Amino acid dipepetide frequency for Streptococcus satellite phage Javan572

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.718AlaAla: 0.718 ± 0.642
1.078AlaCys: 1.078 ± 0.557
6.466AlaAsp: 6.466 ± 2.347
5.388AlaGlu: 5.388 ± 1.355
2.514AlaPhe: 2.514 ± 0.818
2.155AlaGly: 2.155 ± 0.942
0.718AlaHis: 0.718 ± 0.609
3.592AlaIle: 3.592 ± 1.445
4.31AlaLys: 4.31 ± 1.145
6.825AlaLeu: 6.825 ± 1.091
2.514AlaMet: 2.514 ± 1.097
3.233AlaAsn: 3.233 ± 0.795
1.796AlaPro: 1.796 ± 0.565
1.437AlaGln: 1.437 ± 0.593
3.592AlaArg: 3.592 ± 1.109
2.874AlaSer: 2.874 ± 0.674
4.67AlaThr: 4.67 ± 1.559
1.078AlaVal: 1.078 ± 0.63
0.718AlaTrp: 0.718 ± 0.36
1.437AlaTyr: 1.437 ± 0.58
0.0AlaXaa: 0.0 ± 0.0
Cys
0.359CysAla: 0.359 ± 0.44
0.0CysCys: 0.0 ± 0.0
1.437CysAsp: 1.437 ± 0.524
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.718CysGly: 0.718 ± 0.73
0.0CysHis: 0.0 ± 0.0
0.718CysIle: 0.718 ± 0.561
0.359CysLys: 0.359 ± 0.425
1.078CysLeu: 1.078 ± 0.523
0.0CysMet: 0.0 ± 0.0
0.718CysAsn: 0.718 ± 0.448
0.359CysPro: 0.359 ± 0.365
0.718CysGln: 0.718 ± 0.73
0.718CysArg: 0.718 ± 0.443
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.359CysVal: 0.359 ± 0.388
0.0CysTrp: 0.0 ± 0.0
0.718CysTyr: 0.718 ± 0.416
0.0CysXaa: 0.0 ± 0.0
Asp
1.078AspAla: 1.078 ± 0.785
1.437AspCys: 1.437 ± 0.791
4.31AspAsp: 4.31 ± 1.271
3.233AspGlu: 3.233 ± 0.975
3.592AspPhe: 3.592 ± 1.47
2.155AspGly: 2.155 ± 1.156
0.359AspHis: 0.359 ± 0.38
6.106AspIle: 6.106 ± 1.163
7.184AspLys: 7.184 ± 0.965
5.747AspLeu: 5.747 ± 1.131
1.796AspMet: 1.796 ± 0.81
4.67AspAsn: 4.67 ± 1.281
1.437AspPro: 1.437 ± 0.55
1.437AspGln: 1.437 ± 0.581
1.078AspArg: 1.078 ± 0.51
3.592AspSer: 3.592 ± 1.212
2.514AspThr: 2.514 ± 1.081
1.796AspVal: 1.796 ± 0.651
0.718AspTrp: 0.718 ± 0.446
5.747AspTyr: 5.747 ± 1.376
0.0AspXaa: 0.0 ± 0.0
Glu
4.31GluAla: 4.31 ± 1.349
0.0GluCys: 0.0 ± 0.0
2.514GluAsp: 2.514 ± 0.734
3.592GluGlu: 3.592 ± 1.18
2.155GluPhe: 2.155 ± 0.787
1.078GluGly: 1.078 ± 0.486
1.078GluHis: 1.078 ± 0.558
6.466GluIle: 6.466 ± 1.138
5.388GluLys: 5.388 ± 1.693
11.853GluLeu: 11.853 ± 1.425
1.078GluMet: 1.078 ± 0.677
5.388GluAsn: 5.388 ± 1.304
2.514GluPro: 2.514 ± 0.634
3.592GluGln: 3.592 ± 1.859
3.592GluArg: 3.592 ± 1.556
3.233GluSer: 3.233 ± 0.83
2.874GluThr: 2.874 ± 0.929
