± 0.03	2.605GlnGlu: 2.605 ± 0.046	1.72GlnPhe: 1.72 ± 0.03	2.77GlnGly: 2.77 ± 0.044	0.906GlnHis: 0.906 ± 0.024	2.838GlnIle: 2.838 ± 0.041	2.06GlnLys: 2.06 ± 0.034	4.483GlnLeu: 4.483 ± 0.052	1.28GlnMet: 1.28 ± 0.026	1.489GlnAsn: 1.489 ± 0.029	1.557GlnPro: 1.557 ± 0.029	1.993GlnGln: 1.993 ± 0.052	1.72GlnArg: 1.72 ± 0.033	2.535GlnSer: 2.535 ± 0.037	2.426GlnThr: 2.426 ± 0.037	2.913GlnVal: 2.913 ± 0.08	0.562GlnTrp: 0.562 ± 0.018	1.363GlnTyr: 1.363 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.951ArgAla: 2.951 ± 0.037	0.293ArgCys: 0.293 ± 0.013	2.174ArgAsp: 2.174 ± 0.031	2.982ArgGlu: 2.982 ± 0.044	2.002ArgPhe: 2.002 ± 0.036	2.598ArgGly: 2.598 ± 0.045	0.894ArgHis: 0.894 ± 0.023	3.483ArgIle: 3.483 ± 0.045	2.783ArgLys: 2.783 ± 0.039	4.408ArgLeu: 4.408 ± 0.059	1.526ArgMet: 1.526 ± 0.028	1.961ArgAsn: 1.961 ± 0.035	1.412ArgPro: 1.412 ± 0.028	1.666ArgGln: 1.666 ± 0.035	2.031ArgArg: 2.031 ± 0.042	2.747ArgSer: 2.747 ± 0.04	2.505ArgThr: 2.505 ± 0.036	2.983ArgVal: 2.983 ± 0.039	0.617ArgTrp: 0.617 ± 0.016	1.72ArgTyr: 1.72 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	4.845SerAla: 4.845 ± 0.056	0.415SerCys: 0.415 ± 0.014	3.353SerAsp: 3.353 ± 0.045	3.662SerGlu: 3.662 ± 0.047	3.146SerPhe: 3.146 ± 0.043	5.326SerGly: 5.326 ± 0.059	1.351SerHis: 1.351 ± 0.028	4.599SerIle: 4.599 ± 0.046	3.598SerLys: 3.598 ± 0.046	6.758SerLeu: 6.758 ± 0.062	1.826SerMet: 1.826 ± 0.032	2.805SerAsn: 2.805 ± 0.047	2.537SerPro: 2.537 ± 0.039	2.362SerGln: 2.362 ± 0.038	2.664SerArg: 2.664 ± 0.039	4.974SerSer: 4.974 ± 0.072	4.0SerThr: 4.0 ± 0.06	4.656SerVal: 4.656 ± 0.054	0.954SerTrp: 0.954 ± 0.025	2.554SerTyr: 2.554 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.976ThrAla: 4.976 ± 0.071	0.388ThrCys: 0.388 ± 0.014	3.216ThrAsp: 3.216 ± 0.053	3.076ThrGlu: 3.076 ± 0.036	2.704ThrPhe: 2.704 ± 0.039	4.873ThrGly: 4.873 ± 0.131	1.133ThrHis: 1.133 ± 0.023	4.314ThrIle: 4.314 ± 0.058	2.891ThrLys: 2.891 ± 0.04	5.866ThrLeu: 5.866 ± 0.055	1.527ThrMet: 1.527 ± 0.025	2.7ThrAsn: 2.7 ± 0.055	2.798ThrPro: 2.798 ± 0.049	1.952ThrGln: 1.952 ± 0.034	2.147ThrArg: 2.147 ± 0.029	4.222ThrSer: 4.222 ± 0.063	3.85ThrThr: 3.85 ± 0.067	4.721ThrVal: 4.721 ± 0.073	0.865ThrTrp: 0.865 ± 0.02	2.437ThrTyr: 2.437 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.395ValAla: 5.395 ± 0.06	0.607ValCys: 0.607 ± 0.017	3.808ValAsp: 3.808 ± 0.044	4.05ValGlu: 4.05 ± 0.059	2.865ValPhe: 2.865 ± 0.039	4.781ValGly: 4.781 ± 0.051	1.431ValHis: 1.431 ± 0.026	5.046ValIle: 5.046 ± 0.049	3.987ValLys: 3.987 ± 0.04	6.73ValLeu: 6.73 ± 0.062	1.972ValMet: 1.972 ± 0.025	3.187ValAsn: 3.187 ± 0.051	2.989ValPro: 2.989 ± 0.041	2.827ValGln: 2.827 ± 0.079	3.09ValArg: 3.09 ± 0.039	4.994ValSer: 4.994 ± 0.047	4.976ValThr: 4.976 ± 0.087	5.118ValVal: 5.118 ± 0.062	0.853ValTrp: 0.853 ± 0.022	2.464ValTyr: 2.464 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.874TrpAla: 0.874 ± 0.023	0.11TrpCys: 0.11 ± 0.007	0.756TrpAsp: 0.756 ± 0.021	0.734TrpGlu: 0.734 ± 0.021	0.589TrpPhe: 0.589 ± 0.017	0.918TrpGly: 0.918 ± 0.022	0.342TrpHis: 0.342 ± 0.012	0.898TrpIle: 0.898 ± 0.018	0.759TrpLys: 0.759 ± 0.019	1.419TrpLeu: 1.419 ± 0.027	0.465TrpMet: 0.465 ± 0.016	0.743TrpAsn: 0.743 ± 0.02	0.393TrpPro: 0.393 ± 0.016	0.598TrpGln: 0.598 ± 0.017	0.589TrpArg: 0.589 ± 0.018	0.929TrpSer: 0.929 ± 0.023	0.801TrpThr: 0.801 ± 0.023	0.894TrpVal: 0.894 ± 0.022	0.202TrpTrp: 0.202 ± 0.01	0.468TrpTyr: 0.468 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.772TyrAla: 2.772 ± 0.04	0.277TyrCys: 0.277 ± 0.012	1.853TyrAsp: 1.853 ± 0.032	2.112TyrGlu: 2.112 ± 0.035	1.711TyrPhe: 1.711 ± 0.029	2.7TyrGly: 2.7 ± 0.036	0.805TyrHis: 0.805 ± 0.019	2.145TyrIle: 2.145 ± 0.038	1.788TyrLys: 1.788 ± 0.035	3.499TyrLeu: 3.499 ± 0.035	0.982TyrMet: 0.982 ± 0.021	1.645TyrAsn: 1.645 ± 0.037	1.552TyrPro: 1.552 ± 0.028	1.437TyrGln: 1.437 ± 0.024	1.872TyrArg: 1.872 ± 0.033	2.204TyrSer: 2.204 ± 0.039	2.155TyrThr: 2.155 ± 0.042	2.602TyrVal: 2.602 ± 0.034	0.533TyrTrp: 0.533 ± 0.014	1.463TyrTyr: 1.463 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6496 proteins (2286042 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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