Amino acid dipepetide frequency for Nonomuraea fuscirosea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.858AlaAla: 20.858 ± 0.125	1.128AlaCys: 1.128 ± 0.019	7.611AlaAsp: 7.611 ± 0.049	8.474AlaGlu: 8.474 ± 0.06	3.687AlaPhe: 3.687 ± 0.031	14.102AlaGly: 14.102 ± 0.078	2.616AlaHis: 2.616 ± 0.029	4.159AlaIle: 4.159 ± 0.034	2.707AlaLys: 2.707 ± 0.035	14.155AlaLeu: 14.155 ± 0.092	2.726AlaMet: 2.726 ± 0.03	1.985AlaAsn: 1.985 ± 0.024	6.301AlaPro: 6.301 ± 0.045	3.475AlaGln: 3.475 ± 0.037	10.324AlaArg: 10.324 ± 0.067	5.631AlaSer: 5.631 ± 0.038	7.091AlaThr: 7.091 ± 0.041	11.632AlaVal: 11.632 ± 0.069	2.005AlaTrp: 2.005 ± 0.029	2.822AlaTyr: 2.822 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.019	0.099CysCys: 0.099 ± 0.005	0.491CysAsp: 0.491 ± 0.011	0.4CysGlu: 0.4 ± 0.01	0.233CysPhe: 0.233 ± 0.008	0.935CysGly: 0.935 ± 0.018	0.226CysHis: 0.226 ± 0.007	0.124CysIle: 0.124 ± 0.005	0.112CysLys: 0.112 ± 0.005	0.77CysLeu: 0.77 ± 0.016	0.116CysMet: 0.116 ± 0.005	0.126CysAsn: 0.126 ± 0.006	0.495CysPro: 0.495 ± 0.013	0.176CysGln: 0.176 ± 0.008	0.601CysArg: 0.601 ± 0.014	0.434CysSer: 0.434 ± 0.013	0.426CysThr: 0.426 ± 0.012	0.667CysVal: 0.667 ± 0.015	0.134CysTrp: 0.134 ± 0.006	0.174CysTyr: 0.174 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	6.701AspAla: 6.701 ± 0.044	0.38AspCys: 0.38 ± 0.012	3.632AspAsp: 3.632 ± 0.035	3.665AspGlu: 3.665 ± 0.034	1.539AspPhe: 1.539 ± 0.022	6.104AspGly: 6.104 ± 0.048	1.383AspHis: 1.383 ± 0.022	1.665AspIle: 1.665 ± 0.023	1.022AspLys: 1.022 ± 0.021	6.671AspLeu: 6.671 ± 0.05	0.791AspMet: 0.791 ± 0.017	0.9AspAsn: 0.9 ± 0.017	4.546AspPro: 4.546 ± 0.039	1.639AspGln: 1.639 ± 0.022	4.794AspArg: 4.794 ± 0.037	2.193AspSer: 2.193 ± 0.025	2.615AspThr: 2.615 ± 0.029	4.937AspVal: 4.937 ± 0.04	0.934AspTrp: 0.934 ± 0.017	1.218AspTyr: 1.218 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.839GluAla: 6.839 ± 0.054	0.354GluCys: 0.354 ± 0.01	2.388GluAsp: 2.388 ± 0.027	3.43GluGlu: 3.43 ± 0.036	1.43GluPhe: 1.43 ± 0.019	3.971GluGly: 3.971 ± 0.037	1.603GluHis: 1.603 ± 0.024	2.379GluIle: 2.379 ± 0.024	1.055GluLys: 1.055 ± 0.017	7.081GluLeu: 7.081 ± 0.05	0.897GluMet: 0.897 ± 0.016	0.886GluAsn: 0.886 ± 0.016	3.545GluPro: 3.545 ± 0.039	2.279GluGln: 2.279 ± 0.027	5.919GluArg: 5.919 ± 0.053	2.62GluSer: 2.62 ± 0.03	2.747GluThr: 2.747 ± 0.035	4.625GluVal: 4.625 ± 0.039	0.808GluTrp: 0.808 ± 0.013	0.999GluTyr: 0.999 