Amino acid dipepetide frequency for Flavobacterium alvei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.341AlaAla: 4.341 ± 0.099	0.547AlaCys: 0.547 ± 0.026	3.305AlaAsp: 3.305 ± 0.076	3.763AlaGlu: 3.763 ± 0.066	3.322AlaPhe: 3.322 ± 0.064	4.301AlaGly: 4.301 ± 0.075	0.958AlaHis: 0.958 ± 0.034	5.558AlaIle: 5.558 ± 0.079	5.117AlaLys: 5.117 ± 0.085	5.9AlaLeu: 5.9 ± 0.083	1.473AlaMet: 1.473 ± 0.045	3.968AlaAsn: 3.968 ± 0.08	2.002AlaPro: 2.002 ± 0.055	2.428AlaGln: 2.428 ± 0.051	1.807AlaArg: 1.807 ± 0.041	4.262AlaSer: 4.262 ± 0.062	4.289AlaThr: 4.289 ± 0.088	4.166AlaVal: 4.166 ± 0.066	0.675AlaTrp: 0.675 ± 0.025	2.249AlaTyr: 2.249 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.44CysAla: 0.44 ± 0.02	0.116CysCys: 0.116 ± 0.011	0.454CysAsp: 0.454 ± 0.022	0.494CysGlu: 0.494 ± 0.02	0.465CysPhe: 0.465 ± 0.023	0.606CysGly: 0.606 ± 0.024	0.21CysHis: 0.21 ± 0.02	0.582CysIle: 0.582 ± 0.024	0.523CysLys: 0.523 ± 0.021	0.661CysLeu: 0.661 ± 0.025	0.163CysMet: 0.163 ± 0.012	0.467CysAsn: 0.467 ± 0.022	0.386CysPro: 0.386 ± 0.025	0.25CysGln: 0.25 ± 0.016	0.215CysArg: 0.215 ± 0.014	0.641CysSer: 0.641 ± 0.028	0.473CysThr: 0.473 ± 0.026	0.489CysVal: 0.489 ± 0.02	0.076CysTrp: 0.076 ± 0.008	0.313CysTyr: 0.313 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.669AspAla: 3.669 ± 0.062	0.443AspCys: 0.443 ± 0.021	2.448AspAsp: 2.448 ± 0.055	3.401AspGlu: 3.401 ± 0.061	3.659AspPhe: 3.659 ± 0.06	3.764AspGly: 3.764 ± 0.087	0.695AspHis: 0.695 ± 0.025	4.016AspIle: 4.016 ± 0.06	4.382AspLys: 4.382 ± 0.071	5.021AspLeu: 5.021 ± 0.062	1.008AspMet: 1.008 ± 0.033	3.07AspAsn: 3.07 ± 0.057	1.569AspPro: 1.569 ± 0.047	1.442AspGln: 1.442 ± 0.04	1.617AspArg: 1.617 ± 0.04	2.97AspSer: 2.97 ± 0.063	2.493AspThr: 2.493 ± 0.054	3.338AspVal: 3.338 ± 0.061	0.751AspTrp: 0.751 ± 0.026	2.713AspTyr: 2.713 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.932GluAla: 3.932 ± 0.081	0.358GluCys: 0.358 ± 0.019	2.947GluAsp: 2.947 ± 0.054	4.115GluGlu: 4.115 ± 0.089	2.852GluPhe: 2.852 ± 0.06	3.422GluGly: 3.422 ± 0.056	0.9GluHis: 0.9 ± 0.03	5.641GluIle: 5.641 ± 0.084	6.225GluLys: 6.225 ± 0.098	5.558GluLeu: 5.558 ± 0.08	1.642GluMet: 1.642 ± 0.044	4.935GluAsn: 4.935 ± 0.078	1.494GluPro: 1.494 ± 0.035	2.034GluGln: 2.034 ± 0.042	2.035GluArg: 2.035 ± 0.059	3.35GluSer: 3.35 ± 0.058	3.606GluThr: 3.606 ± 0.054	3.977GluVal: 3.977 ± 0.056	0.589GluTrp: 0.589 ± 0.024	2.344GluTyr: 2.344 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.221PheAla: 3.221 ± 0.055	0.499PheCys: 0.499 ± 0.021	3.339PheAsp: 3.339 ± 0.051	3.587PheGlu: 3.587 ± 0.066	2.853PhePhe: 2.853 ± 0.061	3.721PheGly: 3.721 ± 0.065	0.793PheHis: 0.793 ± 0.027	3.9PheIle: 3.9 ± 0.064	3.75PheLys: 3.75 ± 0.068	4.805PheLeu: 4.805 ± 0.079	1.185PheMet: 1.185 ± 0.037	3.286PheAsn: 3.286 ± 0.056	1.858PhePro: 1.858 ± 0.044	1.693PheGln: 1.693 ± 0.035	1.534PheArg: 1.534 ± 0.043	4.17PheSer: 4.17 ± 0.064	3.116PheThr: 3.116 ± 0.063	3.301PheVal: 3.301 ± 0.056	0.671PheTrp: 0.671 ± 0.025	2.249PheTyr: 2.249 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.179GlyAla: 4.179 ± 0.085	0.649GlyCys: 0.649 ± 0.035	3.05GlyAsp: 3.05 ± 0.064	3.325GlyGlu: 3.325 ± 0.061	3.636GlyPhe: 3.636 ± 0.064	4.539GlyGly: 4.539 ± 0.086	1.04GlyHis: 1.04 ± 0.034	5.722GlyIle: 5.722 ± 0.084	5.307GlyLys: 5.307 ± 0.076	5.711GlyLeu: 5.711 ± 0.072	1.675GlyMet: 1.675 ± 0.041	3.963GlyAsn: 3.963 ± 0.079	1.312GlyPro: 1.312 ± 0.035	1.953GlyGln: 1.953 ± 0.038	1.916GlyArg: 1.916 ± 0.045	4.108GlySer: 4.108 ± 0.061	4.614GlyThr: 4.614 ± 0.105	4.208GlyVal: 4.208 ± 0.074	0.837GlyTrp: 0.837 ± 0.025	2.843GlyTyr: 2.843 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.753HisAla: 0.753 ± 0.028	0.17HisCys: 0.17 ± 0.013	0.73HisAsp: 0.73 ± 0.028	0.806HisGlu: 0.806 ± 0.026	1.182HisPhe: 1.182 ± 0.034	0.893HisGly: 0.893 ± 0.027	0.426HisHis: 0.426 ± 0.02	1.337HisIle: 1.337 ± 0.038	1.092HisLys: 1.092 ± 0.032	1.608HisLeu: 1.608 ± 0.045	0.256HisMet: 0.256 ± 0.016	0.94HisAsn: 0.94 ± 0.031	0.86HisPro: 0.86 ± 0.028	0.695HisGln: 0.695 ± 0.024	0.53HisArg: 0.53 ± 0.02	1.052HisSer: 1.052 ± 0.033	0.794HisThr: 0.794 ± 0.027	0.697HisVal: 0.697 ± 0.029	0.199HisTrp: 0.199 ± 0.013	0.744HisTyr: 0.744 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.909IleAla: 5.909 ± 0.075	0.659IleCys: 0.659 ± 0.026	4.818IleAsp: 4.818 ± 0.058	5.519IleGlu: 5.519 ± 0.083	3.58IlePhe: 3.58 ± 0.058	5.287IleGly: 5.287 ± 0.085	1.353IleHis: 1.353 ± 0.032	6.416IleIle: 6.416 ± 0.085	6.151IleLys: 6.151 ± 0.081	7.196IleLeu: 7.196 ± 0.11	1.446IleMet: 1.446 ± 0.04	4.916IleAsn: 4.916 ± 0.084	3.42IlePro: 3.42 ± 0.062	2.975IleGln: 2.975 ± 0.055	2.431IleArg: 2.431 ± 0.051	5.88IleSer: 5.88 ± 0.075	5.029IleThr: 5.029 ± 0.09	5.049IleVal: 5.049 ± 0.07	0.771IleTrp: 0.771 ± 0.026	2.944IleTyr: 2.944 