Amino acid dipepetide frequency for Euzebyella marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.411AlaAla: 4.411 ± 0.07	0.571AlaCys: 0.571 ± 0.024	3.608AlaAsp: 3.608 ± 0.067	4.318AlaGlu: 4.318 ± 0.065	3.224AlaPhe: 3.224 ± 0.051	4.299AlaGly: 4.299 ± 0.075	1.233AlaHis: 1.233 ± 0.032	5.064AlaIle: 5.064 ± 0.076	4.408AlaLys: 4.408 ± 0.068	6.442AlaLeu: 6.442 ± 0.093	1.651AlaMet: 1.651 ± 0.04	3.459AlaAsn: 3.459 ± 0.06	2.109AlaPro: 2.109 ± 0.047	2.603AlaGln: 2.603 ± 0.044	2.152AlaArg: 2.152 ± 0.036	4.299AlaSer: 4.299 ± 0.061	3.596AlaThr: 3.596 ± 0.071	4.179AlaVal: 4.179 ± 0.068	0.666AlaTrp: 0.666 ± 0.024	2.568AlaTyr: 2.568 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.461CysAla: 0.461 ± 0.02	0.096CysCys: 0.096 ± 0.009	0.453CysAsp: 0.453 ± 0.052	0.492CysGlu: 0.492 ± 0.026	0.36CysPhe: 0.36 ± 0.016	0.57CysGly: 0.57 ± 0.021	0.204CysHis: 0.204 ± 0.014	0.514CysIle: 0.514 ± 0.021	0.421CysLys: 0.421 ± 0.021	0.644CysLeu: 0.644 ± 0.026	0.158CysMet: 0.158 ± 0.011	0.364CysAsn: 0.364 ± 0.02	0.304CysPro: 0.304 ± 0.016	0.248CysGln: 0.248 ± 0.013	0.224CysArg: 0.224 ± 0.014	0.578CysSer: 0.578 ± 0.023	0.436CysThr: 0.436 ± 0.025	0.38CysVal: 0.38 ± 0.018	0.065CysTrp: 0.065 ± 0.007	0.299CysTyr: 0.299 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.717AspAla: 3.717 ± 0.057	0.429AspCys: 0.429 ± 0.026	3.353AspAsp: 3.353 ± 0.081	4.102AspGlu: 4.102 ± 0.066	3.709AspPhe: 3.709 ± 0.062	4.641AspGly: 4.641 ± 0.203	1.047AspHis: 1.047 ± 0.029	4.315AspIle: 4.315 ± 0.056	3.679AspLys: 3.679 ± 0.057	5.458AspLeu: 5.458 ± 0.065	1.269AspMet: 1.269 ± 0.035	3.073AspAsn: 3.073 ± 0.067	2.049AspPro: 2.049 ± 0.06	1.895AspGln: 1.895 ± 0.045	2.253AspArg: 2.253 ± 0.042	3.706AspSer: 3.706 ± 0.087	2.838AspThr: 2.838 ± 0.066	3.647AspVal: 3.647 ± 0.05	0.886AspTrp: 0.886 ± 0.027	2.864AspTyr: 2.864 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.572GluAla: 4.572 ± 0.061	0.338GluCys: 0.338 ± 0.017	3.827GluAsp: 3.827 ± 0.057	5.511GluGlu: 5.511 ± 0.075	2.935GluPhe: 2.935 ± 0.049	4.457GluGly: 4.457 ± 0.064	1.287GluHis: 1.287 ± 0.032	5.309GluIle: 5.309 ± 0.074	5.813GluLys: 5.813 ± 0.088	6.547GluLeu: 6.547 ± 0.09	1.739GluMet: 1.739 ± 0.037	4.71GluAsn: 4.71 ± 0.058	1.991GluPro: 1.991 ± 0.042	2.482GluGln: 2.482 ± 0.044	2.96GluArg: 2.96 ± 0.055	3.758GluSer: 3.758 ± 0.06	3.613GluThr: 3.613 ± 0.05	4.798GluVal: 4.798 ± 0.067	0.751GluTrp: 0.751 ± 0.026	2.413GluTyr: 