Amino acid dipepetide frequency for Ricinus communis (Castor bean)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.599AlaAla: 7.599 ± 0.049	1.323AlaCys: 1.323 ± 0.012	3.524AlaAsp: 3.524 ± 0.022	4.34AlaGlu: 4.34 ± 0.023	2.889AlaPhe: 2.889 ± 0.017	4.973AlaGly: 4.973 ± 0.034	1.536AlaHis: 1.536 ± 0.013	4.163AlaIle: 4.163 ± 0.023	3.885AlaLys: 3.885 ± 0.021	7.288AlaLeu: 7.288 ± 0.033	1.969AlaMet: 1.969 ± 0.013	2.773AlaAsn: 2.773 ± 0.016	3.083AlaPro: 3.083 ± 0.022	2.573AlaGln: 2.573 ± 0.022	4.172AlaArg: 4.172 ± 0.025	6.075AlaSer: 6.075 ± 0.027	3.911AlaThr: 3.911 ± 0.02	5.276AlaVal: 5.276 ± 0.029	0.854AlaTrp: 0.854 ± 0.009	1.937AlaTyr: 1.937 ± 0.015	0.002AlaXaa: 0.002 ± 0.0
Cys	1.049CysAla: 1.049 ± 0.01	0.51CysCys: 0.51 ± 0.007	0.831CysAsp: 0.831 ± 0.01	0.826CysGlu: 0.826 ± 0.01	0.841CysPhe: 0.841 ± 0.009	1.345CysGly: 1.345 ± 0.015	0.454CysHis: 0.454 ± 0.008	1.005CysIle: 1.005 ± 0.009	1.091CysLys: 1.091 ± 0.011	1.792CysLeu: 1.792 ± 0.016	0.434CysMet: 0.434 ± 0.006	0.85CysAsn: 0.85 ± 0.009	0.918CysPro: 0.918 ± 0.012	0.614CysGln: 0.614 ± 0.008	1.06CysArg: 1.06 ± 0.012	1.725CysSer: 1.725 ± 0.015	0.849CysThr: 0.849 ± 0.011	0.969CysVal: 0.969 ± 0.01	0.258CysTrp: 0.258 ± 0.005	0.545CysTyr: 0.545 ± 0.007	0.001CysXaa: 0.001 ± 0.0
Asp	3.846AspAla: 3.846 ± 0.023	0.925AspCys: 0.925 ± 0.01	3.585AspAsp: 3.585 ± 0.027	3.725AspGlu: 3.725 ± 0.022	2.309AspPhe: 2.309 ± 0.015	3.899AspGly: 3.899 ± 0.022	1.277AspHis: 1.277 ± 0.011	3.06AspIle: 3.06 ± 0.017	2.651AspLys: 2.651 ± 0.016	5.001AspLeu: 5.001 ± 0.024	1.327AspMet: 1.327 ± 0.013	2.12AspAsn: 2.12 ± 0.015	2.594AspPro: 2.594 ± 0.017	1.828AspGln: 1.828 ± 0.015	2.59AspArg: 2.59 ± 0.02	4.009AspSer: 4.009 ± 0.025	2.192AspThr: 2.192 ± 0.016	3.545AspVal: 3.545 ± 0.02	0.724AspTrp: 0.724 ± 0.009	1.554AspTyr: 1.554 ± 0.013	0.001AspXaa: 0.001 ± 0.0
Glu	4.818GluAla: 4.818 ± 0.024	0.861GluCys: 0.861 ± 0.011	3.662GluAsp: 3.662 ± 0.024	5.765GluGlu: 5.765 ± 0.04	2.263GluPhe: 2.263 ± 0.016	3.632GluGly: 3.632 ± 0.02	1.256GluHis: 1.256 ± 0.011	3.719GluIle: 3.719 ± 0.019	4.433GluLys: 4.433 ± 0.03	5.843GluLeu: 5.843 ± 0.03	1.758GluMet: 1.758 ± 0.014	2.96GluAsn: 2.96 ± 0.019	2.037GluPro: 2.037 ± 0.013	2.24GluGln: 2.24 ± 0.017	3.544GluArg: 3.544 ± 0.024	4.299GluSer: 4.299 ± 0.024	2.934GluThr: 2.934 ± 0.018	4.011GluVal: 4.011 ± 0.021	0.733GluTrp: 0.733 ± 0.008	1.582GluTyr: 1.582 ± 0.013	0.002GluXaa: 0.002 ± 0.0
