Amino acid dipepetide frequency for Candidatus Accumulibacter sp. SK-02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.89AlaAla: 15.89 ± 0.145	1.49AlaCys: 1.49 ± 0.039	6.288AlaAsp: 6.288 ± 0.083	6.957AlaGlu: 6.957 ± 0.089	3.802AlaPhe: 3.802 ± 0.055	10.143AlaGly: 10.143 ± 0.107	2.454AlaHis: 2.454 ± 0.044	5.894AlaIle: 5.894 ± 0.065	3.234AlaLys: 3.234 ± 0.053	13.516AlaLeu: 13.516 ± 0.138	2.923AlaMet: 2.923 ± 0.048	3.05AlaAsn: 3.05 ± 0.049	4.592AlaPro: 4.592 ± 0.065	4.411AlaGln: 4.411 ± 0.065	9.067AlaArg: 9.067 ± 0.097	6.527AlaSer: 6.527 ± 0.079	5.747AlaThr: 5.747 ± 0.076	8.209AlaVal: 8.209 ± 0.084	1.724AlaTrp: 1.724 ± 0.042	2.529AlaTyr: 2.529 ± 0.047	0.002AlaXaa: 0.002 ± 0.001
Cys	1.174CysAla: 1.174 ± 0.032	0.184CysCys: 0.184 ± 0.013	0.595CysAsp: 0.595 ± 0.023	0.642CysGlu: 0.642 ± 0.023	0.406CysPhe: 0.406 ± 0.018	1.094CysGly: 1.094 ± 0.03	0.352CysHis: 0.352 ± 0.018	0.484CysIle: 0.484 ± 0.019	0.285CysLys: 0.285 ± 0.015	1.143CysLeu: 1.143 ± 0.031	0.213CysMet: 0.213 ± 0.012	0.293CysAsn: 0.293 ± 0.019	0.582CysPro: 0.582 ± 0.021	0.375CysGln: 0.375 ± 0.017	0.876CysArg: 0.876 ± 0.026	0.713CysSer: 0.713 ± 0.026	0.54CysThr: 0.54 ± 0.032	0.708CysVal: 0.708 ± 0.026	0.18CysTrp: 0.18 ± 0.011	0.251CysTyr: 0.251 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.116AspAla: 6.116 ± 0.084	0.592AspCys: 0.592 ± 0.022	3.031AspAsp: 3.031 ± 0.055	3.476AspGlu: 3.476 ± 0.06	2.298AspPhe: 2.298 ± 0.037	4.423AspGly: 4.423 ± 0.094	1.247AspHis: 1.247 ± 0.035	2.55AspIle: 2.55 ± 0.055	1.562AspLys: 1.562 ± 0.04	6.02AspLeu: 6.02 ± 0.073	0.955AspMet: 0.955 ± 0.027	1.275AspAsn: 1.275 ± 0.035	3.115AspPro: 3.115 ± 0.052	1.82AspGln: 1.82 ± 0.041	3.797AspArg: 3.797 ± 0.062	2.742AspSer: 2.742 ± 0.054	2.365AspThr: 2.365 ± 0.066	3.325AspVal: 3.325 ± 0.056	0.972AspTrp: 0.972 ± 0.032	1.552AspTyr: 1.552 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.718GluAla: 6.718 ± 0.084	0.503GluCys: 0.503 ± 0.019	2.287GluAsp: 2.287 ± 0.043	2.982GluGlu: 2.982 ± 0.054	1.993GluPhe: 1.993 ± 0.039	3.524GluGly: 3.524 ± 0.059	1.454GluHis: 1.454 ± 0.039	3.469GluIle: 3.469 ± 0.068	2.279GluLys: 2.279 ± 0.049	6.364GluLeu: 6.364 ± 0.073	1.499GluMet: 1.499 ± 0.038	1.622GluAsn: 1.622 ± 0.038	2.288GluPro: 2.288 ± 0.046	2.756GluGln: 2.756 ± 0.05	4.993GluArg: 4.993 ± 0.08	2.938GluSer: 2.938 ± 0.048	2.908GluThr: 2.908 ± 0.049	4.351GluVal: 4.351 ± 0.064	0.859GluTrp: 0.859 ± 0.027	1.264GluTyr: 1.264 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.499PheAla: 4.499 ± 0.065	0.454PheCys: 0.454 ± 0.018	2.458PheAsp: 2.458 ± 0.04	2.067PheGlu: 2.067 ± 0.043	1.528PhePhe: 1.528 ± 0.043	3.226PheGly: 3.226 ± 0.049	0.763PheHis: 0.763 ± 0.025	1.635PheIle: 1.635 ± 0.039	0.959PheLys: 0.959 ± 0.032	3.561PheLeu: 3.561 ± 0.061	0.729PheMet: 0.729 ± 0.027	1.079PheAsn: 1.079 ± 0.03	1.658PhePro: 1.658 ± 0.034	1.062PheGln: 1.062 ± 0.026	2.324PheArg: 2.324 ± 0.041	2.465PheSer: 2.465 ± 0.046	1.724PheThr: 1.724 ± 0.041	2.791PheVal: 2.791 ± 0.051	0.516PheTrp: 0.516 ± 0.02	0.916PheTyr: 0.916 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.327GlyAla: 7.327 ± 0.085	1.053GlyCys: 1.053 ± 0.027	4.155GlyAsp: 4.155 ± 0.084	4.921GlyGlu: 4.921 ± 0.065	3.169GlyPhe: 3.169 ± 0.054	6.251GlyGly: 6.251 ± 0.11	1.936GlyHis: 1.936 ± 0.039	4.363GlyIle: 4.363 ± 0.062	3.394GlyLys: 3.394 ± 0.056	8.351GlyLeu: 8.351 ± 0.089	2.149GlyMet: 2.149 ± 0.048	2.438GlyAsn: 2.438 ± 0.088	2.52GlyPro: 2.52 ± 0.048	3.205GlyGln: 3.205 ± 0.05	5.724GlyArg: 5.724 ± 0.068	4.835GlySer: 4.835 ± 0.08	3.979GlyThr: 3.979 ± 0.079	5.847GlyVal: 5.847 ± 0.08	1.287GlyTrp: 1.287 ± 0.036	2.137GlyTyr: 2.137 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.05	0.345HisCys: 0.345 ± 0.017	1.271HisAsp: 1.271 ± 0.03	1.155HisGlu: 1.155 ± 0.029	1.038HisPhe: 1.038 ± 0.034	1.981HisGly: 1.981 ± 0.043	0.655HisHis: 0.655 ± 0.023	0.878HisIle: 0.878 ± 0.028	0.541HisLys: 0.541 ± 0.02	2.738HisLeu: 2.738 ± 0.052	0.382HisMet: 0.382 ± 0.017	0.512HisAsn: 0.512 ± 0.02	1.58HisPro: 1.58 ± 0.041	0.88HisGln: 0.88 ± 0.026	1.749HisArg: 1.749 ± 0.041	1.202HisSer: 1.202 ± 0.033	0.966HisThr: 0.966 ± 0.029	1.409HisVal: 1.409 ± 0.036	0.396HisTrp: 0.396 ± 0.018	0.742HisTyr: 0.742 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.28IleAla: 6.28 ± 0.081	0.544IleCys: 0.544 ± 0.022	3.51IleAsp: 3.51 ± 0.053	3.62IleGlu: 3.62 ± 0.054	1.559IlePhe: 1.559 ± 0.035	4.522IleGly: 4.522 ± 0.062	1.024IleHis: 1.024 ± 0.029	2.056IleIle: 2.056 ± 0.044	1.545IleLys: 1.545 ± 0.043	4.44IleLeu: 4.44 ± 0.064	0.797IleMet: 0.797 ± 0.026	1.586IleAsn: 1.586 ± 0.035	2.287IlePro: 2.287 ± 0.046	1.381IleGln: 1.381 ± 0.037	3.385IleArg: 3.385 ± 0.055	2.901IleSer: 2.901 ± 0.051	2.392IleThr: 2.392 ± 0.05	3.83IleVal: 3.83 ± 0.063	0.499IleTrp: 0.499 ± 0.021	1.064IleTyr: 1.064 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.429LysAla: 3.429 ± 0.064	0.209LysCys: 0.209 ± 0.012	1.504LysAsp: 1.504 ± 0.042	1.665LysGlu: 1.665 ± 0.045	0.809LysPhe: 0.809 ± 0.027	2.207LysGly: 2.207 ± 0.052	0.702LysHis: 0.702 ± 0.026	1.655LysIle: 1.655 ± 0.041	1.235LysLys: 1.235 ± 0.036	3.412LysLeu: 3.412 ± 0.059	0.782LysMet: 0.782 ± 0.026	0.931LysAsn: 0.931 ± 0.028	1.927LysPro: 1.927 ± 0.044	1.211LysGln: 1.211 ± 0.031	2.354LysArg: 2.354 ± 0.047	1.694LysSer: 1.694 ± 0.043	1.779LysThr: 1.779 ± 0.039	2.258LysVal: 2.258 ± 0.042	0.327LysTrp: 0.327 ± 0.015	0.67LysTyr: 0.67 ± 0.022	0.001LysXaa: 0.001 ± 0.001
Leu	15.564LeuAla: 15.564 ± 0.157	1.247LeuCys: 1.247 ± 0.031	6.231LeuAsp: 6.231 ± 0.075	5.665LeuGlu: 5.665 ± 0.074	3.867LeuPhe: 3.867 ± 0.06	8.339LeuGly: 8.339 ± 0.09	2.403LeuHis: 2.403 ± 0.051	5.24LeuIle: 5.24 ± 0.07	3.426LeuLys: 3.426 ± 0.061	13.764LeuLeu: 13.764 ± 0.168	2.185LeuMet: 2.185 ± 0.044	2.698LeuAsn: 2.698 ± 0.054	6.793LeuPro: 6.793 ± 0.084	4.311LeuGln: 4.311 ± 0.064	8.458LeuArg: 8.458 ± 0.097	6.614LeuSer: 6.614 ± 0.08	5.586LeuThr: 5.586 ± 0.087	7.528LeuVal: 7.528 ± 0.086	1.396LeuTrp: 1.396 ± 0.039	2.239LeuTyr: 2.239 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.756MetAla: 2.756 ± 0.043	0.165MetCys: 0.165 ± 0.011	0.964MetAsp: 0.964 ± 0.029	0.978MetGlu: 0.978 ± 0.027	0.657MetPhe: 0.657 ± 0.025	1.463MetGly: 1.463 ± 0.041	0.533MetHis: 0.533 ± 0.022	1.139MetIle: 1.139 ± 0.029	0.849MetLys: 0.849 ± 0.025	2.567MetLeu: 2.567 ± 0.05	0.532MetMet: 0.532 ± 0.022	0.838MetAsn: 0.838 ± 0.025	1.401MetPro: 1.401 ± 0.03	0.912MetGln: 0.912 ± 0.025	1.601MetArg: 1.601 ± 0.034	1.46MetSer: 1.46 ± 0.035	1.354MetThr: 1.354 ± 0.031	1.549MetVal: 1.549 ± 0.028	0.173MetTrp: 0.173 ± 0.012	0.324MetTyr: 0.324 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	3.089AsnAla: 3.089 ± 0.055	0.327AsnCys: 0.327 ± 0.014	1.497AsnAsp: 1.497 ± 0.058	1.4AsnGlu: 1.4 ± 0.032	0.986AsnPhe: 0.986 ± 0.03	2.245AsnGly: 2.245 ± 0.047	0.604AsnHis: 0.604 ± 0.023	1.277AsnIle: 1.277 ± 0.038	0.79AsnLys: 0.79 ± 0.029	2.9AsnLeu: 2.9 ± 0.049	0.507AsnMet: 0.507 ± 0.019	0.773AsnAsn: 0.773 ± 0.028	1.856AsnPro: 1.856 ± 0.041	0.968AsnGln: 0.968 ± 0.031	1.966AsnArg: 1.966 ± 0.042	1.398AsnSer: 1.398 ± 0.039	1.331AsnThr: 1.331 ± 0.041	1.868AsnVal: 1.868 ± 0.056	0.417AsnTrp: 0.417 ± 0.018	0.68AsnTyr: 0.68 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.488ProAla: 6.488 ± 0.097	0.47ProCys: 0.47 ± 0.018	3.055ProAsp: 3.055 ± 0.049	3.509ProGlu: 3.509 ± 0.054	1.792ProPhe: 1.792 ± 0.037	4.389ProGly: 4.389 ± 0.064	0.958ProHis: 0.958 ± 0.027	2.038ProIle: 2.038 ± 0.042	1.396ProLys: 1.396 ± 0.044	5.463ProLeu: 5.463 ± 0.074	1.171ProMet: 1.171 ± 0.027	1.264ProAsn: 1.264 ± 0.032	2.9ProPro: 2.9 ± 0.052	1.965ProGln: 1.965 ± 0.041	2.976ProArg: 2.976 ± 0.052	2.563ProSer: 2.563 ± 0.043	2.452ProThr: 2.452 ± 0.055	4.063ProVal: 4.063 ± 0.057	0.732ProTrp: 0.732 ± 0.027	1.178ProTyr: 1.178 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.059GlnAla: 5.059 ± 0.067	0.314GlnCys: 0.314 ± 0.015	1.501GlnAsp: 1.501 ± 0.035	2.019GlnGlu: 2.019 ± 0.041	1.256GlnPhe: 1.256 ± 0.031	2.787GlnGly: 2.787 ± 0.05	0.963GlnHis: 0.963 ± 0.029	2.019GlnIle: 2.019 ± 0.045	1.298GlnLys: 1.298 ± 0.031	4.275GlnLeu: 4.275 ± 0.061	0.967GlnMet: 0.967 ± 0.03	0.912GlnAsn: 0.912 ± 0.029	2.089GlnPro: 2.089 ± 0.039	1.964GlnGln: 1.964 ± 0.042	3.44GlnArg: 3.44 ± 0.052	1.968GlnSer: 1.968 ± 0.04	1.892GlnThr: 1.892 ± 0.038	2.924GlnVal: 2.924 ± 0.049	0.54GlnTrp: 0.54 ± 0.018	0.755GlnTyr: 0.755 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.324ArgAla: 7.324 ± 0.077	0.794ArgCys: 0.794 ± 0.026	3.662ArgAsp: 3.662 ± 0.056	4.545ArgGlu: 4.545 ± 0.065	3.081ArgPhe: 3.081 ± 0.053	4.494ArgGly: 4.494 ± 0.067	2.151ArgHis: 2.151 ± 0.05	4.135ArgIle: 4.135 ± 0.053	2.326ArgLys: 2.326 ± 0.047	9.25ArgLeu: 9.25 ± 0.102	1.85ArgMet: 1.85 ± 0.042	2.015ArgAsn: 2.015 ± 0.04	3.495ArgPro: 3.495 ± 0.064	3.82ArgGln: 3.82 ± 0.071	6.066ArgArg: 6.066 ± 0.09	4.063ArgSer: 4.063 ± 0.055	3.226ArgThr: 3.226 ± 0.048	5.13ArgVal: 5.13 ± 0.065	1.153ArgTrp: 1.153 ± 0.03	2.025ArgTyr: 2.025 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.234SerAla: 6.234 ± 0.073	0.606SerCys: 0.606 ± 0.025	2.952SerAsp: 2.952 ± 0.052	3.229SerGlu: 3.229 ± 0.057	2.128SerPhe: 2.128 ± 0.04	5.48SerGly: 5.48 ± 0.078	1.256SerHis: 1.256 ± 0.033	2.758SerIle: 2.758 ± 0.046	1.494SerLys: 1.494 ± 0.035	6.226SerLeu: 6.226 ± 0.073	1.302SerMet: 1.302 ± 0.031	1.456SerAsn: 1.456 ± 0.039	3.1SerPro: 3.1 ± 0.051	1.929SerGln: 1.929 ± 0.045	3.977SerArg: 3.977 ± 0.063	3.456SerSer: 3.456 ± 0.066	2.883SerThr: 2.883 ± 0.062	3.861SerVal: 3.861 ± 0.06	0.785SerTrp: 0.785 ± 0.023	1.335SerTyr: 1.335 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.709ThrAla: 5.709 ± 0.08	0.482ThrCys: 0.482 ± 0.031	2.423ThrAsp: 2.423 ± 0.044	2.264ThrGlu: 2.264 ± 0.044	1.667ThrPhe: 1.667 ± 0.04	4.396ThrGly: 4.396 ± 0.085	1.125ThrHis: 1.125 ± 0.031	2.417ThrIle: 2.417 ± 0.05	1.031ThrLys: 1.031 ± 0.029	6.416ThrLeu: 6.416 ± 0.081	0.987ThrMet: 0.987 ± 0.029	1.102ThrAsn: 1.102 ± 0.035	3.24ThrPro: 3.24 ± 0.053	1.689ThrGln: 1.689 ± 0.035	3.524ThrArg: 3.524 ± 0.05	2.59ThrSer: 2.59 ± 0.061	2.677ThrThr: 2.677 ± 0.083	3.821ThrVal: 3.821 ± 0.069	0.615ThrTrp: 0.615 ± 0.023	1.05ThrTyr: 1.05 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	8.573ValAla: 8.573 ± 0.094	0.825ValCys: 0.825 ± 0.024	4.063ValAsp: 4.063 ± 0.058	4.188ValGlu: 4.188 ± 0.071	2.835ValPhe: 2.835 ± 0.057	5.308ValGly: 5.308 ± 0.072	1.462ValHis: 1.462 ± 0.035	3.746ValIle: 3.746 ± 0.055	2.14ValLys: 2.14 ± 0.041	8.151ValLeu: 8.151 ± 0.083	1.624ValMet: 1.624 ± 0.038	1.984ValAsn: 1.984 ± 0.039	3.408ValPro: 3.408 ± 0.055	2.342ValGln: 2.342 ± 0.044	4.935ValArg: 4.935 ± 0.059	4.253ValSer: 4.253 ± 0.058	3.696ValThr: 3.696 ± 0.056	5.664ValVal: 5.664 ± 0.071	0.958ValTrp: 0.958 ± 0.03	1.495ValTyr: 1.495 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.033	0.18TrpCys: 0.18 ± 0.012	0.561TrpAsp: 0.561 ± 0.021	0.67TrpGlu: 0.67 ± 0.025	0.536TrpPhe: 0.536 ± 0.026	0.837TrpGly: 0.837 ± 0.026	0.397TrpHis: 0.397 ± 0.018	0.668TrpIle: 0.668 ± 0.023	0.422TrpLys: 0.422 ± 0.019	2.189TrpLeu: 2.189 ± 0.056	0.314TrpMet: 0.314 ± 0.017	0.469TrpAsn: 0.469 ± 0.02	0.722TrpPro: 0.722 ± 0.025	0.883TrpGln: 0.883 ± 0.029	1.282TrpArg: 1.282 ± 0.036	0.822TrpSer: 0.822 ± 0.024	0.605TrpThr: 0.605 ± 0.025	0.936TrpVal: 0.936 ± 0.031	0.266TrpTrp: 0.266 ± 0.017	0.318TrpTyr: 0.318 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.492TyrAla: 2.492 ± 0.056	0.305TyrCys: 0.305 ± 0.016	1.224TyrAsp: 1.224 ± 0.028	1.098TyrGlu: 1.098 ± 0.03	1.007TyrPhe: 1.007 ± 0.029	1.932TyrGly: 1.932 ± 0.036	0.6TyrHis: 0.6 ± 0.022	0.801TyrIle: 0.801 ± 0.024	0.556TyrLys: 0.556 ± 0.023	2.809TyrLeu: 2.809 ± 0.043	0.348TyrMet: 0.348 ± 0.017	0.582TyrAsn: 0.582 ± 0.021	1.271TyrPro: 1.271 ± 0.036	1.059TyrGln: 1.059 ± 0.03	2.107TyrArg: 2.107 ± 0.038	1.244TyrSer: 1.244 ± 0.032	1.126TyrThr: 1.126 ± 0.037	1.576TyrVal: 1.576 ± 0.035	0.386TyrTrp: 0.386 ± 0.018	0.633TyrTyr: 0.633 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.01

Statistics based on 3953 proteins (1291537 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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