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.131LysAla: 5.131 ± 0.087	0.4LysCys: 0.4 ± 0.018	4.385LysAsp: 4.385 ± 0.058	5.853LysGlu: 5.853 ± 0.094	3.1LysPhe: 3.1 ± 0.057	4.854LysGly: 4.854 ± 0.078	1.147LysHis: 1.147 ± 0.033	7.234LysIle: 7.234 ± 0.091	7.064LysLys: 7.064 ± 0.096	6.467LysLeu: 6.467 ± 0.094	2.326LysMet: 2.326 ± 0.051	5.986LysAsn: 5.986 ± 0.084	2.657LysPro: 2.657 ± 0.05	2.662LysGln: 2.662 ± 0.057	2.435LysArg: 2.435 ± 0.051	4.988LysSer: 4.988 ± 0.074	5.24LysThr: 5.24 ± 0.068	4.877LysVal: 4.877 ± 0.073	0.842LysTrp: 0.842 ± 0.031	3.212LysTyr: 3.212 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.816LeuAla: 5.816 ± 0.081	0.718LeuCys: 0.718 ± 0.028	4.812LeuAsp: 4.812 ± 0.06	5.609LeuGlu: 5.609 ± 0.084	5.145LeuPhe: 5.145 ± 0.083	5.603LeuGly: 5.603 ± 0.08	1.434LeuHis: 1.434 ± 0.034	6.884LeuIle: 6.884 ± 0.106	7.743LeuLys: 7.743 ± 0.098	8.386LeuLeu: 8.386 ± 0.121	2.091LeuMet: 2.091 ± 0.047	5.655LeuAsn: 5.655 ± 0.079	3.524LeuPro: 3.524 ± 0.06	2.986LeuGln: 2.986 ± 0.063	2.664LeuArg: 2.664 ± 0.056	6.425LeuSer: 6.425 ± 0.069	5.096LeuThr: 5.096 ± 0.086	5.397LeuVal: 5.397 ± 0.073	0.843LeuTrp: 0.843 ± 0.03	3.19LeuTyr: 3.19 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.578MetAla: 1.578 ± 0.044	0.15MetCys: 0.15 ± 0.012	1.126MetAsp: 1.126 ± 0.029	1.301MetGlu: 1.301 ± 0.04	0.858MetPhe: 0.858 ± 0.028	1.445MetGly: 1.445 ± 0.042	0.364MetHis: 0.364 ± 0.019	1.625MetIle: 1.625 ± 0.043	2.296MetLys: 2.296 ± 0.044	1.873MetLeu: 1.873 ± 0.042	0.66MetMet: 0.66 ± 0.027	1.465MetAsn: 1.465 ± 0.037	0.855MetPro: 0.855 ± 0.026	0.84MetGln: 0.84 ± 0.029	0.782MetArg: 0.782 ± 0.027	1.424MetSer: 1.424 ± 0.034	1.174MetThr: 1.174 ± 0.035	1.319MetVal: 1.319 ± 0.033	0.189MetTrp: 0.189 ± 0.013	0.705MetTyr: 0.705 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.073AsnAla: 4.073 ± 0.068	0.595AsnCys: 0.595 ± 0.027	3.228AsnAsp: 3.228 ± 0.06	3.87AsnGlu: 3.87 ± 0.058	3.38AsnPhe: 3.38 ± 0.067	4.46AsnGly: 4.46 ± 0.082	1.128AsnHis: 1.128 ± 0.036	4.847AsnIle: 4.847 ± 0.069	4.71AsnLys: 4.71 ± 0.084	5.781AsnLeu: 5.781 ± 0.08	1.18AsnMet: 1.18 ± 0.033	4.12AsnAsn: 4.12 ± 0.079	3.181AsnPro: 3.181 ± 0.061	2.538AsnGln: 2.538 ± 0.052	2.038AsnArg: 2.038 ± 0.049	4.471AsnSer: 4.471 ± 0.07	3.894AsnThr: 3.894 ± 0.073	3.705AsnVal: 3.705 ± 0.076	0.946AsnTrp: 0.946 ± 0.027	3.119AsnTyr: 3.119 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.164ProAla: 2.164 ± 0.05	0.216ProCys: 0.216 ± 0.013	1.912ProAsp: 1.912 ± 0.042	2.685ProGlu: 2.685 ± 0.056	2.019ProPhe: 2.019 ± 0.039	1.917ProGly: 1.917 ± 0.048	0.538ProHis: 0.538 ± 0.024	2.912ProIle: 2.912 ± 0.057	2.756ProLys: 2.756 ± 0.053	2.92ProLeu: 2.92 ± 0.053	0.762ProMet: 0.762 ± 0.028	2.476ProAsn: 2.476 ± 0.051	0.773ProPro: 0.773 ± 0.031	1.086ProGln: 1.086 ± 0.03	0.864ProArg: 0.864 ± 0.032	2.271ProSer: 2.271 ± 0.054	2.305ProThr: 2.305 ± 0.058	2.432ProVal: 2.432 ± 0.055	0.365ProTrp: 0.365 ± 0.018	1.391ProTyr: 1.391 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.963GlnAla: 1.963 ± 0.042	0.227GlnCys: 0.227 ± 0.017	1.572GlnAsp: 1.572 ± 0.038	2.276GlnGlu: 2.276 ± 0.049	1.76GlnPhe: 1.76 ± 0.041	1.828GlnGly: 1.828 ± 0.065	0.503GlnHis: 0.503 ± 0.022	2.855GlnIle: 2.855 ± 0.052	3.284GlnLys: 3.284 ± 0.065	3.337GlnLeu: 3.337 ± 0.065	0.823GlnMet: 0.823 ± 0.029	2.484GlnAsn: 2.484 ± 0.046	1.032GlnPro: 1.032 ± 0.035	1.264GlnGln: 1.264 ± 0.038	1.066GlnArg: 1.066 ± 0.03	1.995GlnSer: 1.995 ± 0.047	1.979GlnThr: 1.979 ± 0.041	1.852GlnVal: 1.852 ± 0.044	0.366GlnTrp: 0.366 ± 0.018	1.398GlnTyr: 1.398 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.835ArgAla: 1.835 ± 0.041	0.202ArgCys: 0.202 ± 0.015	1.559ArgAsp: 1.559 ± 0.037	1.878ArgGlu: 1.878 ± 0.044	1.717ArgPhe: 1.717 ± 0.039	1.703ArgGly: 1.703 ± 0.043	0.468ArgHis: 0.468 ± 0.021	2.751ArgIle: 2.751 ± 0.057	2.57ArgLys: 2.57 ± 0.052	2.76ArgLeu: 2.76 ± 0.051	0.82ArgMet: 0.82 ± 0.028	1.981ArgAsn: 1.981 ± 0.039	0.987ArgPro: 0.987 ± 0.031	0.903ArgGln: 0.903 ± 0.03	1.04ArgArg: 1.04 ± 0.032	1.63ArgSer: 1.63 ± 0.044	1.709ArgThr: 1.709 ± 0.038	1.888ArgVal: 1.888 ± 0.04	0.383ArgTrp: 0.383 ± 0.018	1.258ArgTyr: 1.258 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.915SerAla: 3.915 ± 0.07	0.674SerCys: 0.674 ± 0.027	3.462SerAsp: 3.462 ± 0.067	3.739SerGlu: 3.739 ± 0.064	4.075SerPhe: 4.075 ± 0.067	4.789SerGly: 4.789 ± 0.082	1.087SerHis: 1.087 ± 0.031	5.48SerIle: 5.48 ± 0.08	5.23SerLys: 5.23 ± 0.072	5.903SerLeu: 5.903 ± 0.086	1.23SerMet: 1.23 ± 0.034	4.42SerAsn: 4.42 ± 0.076	2.263SerPro: 2.263 ± 0.05	2.295SerGln: 2.295 ± 0.048	1.916SerArg: 1.916 ± 0.043	4.452SerSer: 4.452 ± 0.074	3.772SerThr: 3.772 ± 0.077	4.085SerVal: 4.085 ± 0.061	0.73SerTrp: 0.73 ± 0.027	2.787SerTyr: 2.787 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.175ThrAla: 4.175 ± 0.096	0.384ThrCys: 0.384 ± 0.024	3.142ThrAsp: 