Amino acid dipepetide frequency for Frankia sp. (strain EAN1pec)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.133AlaAla: 23.133 ± 0.17	1.118AlaCys: 1.118 ± 0.022	8.976AlaAsp: 8.976 ± 0.077	7.906AlaGlu: 7.906 ± 0.057	3.4AlaPhe: 3.4 ± 0.04	15.554AlaGly: 15.554 ± 0.112	2.718AlaHis: 2.718 ± 0.031	3.793AlaIle: 3.793 ± 0.042	1.816AlaLys: 1.816 ± 0.029	13.515AlaLeu: 13.515 ± 0.095	2.44AlaMet: 2.44 ± 0.032	2.007AlaAsn: 2.007 ± 0.032	7.686AlaPro: 7.686 ± 0.077	3.438AlaGln: 3.438 ± 0.037	11.669AlaArg: 11.669 ± 0.091	6.534AlaSer: 6.534 ± 0.062	7.785AlaThr: 7.785 ± 0.065	12.61AlaVal: 12.61 ± 0.093	1.744AlaTrp: 1.744 ± 0.029	2.255AlaTyr: 2.255 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.067CysAla: 1.067 ± 0.022	0.098CysCys: 0.098 ± 0.007	0.5CysAsp: 0.5 ± 0.013	0.387CysGlu: 0.387 ± 0.012	0.223CysPhe: 0.223 ± 0.009	0.937CysGly: 0.937 ± 0.02	0.208CysHis: 0.208 ± 0.01	0.172CysIle: 0.172 ± 0.009	0.068CysLys: 0.068 ± 0.005	0.781CysLeu: 0.781 ± 0.019	0.117CysMet: 0.117 ± 0.007	0.118CysAsn: 0.118 ± 0.006	0.536CysPro: 0.536 ± 0.017	0.211CysGln: 0.211 ± 0.009	0.701CysArg: 0.701 ± 0.019	0.489CysSer: 0.489 ± 0.015	0.399CysThr: 0.399 ± 0.013	0.653CysVal: 0.653 ± 0.018	0.145CysTrp: 0.145 ± 0.008	0.157CysTyr: 0.157 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.575AspAla: 7.575 ± 0.065	0.409AspCys: 0.409 ± 0.015	3.906AspAsp: 3.906 ± 0.046	3.687AspGlu: 3.687 ± 0.038	1.434AspPhe: 1.434 ± 0.026	6.509AspGly: 6.509 ± 0.063	1.517AspHis: 1.517 ± 0.023	1.959AspIle: 1.959 ± 0.03	0.699AspLys: 0.699 ± 0.019	6.992AspLeu: 6.992 ± 0.069	0.742AspMet: 0.742 ± 0.018	0.917AspAsn: 0.917 ± 0.019	5.069AspPro: 5.069 ± 0.051	1.754AspGln: 1.754 ± 0.031	5.357AspArg: 5.357 ± 0.055	2.531AspSer: 2.531 ± 0.032	3.068AspThr: 3.068 ± 0.043	5.204AspVal: 5.204 ± 0.051	0.88AspTrp: 0.88 ± 0.019	1.08AspTyr: 1.08 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.306GluAla: 6.306 ± 0.055	0.332GluCys: 0.332 ± 0.012	2.267GluAsp: 2.267 ± 0.035	2.421GluGlu: 2.421 ± 0.035	1.4GluPhe: 1.4 ± 0.029	3.267GluGly: 3.267 ± 0.044	1.45GluHis: 1.45 ± 0.026	2.532GluIle: 2.532 ± 0.034	1.026GluLys: 1.026 ± 0.024	6.253GluLeu: 6.253 ± 0.063	0.815GluMet: 0.815 ± 0.017	0.948GluAsn: 0.948 ± 0.018	3.45GluPro: 3.45 ± 0.045	2.012GluGln: 2.012 ± 0.031	5.17GluArg: 5.17 ± 0.05	2.354GluSer: 2.354 ± 0.033	2.772GluThr: 2.772 ± 0.032	4.202GluVal: 4.202 ± 0.05	0.722GluTrp: 0.722 ± 0.017	0.941GluTyr: 0.941 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.574PheAla: 3.574 ± 0.041	0.278PheCys: 0.278 ± 0.01	2.058PheAsp: 2.058 ± 0.034	1.338PheGlu: 1.338 ± 0.027	0.811PhePhe: 0.811 ± 0.021	3.056PheGly: 3.056 ± 0.044	0.587PheHis: 0.587 ± 0.016	0.7PheIle: 0.7 ± 0.019	0.305PheLys: 0.305 ± 0.012	2.434PheLeu: 2.434 ± 0.033	0.336PheMet: 0.336 ± 0.012	0.484PheAsn: 0.484 ± 0.015	1.434PhePro: 1.434 ± 0.024	0.602PheGln: 0.602 ± 0.016	1.834PheArg: 1.834 ± 0.028	1.365PheSer: 1.365 ± 0.027	1.866PheThr: 1.866 ± 0.03	2.345PheVal: 2.345 ± 0.033	0.361PheTrp: 0.361 ± 0.013	0.542PheTyr: 0.542 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.741GlyAla: 11.741 ± 0.093	0.829GlyCys: 0.829 ± 0.021	5.254GlyAsp: 5.254 ± 0.047	4.533GlyGlu: 4.533 ± 0.049	2.759GlyPhe: 2.759 ± 0.038	9.738GlyGly: 9.738 ± 0.115	2.324GlyHis: 2.324 ± 0.033	3.372GlyIle: 3.372 ± 0.042	1.603GlyLys: 1.603 ± 0.028	9.56GlyLeu: 9.56 ± 0.08	1.852GlyMet: 1.852 ± 0.033	1.505GlyAsn: 1.505 ± 0.028	6.471GlyPro: 6.471 ± 0.079	2.881GlyGln: 2.881 ± 0.04	8.993GlyArg: 8.993 ± 0.07	5.826GlySer: 5.826 ± 0.057	6.194GlyThr: 6.194 ± 0.061	7.611GlyVal: 7.611 ± 0.062	1.796GlyTrp: 1.796 ± 0.03	2.141GlyTyr: 2.141 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.625HisAla: 2.625 ± 0.032	0.195HisCys: 0.195 ± 0.01	1.349HisAsp: 1.349 ± 0.026	1.046HisGlu: 1.046 ± 0.02	0.563HisPhe: 0.563 ± 0.016	2.276HisGly: 2.276 ± 0.035	0.707HisHis: 0.707 ± 0.022	0.632HisIle: 0.632 ± 0.017	0.205HisLys: 0.205 ± 0.01	2.412HisLeu: 2.412 ± 0.032	0.288HisMet: 0.288 ± 0.011	0.357HisAsn: 0.357 ± 0.012	1.939HisPro: 1.939 ± 0.033	0.67HisGln: 0.67 ± 0.018	2.279HisArg: 2.279 ± 0.033	1.046HisSer: 1.046 ± 0.019	1.235HisThr: 1.235 ± 0.028	1.667HisVal: 1.667 ± 0.028	0.32HisTrp: 0.32 ± 0.012	0.447HisTyr: 0.447 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.866IleAla: 4.866 ± 0.048	0.304IleCys: 0.304 ± 0.011	2.465IleAsp: 2.465 ± 0.035	2.018IleGlu: 2.018 ± 0.032	0.766IlePhe: 0.766 ± 0.02	3.474IleGly: 3.474 ± 0.044	0.676IleHis: 0.676 ± 0.017	1.092IleIle: 1.092 ± 0.023	0.506IleLys: 0.506 ± 0.018	2.7IleLeu: 2.7 ± 0.038	0.482IleMet: 0.482 ± 0.016	0.695IleAsn: 0.695 ± 0.018	1.978IlePro: 1.978 ± 0.029	0.742IleGln: 0.742 ± 0.018	2.666IleArg: 2.666 ± 0.034	1.927IleSer: 1.927 ± 0.03	2.207IleThr: 2.207 ± 0.037	3.031IleVal: 3.031 ± 0.041	0.4IleTrp: 0.4 ± 0.013	0.592IleTyr: 0.592 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	1.841LysAla: 1.841 ± 0.031	0.079LysCys: 0.079 ± 0.006	0.739LysAsp: 0.739 ± 0.023	0.694LysGlu: 0.694 ± 0.018	0.313LysPhe: 0.313 ± 0.01	1.062LysGly: 1.062 ± 0.024	0.293LysHis: 0.293 ± 0.012	0.798LysIle: 0.798 ± 0.02	0.393LysLys: 0.393 ± 0.013	1.325LysLeu: 1.325 ± 0.026	0.266LysMet: 0.266 ± 0.011	0.316LysAsn: 0.316 ± 0.012	0.924LysPro: 0.924 ± 0.024	0.405LysGln: 0.405 ± 0.012	1.05LysArg: 1.05 ± 0.025	0.764LysSer: 0.764 ± 0.018	0.853LysThr: 0.853 ± 0.021	1.403LysVal: 1.403 ± 0.029	0.155LysTrp: 0.155 ± 0.008	0.29LysTyr: 0.29 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.056LeuAla: 16.056 ± 0.119	0.801LeuCys: 0.801 ± 0.018	6.929LeuAsp: 6.929 ± 0.065	4.38LeuGlu: 4.38 ± 0.045	2.513LeuPhe: 2.513 ± 0.035	9.038LeuGly: 9.038 ± 0.076	2.104LeuHis: 2.104 ± 0.031	3.149LeuIle: 3.149 ± 0.044	1.188LeuLys: 1.188 ± 0.028	10.647LeuLeu: 10.647 ± 0.096	1.332LeuMet: 1.332 ± 0.026	1.528LeuAsn: 1.528 ± 0.028	6.345LeuPro: 6.345 ± 0.055	1.812LeuGln: 1.812 ± 0.029	9.154LeuArg: 9.154 ± 0.082	5.087LeuSer: 5.087 ± 0.047	6.59LeuThr: 6.59 ± 0.058	9.06LeuVal: 9.06 ± 0.072	1.195LeuTrp: 1.195 ± 0.023	1.574LeuTyr: 1.574 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.108MetAla: 2.108 ± 0.029	0.15MetCys: 0.15 ± 0.007	0.815MetAsp: 0.815 ± 0.019	0.599MetGlu: 0.599 ± 0.017	0.462MetPhe: 0.462 ± 0.014	1.127MetGly: 1.127 ± 0.024	0.315MetHis: 0.315 ± 0.012	0.816MetIle: 0.816 ± 0.018	0.289MetLys: 0.289 ± 0.012	1.657MetLeu: 1.657 ± 0.027	0.291MetMet: 0.291 ± 0.011	0.384MetAsn: 0.384 ± 0.013	1.133MetPro: 1.133 ± 0.023	0.347MetGln: 0.347 ± 0.012	1.414MetArg: 1.414 ± 0.026	1.229MetSer: 1.229 ± 0.023	1.474MetThr: 1.474 ± 0.023	1.283MetVal: 1.283 ± 0.023	0.193MetTrp: 0.193 ± 0.008	0.25MetTyr: 0.25 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.1AsnAla: 2.1 ± 0.033	0.136AsnCys: 0.136 ± 0.008	0.863AsnAsp: 0.863 ± 0.021	0.765AsnGlu: 0.765 ± 0.017	0.426AsnPhe: 0.426 ± 0.013	1.771AsnGly: 1.771 ± 0.033	0.391AsnHis: 0.391 ± 0.013	0.683AsnIle: 0.683 ± 0.017	0.244AsnLys: 0.244 ± 0.01	1.724AsnLeu: 1.724 ± 0.031	0.255AsnMet: 0.255 ± 0.01	0.378AsnAsn: 0.378 ± 0.014	1.387AsnPro: 1.387 ± 0.024	0.481AsnGln: 0.481 ± 0.014	1.374AsnArg: 1.374 ± 0.025	0.833AsnSer: 0.833 ± 0.016	1.034AsnThr: 1.034 ± 0.023	1.248AsnVal: 1.248 ± 0.026	0.264AsnTrp: 0.264 ± 0.011	0.342AsnTyr: 0.342 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.785ProAla: 10.785 ± 0.113	0.365ProCys: 0.365 ± 0.013	4.959ProAsp: 4.959 ± 0.05	3.712ProGlu: 3.712 ± 0.041	1.629ProPhe: 1.629 ± 0.025	7.792ProGly: 7.792 ± 0.086	1.337ProHis: 1.337 ± 0.027	1.642ProIle: 1.642 ± 0.029	0.86ProLys: 0.86 ± 0.022	5.083ProLeu: 5.083 ± 0.053	1.032ProMet: 1.032 ± 0.021	1.005ProAsn: 1.005 ± 0.022	4.997ProPro: 4.997 ± 0.08	1.401ProGln: 1.401 ± 0.026	4.925ProArg: 4.925 ± 0.057	3.759ProSer: 3.759 ± 0.046	4.073ProThr: 4.073 ± 0.042	5.717ProVal: 5.717 ± 0.053	0.891ProTrp: 0.891 ± 0.02	1.081ProTyr: 1.081 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.76GlnAla: 3.76 ± 0.041	0.168GlnCys: 0.168 ± 0.009	1.163GlnAsp: 1.163 ± 0.025	1.159GlnGlu: 1.159 ± 0.023	0.694GlnPhe: 0.694 ± 0.018	1.827GlnGly: 1.827 ± 0.033	0.578GlnHis: 0.578 ± 0.015	1.19GlnIle: 1.19 ± 0.022	0.385GlnLys: 0.385 ± 0.013	2.803GlnLeu: 2.803 ± 0.04	0.451GlnMet: 0.451 ± 0.014	0.467GlnAsn: 0.467 ± 0.014	1.896GlnPro: 1.896 ± 0.036	0.978GlnGln: 0.978 ± 0.028	2.451GlnArg: 2.451 ± 0.03	1.125GlnSer: 1.125 ± 0.02	1.363GlnThr: 1.363 ± 0.026	2.496GlnVal: 2.496 ± 0.033	0.399GlnTrp: 0.399 ± 0.012	0.493GlnTyr: 0.493 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	11.222ArgAla: 11.222 ± 0.096	0.715ArgCys: 0.715 ± 0.018	4.785ArgAsp: 4.785 ± 0.048	4.38ArgGlu: 4.38 ± 0.047	2.456ArgPhe: 2.456 ± 0.031	6.651ArgGly: 6.651 ± 0.055	2.282ArgHis: 2.282 ± 0.028	3.303ArgIle: 3.303 ± 0.038	1.169ArgLys: 1.169 ± 0.024	9.336ArgLeu: 9.336 ± 0.076	1.789ArgMet: 1.789 ± 0.028	1.4ArgAsn: 1.4 ± 0.026	6.344ArgPro: 6.344 ± 0.066	2.574ArgGln: 2.574 ± 0.039	9.745ArgArg: 9.745 ± 0.094	4.82ArgSer: 4.82 ± 0.048	5.06ArgThr: 5.06 ± 0.048	6.59ArgVal: 6.59 ± 0.059	1.562ArgTrp: 1.562 ± 0.03	1.835ArgTyr: 1.835 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.099SerAla: 7.099 ± 0.059	0.432SerCys: 0.432 ± 0.015	2.89SerAsp: 2.89 ± 0.037	2.344SerGlu: 2.344 ± 0.03	1.547SerPhe: 1.547 ± 0.024	6.112SerGly: 6.112 ± 0.062	1.01SerHis: 1.01 ± 0.021	1.621SerIle: 1.621 ± 0.025	0.732SerLys: 0.732 ± 0.019	4.676SerLeu: 4.676 ± 0.051	1.064SerMet: 1.064 ± 0.019	0.821SerAsn: 0.821 ± 0.018	3.809SerPro: 3.809 ± 0.038	1.298SerGln: 1.298 ± 0.025	4.361SerArg: 4.361 ± 0.04	3.189SerSer: 3.189 ± 0.048	3.466SerThr: 3.466 ± 0.039	4.31SerVal: 4.31 ± 0.044	0.905SerTrp: 0.905 ± 0.019	1.142SerTyr: 1.142 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.771ThrAla: 8.771 ± 0.07	0.477ThrCys: 0.477 ± 0.014	3.643ThrAsp: 3.643 ± 0.041	2.907ThrGlu: 2.907 ± 0.035	1.603ThrPhe: 1.603 ± 0.024	6.813ThrGly: 6.813 ± 0.069	1.149ThrHis: 1.149 ± 0.022	2.037ThrIle: 2.037 ± 0.036	0.852ThrLys: 0.852 ± 0.021	5.519ThrLeu: 5.519 ± 0.053	1.023ThrMet: 1.023 ± 0.025	1.012ThrAsn: 1.012 ± 0.02	4.243ThrPro: 4.243 ± 0.054	1.28ThrGln: 1.28 ± 0.023	4.481ThrArg: 4.481 ± 0.049	3.553ThrSer: 3.553 ± 0.039	3.96ThrThr: 3.96 ± 0.049	5.678ThrVal: 5.678 ± 0.05	0.881ThrTrp: 0.881 ± 0.019	1.098ThrTyr: 1.098 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	11.655ValAla: 11.655 ± 0.082	0.743ValCys: 0.743 ± 0.018	5.74ValAsp: 5.74 ± 0.054	4.707ValGlu: 4.707 ± 0.055	2.295ValPhe: 2.295 ± 0.031	7.247ValGly: 7.247 ± 0.059	1.822ValHis: 1.822 ± 0.027	3.062ValIle: 3.062 ± 0.043	1.113ValLys: 1.113 ± 0.024	9.279ValLeu: 9.279 ± 0.067	1.28ValMet: 1.28 ± 0.025	1.663ValAsn: 1.663 ± 0.029	5.392ValPro: 5.392 ± 0.055	1.858ValGln: 1.858 ± 0.026	7.102ValArg: 7.102 ± 0.058	4.504ValSer: 4.504 ± 0.051	5.616ValThr: 5.616 ± 0.049	8.323ValVal: 8.323 ± 0.071	1.063ValTrp: 1.063 ± 0.02	1.378ValTyr: 1.378 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.63TrpAla: 1.63 ± 0.025	0.163TrpCys: 0.163 ± 0.008	0.825TrpAsp: 0.825 ± 0.022	0.691TrpGlu: 0.691 ± 0.017	0.428TrpPhe: 0.428 ± 0.014	0.923TrpGly: 0.923 ± 0.019	0.391TrpHis: 0.391 ± 0.013	0.54TrpIle: 0.54 ± 0.015	0.258TrpLys: 0.258 ± 0.011	1.659TrpLeu: 1.659 ± 0.028	0.28TrpMet: 0.28 ± 0.011	0.33TrpAsn: 0.33 ± 0.012	0.884TrpPro: 0.884 ± 0.02	0.46TrpGln: 0.46 ± 0.011	1.498TrpArg: 1.498 ± 0.027	0.953TrpSer: 0.953 ± 0.02	0.976TrpThr: 0.976 ± 0.023	0.997TrpVal: 0.997 ± 0.019	0.333TrpTrp: 0.333 ± 0.013	0.29TrpTyr: 0.29 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.184TyrAla: 2.184 ± 0.029	0.176TyrCys: 0.176 ± 0.008	1.167TyrAsp: 1.167 ± 0.025	0.966TyrGlu: 0.966 ± 0.021	0.591TyrPhe: 0.591 ± 0.016	1.807TyrGly: 1.807 ± 0.031	0.402TyrHis: 0.402 ± 0.013	0.491TyrIle: 0.491 ± 0.017	0.254TyrLys: 0.254 ± 0.011	2.124TyrLeu: 2.124 ± 0.029	0.2TyrMet: 0.2 ± 0.009	0.362TyrAsn: 0.362 ± 0.014	1.131TyrPro: 1.131 ± 0.024	0.641TyrGln: 0.641 ± 0.019	1.791TyrArg: 1.791 ± 0.026	0.938TyrSer: 0.938 ± 0.022	0.986TyrThr: 0.986 ± 0.021	1.415TyrVal: 1.415 ± 0.026	0.302TyrTrp: 0.302 ± 0.011	0.397TyrTyr: 0.397 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7133 proteins (2476290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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