6.106GluVal: 6.106 ± 1.534
0.718GluTrp: 0.718 ± 0.413
2.155GluTyr: 2.155 ± 0.721
0.0GluXaa: 0.0 ± 0.0
Phe
0.359PheAla: 0.359 ± 0.319
0.0PheCys: 0.0 ± 0.0
3.592PheAsp: 3.592 ± 0.982
3.233PheGlu: 3.233 ± 1.031
1.796PhePhe: 1.796 ± 0.654
2.514PheGly: 2.514 ± 0.755
0.718PheHis: 0.718 ± 0.535
3.951PheIle: 3.951 ± 1.348
1.437PheLys: 1.437 ± 0.584
2.514PheLeu: 2.514 ± 0.902
0.718PheMet: 0.718 ± 0.589
2.155PheAsn: 2.155 ± 0.914
0.718PhePro: 0.718 ± 0.512
1.437PheGln: 1.437 ± 0.697
2.155PheArg: 2.155 ± 0.906
3.233PheSer: 3.233 ± 0.842
2.155PheThr: 2.155 ± 0.811
1.796PheVal: 1.796 ± 0.713
0.0PheTrp: 0.0 ± 0.0
2.155PheTyr: 2.155 ± 0.869
0.0PheXaa: 0.0 ± 0.0
Gly
3.951GlyAla: 3.951 ± 1.608
0.718GlyCys: 0.718 ± 0.443
2.155GlyAsp: 2.155 ± 0.961
3.592GlyGlu: 3.592 ± 1.29
2.874GlyPhe: 2.874 ± 1.487
2.155GlyGly: 2.155 ± 0.799
1.078GlyHis: 1.078 ± 0.71
3.951GlyIle: 3.951 ± 0.859
4.67GlyLys: 4.67 ± 0.964
4.31GlyLeu: 4.31 ± 1.504
1.078GlyMet: 1.078 ± 0.656
1.437GlyAsn: 1.437 ± 0.844
0.0GlyPro: 0.0 ± 0.0
0.718GlyGln: 0.718 ± 0.88
2.155GlyArg: 2.155 ± 0.739
1.078GlySer: 1.078 ± 0.693
4.31GlyThr: 4.31 ± 1.567
3.951GlyVal: 3.951 ± 0.85
1.437GlyTrp: 1.437 ± 0.832
2.514GlyTyr: 2.514 ± 0.865
0.0GlyXaa: 0.0 ± 0.0
His
2.514HisAla: 2.514 ± 1.375
0.0HisCys: 0.0 ± 0.0
0.359HisAsp: 0.359 ± 0.44
1.078HisGlu: 1.078 ± 0.636
0.0HisPhe: 0.0 ± 0.0
1.437HisGly: 1.437 ± 1.129
0.718HisHis: 0.718 ± 0.633
1.078HisIle: 1.078 ± 0.791
0.718HisLys: 0.718 ± 0.467
2.514HisLeu: 2.514 ± 1.035
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.437HisPro: 1.437 ± 0.751
0.718HisGln: 0.718 ± 0.524
0.718HisArg: 0.718 ± 0.416
1.078HisSer: 1.078 ± 0.48
1.437HisThr: 1.437 ± 0.641
1.437HisVal: 1.437 ± 0.678
0.0HisTrp: 0.0 ± 0.0
0.718HisTyr: 0.718 ± 0.443
0.0HisXaa: 0.0 ± 0.0
Ile
5.747IleAla: 5.747 ± 1.378
0.359IleCys: 0.359 ± 0.321
5.029IleAsp: 5.029 ± 2.158
7.184IleGlu: 7.184 ± 1.498
2.155IlePhe: 2.155 ± 0.838
3.233IleGly: 3.233 ± 0.99
0.718IleHis: 0.718 ± 0.67
4.67IleIle: 4.67 ± 1.385
7.184IleLys: 7.184 ± 1.263
5.029IleLeu: 5.029 ± 1.411
0.0IleMet: 0.0 ± 0.0
4.67IleAsn: 4.67 ± 1.495
5.029IlePro: 5.029 ± 1.153
2.514IleGln: 2.514 ± 0.776
3.951IleArg: 3.951 ± 1.829
4.31IleSer: 4.31 ± 1.284
6.825IleThr: 6.825 ± 1.038
4.67IleVal: 4.67 ± 1.332
0.718IleTrp: 0.718 ± 0.587