Phe	2.654PheAla: 2.654 ± 0.015	0.86PheCys: 0.86 ± 0.009	2.343PheAsp: 2.343 ± 0.015	2.204PheGlu: 2.204 ± 0.015	1.92PhePhe: 1.92 ± 0.017	3.023PheGly: 3.023 ± 0.019	1.088PheHis: 1.088 ± 0.011	2.11PheIle: 2.11 ± 0.015	2.048PheLys: 2.048 ± 0.015	4.283PheLeu: 4.283 ± 0.021	0.963PheMet: 0.963 ± 0.01	1.765PheAsn: 1.765 ± 0.013	1.988PhePro: 1.988 ± 0.014	1.576PheGln: 1.576 ± 0.012	2.042PheArg: 2.042 ± 0.015	3.935PheSer: 3.935 ± 0.022	2.005PheThr: 2.005 ± 0.015	2.605PheVal: 2.605 ± 0.018	0.558PheTrp: 0.558 ± 0.008	1.255PheTyr: 1.255 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	4.493GlyAla: 4.493 ± 0.029	1.272GlyCys: 1.272 ± 0.013	3.42GlyAsp: 3.42 ± 0.02	3.599GlyGlu: 3.599 ± 0.022	3.139GlyPhe: 3.139 ± 0.021	5.53GlyGly: 5.53 ± 0.045	1.656GlyHis: 1.656 ± 0.014	3.816GlyIle: 3.816 ± 0.023	4.012GlyLys: 4.012 ± 0.021	6.155GlyLeu: 6.155 ± 0.035	1.579GlyMet: 1.579 ± 0.013	3.113GlyAsn: 3.113 ± 0.021	2.478GlyPro: 2.478 ± 0.018	2.317GlyGln: 2.317 ± 0.016	4.0GlyArg: 4.0 ± 0.026	5.722GlySer: 5.722 ± 0.031	3.315GlyThr: 3.315 ± 0.018	4.289GlyVal: 4.289 ± 0.024	0.943GlyTrp: 0.943 ± 0.01	2.13GlyTyr: 2.13 ± 0.017	0.003GlyXaa: 0.003 ± 0.0
His	1.701HisAla: 1.701 ± 0.015	0.51HisCys: 0.51 ± 0.006	1.172HisAsp: 1.172 ± 0.011	1.292HisGlu: 1.292 ± 0.012	1.072HisPhe: 1.072 ± 0.011	1.822HisGly: 1.822 ± 0.015	1.035HisHis: 1.035 ± 0.013	1.21HisIle: 1.21 ± 0.011	1.1HisLys: 1.1 ± 0.012	2.451HisLeu: 2.451 ± 0.015	0.567HisMet: 0.567 ± 0.008	0.957HisAsn: 0.957 ± 0.01	1.367HisPro: 1.367 ± 0.011	1.136HisGln: 1.136 ± 0.011	1.535HisArg: 1.535 ± 0.016	1.844HisSer: 1.844 ± 0.014	0.938HisThr: 0.938 ± 0.008	1.565HisVal: 1.565 ± 0.014	0.308HisTrp: 0.308 ± 0.005	0.687HisTyr: 0.687 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	4.044IleAla: 4.044 ± 0.025	1.07IleCys: 1.07 ± 0.011	3.044IleAsp: 3.044 ± 0.02	3.266IleGlu: 3.266 ± 0.022	2.272IlePhe: 2.272 ± 0.016	3.632IleGly: 3.632 ± 0.023	1.285IleHis: 1.285 ± 0.012	2.91IleIle: 2.91 ± 0.021	2.935IleLys: 2.935 ± 0.017	5.269IleLeu: 5.269 ± 0.025	1.192IleMet: 1.192 ± 0.009	2.281IleAsn: 2.281 ± 0.018	2.89IlePro: 2.89 ± 0.018	1.988IleGln: 1.988 ± 0.015	2.74IleArg: 2.74 ± 0.018	4.898IleSer: 4.898 ± 0.027	2.66IleThr: 2.66 ± 0.017	3.508IleVal: 3.508 ± 0.02	0.718IleTrp: 0.718 ± 0.011	1.5IleTyr: 1.5 ± 0.013	0.002IleXaa: 0.002 ± 0.0
Lys	4.024LysAla: 4.024 ± 0.024	0.924LysCys: 0.924 ± 0.011	3.138LysAsp: 3.138 ± 0.018	4.401LysGlu: 4.401 ± 0.03	2.065LysPhe: 2.065 ± 0.014	3.526LysGly: 3.526 ± 0.02	1.288LysHis: 1.288 ± 0.011	3.147LysIle: 3.147 ± 0.018	4.408LysLys: 4.408 ± 0.032	5.734LysLeu: 5.734 ± 0.025	1.44LysMet: 1.44 ± 0.012	2.599LysAsn: 2.599 ± 0.018	2.633LysPro: 2.633 ± 0.02	2.274LysGln: 2.274 ± 0.018	3.47LysArg: 3.47 ± 0.021	4.307LysSer: 4.307 ± 0.023	2.708LysThr: 2.708 ± 0.017	3.627LysVal: 3.627 ± 0.02	0.776LysTrp: 0.776 ± 0.009	1.543LysTyr: 1.543 ± 0.012	0.002LysXaa: 0.002 ± 0.0
Leu	7.315LeuAla: 7.315 ± 0.035	1.759LeuCys: 1.759 ± 0.015	5.168LeuAsp: 5.168 ± 0.027	6.159LeuGlu: 6.159 ± 0.031	3.818LeuPhe: 3.818 ± 0.025	5.938LeuGly: 5.938 ± 0.029	2.613LeuHis: 2.613 ± 0.017	4.786LeuIle: 4.786 ± 0.025	5.914LeuLys: 5.914 ± 0.033	9.945LeuLeu: 9.945 ± 0.042	2.189LeuMet: 2.189 ± 0.014	3.928LeuAsn: 3.928 ± 0.021	5.179LeuPro: 5.179 ± 0.029	4.39LeuGln: 4.39 ± 0.026	5.481LeuArg: 5.481 ± 0.025	8.347LeuSer: 8.347 ± 0.036	4.48LeuThr: 4.48 ± 0.022	6.329LeuVal: 6.329 ± 0.029	1.167LeuTrp: 1.167 ± 0.011	2.48LeuTyr: 2.48 ± 0.018	0.004LeuXaa: 0.004 ± 0.001
Met	2.253MetAla: 2.253 ± 0.016	0.307MetCys: 0.307 ± 0.005	1.385MetAsp: 1.385 ± 0.012	1.958MetGlu: 1.958 ± 0.014	0.789MetPhe: 0.789 ± 0.009	1.611MetGly: 1.611 ± 0.013	0.574MetHis: 0.574 ± 0.008	1.251MetIle: 1.251 ± 0.012	1.571MetLys: 1.571 ± 0.014	2.236MetLeu: 2.236 ± 0.014	0.657MetMet: 0.657 ± 0.009	1.014MetAsn: 1.014 ± 0.009	1.126MetPro: 1.126 ± 0.009	0.994MetGln: 0.994 ± 0.011	1.286MetArg: 1.286 ± 0.012	1.725MetSer: 1.725 ± 0.015	1.092MetThr: 1.092 ± 0.009	1.624MetVal: 1.624 ± 0.012	0.259MetTrp: 0.259 ± 0.005	0.575MetTyr: 0.575 ± 0.009	0.001MetXaa: 0.001 ± 0.0
Asn	2.82AsnAla: 2.82 ± 0.015	0.849AsnCys: 0.849 ± 0.009	2.111AsnAsp: 2.111 ± 0.014	2.456AsnGlu: 2.456 ± 0.016	1.875AsnPhe: 1.875 ± 0.014	3.299AsnGly: 3.299 ± 0.021	1.079AsnHis: 1.079 ± 0.011	2.423AsnIle: 2.423 ± 0.017	2.327AsnLys: 2.327 ± 0.018	4.511AsnLeu: 4.511 ± 0.027	1.065AsnMet: 1.065 ± 0.011	2.416AsnAsn: 2.416 ± 0.024	2.31AsnPro: 2.31 ± 0.015	1.712AsnGln: 1.712 ± 0.015	2.03AsnArg: 2.03 ± 0.015	3.943AsnSer: 3.943 ± 0.024	1.962AsnThr: 1.962 ± 0.018	2.697AsnVal: 2.697 ± 0.018	0.589AsnTrp: 0.589 ± 0.008	1.339AsnTyr: 1.339 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	3.476ProAla: 3.476 ± 0.025	0.772ProCys: 0.772 ± 0.009	2.55ProAsp: 2.55 ± 0.018	2.996ProGlu: 2.996 ± 0.018	1.996ProPhe: 1.996 ± 0.016	2.851ProGly: 2.851 ± 0.019	1.108ProHis: 1.108 ± 0.012	2.337ProIle: 2.337 ± 0.015	2.527ProLys: 2.527 ± 0.018	4.342ProLeu: 4.342 ± 0.02	0.987ProMet: 0.987 ± 0.01	2.161ProAsn: 2.161 ± 0.016	3.69ProPro: 3.69 ± 0.046	1.785ProGln: 1.785 ± 0.018	2.449ProArg: 2.449 ± 0.016	4.801ProSer: 4.801 ± 0.029	2.543ProThr: 2.543 ± 0.017	3.179ProVal: 3.179 ± 0.018	0.614ProTrp: 0.614 ± 0.009	1.298ProTyr: 1.298 ± 0.013	0.002ProXaa: 0.002 ± 0.0
Gln	2.81GlnAla: 2.81 ± 0.022	0.574GlnCys: 0.574 ± 0.007	1.723GlnAsp: 1.723 ± 0.014	2.52GlnGlu: 2.52 ± 0.018	1.456GlnPhe: 1.456 ± 0.011	2.209GlnGly: 2.209 ± 0.014	1.072GlnHis: 1.072 ± 0.012	2.04GlnIle: 2.04 ± 0.014	2.246GlnLys: 2.246 ± 0.016	3.826GlnLeu: 3.826 ± 0.021	0.993GlnMet: 0.993 ± 0.01	1.765GlnAsn: 1.765 ± 0.015	1.852GlnPro: 1.852 ± 0.018	2.336GlnGln: 2.336 ± 0.034	2.457GlnArg: 2.457 ± 0.02	2.831GlnSer: 2.831 ± 0.022	1.728GlnThr: 1.728 ± 0.013	2.475GlnVal: 2.475 ± 0.016	0.477GlnTrp: 0.477 ± 0.007	0.947GlnTyr: 0.947 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	3.941ArgAla: 3.941 ± 0.026	0.981ArgCys: 0.981 ± 0.012	2.772ArgAsp: 2.772 ± 0.018	3.371ArgGlu: 3.371 ± 0.025	2.241ArgPhe: 2.241 ± 0.016	3.419ArgGly: 3.419 ± 0.022	1.505ArgHis: 1.505 ± 0.013	3.1ArgIle: 3.1 ± 0.018	3.681ArgLys: 3.681 ± 0.022	5.31ArgLeu: 5.31 ± 0.024	1.405ArgMet: 1.405 ± 0.012	2.484ArgAsn: 2.484 ± 0.015	2.532ArgPro: 2.532 ± 0.02	2.228ArgGln: 2.228 ± 0.017	4.422ArgArg: 4.422 ± 0.033	4.226ArgSer: 4.226 ± 0.027	2.56ArgThr: 2.56 ± 0.017	3.438ArgVal: 3.438 ± 0.022	0.773ArgTrp: 0.773 ± 0.008	1.453ArgTyr: 1.453 ± 0.013	0.001ArgXaa: 0.001 ± 0.0
Ser	5.508SerAla: 5.508 ± 0.027	1.659SerCys: 1.659 ± 0.014	4.147SerAsp: 4.147 ± 0.023	4.379SerGlu: 4.379 ± 0.024	3.857SerPhe: 3.857 ± 0.021	5.766SerGly: 5.766 ± 0.03	1.903SerHis: 1.903 ± 0.016	4.618SerIle: 4.618 ± 0.022	4.661SerLys: 4.661 ± 0.025	8.477SerLeu: 8.477 ± 0.036	2.039SerMet: 2.039 ± 0.014	3.986SerAsn: 3.986 ± 0.025	4.299SerPro: 4.299 ± 0.031	2.919SerGln: 2.919 ± 0.023	4.409SerArg: 4.409 ± 0.024	10.357SerSer: 10.357 ± 0.063	4.56SerThr: 4.56 ± 0.024	4.965SerVal: 4.965 ± 0.024	1.159SerTrp: 1.159 ± 0.01	2.265SerTyr: 2.265 ± 0.016	0.003SerXaa: 0.003 ± 0.001
Thr	3.809ThrAla: 3.809 ± 0.02	0.897ThrCys: 0.897 ± 0.01	2.306ThrAsp: 2.306 ± 0.015	2.687ThrGlu: 2.687 ± 0.017	1.994ThrPhe: 1.994 ± 0.014	3.446ThrGly: 3.446 ± 0.019	1.024ThrHis: 1.024 ± 0.011	2.744ThrIle: 2.744 ± 0.019	2.487ThrLys: 2.487 ± 0.019	4.603ThrLeu: 4.603 ± 0.024	1.131ThrMet: 1.131 ± 0.011	2.043ThrAsn: 2.043 ± 0.017	2.545ThrPro: 2.545 ± 0.019	1.544ThrGln: 1.544 ± 0.013	2.464ThrArg: 2.464 ± 0.015	4.497ThrSer: 4.497 ± 0.025	3.012ThrThr: 3.012 ± 0.024	3.361ThrVal: 3.361 ± 0.017	0.661ThrTrp: 0.661 ± 0.009	1.361ThrTyr: 1.361 ± 0.014	0.003ThrXaa: 0.003 ± 0.0
Val	5.269ValAla: 5.269 ± 0.029	1.075ValCys: 1.075 ± 0.011	3.695ValAsp: 3.695 ± 0.022	4.178ValGlu: 4.178 ± 0.023	2.626ValPhe: 2.626 ± 0.016	4.215ValGly: 4.215 ± 0.024	1.514ValHis: 1.514 ± 0.013	3.486ValIle: 3.486 ± 0.02	3.674ValLys: 3.674 ± 0.022	6.325ValLeu: 6.325 ± 0.031	1.522ValMet: 1.522 ± 0.013	2.584ValAsn: 2.584 ± 0.017	3.155ValPro: 3.155 ± 0.02	2.392ValGln: 2.392 ± 0.014	3.294ValArg: 3.294 ± 0.022	5.184ValSer: 5.184 ± 0.026	3.22ValThr: 3.22 ± 0.017	4.838ValVal: 4.838 ± 0.025	0.754ValTrp: 0.754 ± 0.01	1.839ValTyr: 1.839 ± 0.012	0.003ValXaa: 0.003 ± 0.001
Trp	0.825TrpAla: 0.825 ± 0.009	0.235TrpCys: 0.235 ± 0.005	0.678TrpAsp: 0.678 ± 0.01	0.72TrpGlu: 0.72 ± 0.009	0.527TrpPhe: 0.527 ± 0.008	0.74TrpGly: 0.74 ± 0.01	0.313TrpHis: 0.313 ± 0.005	0.733TrpIle: 0.733 ± 0.009	0.911TrpLys: 0.911 ± 0.009	1.289TrpLeu: 1.289 ± 0.012	0.344TrpMet: 0.344 ± 0.006	0.704TrpAsn: 0.704 ± 0.009	0.528TrpPro: 0.528 ± 0.007	0.499TrpGln: 0.499 ± 0.007	0.887TrpArg: 0.887 ± 0.009	0.976TrpSer: 0.976 ± 0.012	0.655TrpThr: 0.655 ± 0.008	0.816TrpVal: 0.816 ± 0.01	0.243TrpTrp: 0.243 ± 0.005	0.349TrpTyr: 0.349 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.889TyrAla: 1.889 ± 0.013	0.606TyrCys: 0.606 ± 0.008	1.506TyrAsp: 1.506 ± 0.012	1.507TyrGlu: 1.507 ± 0.01	1.272TyrPhe: 1.272 ± 0.012	2.105TyrGly: 2.105 ± 0.018	0.689TyrHis: 0.689 ± 0.008	1.443TyrIle: 1.443 ± 0.015	1.473TyrLys: 1.473 ± 0.012	2.709TyrLeu: 2.709 ± 0.018	0.728TyrMet: 0.728 ± 0.008	1.308TyrAsn: 1.308 ± 0.014	1.257TyrPro: 1.257 ± 0.012	0.996TyrGln: 0.996 ± 0.01	1.507TyrArg: 1.507 ± 0.013	2.229TyrSer: 2.229 ± 0.015	1.292TyrThr: 1.292 ± 0.013	1.72TyrVal: 1.72 ± 0.013	0.404TyrTrp: 0.404 ± 0.006	0.951TyrTyr: 0.951 ± 0.011	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.005XaaSer: 0.005 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.025XaaXaa: 0.025 ± 0.002

Statistics based on 31219 proteins (10431927 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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