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.812PheAla: 3.812 ± 0.032	0.266PheCys: 0.266 ± 0.008	2.006PheAsp: 2.006 ± 0.028	1.456PheGlu: 1.456 ± 0.022	0.903PhePhe: 0.903 ± 0.017	3.113PheGly: 3.113 ± 0.029	0.624PheHis: 0.624 ± 0.013	0.785PheIle: 0.785 ± 0.017	0.514PheLys: 0.514 ± 0.012	2.687PheLeu: 2.687 ± 0.034	0.456PheMet: 0.456 ± 0.012	0.569PheAsn: 0.569 ± 0.012	1.411PhePro: 1.411 ± 0.019	0.722PheGln: 0.722 ± 0.013	1.81PheArg: 1.81 ± 0.023	1.45PheSer: 1.45 ± 0.022	2.053PheThr: 2.053 ± 0.026	2.393PheVal: 2.393 ± 0.027	0.48PheTrp: 0.48 ± 0.011	0.625PheTyr: 0.625 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.577GlyAla: 10.577 ± 0.06	0.831GlyCys: 0.831 ± 0.017	5.254GlyAsp: 5.254 ± 0.041	5.255GlyGlu: 5.255 ± 0.046	2.928GlyPhe: 2.928 ± 0.033	8.965GlyGly: 8.965 ± 0.081	2.307GlyHis: 2.307 ± 0.03	3.299GlyIle: 3.299 ± 0.031	2.279GlyLys: 2.279 ± 0.03	10.03GlyLeu: 10.03 ± 0.063	2.041GlyMet: 2.041 ± 0.028	1.667GlyAsn: 1.667 ± 0.029	5.241GlyPro: 5.241 ± 0.054	2.885GlyGln: 2.885 ± 0.038	8.176GlyArg: 8.176 ± 0.055	5.012GlySer: 5.012 ± 0.043	5.758GlyThr: 5.758 ± 0.053	7.957GlyVal: 7.957 ± 0.053	1.776GlyTrp: 1.776 ± 0.022	2.421GlyTyr: 2.421 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.676HisAla: 2.676 ± 0.033	0.2HisCys: 0.2 ± 0.008	1.432HisAsp: 1.432 ± 0.021	1.227HisGlu: 1.227 ± 0.02	0.591HisPhe: 0.591 ± 0.014	2.238HisGly: 2.238 ± 0.027	0.693HisHis: 0.693 ± 0.017	0.631HisIle: 0.631 ± 0.014	0.306HisLys: 0.306 ± 0.01	2.499HisLeu: 2.499 ± 0.031	0.332HisMet: 0.332 ± 0.011	0.37HisAsn: 0.37 ± 0.011	1.718HisPro: 1.718 ± 0.024	0.638HisGln: 0.638 ± 0.015	2.009HisArg: 2.009 ± 0.026	0.869HisSer: 0.869 ± 0.019	1.136HisThr: 1.136 ± 0.02	1.832HisVal: 1.832 ± 0.025	0.36HisTrp: 0.36 ± 0.009	0.475HisTyr: 0.475 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	5.094IleAla: 5.094 ± 0.039	0.318IleCys: 0.318 ± 0.008	2.466IleAsp: 2.466 ± 0.03	2.219IleGlu: 2.219 ± 0.027	0.855IlePhe: 0.855 ± 0.018	3.717IleGly: 3.717 ± 0.035	0.623IleHis: 0.623 ± 0.013	1.075IleIle: 1.075 ± 0.021	0.795IleLys: 0.795 ± 0.016	2.662IleLeu: 2.662 ± 0.031	0.612IleMet: 0.612 ± 0.014	0.719IleAsn: 0.719 ± 0.015	1.864IlePro: 1.864 ± 0.024	0.771IleGln: 0.771 ± 0.017	2.484IleArg: 2.484 ± 0.027	1.924IleSer: 1.924 ± 0.027	2.455IleThr: 2.455 ± 0.029	3.239IleVal: 3.239 ± 0.036	0.47IleTrp: 0.47 ± 0.01	0.63IleTyr: 0.63 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.552LysAla: 2.552 ± 0.037	0.119LysCys: 0.119 ± 0.007	1.095LysAsp: 1.095 ± 0.019	1.141LysGlu: 1.141 ± 0.021	0.43LysPhe: 0.43 ± 0.011	1.694LysGly: 1.694 ± 0.025	0.389LysHis: 0.389 ± 0.01	0.916LysIle: 0.916 ± 0.017	0.641LysLys: 0.641 ± 0.016	1.966LysLeu: 1.966 ± 0.026	0.353LysMet: 0.353 ± 0.01	0.45LysAsn: 0.45 ± 0.013	1.278LysPro: 1.278 ± 0.021	0.635LysGln: 0.635 ± 0.015	1.424LysArg: 1.424 ± 0.023	1.033LysSer: 1.033 ± 0.018	1.169LysThr: 1.169 ± 0.022	1.888LysVal: 1.888 ± 0.028	0.289LysTrp: 0.289 ± 0.011	0.409LysTyr: 0.409 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.781LeuAla: 15.781 ± 0.087	0.787LeuCys: 0.787 ± 0.014	6.675LeuAsp: 6.675 ± 0.047	4.749LeuGlu: 4.749 ± 0.039	2.772LeuPhe: 2.772 ± 0.031	9.455LeuGly: 9.455 ± 0.062	2.129LeuHis: 2.129 ± 0.026	4.017LeuIle: 4.017 ± 0.039	1.918LeuLys: 1.918 ± 0.03	11.584LeuLeu: 11.584 ± 0.083	1.842LeuMet: 1.842 ± 0.023	1.786LeuAsn: 1.786 ± 0.022	6.59LeuPro: 6.59 ± 0.05	2.064LeuGln: 2.064 ± 0.023	9.158LeuArg: 9.158 ± 0.057	5.807LeuSer: 5.807 ± 0.044	6.961LeuThr: 6.961 ± 0.045	8.997LeuVal: 8.997 ± 0.061	1.356LeuTrp: 1.356 ± 0.021	1.919LeuTyr: 1.919 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.424MetAla: 2.424 ± 0.027	0.136MetCys: 0.136 ± 0.006	0.908MetAsp: 0.908 ± 0.014	0.834MetGlu: 0.834 ± 0.018	0.506MetPhe: 0.506 ± 0.013	1.372MetGly: 1.372 ± 0.019	0.341MetHis: 0.341 ± 0.009	0.891MetIle: 0.891 ± 0.016	0.459MetLys: 0.459 ± 0.013	1.918MetLeu: 1.918 ± 0.022	0.332MetMet: 0.332 ± 0.009	0.478MetAsn: 0.478 ± 0.013	1.157MetPro: 1.157 ± 0.02	0.389MetGln: 0.389 ± 0.011	1.732MetArg: 1.732 ± 0.021	1.393MetSer: 1.393 ± 0.017	1.601MetThr: 1.601 ± 0.022	1.402MetVal: 1.402 ± 0.023	0.236MetTrp: 0.236 ± 0.007	0.333MetTyr: 0.333 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.174AsnAla: 2.174 ± 0.027	0.162AsnCys: 0.162 ± 0.007	0.961AsnAsp: 0.961 ± 0.015	0.83AsnGlu: 0.83 ± 0.015	0.485AsnPhe: 0.485 ± 0.013	1.847AsnGly: 1.847 ± 0.031	0.38AsnHis: 0.38 ± 0.011	0.595AsnIle: 0.595 ± 0.013	0.353AsnLys: 0.353 ± 0.01	1.809AsnLeu: 1.809 ± 0.022	0.299AsnMet: 0.299 ± 0.008	0.395AsnAsn: 0.395 ± 0.014	1.395AsnPro: 1.395 ± 0.023	0.507AsnGln: 0.507 ± 0.013	1.282AsnArg: 1.282 ± 0.018	0.815AsnSer: 0.815 ± 0.018	1.006AsnThr: 1.006 ± 0.016	1.536AsnVal: 1.536 ± 0.019	0.297AsnTrp: 0.297 ± 0.01	0.404AsnTyr: 0.404 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.764ProAla: 8.764 ± 0.062	0.346ProCys: 