2.514IleTyr: 2.514 ± 1.111
0.0IleXaa: 0.0 ± 0.0
Lys
4.31LysAla: 4.31 ± 1.639
0.0LysCys: 0.0 ± 0.0
3.951LysAsp: 3.951 ± 1.483
10.057LysGlu: 10.057 ± 2.212
2.155LysPhe: 2.155 ± 0.845
6.825LysGly: 6.825 ± 2.082
3.592LysHis: 3.592 ± 1.18
6.106LysIle: 6.106 ± 1.771
10.057LysLys: 10.057 ± 1.196
7.902LysLeu: 7.902 ± 1.68
1.078LysMet: 1.078 ± 0.518
3.951LysAsn: 3.951 ± 1.325
5.029LysPro: 5.029 ± 1.48
5.388LysGln: 5.388 ± 1.188
5.029LysArg: 5.029 ± 1.44
3.233LysSer: 3.233 ± 0.826
5.388LysThr: 5.388 ± 1.484
5.388LysVal: 5.388 ± 1.313
1.437LysTrp: 1.437 ± 0.622
1.078LysTyr: 1.078 ± 0.549
0.0LysXaa: 0.0 ± 0.0
Leu
6.825LeuAla: 6.825 ± 1.411
1.078LeuCys: 1.078 ± 0.589
7.902LeuAsp: 7.902 ± 1.407
9.339LeuGlu: 9.339 ± 2.622
1.437LeuPhe: 1.437 ± 0.695
5.029LeuGly: 5.029 ± 1.476
1.796LeuHis: 1.796 ± 0.793
6.466LeuIle: 6.466 ± 1.587
8.621LeuLys: 8.621 ± 1.909
12.931LeuLeu: 12.931 ± 1.93
2.514LeuMet: 2.514 ± 0.8
6.825LeuAsn: 6.825 ± 1.34
4.31LeuPro: 4.31 ± 1.113
4.67LeuGln: 4.67 ± 1.519
1.437LeuArg: 1.437 ± 0.585
6.466LeuSer: 6.466 ± 1.102
5.388LeuThr: 5.388 ± 1.054
3.233LeuVal: 3.233 ± 1.103
1.078LeuTrp: 1.078 ± 0.516
4.67LeuTyr: 4.67 ± 1.204
0.0LeuXaa: 0.0 ± 0.0
Met
4.67MetAla: 4.67 ± 1.608
0.359MetCys: 0.359 ± 0.365
0.718MetAsp: 0.718 ± 0.493
0.718MetGlu: 0.718 ± 0.427
0.359MetPhe: 0.359 ± 0.361
0.359MetGly: 0.359 ± 0.321
0.0MetHis: 0.0 ± 0.0
1.437MetIle: 1.437 ± 0.789
1.437MetLys: 1.437 ± 0.537
1.437MetLeu: 1.437 ± 0.67
0.0MetMet: 0.0 ± 0.0
2.514MetAsn: 2.514 ± 0.727
0.359MetPro: 0.359 ± 0.476
0.718MetGln: 0.718 ± 0.433
1.078MetArg: 1.078 ± 0.555
0.718MetSer: 0.718 ± 0.467
3.233MetThr: 3.233 ± 1.268
2.155MetVal: 2.155 ± 0.994
0.359MetTrp: 0.359 ± 0.489
0.359MetTyr: 0.359 ± 0.321
0.0MetXaa: 0.0 ± 0.0
Asn
3.233AsnAla: 3.233 ± 0.849
0.718AsnCys: 0.718 ± 0.448
2.155AsnAsp: 2.155 ± 0.655
1.796AsnGlu: 1.796 ± 0.645
1.796AsnPhe: 1.796 ± 0.794
4.67AsnGly: 4.67 ± 1.971
0.359AsnHis: 0.359 ± 0.319
4.31AsnIle: 4.31 ± 1.033
5.029AsnLys: 5.029 ± 1.228
5.747AsnLeu: 5.747 ± 1.562
2.155AsnMet: 2.155 ± 0.737
3.592AsnAsn: 3.592 ± 1.117
2.874AsnPro: 2.874 ± 1.031
2.514AsnGln: 2.514 ± 0.891
2.874AsnArg: 2.874 ± 0.999
2.514AsnSer: 2.514 ± 1.07
2.155AsnThr: 2.155 ± 0.875
1.078AsnVal: 1.078 ± 0.536
0.0AsnTrp: 0.0 ± 0.0
3.233AsnTyr: 3.233 ± 1.211
0.0AsnXaa: 0.0 ± 0.0
Pro
2.514ProAla: 2.514 ± 0.788
0.0ProCys: 0.0 ± 0.0
2.155ProAsp: 2.155 ± 0.865
1.796ProGlu: 1.796 ± 0.691
2.874ProPhe: 2.874 ± 1.004
0.359ProGly: 0.359 ± 0.365
0.359ProHis: 0.359 ± 0.476
3.233ProIle: 3.233 ± 1.04
6.106ProLys: 6.106 ± 1.2
3.951ProLeu: 3.951 ± 1.192
1.078ProMet: 1.078 ± 0.549
1.796ProAsn: 1.796 ± 0.841
1.078ProPro: 1.078 ± 0.663
2.155ProGln: 2.155 ± 0.598
1.796ProArg: 1.796 ± 0.678
2.874ProSer: 2.874 ± 0.915
2.514ProThr: 2.514 ± 1.008
2.155ProVal: 2.155 ± 0.641
0.0ProTrp: 0.0 ± 0.0
2.514ProTyr: 2.514 ± 0.8
0.0ProXaa: 0.0 ± 0.0
Gln
5.388GlnAla: 5.388 ± 2.386
0.359GlnCys: 0.359 ± 0.425
1.078GlnAsp: 1.078 ± 0.619
4.67GlnGlu: 4.67 ± 1.109
1.078GlnPhe: 1.078 ± 0.537
1.796GlnGly: 1.796 ± 0.674
1.437GlnHis: 1.437 ± 0.592
2.514GlnIle: 2.514 ± 0.865
3.592GlnLys: 3.592 ± 1.272
3.951GlnLeu: 3.951 ± 1.124
1.078GlnMet: 1.078 ± 0.948
1.437GlnAsn: 1.437 ± 0.714
1.437GlnPro: 1.437 ± 0.724
3.951GlnGln: 3.951 ± 1.781
3.233GlnArg: 3.233 ± 1.187
1.796GlnSer: 1.796 ± 0.627
1.796GlnThr: 1.796 ± 0.704
2.514GlnVal: 2.514 ± 0.756
0.359GlnTrp: 0.359 ± 0.28
2.514GlnTyr: 2.514 ± 1.004
0.0GlnXaa: 0.0 ± 0.0
Arg
1.437ArgAla: 1.437 ± 0.622
0.359ArgCys: 0.359 ± 0.365
3.233ArgAsp: 3.233 ± 1.034
2.514ArgGlu: 2.514 ± 0.926
2.155ArgPhe: 2.155 ± 1.18
2.155ArgGly: 2.155 ± 0.973
1.078ArgHis: 1.078 ± 0.576
1.437ArgIle: 1.437 ± 0.73
5.388ArgLys: 5.388 ± 1.342
5.747ArgLeu: 5.747 ± 1.414
2.155ArgMet: 2.155 ± 0.8
2.155ArgAsn: 2.155 ± 0.992
2.155ArgPro: 2.155 ± 0.762
2.155ArgGln: 2.155 ± 1.179
2.155ArgArg: 2.155 ± 0.766
1.078ArgSer: 1.078 ± 0.47
2.514ArgThr: 2.514 ± 0.912
3.233ArgVal: 3.233 ± 0.969
0.359ArgTrp: 0.359 ± 0.335
2.514ArgTyr: 2.514 ± 1.688
0.0ArgXaa: 0.0 ± 0.0
Ser
2.514SerAla: 2.514 ± 0.678
0.359SerCys: 0.359 ± 0.321
3.951SerAsp: 3.951 ± 1.006
1.078SerGlu: 1.078 ± 0.754
2.514SerPhe: 2.514 ± 0.911
2.874SerGly: 2.874 ± 1.032
0.718SerHis: 0.718 ± 0.613
6.106SerIle: 6.106 ± 1.277
4.67SerLys: 4.67 ± 1.502
5.029SerLeu: 5.029 ± 1.251
1.437SerMet: 1.437 ± 0.73
2.155SerAsn: 2.155 ± 0.898
0.718SerPro: 0.718 ± 0.433
4.31SerGln: 4.31 ± 1.017
2.874SerArg: 2.874 ± 1.228
2.874SerSer: 2.874 ± 1.087
1.078SerThr: 1.078 ± 0.629
3.951SerVal: 3.951 ± 1.465
0.0SerTrp: 0.0 ± 0.0
4.67SerTyr: 4.67 ± 1.595