2.413 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.957PheAla: 2.957 ± 0.052	0.417PheCys: 0.417 ± 0.018	3.366PheAsp: 3.366 ± 0.055	3.605PheGlu: 3.605 ± 0.056	2.681PhePhe: 2.681 ± 0.052	3.669PheGly: 3.669 ± 0.062	0.877PheHis: 0.877 ± 0.03	3.373PheIle: 3.373 ± 0.062	3.312PheLys: 3.312 ± 0.06	4.791PheLeu: 4.791 ± 0.066	1.128PheMet: 1.128 ± 0.031	2.88PheAsn: 2.88 ± 0.058	1.756PhePro: 1.756 ± 0.036	1.599PheGln: 1.599 ± 0.036	1.756PheArg: 1.756 ± 0.036	3.808PheSer: 3.808 ± 0.058	2.88PheThr: 2.88 ± 0.049	2.902PheVal: 2.902 ± 0.055	0.619PheTrp: 0.619 ± 0.021	2.087PheTyr: 2.087 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.493GlyAla: 4.493 ± 0.076	0.61GlyCys: 0.61 ± 0.027	3.905GlyAsp: 3.905 ± 0.097	4.209GlyGlu: 4.209 ± 0.061	3.613GlyPhe: 3.613 ± 0.057	4.903GlyGly: 4.903 ± 0.09	1.431GlyHis: 1.431 ± 0.036	5.348GlyIle: 5.348 ± 0.071	4.876GlyLys: 4.876 ± 0.07	6.369GlyLeu: 6.369 ± 0.072	1.72GlyMet: 1.72 ± 0.044	3.753GlyAsn: 3.753 ± 0.068	1.637GlyPro: 1.637 ± 0.036	2.293GlyGln: 2.293 ± 0.054	2.478GlyArg: 2.478 ± 0.045	4.538GlySer: 4.538 ± 0.074	4.194GlyThr: 4.194 ± 0.109	4.594GlyVal: 4.594 ± 0.07	0.9GlyTrp: 0.9 ± 0.032	2.975GlyTyr: 2.975 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.994HisAla: 0.994 ± 0.024	0.193HisCys: 0.193 ± 0.014	0.913HisAsp: 0.913 ± 0.027	1.069HisGlu: 1.069 ± 0.029	1.198HisPhe: 1.198 ± 0.029	1.171HisGly: 1.171 ± 0.037	0.497HisHis: 0.497 ± 0.023	1.424HisIle: 1.424 ± 0.036	1.091HisLys: 1.091 ± 0.027	1.973HisLeu: 1.973 ± 0.043	0.431HisMet: 0.431 ± 0.018	0.877HisAsn: 0.877 ± 0.027	0.952HisPro: 0.952 ± 0.028	0.779HisGln: 0.779 ± 0.024	0.798HisArg: 0.798 ± 0.025	1.14HisSer: 1.14 ± 0.028	0.988HisThr: 0.988 ± 0.027	0.984HisVal: 0.984 ± 0.027	0.278HisTrp: 0.278 ± 0.015	0.829HisTyr: 0.829 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.203IleAla: 5.203 ± 0.074	0.568IleCys: 0.568 ± 0.022	4.832IleAsp: 4.832 ± 0.061	5.162IleGlu: 5.162 ± 0.069	3.301IlePhe: 3.301 ± 0.055	4.901IleGly: 4.901 ± 0.074	1.191IleHis: 1.191 ± 0.027	4.712IleIle: 4.712 ± 0.077	4.747IleLys: 4.747 ± 0.07	6.516IleLeu: 6.516 ± 0.084	1.36IleMet: 1.36 ± 0.031	3.877IleAsn: 3.877 ± 0.065	3.009IlePro: 3.009 ± 0.052	2.21IleGln: 2.21 ± 0.041	2.657IleArg: 2.657 ± 0.047	5.178IleSer: 5.178 ± 0.078	4.211IleThr: 4.211 ± 0.077	4.377IleVal: 4.377 ± 0.055	0.726IleTrp: 0.726 ± 0.023	2.601IleTyr: 2.601 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.624LysAla: 4.624 ± 0.068	0.299LysCys: 0.299 ± 0.016	4.024LysAsp: 4.024 ± 0.064	5.869LysGlu: 5.869 ± 0.085	2.733LysPhe: 2.733 ± 0.049	4.469LysGly: 4.469 ± 0.067	1.221LysHis: 1.221 ± 0.032	5.111LysIle: 5.111 ± 0.07	6.103LysLys: 6.103 ± 0.102	5.867LysLeu: 5.867 ± 0.08	1.895LysMet: 1.895 ± 0.042	4.546LysAsn: 4.546 ± 0.069	2.232LysPro: 2.232 ± 0.048	2.241LysGln: 2.241 ± 0.047	2.992LysArg: 2.992 ± 0.056	4.416LysSer: 4.416 ± 0.07	3.803LysThr: 3.803 ± 0.048	4.543LysVal: 4.543 ± 0.066	0.8LysTrp: 0.8 ± 0.024	2.567LysTyr: 2.567 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.382LeuAla: 6.382 ± 0.081	0.627LeuCys: 0.627 ± 0.025	5.219LeuAsp: 5.219 ± 0.068	6.42LeuGlu: 6.42 ± 0.083	4.769LeuPhe: 4.769 ± 0.081	6.345LeuGly: 6.345 ± 0.084	1.603LeuHis: 1.603 ± 0.034	6.244LeuIle: 6.244 ± 0.084	7.298LeuLys: 7.298 ± 0.097	8.972LeuLeu: 8.972 ± 0.122	2.213LeuMet: 2.213 ± 0.043	5.581LeuAsn: 5.581 ± 0.066	3.784LeuPro: 3.784 ± 0.052	3.307LeuGln: 3.307 ± 0.051	3.622LeuArg: 3.622 ± 0.054	6.723LeuSer: 6.723 ± 0.069	5.13LeuThr: 5.13 ± 0.068	5.817LeuVal: 5.817 ± 0.075	0.931LeuTrp: 0.931 ± 0.027	3.222LeuTyr: 3.222 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.969MetAla: 1.969 ± 0.039	0.136MetCys: 0.136 ± 0.012	1.267MetAsp: 1.267 ± 0.032	1.567MetGlu: 1.567 ± 0.037	0.885MetPhe: 0.885 ± 0.029	1.683MetGly: 1.683 ± 0.034	0.414MetHis: 0.414 ± 0.022	1.347MetIle: 1.347 ± 0.037	2.022MetLys: 2.022 ± 0.037	1.937MetLeu: 1.937 ± 0.04	0.577MetMet: 0.577 ± 0.022	1.355MetAsn: 1.355 ± 0.033	0.993MetPro: 0.993 ± 0.028	0.889MetGln: 0.889 ± 0.027	0.915MetArg: 0.915 ± 0.026	1.362MetSer: 1.362 ± 0.03	1.169MetThr: 1.169 ± 0.029	1.673MetVal: 1.673 ± 0.035	0.186MetTrp: 0.186 ± 0.012	0.73MetTyr: 0.73 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.59AsnAla: 3.59 ± 0.056	0.442AsnCys: 0.442 ± 0.02	3.462AsnAsp: 3.462 ± 0.085	3.805AsnGlu: 3.805 ± 0.053	2.843AsnPhe: 2.843 ± 0.051	4.347AsnGly: 4.347 ± 0.097	1.073AsnHis: 1.073 ± 0.03	3.948AsnIle: 3.948 ± 0.059	3.36AsnLys: 3.36 ± 0.05	5.393AsnLeu: 5.393 ± 0.065	1.208AsnMet: 1.208 ± 0.028	3.238AsnAsn: 3.238 ± 0.072	2.601AsnPro: 2.601 ± 0.047	2.142AsnGln: 2.142 ± 0.046	2.369AsnArg: 2.369 ± 0.046	3.724AsnSer: 3.724 ± 0.063	3.157AsnThr: 3.157 ± 0.071	3.368AsnVal: 3.368 ± 0.062	0.736AsnTrp: 0.736 ± 0.025	2.518AsnTyr: 2.518 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	1.989ProAla: 1.989 ± 0.043	0.206ProCys: 