0.346 ± 0.011	4.268ProAsp: 4.268 ± 0.039	4.105ProGlu: 4.105 ± 0.034	1.636ProPhe: 1.636 ± 0.021	6.938ProGly: 6.938 ± 0.058	1.287ProHis: 1.287 ± 0.02	1.778ProIle: 1.778 ± 0.023	1.131ProLys: 1.131 ± 0.021	5.329ProLeu: 5.329 ± 0.044	1.168ProMet: 1.168 ± 0.018	0.897ProAsn: 0.897 ± 0.017	3.889ProPro: 3.889 ± 0.045	1.571ProGln: 1.571 ± 0.026	3.931ProArg: 3.931 ± 0.032	3.251ProSer: 3.251 ± 0.036	2.926ProThr: 2.926 ± 0.039	5.3ProVal: 5.3 ± 0.043	0.972ProTrp: 0.972 ± 0.018	1.492ProTyr: 1.492 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	4.048GlnAla: 4.048 ± 0.04	0.146GlnCys: 0.146 ± 0.007	1.367GlnAsp: 1.367 ± 0.02	1.436GlnGlu: 1.436 ± 0.02	0.684GlnPhe: 0.684 ± 0.015	2.236GlnGly: 2.236 ± 0.03	0.576GlnHis: 0.576 ± 0.014	1.162GlnIle: 1.162 ± 0.019	0.485GlnLys: 0.485 ± 0.013	2.758GlnLeu: 2.758 ± 0.033	0.451GlnMet: 0.451 ± 0.011	0.497GlnAsn: 0.497 ± 0.014	1.724GlnPro: 1.724 ± 0.029	1.08GlnGln: 1.08 ± 0.03	2.322GlnArg: 2.322 ± 0.028	1.185GlnSer: 1.185 ± 0.02	1.322GlnThr: 1.322 ± 0.021	2.61GlnVal: 2.61 ± 0.027	0.435GlnTrp: 0.435 ± 0.011	0.514GlnTyr: 0.514 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	10.056ArgAla: 10.056 ± 0.068	0.605ArgCys: 0.605 ± 0.015	4.494ArgAsp: 4.494 ± 0.043	4.825ArgGlu: 4.825 ± 0.041	2.448ArgPhe: 2.448 ± 0.026	5.803ArgGly: 5.803 ± 0.048	2.217ArgHis: 2.217 ± 0.026	3.218ArgIle: 3.218 ± 0.03	1.592ArgLys: 1.592 ± 0.023	9.781ArgLeu: 9.781 ± 0.064	1.895ArgMet: 1.895 ± 0.022	1.386ArgAsn: 1.386 ± 0.022	5.177ArgPro: 5.177 ± 0.042	2.467ArgGln: 2.467 ± 0.03	8.28ArgArg: 8.28 ± 0.057	4.018ArgSer: 4.018 ± 0.035	4.861ArgThr: 4.861 ± 0.039	6.321ArgVal: 6.321 ± 0.043	1.497ArgTrp: 1.497 ± 0.02	1.887ArgTyr: 1.887 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.498SerAla: 6.498 ± 0.045	0.417SerCys: 0.417 ± 0.011	2.564SerAsp: 2.564 ± 0.026	2.35SerGlu: 2.35 ± 0.029	1.564SerPhe: 1.564 ± 0.021	5.948SerGly: 5.948 ± 0.052	0.976SerHis: 0.976 ± 0.018	1.729SerIle: 1.729 ± 0.023	0.951SerLys: 0.951 ± 0.019	4.848SerLeu: 4.848 ± 0.038	1.22SerMet: 1.22 ± 0.018	0.832SerAsn: 0.832 ± 0.015	3.283SerPro: 3.283 ± 0.042	1.215SerGln: 1.215 ± 0.016	3.846SerArg: 3.846 ± 0.031	2.84SerSer: 2.84 ± 0.032	2.876SerThr: 2.876 ± 0.027	4.114SerVal: 4.114 ± 0.038	0.958SerTrp: 0.958 ± 0.017	1.198SerTyr: 1.198 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	7.824ThrAla: 7.824 ± 0.053	0.444ThrCys: 0.444 ± 0.013	3.011ThrAsp: 3.011 ± 0.03	