3.142 ± 0.072	3.218ThrGlu: 3.218 ± 0.056	3.228ThrPhe: 3.228 ± 0.059	4.21ThrGly: 4.21 ± 0.084	0.907ThrHis: 0.907 ± 0.03	5.506ThrIle: 5.506 ± 0.09	4.243ThrLys: 4.243 ± 0.056	5.388ThrLeu: 5.388 ± 0.077	1.048ThrMet: 1.048 ± 0.034	3.938ThrAsn: 3.938 ± 0.082	2.627ThrPro: 2.627 ± 0.056	1.97ThrGln: 1.97 ± 0.042	1.517ThrArg: 1.517 ± 0.032	4.021ThrSer: 4.021 ± 0.085	4.19ThrThr: 4.19 ± 0.103	3.956ThrVal: 3.956 ± 0.089	0.625ThrTrp: 0.625 ± 0.026	2.331ThrTyr: 2.331 ± 0.062	0.002ThrXaa: 0.002 ± 0.001
Val	4.356ValAla: 4.356 ± 0.071	0.547ValCys: 0.547 ± 0.027	3.296ValAsp: 3.296 ± 0.058	3.623ValGlu: 3.623 ± 0.063	3.566ValPhe: 3.566 ± 0.057	3.813ValGly: 3.813 ± 0.07	0.894ValHis: 0.894 ± 0.03	4.799ValIle: 4.799 ± 0.077	4.5ValLys: 4.5 ± 0.066	5.948ValLeu: 5.948 ± 0.073	1.215ValMet: 1.215 ± 0.036	3.732ValAsn: 3.732 ± 0.067	2.16ValPro: 2.16 ± 0.047	1.886ValGln: 1.886 ± 0.044	1.826ValArg: 1.826 ± 0.045	4.533ValSer: 4.533 ± 0.075	3.799ValThr: 3.799 ± 0.088	4.385ValVal: 4.385 ± 0.077	0.64ValTrp: 0.64 ± 0.023	2.413ValTyr: 2.413 ± 0.048	0.002ValXaa: 0.002 ± 0.001
Trp	0.676TrpAla: 0.676 ± 0.026	0.094TrpCys: 0.094 ± 0.009	0.63TrpAsp: 0.63 ± 0.025	0.681TrpGlu: 0.681 ± 0.024	0.582TrpPhe: 0.582 ± 0.026	0.764TrpGly: 0.764 ± 0.029	0.213TrpHis: 0.213 ± 0.014	0.808TrpIle: 0.808 ± 0.031	0.886TrpLys: 0.886 ± 0.031	0.932TrpLeu: 0.932 ± 0.031	0.314TrpMet: 0.314 ± 0.019	0.821TrpAsn: 0.821 ± 0.031	0.263TrpPro: 0.263 ± 0.017	0.443TrpGln: 0.443 ± 0.018	0.399TrpArg: 0.399 ± 0.022	0.741TrpSer: 0.741 ± 0.03	0.685TrpThr: 0.685 ± 0.024	0.616TrpVal: 0.616 ± 0.024	0.165TrpTrp: 0.165 ± 0.014	0.488TrpTyr: 0.488 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.303TyrAla: 2.303 ± 0.045	0.374TyrCys: 0.374 ± 0.017	2.255TyrAsp: 2.255 ± 0.048	2.213TyrGlu: 2.213 ± 0.044	2.553TyrPhe: 2.553 ± 0.051	2.665TyrGly: 2.665 ± 0.053	0.706TyrHis: 0.706 ± 0.028	2.874TyrIle: 2.874 ± 0.053	3.03TyrLys: 3.03 ± 0.05	3.867TyrLeu: 3.867 ± 0.061	0.712TyrMet: 0.712 ± 0.023	2.642TyrAsn: 2.642 ± 0.056	1.539TyrPro: 1.539 ± 0.039	1.524TyrGln: 1.524 ± 0.039	1.41TyrArg: 1.41 ± 0.038	2.919TyrSer: 2.919 ± 0.056	2.368TyrThr: 2.368 ± 0.068	2.199TyrVal: 2.199 ± 0.048	0.535TyrTrp: 0.535 ± 0.022	1.891TyrTyr: 1.891 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3153 proteins (1138329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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