0.206 ± 0.015	2.401ProAsp: 2.401 ± 0.048	3.139ProGlu: 3.139 ± 0.051	1.919ProPhe: 1.919 ± 0.037	2.112ProGly: 2.112 ± 0.047	0.699ProHis: 0.699 ± 0.027	2.689ProIle: 2.689 ± 0.042	2.532ProLys: 2.532 ± 0.053	3.273ProLeu: 3.273 ± 0.059	0.841ProMet: 0.841 ± 0.025	2.222ProAsn: 2.222 ± 0.052	1.023ProPro: 1.023 ± 0.034	1.259ProGln: 1.259 ± 0.029	1.025ProArg: 1.025 ± 0.027	2.452ProSer: 2.452 ± 0.052	2.009ProThr: 2.009 ± 0.053	2.507ProVal: 2.507 ± 0.043	0.422ProTrp: 0.422 ± 0.02	1.394ProTyr: 1.394 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.014GlnAla: 2.014 ± 0.042	0.168GlnCys: 0.168 ± 0.013	1.722GlnAsp: 1.722 ± 0.038	2.547GlnGlu: 2.547 ± 0.042	1.638GlnPhe: 1.638 ± 0.037	2.023GlnGly: 2.023 ± 0.038	0.624GlnHis: 0.624 ± 0.025	2.613GlnIle: 2.613 ± 0.043	2.831GlnLys: 2.831 ± 0.053	3.633GlnLeu: 3.633 ± 0.061	0.947GlnMet: 0.947 ± 0.026	2.095GlnAsn: 2.095 ± 0.05	1.235GlnPro: 1.235 ± 0.035	1.392GlnGln: 1.392 ± 0.037	1.417GlnArg: 1.417 ± 0.032	2.088GlnSer: 2.088 ± 0.048	1.861GlnThr: 1.861 ± 0.039	2.218GlnVal: 2.218 ± 0.039	0.447GlnTrp: 0.447 ± 0.017	1.271GlnTyr: 1.271 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.268ArgAla: 2.268 ± 0.043	0.213ArgCys: 0.213 ± 0.011	1.968ArgAsp: 1.968 ± 0.039	2.478ArgGlu: 2.478 ± 0.043	2.121ArgPhe: 2.121 ± 0.036	2.189ArgGly: 2.189 ± 0.039	0.707ArgHis: 0.707 ± 0.023	2.933ArgIle: 2.933 ± 0.047	2.909ArgLys: 2.909 ± 0.06	3.781ArgLeu: 3.781 ± 0.055	1.033ArgMet: 1.033 ± 0.027	2.26ArgAsn: 2.26 ± 0.041	1.472ArgPro: 1.472 ± 0.032	1.311ArgGln: 1.311 ± 0.034	1.563ArgArg: 1.563 ± 0.042	2.152ArgSer: 2.152 ± 0.048	2.1ArgThr: 2.1 ± 0.045	2.266ArgVal: 2.266 ± 0.043	0.475ArgTrp: 0.475 ± 0.017	1.717ArgTyr: 1.717 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.032SerAla: 4.032 ± 0.059	0.644SerCys: 0.644 ± 0.029	3.896SerAsp: 3.896 ± 0.064	4.573SerGlu: 4.573 ± 0.062	3.68SerPhe: 3.68 ± 0.055	4.908SerGly: 4.908 ± 0.081	1.196SerHis: 1.196 ± 0.033	4.786SerIle: 4.786 ± 0.062	4.499SerLys: 4.499 ± 0.068	6.254SerLeu: 6.254 ± 0.078	1.398SerMet: 1.398 ± 0.032	3.648SerAsn: 3.648 ± 0.075	2.197SerPro: 2.197 ± 0.048	2.23SerGln: 2.23 ± 0.041	2.342SerArg: 2.342 ± 0.038	4.508SerSer: 4.508 ± 0.067	3.586SerThr: 3.586 ± 0.062	4.2SerVal: 4.2 ± 0.053	0.754SerTrp: 0.754 ± 0.026	2.765SerTyr: 2.765 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.668ThrAla: 3.668 ± 0.076	0.356ThrCys: 0.356 ± 0.021	3.61ThrAsp: 3.61 ± 0.132	3.543ThrGlu: 3.543 ± 0.054	2.815ThrPhe: 2.815 ± 0.044	4.186ThrGly: 4.186 ± 0.071	0.952ThrHis: 0.952 ± 0.029	4.283ThrIle: 4.283 ± 0.075	3.23ThrLys: 3.23 ± 0.059	5.162ThrLeu: 5.162 ± 0.065	1.017ThrMet: 1.017 ± 0.028	2.905ThrAsn: 2.905 ± 0.065	2.407ThrPro: 2.407 ± 0.058	1.748ThrGln: 1.748 ± 0.037	1.682ThrArg: 1.682 ± 0.034	3.619ThrSer: 3.619 ± 0.062	3.112ThrThr: 3.112 ± 0.084	3.908ThrVal: 3.908 ± 0.075	0.584ThrTrp: 0.584 ± 0.023	2.315ThrTyr: 2.315 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.346ValAla: 4.346 ± 0.065	0.529ValCys: 0.529 ± 0.023	3.996ValAsp: 3.996 ± 0.058	4.115ValGlu: 4.115 ± 0.058	3.205ValPhe: 3.205 ± 0.053	4.301ValGly: 4.301 ± 0.06	1.157ValHis: 1.157 ± 0.03	4.259ValIle: 4.259 ± 0.059	3.985ValLys: 3.985 ± 0.055	6.235ValLeu: 6.235 ± 0.074	1.423ValMet: 1.423 ± 0.038	3.483ValAsn: 3.483 ± 0.065	2.48ValPro: 2.48 ± 0.05	2.093ValGln: 2.093 ± 0.042	2.34ValArg: 2.34 ± 0.041	4.67ValSer: 4.67 ± 0.068	3.635ValThr: 3.635 ± 0.076	4.441ValVal: 4.441 ± 0.062	0.668ValTrp: 0.668 ± 0.023	2.354ValTyr: 2.354 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.764TrpAla: 0.764 ± 0.022	0.097TrpCys: 0.097 ± 0.009	0.663TrpAsp: 0.663 ± 0.025	0.713TrpGlu: 0.713 ± 0.022	0.551TrpPhe: 0.551 ± 0.021	0.846TrpGly: 0.846 ± 0.027	0.299TrpHis: 0.299 ± 0.014	0.635TrpIle: 0.635 ± 0.024	0.807TrpLys: 0.807 ± 0.025	1.103TrpLeu: 1.103 ± 0.032	0.326TrpMet: 0.326 ± 0.016	0.749TrpAsn: 0.749 ± 0.03	0.371TrpPro: 0.371 ± 0.017	0.531TrpGln: 0.531 ± 0.02	0.502TrpArg: 0.502 ± 0.02	0.756TrpSer: 0.756 ± 0.029	0.556TrpThr: 0.556 ± 0.02	0.732TrpVal: 0.732 ± 0.025	0.184TrpTrp: 0.184 ± 0.011	0.444TrpTyr: 0.444 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.406TyrAla: 2.406 ± 0.041	0.33TyrCys: 0.33 ± 0.017	2.444TyrAsp: 2.444 ± 0.041	2.573TyrGlu: 2.573 ± 0.043	2.281TyrPhe: 2.281 ± 0.049	2.818TyrGly: 2.818 ± 0.043	0.869TyrHis: 0.869 ± 0.025	2.428TyrIle: 2.428 ± 0.045	2.431TyrLys: 2.431 ± 0.045	3.86TyrLeu: 3.86 ± 0.057	0.741TyrMet: 0.741 ± 0.023	2.249TyrAsn: 2.249 ± 0.044	1.509TyrPro: 1.509 ± 0.033	1.535TyrGln: 1.535 ± 0.036	1.872TyrArg: 1.872 ± 0.038	2.622TyrSer: 2.622 ± 0.049	2.232TyrThr: 2.232 ± 0.052	2.181TyrVal: 2.181 ± 0.037	0.553TyrTrp: 0.553 ± 0.019	1.662TyrTyr: 1.662 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3952 proteins (1409240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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