2.799ThrGlu: 2.799 ± 0.03	1.788ThrPhe: 1.788 ± 0.022	6.51ThrGly: 6.51 ± 0.048	1.126ThrHis: 1.126 ± 0.018	2.099ThrIle: 2.099 ± 0.025	1.105ThrLys: 1.105 ± 0.02	5.925ThrLeu: 5.925 ± 0.047	1.158ThrMet: 1.158 ± 0.02	0.942ThrAsn: 0.942 ± 0.017	4.064ThrPro: 4.064 ± 0.042	1.312ThrGln: 1.312 ± 0.017	4.086ThrArg: 4.086 ± 0.033	3.148ThrSer: 3.148 ± 0.034	3.69ThrThr: 3.69 ± 0.039	5.457ThrVal: 5.457 ± 0.041	1.013ThrTrp: 1.013 ± 0.017	1.314ThrTyr: 1.314 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	11.283ValAla: 11.283 ± 0.063	0.704ValCys: 0.704 ± 0.015	4.437ValAsp: 4.437 ± 0.04	4.686ValGlu: 4.686 ± 0.037	2.486ValPhe: 2.486 ± 0.027	6.372ValGly: 6.372 ± 0.056	1.849ValHis: 1.849 ± 0.024	3.347ValIle: 3.347 ± 0.029	1.764ValLys: 1.764 ± 0.025	9.693ValLeu: 9.693 ± 0.069	1.544ValMet: 1.544 ± 0.022	1.772ValAsn: 1.772 ± 0.026	5.285ValPro: 5.285 ± 0.037	1.966ValGln: 1.966 ± 0.026	7.199ValArg: 7.199 ± 0.053	4.645ValSer: 4.645 ± 0.031	5.865ValThr: 5.865 ± 0.05	8.07ValVal: 8.07 ± 0.056	1.173ValTrp: 1.173 ± 0.018	1.64ValTyr: 1.64 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.707TrpAla: 1.707 ± 0.023	0.153TrpCys: 0.153 ± 0.006	0.818TrpAsp: 0.818 ± 0.018	0.744TrpGlu: 0.744 ± 0.014	0.513TrpPhe: 0.513 ± 0.013	1.078TrpGly: 1.078 ± 0.018	0.441TrpHis: 0.441 ± 0.011	0.621TrpIle: 0.621 ± 0.013	0.331TrpLys: 0.331 ± 0.011	1.876TrpLeu: 1.876 ± 0.024	0.335TrpMet: 0.335 ± 0.01	0.463TrpAsn: 0.463 ± 0.013	0.913TrpPro: 0.913 ± 0.016	0.601TrpGln: 0.601 ± 0.013	1.542TrpArg: 1.542 ± 0.021	1.008TrpSer: 1.008 ± 0.018	1.04TrpThr: 1.04 ± 0.018	1.002TrpVal: 1.002 ± 0.017	0.365TrpTrp: 0.365 ± 0.01	0.373TrpTyr: 0.373 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.776TyrAla: 2.776 ± 0.031	0.188TyrCys: 0.188 ± 0.008	1.451TyrAsp: 1.451 ± 0.021	1.226TyrGlu: 1.226 ± 0.02	0.658TyrPhe: 0.658 ± 0.013	2.262TyrGly: 2.262 ± 0.028	0.445TyrHis: 0.445 ± 0.012	0.504TyrIle: 0.504 ± 0.013	0.351TyrLys: 0.351 ± 0.01	2.306TyrLeu: 2.306 ± 0.025	0.274TyrMet: 0.274 ± 0.009	0.412TyrAsn: 0.412 ± 0.011	1.105TyrPro: 1.105 ± 0.016	0.646TyrGln: 0.646 ± 0.014	1.908TyrArg: 1.908 ± 0.024	0.952TyrSer: 0.952 ± 0.016	1.215TyrThr: 1.215 ± 0.021	1.8TyrVal: 1.8 ± 0.023	0.368TyrTrp: 0.368 ± 0.008	0.49TyrTyr: 0.49 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11276 proteins (3590346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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