0.0SerXaa: 0.0 ± 0.0
Thr
2.874ThrAla: 2.874 ± 1.598
0.0ThrCys: 0.0 ± 0.0
3.592ThrAsp: 3.592 ± 1.077
3.951ThrGlu: 3.951 ± 1.062
2.514ThrPhe: 2.514 ± 0.759
4.31ThrGly: 4.31 ± 1.4
0.718ThrHis: 0.718 ± 0.521
4.67ThrIle: 4.67 ± 1.207
5.388ThrLys: 5.388 ± 1.595
6.466ThrLeu: 6.466 ± 1.307
1.078ThrMet: 1.078 ± 0.496
0.0ThrAsn: 0.0 ± 0.0
4.67ThrPro: 4.67 ± 1.177
2.155ThrGln: 2.155 ± 0.983
2.874ThrArg: 2.874 ± 0.693
2.514ThrSer: 2.514 ± 0.759
2.874ThrThr: 2.874 ± 1.103
3.592ThrVal: 3.592 ± 0.985
0.718ThrTrp: 0.718 ± 0.509
2.874ThrTyr: 2.874 ± 0.986
0.0ThrXaa: 0.0 ± 0.0
Val
3.233ValAla: 3.233 ± 1.107
1.078ValCys: 1.078 ± 0.524
1.796ValAsp: 1.796 ± 0.977
2.155ValGlu: 2.155 ± 0.691
1.078ValPhe: 1.078 ± 0.705
1.437ValGly: 1.437 ± 0.7
1.437ValHis: 1.437 ± 0.741
4.31ValIle: 4.31 ± 1.231
6.106ValLys: 6.106 ± 1.158
2.874ValLeu: 2.874 ± 1.115
1.437ValMet: 1.437 ± 0.571
3.233ValAsn: 3.233 ± 0.904
3.592ValPro: 3.592 ± 1.278
1.078ValGln: 1.078 ± 0.637
1.437ValArg: 1.437 ± 0.57
7.184ValSer: 7.184 ± 1.806
3.951ValThr: 3.951 ± 1.303
2.514ValVal: 2.514 ± 1.391
0.359ValTrp: 0.359 ± 0.38
2.514ValTyr: 2.514 ± 0.854
0.0ValXaa: 0.0 ± 0.0
Trp
1.078TrpAla: 1.078 ± 0.817
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.359TrpGlu: 0.359 ± 0.44
0.718TrpPhe: 0.718 ± 0.36
0.0TrpGly: 0.0 ± 0.0
0.359TrpHis: 0.359 ± 0.28
0.359TrpIle: 0.359 ± 0.321
0.359TrpLys: 0.359 ± 0.365
2.514TrpLeu: 2.514 ± 0.698
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.359TrpGln: 0.359 ± 0.28
0.718TrpArg: 0.718 ± 0.433
0.718TrpSer: 0.718 ± 0.455
0.718TrpThr: 0.718 ± 0.782
0.718TrpVal: 0.718 ± 0.421
0.359TrpTrp: 0.359 ± 0.321
0.718TrpTyr: 0.718 ± 0.36
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.359TyrCys: 0.359 ± 0.358
3.592TyrAsp: 3.592 ± 1.483
3.951TyrGlu: 3.951 ± 0.968
2.874TyrPhe: 2.874 ± 1.168
2.874TyrGly: 2.874 ± 0.989
0.718TyrHis: 0.718 ± 0.561
5.029TyrIle: 5.029 ± 1.108
4.31TyrLys: 4.31 ± 1.288
3.592TyrLeu: 3.592 ± 1.147
1.437TyrMet: 1.437 ± 0.83
2.874TyrAsn: 2.874 ± 0.979
1.796TyrPro: 1.796 ± 0.81
3.951TyrGln: 3.951 ± 1.345
2.514TyrArg: 2.514 ± 0.772
2.514TyrSer: 2.514 ± 1.07
1.437TyrThr: 1.437 ± 0.626
1.078TyrVal: 1.078 ± 0.599
0.718TyrTrp: 0.718 ± 0.73
2.514TyrTyr: 2.514 ± 0.924
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski