Amino acid dipepetide frequency for Streptococcus phage Javan633

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.948AlaAla: 3.948 ± 1.168
0.175AlaCys: 0.175 ± 0.122
5.001AlaAsp: 5.001 ± 1.0
5.264AlaGlu: 5.264 ± 0.879
3.246AlaPhe: 3.246 ± 0.59
4.65AlaGly: 4.65 ± 1.308
0.439AlaHis: 0.439 ± 0.209
6.668AlaIle: 6.668 ± 1.067
5.615AlaLys: 5.615 ± 0.592
6.756AlaLeu: 6.756 ± 0.758
2.544AlaMet: 2.544 ± 0.692
4.124AlaAsn: 4.124 ± 0.648
1.579AlaPro: 1.579 ± 0.383
3.158AlaGln: 3.158 ± 0.856
2.895AlaArg: 2.895 ± 0.569
4.825AlaSer: 4.825 ± 0.894
5.352AlaThr: 5.352 ± 1.21
4.387AlaVal: 4.387 ± 1.014
0.526AlaTrp: 0.526 ± 0.2
3.071AlaTyr: 3.071 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
0.088CysAla: 0.088 ± 0.079
0.0CysCys: 0.0 ± 0.0
0.175CysAsp: 0.175 ± 0.122
0.79CysGlu: 0.79 ± 0.237
0.088CysPhe: 0.088 ± 0.105
0.614CysGly: 0.614 ± 0.245
0.263CysHis: 0.263 ± 0.132
0.439CysIle: 0.439 ± 0.184
0.702CysLys: 0.702 ± 0.248
0.526CysLeu: 0.526 ± 0.243
0.175CysMet: 0.175 ± 0.104
0.175CysAsn: 0.175 ± 0.124
0.088CysPro: 0.088 ± 0.082
0.0CysGln: 0.0 ± 0.0
0.263CysArg: 0.263 ± 0.163
0.439CysSer: 0.439 ± 0.193
0.088CysThr: 0.088 ± 0.079
0.351CysVal: 0.351 ± 0.171
0.0CysTrp: 0.0 ± 0.0
0.263CysTyr: 0.263 ± 0.161
0.0CysXaa: 0.0 ± 0.0
Asp
5.264AspAla: 5.264 ± 0.652
0.175AspCys: 0.175 ± 0.128
4.65AspAsp: 4.65 ± 0.799
5.79AspGlu: 5.79 ± 0.839
4.474AspPhe: 4.474 ± 0.667
4.65AspGly: 4.65 ± 0.774
0.877AspHis: 0.877 ± 0.256
4.299AspIle: 4.299 ± 0.75
5.352AspLys: 5.352 ± 0.816
4.474AspLeu: 4.474 ± 0.689
2.018AspMet: 2.018 ± 0.433
2.544AspAsn: 2.544 ± 0.668
1.579AspPro: 1.579 ± 0.32
1.579AspGln: 1.579 ± 0.342
2.281AspArg: 2.281 ± 0.464
4.036AspSer: 4.036 ± 0.579
3.773AspThr: 3.773 ± 0.522
3.773AspVal: 3.773 ± 0.683
1.053AspTrp: 1.053 ± 0.304
3.948AspTyr: 3.948 ± 0.542
0.0AspXaa: 0.0 ± 0.0
Glu
5.089GluAla: 5.089 ± 0.804
0.439GluCys: 0.439 ± 0.186
3.86GluAsp: 3.86 ± 0.646
5.966GluGlu: 5.966 ± 1.157
3.509GluPhe: 3.509 ± 0.706
3.246GluGly: 3.246 ± 0.51
1.141GluHis: 1.141 ± 0.304
7.019GluIle: 7.019 ± 1.097
7.37GluLys: 7.37 ± 1.154
7.721GluLeu: 7.721 ± 1.094
3.246GluMet: 3.246 ± 0.699
3.86GluAsn: 3.86 ± 0.597
1.93GluPro: 1.93 ± 0.415
2.808GluGln: 2.808 ± 0.576
4.474GluArg: 4.474 ± 0.96
3.334GluSer: 3.334 ± 0.491
2.895GluThr: 2.895 ± 0.5
5.001GluVal: 5.001 ± 0.751
0.965GluTrp: 0.965 ± 0.275
2.72GluTyr: 2.72 ± 0.542
0.0GluXaa: 0.0 ± 0.0
Phe
2.808PheAla: 2.808 ± 0.569
0.702PheCys: 0.702 ± 0.284
4.036PheAsp: 4.036 ± 0.663
3.86PheGlu: 3.86 ± 0.702
1.141PhePhe: 1.141 ± 0.343
3.334PheGly: 3.334 ± 0.558
0.877PheHis: 0.877 ± 0.288
2.018PheIle: 2.018 ± 0.418
3.422PheLys: 3.422 ± 0.59
2.72PheLeu: 2.72 ± 0.524
1.053PheMet: 1.053 ± 0.31
2.281PheAsn: 2.281 ± 0.323
0.965PhePro: 0.965 ± 0.337
1.316PheGln: 1.316 ± 0.302
1.842PheArg: 1.842 ± 0.334
2.72PheSer: 2.72 ± 0.615
2.369PheThr: 2.369 ± 0.47
1.755PheVal: 1.755 ± 0.351
0.526PheTrp: 0.526 ± 0.214
1.667PheTyr: 1.667 ± 0.407
0.0PheXaa: 0.0 ± 0.0
Gly
4.562GlyAla: 4.562 ± 0.954
0.351GlyCys: 0.351 ± 0.222
3.158GlyAsp: 3.158 ± 0.441
2.895GlyGlu: 2.895 ± 0.503
2.632GlyPhe: 2.632 ± 0.5
4.65GlyGly: 4.65 ± 0.846
1.316GlyHis: 1.316 ± 0.323
6.054GlyIle: 6.054 ± 0.9
6.054GlyLys: 6.054 ± 0.707
5.79GlyLeu: 5.79 ± 0.984
2.106GlyMet: 2.106 ± 0.785
3.246GlyAsn: 3.246 ± 0.657
1.053GlyPro: 1.053 ± 0.238
2.193GlyGln: 2.193 ± 0.457
2.632GlyArg: 2.632 ± 0.502
2.808GlySer: 2.808 ± 0.776
3.597GlyThr: 3.597 ± 0.754
3.685GlyVal: 3.685 ± 0.588
0.439GlyTrp: 0.439 ± 0.153
2.72GlyTyr: 2.72 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
1.053HisAla: 1.053 ± 0.295
0.175HisCys: 0.175 ± 0.113
1.228HisAsp: 1.228 ± 0.433
0.965HisGlu: 0.965 ± 0.299
0.439HisPhe: 0.439 ± 0.183
1.053HisGly: 1.053 ± 0.283
0.175HisHis: 0.175 ± 0.096
1.053HisIle: 1.053 ± 0.332
1.491HisLys: 1.491 ± 0.359
1.316HisLeu: 1.316 ± 0.36
0.175HisMet: 0.175 ± 0.132
0.79HisAsn: 0.79 ± 0.274
0.79HisPro: 0.79 ± 0.246
0.351HisGln: 0.351 ± 0.224
0.263HisArg: 0.263 ± 0.182
0.877HisSer: 0.877 ± 0.265
0.965HisThr: 0.965 ± 0.296
0.439HisVal: 0.439 ± 0.169
0.0HisTrp: 0.0 ± 0.0
0.79HisTyr: 0.79 ± 0.316
0.0HisXaa: 0.0 ± 0.0
Ile
6.317IleAla: 6.317 ± 1.263
0.175IleCys: 0.175 ± 0.131
5.615IleAsp: 5.615 ± 1.067
6.405IleGlu: 6.405 ± 1.037
3.158IlePhe: 3.158 ± 0.478
3.86IleGly: 3.86 ± 0.801
1.228IleHis: 1.228 ± 0.333
4.387IleIle: 4.387 ± 0.62
5.79IleLys: 5.79 ± 0.877
6.229IleLeu: 6.229 ± 0.591
1.141IleMet: 1.141 ± 0.355
4.913IleAsn: 4.913 ± 0.654
1.579IlePro: 1.579 ± 0.359
2.106IleGln: 2.106 ± 0.499
2.895IleArg: 2.895 ± 0.482
5.878IleSer: 5.878 ± 0.743
3.509IleThr: 3.509 ± 0.619
4.124IleVal: 4.124 ± 0.81
0.702IleTrp: 0.702 ± 0.205
3.246IleTyr: 3.246 ± 0.516
0.0IleXaa: 0.0 ± 0.0
Lys
6.317LysAla: 6.317 ± 0.766
0.526LysCys: 0.526 ± 0.242
5.176LysAsp: 5.176 ± 0.819
7.107LysGlu: 7.107 ± 1.195
2.808LysPhe: 2.808 ± 0.452
5.089LysGly: 5.089 ± 0.591
0.702LysHis: 0.702 ± 0.267
6.229LysIle: 6.229 ± 0.834
6.756LysLys: 6.756 ± 1.192
6.756LysLeu: 6.756 ± 0.872
2.193LysMet: 2.193 ± 0.41
4.738LysAsn: 4.738 ± 0.86
3.158LysPro: 3.158 ± 0.442
3.509LysGln: 3.509 ± 0.565
3.158LysArg: 3.158 ± 0.594
3.948LysSer: 3.948 ± 0.902
4.65LysThr: 4.65 ± 0.732
5.264LysVal: 5.264 ± 0.736
1.316LysTrp: 1.316 ± 0.359
2.895LysTyr: 2.895 ± 0.654
0.0LysXaa: 0.0 ± 0.0
Leu
5.615LeuAla: 5.615 ± 0.801
0.614LeuCys: 0.614 ± 0.234
5.79LeuAsp: 5.79 ± 0.593
7.282LeuGlu: 7.282 ± 0.89
2.193LeuPhe: 2.193 ± 0.393
5.44LeuGly: 5.44 ± 0.881
1.053LeuHis: 1.053 ± 0.404
5.527LeuIle: 5.527 ± 0.904
7.984LeuLys: 7.984 ± 1.256
5.264LeuLeu: 5.264 ± 0.935
2.018LeuMet: 2.018 ± 0.359
5.176LeuAsn: 5.176 ± 0.583
2.808LeuPro: 2.808 ± 0.509
2.983LeuGln: 2.983 ± 0.46
3.422LeuArg: 3.422 ± 0.595
5.264LeuSer: 5.264 ± 0.76
6.931LeuThr: 6.931 ± 1.076
4.65LeuVal: 4.65 ± 0.557
0.263LeuTrp: 0.263 ± 0.137
2.808LeuTyr: 2.808 ± 0.554
0.0LeuXaa: 0.0 ± 0.0
Met
3.158MetAla: 3.158 ± 0.73
0.088MetCys: 0.088 ± 0.079
1.842MetAsp: 1.842 ± 0.516
1.316MetGlu: 1.316 ± 0.39
0.965MetPhe: 0.965 ± 0.311
1.579MetGly: 1.579 ± 0.447
0.439MetHis: 0.439 ± 0.186
2.106MetIle: 2.106 ± 0.537
2.193MetLys: 2.193 ± 0.436
1.667MetLeu: 1.667 ± 0.316
0.877MetMet: 0.877 ± 0.323
1.491MetAsn: 1.491 ± 0.389
0.79MetPro: 0.79 ± 0.306
1.667MetGln: 1.667 ± 0.496
1.316MetArg: 1.316 ± 0.359
1.93MetSer: 1.93 ± 0.434
2.193MetThr: 2.193 ± 0.483
1.579MetVal: 1.579 ± 0.469
0.175MetTrp: 0.175 ± 0.12
0.439MetTyr: 0.439 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
4.036AsnAla: 4.036 ± 0.66
0.263AsnCys: 0.263 ± 0.139
3.509AsnAsp: 3.509 ± 0.702
3.334AsnGlu: 3.334 ± 0.654
1.579AsnPhe: 1.579 ± 0.377
4.036AsnGly: 4.036 ± 0.594
0.614AsnHis: 0.614 ± 0.244
4.65AsnIle: 4.65 ± 0.762
3.773AsnLys: 3.773 ± 0.69
4.562AsnLeu: 4.562 ± 0.736
1.491AsnMet: 1.491 ± 0.337
2.544AsnAsn: 2.544 ± 0.66
2.281AsnPro: 2.281 ± 0.52
2.193AsnGln: 2.193 ± 0.569
2.457AsnArg: 2.457 ± 0.578
3.246AsnSer: 3.246 ± 0.399
2.281AsnThr: 2.281 ± 0.477
3.071AsnVal: 3.071 ± 0.464
0.79AsnTrp: 0.79 ± 0.297
2.808AsnTyr: 2.808 ± 0.536
0.0AsnXaa: 0.0 ± 0.0
Pro
1.667ProAla: 1.667 ± 0.364
0.175ProCys: 0.175 ± 0.113
1.491ProAsp: 1.491 ± 0.372
1.667ProGlu: 1.667 ± 0.566
1.228ProPhe: 1.228 ± 0.413
1.228ProGly: 1.228 ± 0.322
0.439ProHis: 0.439 ± 0.21
2.369ProIle: 2.369 ± 0.284
2.281ProLys: 2.281 ± 0.489
1.842ProLeu: 1.842 ± 0.345
0.526ProMet: 0.526 ± 0.184
1.667ProAsn: 1.667 ± 0.393
0.351ProPro: 0.351 ± 0.154
1.404ProGln: 1.404 ± 0.383
1.141ProArg: 1.141 ± 0.423
1.667ProSer: 1.667 ± 0.349
1.755ProThr: 1.755 ± 0.319
2.457ProVal: 2.457 ± 0.463
0.175ProTrp: 0.175 ± 0.107
1.141ProTyr: 1.141 ± 0.422
0.0ProXaa: 0.0 ± 0.0
Gln
3.685GlnAla: 3.685 ± 0.679
0.088GlnCys: 0.088 ± 0.079
1.491GlnAsp: 1.491 ± 0.371
3.422GlnGlu: 3.422 ± 0.61
2.018GlnPhe: 2.018 ± 0.427
2.808GlnGly: 2.808 ± 0.388
0.263GlnHis: 0.263 ± 0.133
3.334GlnIle: 3.334 ± 0.693
2.983GlnLys: 2.983 ± 0.532
3.246GlnLeu: 3.246 ± 0.567
1.93GlnMet: 1.93 ± 0.481
1.667GlnAsn: 1.667 ± 0.505
0.79GlnPro: 0.79 ± 0.232
1.755GlnGln: 1.755 ± 0.71
1.053GlnArg: 1.053 ± 0.301
2.983GlnSer: 2.983 ± 0.738
1.579GlnThr: 1.579 ± 0.384
1.667GlnVal: 1.667 ± 0.381
0.439GlnTrp: 0.439 ± 0.184
1.141GlnTyr: 1.141 ± 0.261
0.0GlnXaa: 0.0 ± 0.0
Arg
2.72ArgAla: 2.72 ± 0.432
0.439ArgCys: 0.439 ± 0.336
3.071ArgAsp: 3.071 ± 0.489
2.72ArgGlu: 2.72 ± 0.586
2.193ArgPhe: 2.193 ± 0.524
1.404ArgGly: 1.404 ± 0.303
0.965ArgHis: 0.965 ± 0.318
3.334ArgIle: 3.334 ± 0.599
3.246ArgLys: 3.246 ± 0.48
5.089ArgLeu: 5.089 ± 0.52
1.141ArgMet: 1.141 ± 0.327
2.457ArgAsn: 2.457 ± 0.546
0.877ArgPro: 0.877 ± 0.299
1.404ArgGln: 1.404 ± 0.325
2.106ArgArg: 2.106 ± 0.528
1.141ArgSer: 1.141 ± 0.354
1.842ArgThr: 1.842 ± 0.396
2.544ArgVal: 2.544 ± 0.531
0.614ArgTrp: 0.614 ± 0.239
1.228ArgTyr: 1.228 ± 0.317
0.0ArgXaa: 0.0 ± 0.0
Ser
5.44SerAla: 5.44 ± 1.137
0.263SerCys: 0.263 ± 0.137
3.948SerAsp: 3.948 ± 0.536
4.036SerGlu: 4.036 ± 0.56
2.457SerPhe: 2.457 ± 0.49
4.65SerGly: 4.65 ± 0.58
0.965SerHis: 0.965 ± 0.387
3.071SerIle: 3.071 ± 0.732
5.176SerLys: 5.176 ± 0.687
4.211SerLeu: 4.211 ± 0.593
1.667SerMet: 1.667 ± 0.523
3.071SerAsn: 3.071 ± 0.541
1.316SerPro: 1.316 ± 0.292
2.808SerGln: 2.808 ± 0.46
2.369SerArg: 2.369 ± 0.424
5.001SerSer: 5.001 ± 0.928
3.509SerThr: 3.509 ± 0.829
4.299SerVal: 4.299 ± 1.049
0.526SerTrp: 0.526 ± 0.184
2.457SerTyr: 2.457 ± 0.491
0.0SerXaa: 0.0 ± 0.0
Thr
4.211ThrAla: 4.211 ± 1.198
0.088ThrCys: 0.088 ± 0.079
3.685ThrAsp: 3.685 ± 0.641
3.685ThrGlu: 3.685 ± 0.597
2.808ThrPhe: 2.808 ± 0.429
3.86ThrGly: 3.86 ± 0.782
0.877ThrHis: 0.877 ± 0.266
4.211ThrIle: 4.211 ± 0.624
3.509ThrLys: 3.509 ± 0.546
5.527ThrLeu: 5.527 ± 0.8
1.053ThrMet: 1.053 ± 0.348
2.281ThrAsn: 2.281 ± 0.526
1.491ThrPro: 1.491 ± 0.414
2.018ThrGln: 2.018 ± 0.441
1.228ThrArg: 1.228 ± 0.361
3.86ThrSer: 3.86 ± 0.81
4.387ThrThr: 4.387 ± 0.835
5.878ThrVal: 5.878 ± 0.917
1.053ThrTrp: 1.053 ± 0.327
2.632ThrTyr: 2.632 ± 0.445
0.0ThrXaa: 0.0 ± 0.0
Val
4.65ValAla: 4.65 ± 1.249
0.263ValCys: 0.263 ± 0.126
4.562ValAsp: 4.562 ± 0.655
5.966ValGlu: 5.966 ± 0.973
2.193ValPhe: 2.193 ± 0.446
3.246ValGly: 3.246 ± 0.853
1.141ValHis: 1.141 ± 0.331
4.299ValIle: 4.299 ± 0.626
4.387ValLys: 4.387 ± 0.616
5.001ValLeu: 5.001 ± 0.659
1.316ValMet: 1.316 ± 0.352
3.773ValAsn: 3.773 ± 0.408
2.457ValPro: 2.457 ± 0.435
2.193ValGln: 2.193 ± 0.605
2.369ValArg: 2.369 ± 0.392
3.948ValSer: 3.948 ± 0.514
3.773ValThr: 3.773 ± 0.514
3.948ValVal: 3.948 ± 0.575
0.526ValTrp: 0.526 ± 0.249
2.632ValTyr: 2.632 ± 0.471
0.0ValXaa: 0.0 ± 0.0
Trp
0.79TrpAla: 0.79 ± 0.297
0.088TrpCys: 0.088 ± 0.082
0.965TrpAsp: 0.965 ± 0.225
0.79TrpGlu: 0.79 ± 0.25
0.614TrpPhe: 0.614 ± 0.2
0.526TrpGly: 0.526 ± 0.24
0.175TrpHis: 0.175 ± 0.123
0.175TrpIle: 0.175 ± 0.132
0.614TrpLys: 0.614 ± 0.245
0.877TrpLeu: 0.877 ± 0.316
0.263TrpMet: 0.263 ± 0.17
0.263TrpAsn: 0.263 ± 0.142
0.263TrpPro: 0.263 ± 0.16
0.79TrpGln: 0.79 ± 0.247
0.439TrpArg: 0.439 ± 0.256
0.965TrpSer: 0.965 ± 0.235
0.614TrpThr: 0.614 ± 0.222
0.965TrpVal: 0.965 ± 0.289
0.088TrpTrp: 0.088 ± 0.081
0.263TrpTyr: 0.263 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.808TyrAla: 2.808 ± 0.48
0.439TyrCys: 0.439 ± 0.183
3.334TyrAsp: 3.334 ± 0.626
3.334TyrGlu: 3.334 ± 0.613
1.755TyrPhe: 1.755 ± 0.5
2.018TyrGly: 2.018 ± 0.469
0.439TyrHis: 0.439 ± 0.169
2.018TyrIle: 2.018 ± 0.466
3.597TyrLys: 3.597 ± 0.606
3.509TyrLeu: 3.509 ± 0.489
0.79TyrMet: 0.79 ± 0.244
2.457TyrAsn: 2.457 ± 0.49
0.526TyrPro: 0.526 ± 0.21
2.106TyrGln: 2.106 ± 0.605
1.93TyrArg: 1.93 ± 0.421
2.369TyrSer: 2.369 ± 0.431
2.281TyrThr: 2.281 ± 0.454
2.808TyrVal: 2.808 ± 0.556
0.351TyrTrp: 0.351 ± 0.176
2.193TyrTyr: 2.193 ± 0.393
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski